ES2172923T3 - Procedimiento para la obtencion de 2-halogenindan-1-onas. - Google Patents
Procedimiento para la obtencion de 2-halogenindan-1-onas.Info
- Publication number
- ES2172923T3 ES2172923T3 ES98948831T ES98948831T ES2172923T3 ES 2172923 T3 ES2172923 T3 ES 2172923T3 ES 98948831 T ES98948831 T ES 98948831T ES 98948831 T ES98948831 T ES 98948831T ES 2172923 T3 ES2172923 T3 ES 2172923T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hal
- halogenindan
- procedure
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- -1 acrylic compound Chemical class 0.000 abstract 1
- 239000012954 diazonium Substances 0.000 abstract 1
- 150000001989 diazonium salts Chemical class 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento para la obtención de 2- halogenindan-1-onas de la fórmula en la cual significan X hidrógeno, flúor, cloro, bromo, metilo, triflúormetilo o metoxi, y Hal cloro o bromo, caracterizado porque se transforma una anilina de la fórmula en la cual X tiene el significado indicado en la fórmula (I), a la correspondiente sal de diazonio de la fórmula (III) en la cual X y Hal tienen el significado indicado en la fórmula (I), se hace reaccionar la misma con un compuesto acrílico de la fórmula (IV) en la cual Y significa COR con R = OH, Cl, Br, OC1-C4-alquilo o CN, y se obtiene de esta manera un compuesto de la fórmula (V) en la cual X y Hal tienen los significados en la fórmula (I), e Y los indicados en la fórmula (IV), se transforman entonces compuestos de la fórmula (V) en compuestos de la fórmula (V)¿ en la cual X y Hal tienen los significados indicados en la fórmula (I), e Y¿ significa COOH, COCl o COBr, y se cicla un compuesto de la fórmula (V)¿ para dar una 2- halogenindan-1-ona de la fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19736922A DE19736922A1 (de) | 1997-08-25 | 1997-08-25 | Verfahren zur Herstellung von 2-Halogenindan-1-onen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2172923T3 true ES2172923T3 (es) | 2002-10-01 |
Family
ID=7840075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98948831T Expired - Lifetime ES2172923T3 (es) | 1997-08-25 | 1998-08-13 | Procedimiento para la obtencion de 2-halogenindan-1-onas. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6433228B1 (es) |
| EP (1) | EP1007498B1 (es) |
| JP (1) | JP2001514158A (es) |
| CN (1) | CN1117725C (es) |
| AT (1) | ATE212969T1 (es) |
| AU (1) | AU9531898A (es) |
| CA (1) | CA2301833A1 (es) |
| DE (2) | DE19736922A1 (es) |
| ES (1) | ES2172923T3 (es) |
| HU (1) | HUP0003060A3 (es) |
| IL (1) | IL134171A0 (es) |
| PT (1) | PT1007498E (es) |
| WO (1) | WO1999010306A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293820B (zh) * | 2007-04-27 | 2012-10-10 | 天津药明康德新药开发有限公司 | 5-三氟甲基-1-茚酮的合成方法 |
| JP5566004B2 (ja) * | 2007-11-14 | 2014-08-06 | 株式会社Ｄｎｐファインケミカル宇都宮 | アルコキシインダノン誘導体の製造方法 |
| DE102009002514A1 (de) * | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| WO1996020151A1 (en) * | 1994-12-28 | 1996-07-04 | E.I. Du Pont De Nemours And Company | A process for preparing 5-chloro-2,3-dihydro-1h-inden-1-one |
-
1997
- 1997-08-25 DE DE19736922A patent/DE19736922A1/de not_active Withdrawn
-
1998
- 1998-08-13 ES ES98948831T patent/ES2172923T3/es not_active Expired - Lifetime
- 1998-08-13 CN CN98808503A patent/CN1117725C/zh not_active Expired - Fee Related
- 1998-08-13 DE DE59803029T patent/DE59803029D1/de not_active Expired - Fee Related
- 1998-08-13 WO PCT/EP1998/005141 patent/WO1999010306A1/de not_active Ceased
- 1998-08-13 PT PT98948831T patent/PT1007498E/pt unknown
- 1998-08-13 JP JP2000507638A patent/JP2001514158A/ja active Pending
- 1998-08-13 AT AT98948831T patent/ATE212969T1/de not_active IP Right Cessation
- 1998-08-13 HU HU0003060A patent/HUP0003060A3/hu unknown
- 1998-08-13 CA CA002301833A patent/CA2301833A1/en not_active Abandoned
- 1998-08-13 US US09/486,010 patent/US6433228B1/en not_active Expired - Fee Related
- 1998-08-13 IL IL13417198A patent/IL134171A0/xx unknown
- 1998-08-13 EP EP98948831A patent/EP1007498B1/de not_active Expired - Lifetime
- 1998-08-13 AU AU95318/98A patent/AU9531898A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007498B1 (de) | 2002-02-06 |
| PT1007498E (pt) | 2002-07-31 |
| DE59803029D1 (de) | 2002-03-21 |
| DE19736922A1 (de) | 1999-03-04 |
| IL134171A0 (en) | 2001-04-30 |
| ATE212969T1 (de) | 2002-02-15 |
| CA2301833A1 (en) | 1999-03-04 |
| WO1999010306A8 (de) | 1999-07-01 |
| HUP0003060A3 (en) | 2001-08-28 |
| WO1999010306A1 (de) | 1999-03-04 |
| JP2001514158A (ja) | 2001-09-11 |
| AU9531898A (en) | 1999-03-16 |
| HUP0003060A2 (hu) | 2001-01-29 |
| EP1007498A1 (de) | 2000-06-14 |
| US6433228B1 (en) | 2002-08-13 |
| CN1117725C (zh) | 2003-08-13 |
| CN1268109A (zh) | 2000-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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