ES2174864T3 - Nuevos tratamientos que utilizan derivados de fenetilo. - Google Patents

Nuevos tratamientos que utilizan derivados de fenetilo.

Info

Publication number
ES2174864T3
ES2174864T3 ES94304252T ES94304252T ES2174864T3 ES 2174864 T3 ES2174864 T3 ES 2174864T3 ES 94304252 T ES94304252 T ES 94304252T ES 94304252 T ES94304252 T ES 94304252T ES 2174864 T3 ES2174864 T3 ES 2174864T3
Authority
ES
Spain
Prior art keywords
rent
hydrogen
amino
compound
fenetile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94304252T
Other languages
English (en)
Inventor
Richard Leslie Rudolph
Albert Thomas Derivan
Eric Anthony Muth
Gertrude Virginia Upton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22181084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2174864(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of ES2174864T3 publication Critical patent/ES2174864T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SUMINISTRA EL USO DE UN COMPUESTO PARA PREPARAR UN MEDICAMENTO PARA TRATAR LA OBESIDAD, LAS ENFERMEDADES DE ANSIEDAD GENERALIZADA, LAS ENFERMEDADES DE ESTRES POSTRAUMATICOS, LOS DESORDENES DISFORICOS DE LA ULTIMA FASE LUTEAL (SINDROME PREMESTRUAL), DESORDENES DE FALTA DE ATENCION, CON O SIN HIPERACTIVIDAD, EL SINDROME DE GILLES DE LA TOURETTE, LA BULIMIA NERVIOSA O EL SINDROME DE SHY DRAGER. EL COMPUESTO ES UN AMINO DE HIDROXICICLOALCANOFENOETIL DE LA SIGUIENTE FORMULA ESTRUCTURAL: EN LA CUAL A ES UNA MOLECULA DE LA FORMULA: EN LA QUE LA LINEA PUNTEADA REPRESENTA UNA INSATURACION OPCIONAL; R1 ES HIDROGENO O ALQUIL; R2 ES ALQUIL; R4 ES HIDROGENO, ALQUIL, FORMIL O ALCANOIL; R5 Y R6 SON INDEPENDIENTEMENTE HIDROGENO, HIDROXIL, ALQUIL, ALCOXIDO, ALCANOILOXIDO, CIANO, NITRO, ALQUILMERCAPTO, AMINO, ALQUILAMINO, DIALQUILAMINO, ALCANOILAMINO, HALO, TRIFLUOROMETIL O TOMADAS JUNTAS DIOXIDO DE METILENO; R7 ES HIDROGENO O ALQUIL; Y N ES 0, 1, 2, 3 O 4; ASIMISMO SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DEL COMPUESTO.
ES94304252T 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilo. Expired - Lifetime ES2174864T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8384893A 1993-06-28 1993-06-28

Publications (1)

Publication Number Publication Date
ES2174864T3 true ES2174864T3 (es) 2002-11-16

Family

ID=22181084

Family Applications (3)

Application Number Title Priority Date Filing Date
ES94304252T Expired - Lifetime ES2174864T3 (es) 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilo.
ES06017469T Expired - Lifetime ES2304041T3 (es) 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilamina.
ES01115854T Expired - Lifetime ES2273764T3 (es) 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilamina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES06017469T Expired - Lifetime ES2304041T3 (es) 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilamina.
ES01115854T Expired - Lifetime ES2273764T3 (es) 1993-06-28 1994-06-13 Nuevos tratamientos que utilizan derivados de fenetilamina.

