ES2173901T3 - Composiciones farmaceuticas que contienen derivados de isoquinolina - Google Patents

Composiciones farmaceuticas que contienen derivados de isoquinolina

Info

Publication number
ES2173901T3
ES2173901T3 ES94120240T ES94120240T ES2173901T3 ES 2173901 T3 ES2173901 T3 ES 2173901T3 ES 94120240 T ES94120240 T ES 94120240T ES 94120240 T ES94120240 T ES 94120240T ES 2173901 T3 ES2173901 T3 ES 2173901T3
Authority
ES
Spain
Prior art keywords
agents
present
compositions containing
pharmaceutical compositions
pdeiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94120240T
Other languages
English (en)
Inventor
Shoichi Imai
Ken-Ichi Mabuchi
Minoru Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2173901T3 publication Critical patent/ES2173901T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCION ES PREVER NUEVAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DERIVADOS DE ISOQUINOLINA QUE EXHIBEN UNA EXCELENTE ACCION INHIBITORIA CONTRA ISOZIMAS DE FOSFODIESTERASA DEL TIPO IV (PDEIV). LOS COMPONENTES ACTIVOS DE LA COMPOSICION FARMACEUTICA DE ACUERDO CON LA PRESENTE INVENCION SON DERIVADOS DE ISOQUINOLINA QUE ESTAN REPRESENTADOS POR LA SIGUIENTE FORMULA GENERAL O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ESTOS. [EN LA FORMULA, R ES HIDROGENO O UN GRUPO ALCOXI]. EL COMPUESTO DE ACUERDO CON LA PRESENTE INVENCION TIENE UNA EXCELENTE ACCION INHIBITORIA QUE ES ALTAMENTE ESPECIFICA A PDEIV. POR LO TANTO, SON MUY UTILES EN PRODUCTOS FARMACEUTICOS TALES COMO AGENTES ANTIDEPRESORES, TRANQUILIZANTES, AGENTES ANTIDEMENCIALES, AGENTES ANTIINFLAMATORIOS, AGENTES ANTIALERGICOS, AGENTES ANTIASMATICOS, AGENTES PROTECTORES DEL HIGADO, AGENTES DIURETICOS, ETC.
ES94120240T 1993-12-28 1994-12-20 Composiciones farmaceuticas que contienen derivados de isoquinolina Expired - Lifetime ES2173901T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP35148193A JP3276762B2 (ja) 1993-12-28 1993-12-28 イソキノリン誘導体を含有する医薬組成物

Publications (1)

Publication Number Publication Date
ES2173901T3 true ES2173901T3 (es) 2002-11-01

Family

ID=18417586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94120240T Expired - Lifetime ES2173901T3 (es) 1993-12-28 1994-12-20 Composiciones farmaceuticas que contienen derivados de isoquinolina

Country Status (6)

Country Link
US (1) US5556862A (es)
EP (1) EP0664127B1 (es)
JP (1) JP3276762B2 (es)
AT (1) ATE213942T1 (es)
DE (1) DE69430047T2 (es)
ES (1) ES2173901T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115661B1 (en) * 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
US6562837B1 (en) * 1998-10-21 2003-05-13 Korea Institute Of Science & Technology Use of tetrahydroisoquinoline compounds for the treatment of septicemia
IL149106A0 (en) * 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
RU2232018C2 (ru) * 2002-10-09 2004-07-10 Открытое акционерное общество "Ирбитский химико-фармацевтический завод" Спазмолитическое лекарственное средство
RU2252024C2 (ru) * 2003-04-22 2005-05-20 Гаврилов Андрей Станиславович Способ получения спазмолитического лекарственного средства
EP2156847A1 (en) * 2008-08-19 2010-02-24 Sanofi-Aventis New combination of active ingredients containing an alpha1-antagonist and a PDE 4 inhibitor.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167246B (es) * 1973-01-25 1975-09-27
HU194179B (en) * 1985-10-03 1988-01-28 Chinoin Gyogyszer Es Vegyeszet Process for production of 1-/3',4'-dietoxi-benzil/-1,6,7-dietoxi-3,4-dihydro-izoquinolinine-teophilin-7-acetate and their new cristallic monohydrate
HU197207B (en) * 1985-12-04 1989-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical comprising 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate or its monohydrate as active ingredient
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
EP0557290A1 (en) * 1990-08-23 1993-09-01 The Children's Medical Center Corporation Treatment of aids dementia, myelopathy, peripheral neuropathy, and vision loss
HUT60926A (en) * 1991-04-12 1992-11-30 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition suitable for reducing or preventing increased thrombocyte-aggregation capability

Also Published As

Publication number Publication date
DE69430047D1 (de) 2002-04-11
ATE213942T1 (de) 2002-03-15
EP0664127B1 (en) 2002-03-06
EP0664127A3 (en) 1999-12-29
US5556862A (en) 1996-09-17
JPH07196509A (ja) 1995-08-01
DE69430047T2 (de) 2002-10-17
JP3276762B2 (ja) 2002-04-22
EP0664127A2 (en) 1995-07-26

Similar Documents

Publication Publication Date Title
ATE226199T1 (de) Antithrombotische organische nitrate
IL109526A0 (en) Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
AU7432100A (en) Compounds, compositions and use
BR0308461A (pt) Derivados de pirimidina
EP1103552A4 (en) BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
CA2023919A1 (en) Light-stabilised ink compositions
DK0659174T3 (da) Derivater af valproinsyre og 2-valproensyreamider samt deres anvendelse som antikonvulsive midler
WO2004103977A3 (en) Process for the preparation of pyrimidine derivatives
CA2398620A1 (en) Pyrazine derivatives, pharmaceutical compositions containing them, and intermediates therefor
DE69004212D1 (de) Hautfärbende Zusammensetzung, die Indol-Derivate und Dihydroxyazeton enthält.
AU2267495A (en) Benzamide derivatives as vasopressin antagonists
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
CA2130344A1 (en) Triazine derivates with uv-filter properties
IL136359A (en) Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same
FI860369A0 (fi) Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
DE69430047D1 (de) Pharmazeutische Zusammensetzungen die Isochinolinderivate enthalten
CA2266759A1 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
CA2168563A1 (en) Benzopyrans and Pharmaceutical Compositions Containing Them
NO973213L (no) Nye 2-(1H)-quinolinforbindelser, fremgangsmåter ved fremstilling av slike samt farmasöytiske sammensetninger omfattende disse
AU3559793A (en) New 3-aminochroman spiro compounds, processes for their preparation and pharmaceutical compositions containing them
AU576926B2 (en) Tetrazole derivatives
CO5080802A1 (es) Nuevos compuestos heterociclicos inhibidores de la fosfodiesteresa iv y su formulacion y uso como productos farmaceuticos
MY103502A (en) Novel compounds
MXPA04001171A (es) Compuestos policiclicos condensados.
CA2127374A1 (fr) Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 664127

Country of ref document: ES