ES2173357T3 - Procedimiento para la preparacion de derivados 4,6 - bis (difluorometoxi) - pirimidina. - Google Patents
Procedimiento para la preparacion de derivados 4,6 - bis (difluorometoxi) - pirimidina.Info
- Publication number
- ES2173357T3 ES2173357T3 ES97111345T ES97111345T ES2173357T3 ES 2173357 T3 ES2173357 T3 ES 2173357T3 ES 97111345 T ES97111345 T ES 97111345T ES 97111345 T ES97111345 T ES 97111345T ES 2173357 T3 ES2173357 T3 ES 2173357T3
- Authority
- ES
- Spain
- Prior art keywords
- pyrimidine
- bis
- difluorometoxi
- derivatives
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS 4,6 ENERAL DONDE R ES ALQUILO C SUB,1-4}, FENILO O BENCILO OPCIONALMENTE SUSTITUIDO, PARTIENDO DE LA CORRESPONDIENTE SAL METALICA DE 4,6 DIHIDROXIPIRIMIDINDIALQUILO. EN ESTE EL EDUCTO REACCIONA CON PRESION CON CLORODIFLUROMETANO, EN UN DISOLVENTE DEL GRUPO DE LAS CETONAS, EN PRESENCIA DE UNA BASE, DE UN CATALIZADOR DE TRANSFERENCIA DE FASE Y EN PRESENCIA DE ENTRE 40 Y 100 MOLES DE AGUA POR MOL DE SAL METALICA DE 4,6 DIHIDROOXIPIRIMIDINDIALQUILO DANDO EL PRODUCTO FINAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH184696 | 1996-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2173357T3 true ES2173357T3 (es) | 2002-10-16 |
Family
ID=4219986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97111345T Expired - Lifetime ES2173357T3 (es) | 1996-07-24 | 1997-07-04 | Procedimiento para la preparacion de derivados 4,6 - bis (difluorometoxi) - pirimidina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5856483A (es) |
| EP (1) | EP0820992B1 (es) |
| JP (1) | JPH1087635A (es) |
| AT (1) | ATE214377T1 (es) |
| CA (1) | CA2208734C (es) |
| DE (1) | DE59706593D1 (es) |
| DK (1) | DK0820992T3 (es) |
| ES (1) | ES2173357T3 (es) |
| PT (1) | PT820992E (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002042943A1 (en) * | 2000-11-27 | 2002-05-30 | Airclic, Inc. | Scalable distributed database system and method for linking codes to internet information |
| US7197870B2 (en) * | 2004-10-14 | 2007-04-03 | Hamilton Sundstrand Corporation | Pressure/flow sensing stall recovery for a ram air turbine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692524A (en) * | 1986-05-02 | 1987-09-08 | Ciba-Geigy Corporation | Process for the preparation of pyrimidine derivatives |
| US4900827A (en) * | 1988-12-22 | 1990-02-13 | Ciba-Geigy Corporation | Process for the preparation of pyrimidine derivatives |
| JPH0662588B2 (ja) * | 1989-01-24 | 1994-08-17 | 川口化学工業株式会社 | ４，６―ビス（ジフルオロメトキシ）―２―メチルチオピリミジンの製造法 |
| CA2076690C (en) * | 1991-08-30 | 2003-01-07 | Jean-Paul Roduit | Process for the production of 2-(methylthio)-disodium barbiturate |
-
1997
- 1997-06-26 CA CA002208734A patent/CA2208734C/en not_active Expired - Fee Related
- 1997-07-04 DK DK97111345T patent/DK0820992T3/da active
- 1997-07-04 PT PT97111345T patent/PT820992E/pt unknown
- 1997-07-04 AT AT97111345T patent/ATE214377T1/de not_active IP Right Cessation
- 1997-07-04 DE DE59706593T patent/DE59706593D1/de not_active Expired - Fee Related
- 1997-07-04 ES ES97111345T patent/ES2173357T3/es not_active Expired - Lifetime
- 1997-07-04 EP EP97111345A patent/EP0820992B1/de not_active Expired - Lifetime
- 1997-07-15 US US08/893,228 patent/US5856483A/en not_active Expired - Fee Related
- 1997-07-17 JP JP9192189A patent/JPH1087635A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0820992B1 (de) | 2002-03-13 |
| JPH1087635A (ja) | 1998-04-07 |
| DE59706593D1 (de) | 2002-04-18 |
| PT820992E (pt) | 2002-08-30 |
| CA2208734A1 (en) | 1998-01-24 |
| DK0820992T3 (da) | 2002-05-06 |
| EP0820992A1 (de) | 1998-01-28 |
| CA2208734C (en) | 2006-05-30 |
| US5856483A (en) | 1999-01-05 |
| ATE214377T1 (de) | 2002-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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