Country Status (16)

Country Link
US (8) US5916923A (es)
EP (3) EP1153603B1 (es)
JP (2) JPH0789851A (es)
KR (1) KR100342762B1 (es)
AT (3) ATE213407T1 (es)
AU (2) AU6592994A (es)
CA (1) CA2126305C (es)
CY (1) CY2315B1 (es)
DE (3) DE69429895T2 (es)
DK (3) DK0639374T3 (es)
ES (3) ES2174864T3 (es)
HK (1) HK1038880B (es)
LV (1) LV12881B (es)
PT (3) PT639374E (es)
PY (1) PY0101636A (es)
SG (1) SG47711A1 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
EP1245228A3 (en) * 1994-02-14 2002-10-09 Wyeth Medicament for the inducement of cognition enhancement
EP1331003B1 (en) * 1996-03-25 2015-08-26 Wyeth LLC Extended release formulation containing venlafaxine
PE57198A1 (es) * 1996-03-25 1998-10-10 American Home Prod Formula de liberacion prolongada
CA2337507A1 (en) * 1998-07-16 2000-01-27 Massachusetts Institute Of Technology Composition for treatment of stress
US6579899B1 (en) 1998-07-16 2003-06-17 Massachusetts Institute Of Technology Composition for treatment of stress
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
US7291646B2 (en) 1999-11-24 2007-11-06 Wyeth Ethers of O-desmethyl venlafaxine
EP1464641B1 (en) * 1999-12-30 2008-05-14 H. Lundbeck A/S 4-Phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine D4 antagonists
US6572890B2 (en) * 2000-01-13 2003-06-03 Osmotica Corp. Osmotic device containing venlafaxine and an anti-psychotic agent
FR2807753B1 (fr) * 2000-04-13 2002-06-07 Adir Nouveaux derives d'heterocycloalkylbenzocyclobutane et d'heteroarylbenzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002250058B2 (en) * 2001-02-12 2007-08-16 Wyeth Llc Novel succinate salt of O-desmethyl-venlafaxine
KR100421508B1 (ko) * 2001-08-07 2004-03-09 김정한 항균 및 항진균 활성을 갖는 신규한 펜에틸아민 유도체와이의 염
UA77234C2 (en) * 2001-12-05 2006-11-15 Wyeth Corp Monohydrate of venlafaxine hydrochloride and methods for its preparation (variants)
CN1630631A (zh) * 2001-12-05 2005-06-22 惠氏公司 新的文拉法星盐酸盐多晶型物及其制备方法
AR039162A1 (es) * 2002-03-28 2005-02-09 Synthon Bv Formulaciones de venlafaxina de liberacion extendida
AR039164A1 (es) 2002-03-28 2005-02-09 Synthon Bv Sales de venlafaxina de baja solubilidad en agua
US20030190352A1 (en) * 2002-03-28 2003-10-09 Synthon Bv Compositions of venlafaxine base
WO2003082804A1 (en) 2002-03-28 2003-10-09 Synthon B.V. Venlafaxine besylate
US20040002500A1 (en) * 2002-06-28 2004-01-01 Fabre Kramer Pharmaceutical, Inc. Methods for treating attention deficit disorder
CA2507685A1 (en) * 2002-11-28 2004-06-10 Themis Laboratories Private Limited Process for manufacturing sustained release microbeads containing venlafaxine hci
US20070077301A1 (en) * 2002-12-23 2007-04-05 Meyer Glenn A Venlafaxine osmotic device formulation
WO2004075902A1 (en) * 2003-02-28 2004-09-10 Amedis Pharmaceuticals Ltd. Use of silicon derivatives of venlafaxine for the treatment or prevention of psoriasis or panic disorder
US20050048118A1 (en) * 2003-07-25 2005-03-03 Joan Cucala Escoi Modified release venlafaxine hydrochloride tablets
US7470435B2 (en) * 2003-11-17 2008-12-30 Andrx Pharmaceuticals, Llc Extended release venlafaxine formulation
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US20050142203A1 (en) * 2003-12-30 2005-06-30 Grant Heinicke Oral dosage formulations of active pharmaceutical ingredients and methods of preparing the same
US20050226923A1 (en) * 2004-04-07 2005-10-13 Gassert Chad M Venlafaxine compositions in the form of microtablets
RU2281788C2 (ru) * 2004-04-19 2006-08-20 Николай Иванович Косенков Способ ультрапарадоксальной психотерапии в лечении психосоматических заболеваний и измененных функциональных состояний человека
RU2276999C2 (ru) * 2004-05-06 2006-05-27 Анатолий Викторович Осницкий Метод коррекции психических состояний и лечения невротических расстройств и патологических зависимостей "интегрально-синергетическая психотерапия"
RU2270036C1 (ru) * 2004-07-14 2006-02-20 Государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии Министерства здравоохранения Российской Федерации" Способ коррекции психоэмоциональных и психосоматических расстройств у детей с термической травмой
US7776358B2 (en) * 2004-07-22 2010-08-17 Synthon Ip Inc. Extended release venlafaxine besylate tablets
RU2273498C1 (ru) * 2004-08-04 2006-04-10 Анатолий Анатолиевич Чумаченко Способ "табу" лечения зависимых форм поведения
RU2272657C1 (ru) * 2005-01-19 2006-03-27 Ирина Анатольевна Нелаева Способ информационно-трансового кодирования в лечении алкоголизма
US20060193911A1 (en) * 2005-02-28 2006-08-31 Penwest Pharmaceuticals Co., Controlled release venlafaxine formulations
CA2604915A1 (en) * 2005-04-22 2006-11-02 Wyeth New therapeutic combinations for the treatment or prevention of depression
TW200718692A (en) * 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
US7368477B2 (en) * 2005-04-22 2008-05-06 Wyeth Benzofuranyl alkanamine derivatives and uses thereof
AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
KR20080056311A (ko) * 2005-10-19 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 고순도1-[2-디메틸아미노-(4-메톡시페닐)에틸)시클로헥산올염산염의 제조 방법
PT1954669E (pt) * 2005-12-01 2015-10-23 Auspex Pharmaceuticals Inc Feniletilaminas substituídas com actividade serotoninérgica e/ou norepinefrinérgica
CA2629609A1 (en) 2005-12-05 2007-06-14 Wyeth Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
EP1998773A2 (en) * 2006-03-24 2008-12-10 Wyeth a Corporation of the State of Delaware New therapeutic combinations for the treatment of depression
US20080027072A1 (en) * 2006-04-20 2008-01-31 Ampla Pharmaceuticals, Inc. Potentiation of MC4 receptor activity
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
AR063376A1 (es) * 2006-10-25 2009-01-28 Wyeth Corp Metabolitos aislados de hidroxi y n-oxido y derivados de o-desmetilvenlafaxina y metodos de tratamiento
SI2125698T1 (sl) 2007-03-15 2016-12-30 Auspex Pharmaceuticals, Inc. Devterirani d9-venlafaksin
US20090048233A1 (en) * 2007-08-16 2009-02-19 Cypress Biosciences, Inc. Enhancing the Tolerability of a Seratonin Antagonist and a NSRI, a SNRI or a RIMA by Using Them in Combination
US20110118304A1 (en) * 2007-11-20 2011-05-19 Neurosearch A/S Method for treating over-eating disorders
KR100965527B1 (ko) * 2008-05-08 2010-06-23 제일약품주식회사 신규(4-(2-(디메틸아미노)-1-(1-하이드록시사이클로헥실)에틸)페녹시)포스페이트 또는 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계질환 예방 및 치료용 조성물
CZ301820B6 (cs) * 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
US20140118944A1 (en) * 2012-10-25 2014-05-01 Inhon International Co. Ltd. Electronic device
KR102132304B1 (ko) 2020-02-17 2020-07-09 박광순 접이식 유아용 비데
RU2741226C1 (ru) * 2020-09-08 2021-01-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РостГМУ Минздрава России) Способ профилактики агрессии лиц с интернет-зависимостью

