ES2174143T3 - Procedimiento para preparar vesiculas cerradas mediante rehidratacion de vesiculas deshidratadas. - Google Patents

Procedimiento para preparar vesiculas cerradas mediante rehidratacion de vesiculas deshidratadas.

Info

Publication number
ES2174143T3
ES2174143T3 ES97105822T ES97105822T ES2174143T3 ES 2174143 T3 ES2174143 T3 ES 2174143T3 ES 97105822 T ES97105822 T ES 97105822T ES 97105822 T ES97105822 T ES 97105822T ES 2174143 T3 ES2174143 T3 ES 2174143T3
Authority
ES
Spain
Prior art keywords
rehydration
vesicles
dehydrated
closed
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97105822T
Other languages
English (en)
Inventor
Toshiaki Tagawa
Saiko Hosokawa
Kazuhiro Nagaike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2174143T3 publication Critical patent/ES2174143T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO DE PREPARACION DE UNA VESICULA CERRADA MEDIANTE REHIDRATACION DE UNA VESICULA CERRADA UTILIZANDO UNA SOLUCION DE REHIDRATACION, DONDE DICHA VESICULA CERRADA COMPRENDE UNA PARTICULA DE MICELA DESHIDRATADA O BICAPAS DESHIDRATADAS DE MICELA ANFIPATICA, PREFERIBLEMENTE UN LIPOSOMA CARGADO CON UNA SUSTANCIA FARMACEUTICAMENTE ACTIVA. DICHO METODO SE CARACTERIZA PORQUE LA REHIDRATACION SE LLEVA A CABO A UNA TEMPERATURA BAJA, P. EJ. ENTRE 0 (GRADOS) C Y 10 (GRADOS) C. EL CITADO METODO PROPORCIONA UNA VESICULA ESTABLE REHIDRATADA SIN PERDIDA DE LA SUSTANCIA CARGADA EN LA MISMA.
ES97105822T 1996-04-11 1997-04-09 Procedimiento para preparar vesiculas cerradas mediante rehidratacion de vesiculas deshidratadas. Expired - Lifetime ES2174143T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8927796 1996-04-11

Publications (1)

Publication Number Publication Date
ES2174143T3 true ES2174143T3 (es) 2002-11-01

Family

ID=13966241

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97105822T Expired - Lifetime ES2174143T3 (es) 1996-04-11 1997-04-09 Procedimiento para preparar vesiculas cerradas mediante rehidratacion de vesiculas deshidratadas.

Country Status (5)

Country Link
US (2) US6475517B1 (es)
EP (1) EP0800822B1 (es)
CA (1) CA2202103C (es)
DE (1) DE69710803T2 (es)
ES (1) ES2174143T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9813100D0 (en) * 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
GB9926843D0 (en) * 1999-11-12 2000-01-12 Pharmacia & Upjohn Spa Lipid complex of alkycyclines
AU2000255610A1 (en) * 2000-06-28 2002-01-08 Insightec-Image Guided Treatment Ltd. Use of temperature sensitive liposomes
WO2002032398A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for drug delivery
US20040092102A1 (en) * 2002-11-12 2004-05-13 Sachem, Inc. Chemical mechanical polishing composition and method
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
DE602005018043D1 (de) * 2004-05-17 2010-01-14 Tekmira Pharmaceuticals Corp Liposomale formulierungen mit dihydrosphingomyelin und verfahren zu ihrer verwendung
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
EP2386647A1 (de) * 2010-05-10 2011-11-16 Qiagen GmbH Verfahren zur Transfektion einer eurkaryotischen Zelle
EP2604331B1 (en) 2011-12-15 2017-01-25 Gambro Lundia AB Doped membranes
EP2735359B1 (en) 2012-11-26 2017-02-08 Gambro Lundia AB Integrated device for liver support systems
CN119570732A (zh) * 2023-09-05 2025-03-07 中国科学院基础医学与肿瘤研究所(筹) 胞质体囊泡的制备方法及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
EP0437479B1 (en) * 1988-10-05 1994-06-22 Vestar, Inc. Method of making liposomes with improved stability during drying
US5221385A (en) * 1988-12-30 1993-06-22 The Yokohama Rubber Co., Ltd. Pneumatic radial tire with noise suppressing rubber sheet in the bead region
JPH05503078A (ja) 1989-10-27 1993-05-27 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 再構成方法
AU657961B2 (en) * 1991-04-19 1995-03-30 Nexstar Pharmaceuticals, Inc. Pharmaceutical formulation and process
JP3220180B2 (ja) 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US5707608A (en) * 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
GB9609779D0 (en) * 1996-05-10 1996-07-17 Univ Bruxelles Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof

Also Published As

Publication number Publication date
CA2202103A1 (en) 1997-10-11
DE69710803T2 (de) 2002-11-28
US6475517B1 (en) 2002-11-05
DE69710803D1 (de) 2002-04-11
EP0800822A2 (en) 1997-10-15
EP0800822B1 (en) 2002-03-06
US20030022379A1 (en) 2003-01-30
EP0800822A3 (en) 1998-11-04
CA2202103C (en) 2007-01-09
US7048944B2 (en) 2006-05-23

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