ES2173163T3 - Derivados de 2-oxoindolina como antagonistas del receptor de colecistoquinina. - Google Patents

Derivados de 2-oxoindolina como antagonistas del receptor de colecistoquinina.

Info

Publication number
ES2173163T3
ES2173163T3 ES95901596T ES95901596T ES2173163T3 ES 2173163 T3 ES2173163 T3 ES 2173163T3 ES 95901596 T ES95901596 T ES 95901596T ES 95901596 T ES95901596 T ES 95901596T ES 2173163 T3 ES2173163 T3 ES 2173163T3
Authority
ES
Spain
Prior art keywords
group
heterocyclic group
substituted
chem
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95901596T
Other languages
English (en)
Inventor
Koichiro Yamada
Masataka Hikota
Toshiro Shikano
Masaaki Nagasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2173163T3 publication Critical patent/ES2173163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO 2-OXOINDOLINA REPRESENTADO POR LA FORMULA (I): EN DONDE EL ANILLO A REPRESENTA UN ANILLO DE BENCENO SUBSTITUIDO O NO SUBSTITUIDO, R{SUP,1} REPRESENTA HIDROGENO, UN GRUPO CICLOALQUILO, UN GRUPO ARILO, UN GRUPO HETEROCICLICO CONTENIENDO NITROGENO, UN GRUPO HETEROCICLICO CONTENIENDO OXIGENO, UN GRUPO HETEROCICLICO CONTENIENDO AZUFRE, UN GRUPO HETEROCICLICO CONTENIENDO N Y O, UN GRUPO HETEROCICLICO CONTENIENDO N Y S, UN GRUPO ALQUILO BAJO, UN GRUPO CARBOXILO, GRUPO CIANO, UN GRUPO ALQUILTIO, UN GRUPO ALQUILSULFINILO, UN GRUPO ALQUILSULFINILO BAJO, UN GRUPO OXIRANILO O UN GRUPO 2-(BAJO ALQUILTIO)-1HIDROXIETILO,R{SUP,2} REPRESENTA UN GRUPO ARILO, UN GRUPO REPRESENTADO POR LA FORMULA: UN GRUPO HETEROMONOCICLICO CONTENIENDO NITROGENO SUBSTITUIDO O NO SUBSTITUIDO, UN GRUPO HETEROBICICLICO CONTENIENDO NITROGENO SUBSTITUIDO O NO SUBSTITUIDO, UN GRUPO REPRESENTADO POR LA FORMULA: ( EN DONDE N REPRESENTA 1 O 2) UN GRUPO HETEROCICLICO CONTENIENDO OXIGENO, UN GRUPO HETEROCICLICO CONTENIENDO AZUFRE, UN GRUPO HETEROCICLICO CONTENIENDO N Y O O UN GRUPO HETEROCICLICO CONTENIENDO N Y S, R{SUP,3} REPRESENTA UN GRUPO ALQUILO INFERIOR SUBSTITUIDO O NO SUBSTITUIDO, Q REPRESENTA UN BRAZO VINCULANTE SENCILLO O UN GRUPO ALQUILENO INFERIOR, Y REPRESENTA UN BRAZO SOLO, UN GRUPO ALQUILENO INFERIOR O UN GRUPO ALQUENILENO INFERIOR.), Y UNA SAL DE ELLO ACEPTABLE FARMACEUTICAMENTE
ES95901596T 1993-11-26 1994-11-25 Derivados de 2-oxoindolina como antagonistas del receptor de colecistoquinina. Expired - Lifetime ES2173163T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29618393 1993-11-26

Publications (1)

Publication Number Publication Date
ES2173163T3 true ES2173163T3 (es) 2002-10-16

Family

ID=17830244

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95901596T Expired - Lifetime ES2173163T3 (es) 1993-11-26 1994-11-25 Derivados de 2-oxoindolina como antagonistas del receptor de colecistoquinina.

Country Status (11)

Country Link
US (1) US5807883A (es)
EP (1) EP0731091B1 (es)
KR (1) KR100235161B1 (es)
CN (1) CN1069314C (es)
AT (1) ATE211464T1 (es)
CA (1) CA2177147C (es)
DE (1) DE69429584T2 (es)
DK (1) DK0731091T3 (es)
ES (1) ES2173163T3 (es)
PT (1) PT731091E (es)
WO (1) WO1995014668A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI314041B (en) * 2002-10-21 2009-09-01 Sankyo Agro Co Ltd Quinolyl-3-carboxamide compound
WO2004103310A2 (en) * 2003-05-20 2004-12-02 New England Medical Center Hospitals, Inc. Methods and compositions for the treatment of metabolic disorders
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304223A3 (en) * 1987-08-17 1990-10-24 Merck & Co. Inc. Beta-carbolines as cholecy-stokinin and gastrin antagonist
US4992437A (en) * 1987-12-22 1991-02-12 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compounds and their pharmaceutical use
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
EP0572235A3 (en) * 1992-05-28 1994-06-01 Tanabe Seiyaku Co Beta-carboline derivatives with anticholecystoquinine activity
JP2610771B2 (ja) * 1992-05-28 1997-05-14 田辺製薬株式会社 β−カルボリン誘導体
TW281669B (es) * 1993-02-17 1996-07-21 Chugai Pharmaceutical Co Ltd

Also Published As

Publication number Publication date
DE69429584T2 (de) 2002-08-08
WO1995014668A1 (en) 1995-06-01
US5807883A (en) 1998-09-15
KR960705778A (ko) 1996-11-08
CA2177147A1 (en) 1995-06-01
CN1069314C (zh) 2001-08-08
CN1136310A (zh) 1996-11-20
ATE211464T1 (de) 2002-01-15
DE69429584D1 (en) 2002-02-07
CA2177147C (en) 2001-10-09
DK0731091T3 (da) 2002-04-15
EP0731091A4 (en) 1997-09-17
PT731091E (pt) 2002-05-31
EP0731091A1 (en) 1996-09-11
KR100235161B1 (ko) 2001-11-22
EP0731091B1 (en) 2002-01-02

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