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017637A (en) * 1973-03-26 1977-04-12 American Home Products Corporation Benzylamine analgesics
US3894051A (en) * 1973-07-05 1975-07-08 Colgate Palmolive Co N-methylenedioxyphenylalkyl)-{62 -(alkyl)-disubstituted phenethylamines
US4435449A (en) * 1981-05-14 1984-03-06 Burroughs Wellcome Co. Treatment of minimal brain dysfunction (MBD)
US4824868A (en) * 1982-09-07 1989-04-25 Ciba-Geigy Corporation Propylamine derivatives useful for the treatment of dementia
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
IE56324B1 (en) * 1982-12-13 1991-06-19 American Home Prod Phenethylamine derivatives and intermediates therefor
AU566673B2 (en) * 1983-09-15 1987-10-29 F. Hoffmann-La Roche Ag Phenethylamine derivatives
US4761501A (en) * 1983-10-26 1988-08-02 American Home Products Corporation Substituted phenylacetamides
US4611078A (en) * 1983-10-26 1986-09-09 American Home Products Corporation Substituted phenylacetonitriles
US4609758A (en) * 1985-05-09 1986-09-02 American Home Products Corporation Phenoxyethylamine derivatives
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
US5135947A (en) * 1987-04-09 1992-08-04 Eli Lilly And Company 1-phenyl-3-naphthalenyloxypropanamines and their use as selective serotonin reuptake inhibitors
JP2938463B2 (ja) * 1987-10-22 1999-08-23 マサチユセツツ・インスチチユート・オブ・テクノロジー 月経前又は後期黄体期症候群の処置
US4996235A (en) * 1987-11-25 1991-02-26 Eli Lilly And Company 3,4-diphenylbutanamines
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
US5114976A (en) * 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US5006525A (en) * 1989-07-24 1991-04-09 Eli Lilly And Company Dopamine agonists method
US5057515A (en) * 1989-07-24 1991-10-15 Eli Lilly And Company Method for agonizing a dopamine receptor
FI910897A7 (fi) * 1990-02-28 1991-08-29 Lilly Co Eli (S)-norfluoksetiiniin liittyviä parannuksia
CA2039103A1 (en) * 1990-03-29 1991-09-30 David Wayne Robertson Improvements in and relating to the selective occupation of serotonin 1c receptors
ATE244563T1 (de) * 1991-11-15 2003-07-15 Sepracor Inc Verwendung von reinem fluoxetin-s(+)-isomer für die herstellung eines medikements gegen migräne
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
TW460478B (en) * 1997-08-15 2001-10-21 Chugai Pharmaceutical Co Ltd Phenethylamine derivatives

