ES2175115T3 - Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio. - Google Patents
Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio.Info
- Publication number
- ES2175115T3 ES2175115T3 ES96925791T ES96925791T ES2175115T3 ES 2175115 T3 ES2175115 T3 ES 2175115T3 ES 96925791 T ES96925791 T ES 96925791T ES 96925791 T ES96925791 T ES 96925791T ES 2175115 T3 ES2175115 T3 ES 2175115T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- nitride
- complex
- myocardium
- understanding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000747 cardiac effect Effects 0.000 title abstract 2
- 150000004767 nitrides Chemical class 0.000 title abstract 2
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 2
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 2
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 2
- 230000010415 tropism Effects 0.000 title abstract 2
- 238000005352 clarification Methods 0.000 title 1
- 210000004165 myocardium Anatomy 0.000 title 1
- 125000001033 ether group Chemical group 0.000 abstract 2
- -1 tetrahydrofurfuryl Chemical group 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION ESTA RELACIONADA CON PRODUCTOS RADIOFARMACEUTICOS DE TROPISMO CARDIACO, QUE COMPRENDEN UN COMPLEJO NITRURO DE UN METAL DE TRANSICION, Y CON ACLARAMIENTO MIOCARDICO RAPIDO. ESTOS COMPLEJOS RESPONDEN A LA FORMULA (I): (M N) L SUP,1) L SUP,2}, DONDE M ES UN METAL DE TRANSICION, POR EJEMPLO SUP,99M}TC, Y L SUP,1} Y L SUP,2} RESPONDEN A LA FORMULA (II), EN LA QUE POR LO MENOS UNO DE LOS DOS R Y R'' REPRESENTA UN GRUPO ALQUIL RAMIFICADO QUE INCLUYE UNA O VARIAS FUNCIONES ETER, UN GRUPO TETRAHIDROFURFURIL O ETER, UN GRUPO TETRAHIDROFURFURIL O DE TIPO DIOXASPIRO O DIALCOXI PIPERIDIN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9508606A FR2736834B1 (fr) | 1995-07-17 | 1995-07-17 | Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2175115T3 true ES2175115T3 (es) | 2002-11-16 |
Family
ID=9481036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96925791T Expired - Lifetime ES2175115T3 (es) | 1995-07-17 | 1996-07-16 | Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6071492A (es) |
| EP (1) | EP0839059B1 (es) |
| JP (1) | JPH11509224A (es) |
| AT (1) | ATE216267T1 (es) |
| AU (1) | AU705807B2 (es) |
| CA (1) | CA2227038A1 (es) |
| DE (1) | DE69620762T2 (es) |
| DK (1) | DK0839059T3 (es) |
| ES (1) | ES2175115T3 (es) |
| FR (1) | FR2736834B1 (es) |
| PT (1) | PT839059E (es) |
| WO (1) | WO1997003705A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1289660B1 (it) * | 1996-10-03 | 1998-10-16 | Sorin Biomedica Diagnost Spa | Procedimento per la riduzione di composti ossigenati del renio o del tecnezio |
| DE19860289C2 (de) * | 1998-12-21 | 2003-11-13 | Schering Ag | Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium |
| FR2797769B1 (fr) * | 1999-09-01 | 2003-07-25 | Cis Bio Int | Produits radiopharmaceutiques et leur procede de preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340899C (en) * | 1988-03-09 | 2000-02-15 | Andre Bardy | Procede de preparation de complexes nitruro 99m tc, 186 re ou 188 re utilisables comme produits radiopharmaceutiques |
| CA2003880C (fr) * | 1988-11-25 | 2002-01-08 | Roberto Pasqualini | Produit radiopharmaceutique ayant notamment un tropisme cardiaque comportant un complexe nitruro d'un metal de transition, et son procede de preparation |
| FR2664166A1 (fr) * | 1990-07-04 | 1992-01-10 | Cis Bio Int | Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques. |
| WO1992010214A1 (en) * | 1990-12-12 | 1992-06-25 | Mallinckrodt Medical, Inc. | Method of radioactive labelling of blood cells and kit therefor |
| FR2679452B1 (fr) * | 1991-07-22 | 1993-11-12 | Cis Bio International | Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation. |
| FR2698272B1 (fr) * | 1992-11-20 | 1994-12-30 | Cis Bio Int | Procédé de marquage cellulaire au moyen de complexes nitruro-bis (dithiocarbamato)Tc-99m et trousse pour la mise en Óoeuvre de ce procédé. |
-
1995
- 1995-07-17 FR FR9508606A patent/FR2736834B1/fr not_active Expired - Fee Related
-
1996
- 1996-07-16 PT PT96925791T patent/PT839059E/pt unknown
- 1996-07-16 AU AU66178/96A patent/AU705807B2/en not_active Ceased
- 1996-07-16 AT AT96925791T patent/ATE216267T1/de not_active IP Right Cessation
- 1996-07-16 ES ES96925791T patent/ES2175115T3/es not_active Expired - Lifetime
- 1996-07-16 WO PCT/FR1996/001103 patent/WO1997003705A1/fr not_active Ceased
- 1996-07-16 CA CA002227038A patent/CA2227038A1/fr not_active Abandoned
- 1996-07-16 DK DK96925791T patent/DK0839059T3/da active
- 1996-07-16 EP EP96925791A patent/EP0839059B1/fr not_active Expired - Lifetime
- 1996-07-16 JP JP9506350A patent/JPH11509224A/ja not_active Ceased
- 1996-07-16 US US08/981,831 patent/US6071492A/en not_active Expired - Fee Related
- 1996-07-16 DE DE69620762T patent/DE69620762T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0839059B1 (fr) | 2002-04-17 |
| US6071492A (en) | 2000-06-06 |
| WO1997003705A1 (fr) | 1997-02-06 |
| DE69620762D1 (de) | 2002-05-23 |
| JPH11509224A (ja) | 1999-08-17 |
| ATE216267T1 (de) | 2002-05-15 |
| FR2736834A1 (fr) | 1997-01-24 |
| DK0839059T3 (da) | 2002-08-12 |
| PT839059E (pt) | 2002-09-30 |
| EP0839059A1 (fr) | 1998-05-06 |
| FR2736834B1 (fr) | 1997-08-29 |
| AU6617896A (en) | 1997-02-18 |
| DE69620762T2 (de) | 2002-11-07 |
| AU705807B2 (en) | 1999-06-03 |
| CA2227038A1 (fr) | 1997-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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