ES2174887T3 - Procedimiento para la produccion de oxiindoles. - Google Patents

Procedimiento para la produccion de oxiindoles.

Info

Publication number
ES2174887T3
ES2174887T3 ES95117344T ES95117344T ES2174887T3 ES 2174887 T3 ES2174887 T3 ES 2174887T3 ES 95117344 T ES95117344 T ES 95117344T ES 95117344 T ES95117344 T ES 95117344T ES 2174887 T3 ES2174887 T3 ES 2174887T3
Authority
ES
Spain
Prior art keywords
acid
salt
reaction
oxindols
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95117344T
Other languages
English (en)
Inventor
Katsuhisa Isogai
Kohei Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KI Chemical Industry Co Ltd
Original Assignee
KI Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KI Chemical Industry Co Ltd filed Critical KI Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2174887T3 publication Critical patent/ES2174887T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN METODO PARA LA PRODUCCION DE OXINDOLAS, QUE SE COMPONE DE LA FASES DE REACCIONAR UN ACIDO 2HALOGENOFENILIACETICO O SU SAL CON AMONIACO EN PRESENCIA DE UN CATALIZADOR DE UNA SAL DE COBRE, Y CALENTAR UNA MEZCLA DEL ACIDO 2-AMINOFENILIACETICO O SU SAL Y OXINDOLAS EN PRESENCIA DE UN CATALIZADOR ACIDO, SOMETER EL ACIDO 2-AMINOFENILACETICO O SU SAL A UNA REACCION DE CIERRE DE NUCLEOS. SEGUN ESTE METODO, ACIDOS 2-HALOGENOFENILACETICOS DE LOS QUE SE PUEDE DISPONER FACILMENTE SE UTILIZAN COMO MATERIA PRIMA INICIADORA PARA PRODUCIR DE FORMA INDUSTRIAL OXINDOLAS DE ELEVADA PUREZA EN ELEVADA CANTIDAD, EN UN SOLO RECIPIENTE SIN NECESIDAD DE LLEVAR A CABO PROCESOS COMPLICADOS. ADEMAS, PUESTO QUE LA AMINACION SE LLEVA A CABO A UNA TEMPERATURA MUY INFERIOR A LA UTILIZADA HABITUALMENTE, LA REDUCCION DEL PH DEL LIQUIDO OBTENIDO PUEDE SUPRIMIRSE. POR LO TANTO, LAS RESTRICCIONES EN LAS ESPECIFICACIONES DEL APARATO DE REACCION, COMO LA PREVENCION DE LA CORROSION Y LA RESISTENCIA A LA PRESION, PUEDEN MITIGARSE.
ES95117344T 1994-11-04 1995-11-03 Procedimiento para la produccion de oxiindoles. Expired - Lifetime ES2174887T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29365494 1994-11-04

Publications (1)

Publication Number Publication Date
ES2174887T3 true ES2174887T3 (es) 2002-11-16

Family

ID=17797521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95117344T Expired - Lifetime ES2174887T3 (es) 1994-11-04 1995-11-03 Procedimiento para la produccion de oxiindoles.

Country Status (5)

Country Link
US (1) US5679799A (es)
EP (1) EP0710648B1 (es)
KR (1) KR100391586B1 (es)
DE (1) DE69526173T2 (es)
ES (1) ES2174887T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6098945A (en) 1998-03-19 2000-08-08 Hubbell Incorporated Mounting bracket and supporting brace
CN102267934B (zh) * 2010-06-02 2013-04-17 金凯美(大连)医药科技有限公司 一种6-甲氧羰基吲哚酮的制备方法
CN104744338A (zh) * 2015-03-31 2015-07-01 天津维智精细化工有限公司 一种6-氯羟吲哚的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6228133A (ja) * 1985-07-30 1987-02-06 Seiatsu:Kk ボルト・ナツト自動締結装置
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
AU658060B2 (en) * 1992-05-13 1995-03-30 Lonza Ltd Process for the preparation of 5-chloroxindole
JP3455315B2 (ja) * 1994-12-15 2003-10-14 株式会社テイエルブイ 蒸気加熱装置

Also Published As

Publication number Publication date
EP0710648B1 (en) 2002-04-03
DE69526173D1 (de) 2002-05-08
DE69526173T2 (de) 2002-09-26
KR100391586B1 (ko) 2004-02-11
KR960017639A (ko) 1996-06-17
EP0710648A1 (en) 1996-05-08
US5679799A (en) 1997-10-21

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