Also Published As

Publication number Publication date
EP0639374A2 (en) 1995-02-22
CY2315B1 (en) 2003-11-14
US20020052405A1 (en) 2002-05-02
PY0101636A (es) 2001-12-03
ES2304041T3 (es) 2008-09-01
JPH0789851A (ja) 1995-04-04
AU5831298A (en) 1998-05-21
EP1153603B1 (en) 2006-10-18
PT1738753E (pt) 2008-06-19
EP1738753B1 (en) 2008-04-23
DE69434872T2 (de) 2007-04-05
US20010053799A1 (en) 2001-12-20
ES2273764T3 (es) 2007-05-16
EP1153603A3 (en) 2003-05-21
ATE342715T1 (de) 2006-11-15
US5916923A (en) 1999-06-29
US6465524B2 (en) 2002-10-15
DE69435095T2 (de) 2009-07-02
US20080176950A1 (en) 2008-07-24
DE69435095D1 (de) 2008-06-05
DE69429895T2 (de) 2002-08-29
EP1738753A3 (en) 2007-01-31
PT639374E (pt) 2002-07-31
KR950000139A (ko) 1995-01-03
JP2006117689A (ja) 2006-05-11
EP0639374A3 (en) 1995-08-02
DE69434872D1 (de) 2006-11-30
ATE392893T1 (de) 2008-05-15
US6555586B2 (en) 2003-04-29
AU6592994A (en) 1995-01-05
US20030181517A1 (en) 2003-09-25
DK0639374T3 (da) 2002-05-06
PT1153603E (pt) 2007-01-31
US20040110829A1 (en) 2004-06-10
US6730706B2 (en) 2004-05-04
CA2126305A1 (en) 1994-12-29
EP1738753A2 (en) 2007-01-03
DK1738753T3 (da) 2008-08-11
KR100342762B1 (ko) 2002-11-18
ATE213407T1 (de) 2002-03-15
US6444708B2 (en) 2002-09-03
HK1038880B (en) 2006-12-22
EP1153603A2 (en) 2001-11-14
DK1153603T3 (da) 2006-12-18
LV12881B (en) 2002-11-20
SG47711A1 (en) 1998-04-17
US20010012855A1 (en) 2001-08-09
HK1038880A1 (en) 2002-04-04
DE69429895D1 (de) 2002-03-28
EP0639374B1 (en) 2002-02-20
US6310101B1 (en) 2001-10-30
CA2126305C (en) 2006-10-17

Similar Documents

Publication Publication Date Title
ES2174864T3 (es) Nuevos tratamientos que utilizan derivados de fenetilo.
ECSP941122A (es) Derivados de 5-arilindoles
AR035936A1 (es) Inhibidores de metaloproteinasas de matriz piridinica, derivados de piridina, composiciones farmaceuticas y usos de los mismos en la fabricacion de medicamentos
PA8493701A1 (es) Compuestos para tratar la obesidad
ES2163090T3 (es) Uso de toxina botulinica para tratar la cefalea tensional.
AR025111A1 (es) Metodos y composiciones para tratar trastornos de ansiedad generalizada
EA200300323A1 (ru) ПРОИЗВОДНЫЕ ГУАНИДИНОБЕНЗАМИДА (ВАРИАНТЫ), КОМПОЗИЦИЯ (ВАРИАНТЫ), СПОСОБ ЛЕЧЕНИЯ ОПОСРЕДОВАННОГО mc4-r ЗАБОЛЕВАНИЯ (ВАРИАНТЫ)
MX9301847A (es) Aminas biciclicas-heterociclicas farmaceuticamente activas
ATE316076T1 (de) Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen
AR021893A1 (es) Compuesto de 2-fenil-1-(3,4-dihidroxi-5-nitrofenil)-1-etanona sustituida , su uso para la manufactura de un medicamento en el tratamiento de algunos trastornos del sistema nervioso central y periférico y composiciones farmacéuticas que las contienen
AR013078A1 (es) Derivados de tetrahidroisoquinoleina, una sal de los mismos, procedimiento para su preparacion, composicion farmaceutica que los comprende y el uso de losmismos en la preparacion de un medicamento.
CY1110417T1 (el) Παραγωγα τρυπταμινης και αναλογες ενωσεις και φαρμακευτικες φαρμακοτεχνικες μορφες που περιεχουν αυτα
AR006401A1 (es) Compuestos de pirrolopirrolona, una composicion farmaceutica que los contiene, su uso en la fabricacion de un medicamento y en terapia, procesospara su preparación y compuestos intermediarios para dichos procesos.
UY28377A1 (es) Agentes terapeuticos
AR007088A1 (es) 2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas
AR012723A1 (es) Derivados triptolidos utiles en el tratamiento de enfermedades autoinmunes y usos en la fabricacion de medicamentos
ES2158996T3 (es) Agonistas beta3 adrenergicos selectivos.
ES8506646A1 (es) Un procedimiento para preparar derivados de pirimidona
ES2176321T3 (es) Derivados tetrasustituidos del imidazol, su procedimiento de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
DK0526313T3 (da) Nye ureaderivater, deres fremstilling og terapeutiske anvendelse
DK1037629T3 (da) Kombination af et retinsyremetabolismeblokerende middel og en tocopherol
UY28839A1 (es) Agentes terapeuticos
CO2025018532A2 (es) Un método para el tratamiento de tumores sólidos con un conjugado anticuerpo-fármaco dirigido a claudina 18.2
ES2093246T3 (es) Compuestos de benzazepina terapeuticos.
BR0213317A (pt) Uso de um composto, método de tratar um distúrbio relacionado com gastrina, composição farmacêutica, kit, usos de uma composição, e de um inibidor de bomba de próton, métodos de preparar uma composição farmacêutica e um composto, e, composto

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 639374

Country of ref document: ES