ES2175115T3 - Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio. - Google Patents

Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio.

Info

Publication number
ES2175115T3
ES2175115T3 ES96925791T ES96925791T ES2175115T3 ES 2175115 T3 ES2175115 T3 ES 2175115T3 ES 96925791 T ES96925791 T ES 96925791T ES 96925791 T ES96925791 T ES 96925791T ES 2175115 T3 ES2175115 T3 ES 2175115T3
Authority
ES
Spain
Prior art keywords
pct
nitride
complex
myocardium
understanding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96925791T
Other languages
English (en)
Inventor
Emmanuel Bellande
Jacques Laine
Veronique Comazzi
Roberto Pasqualini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2175115T3 publication Critical patent/ES2175115T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION ESTA RELACIONADA CON PRODUCTOS RADIOFARMACEUTICOS DE TROPISMO CARDIACO, QUE COMPRENDEN UN COMPLEJO NITRURO DE UN METAL DE TRANSICION, Y CON ACLARAMIENTO MIOCARDICO RAPIDO. ESTOS COMPLEJOS RESPONDEN A LA FORMULA (I): (M N) L SUP,1) L SUP,2}, DONDE M ES UN METAL DE TRANSICION, POR EJEMPLO SUP,99M}TC, Y L SUP,1} Y L SUP,2} RESPONDEN A LA FORMULA (II), EN LA QUE POR LO MENOS UNO DE LOS DOS R Y R'' REPRESENTA UN GRUPO ALQUIL RAMIFICADO QUE INCLUYE UNA O VARIAS FUNCIONES ETER, UN GRUPO TETRAHIDROFURFURIL O ETER, UN GRUPO TETRAHIDROFURFURIL O DE TIPO DIOXASPIRO O DIALCOXI PIPERIDIN.
ES96925791T 1995-07-17 1996-07-16 Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio. Expired - Lifetime ES2175115T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508606A FR2736834B1 (fr) 1995-07-17 1995-07-17 Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide

Publications (1)

Publication Number Publication Date
ES2175115T3 true ES2175115T3 (es) 2002-11-16

Family

ID=9481036

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96925791T Expired - Lifetime ES2175115T3 (es) 1995-07-17 1996-07-16 Productos radiofarmaceuticos con tropismo cardiaco, comprendiendo un complejo del tipo de nitruro de un metal de transicion y teniendo un rapido aclaramiento del miocardio.

Country Status (12)

Country Link
US (1) US6071492A (es)
EP (1) EP0839059B1 (es)
JP (1) JPH11509224A (es)
AT (1) ATE216267T1 (es)
AU (1) AU705807B2 (es)
CA (1) CA2227038A1 (es)
DE (1) DE69620762T2 (es)
DK (1) DK0839059T3 (es)
ES (1) ES2175115T3 (es)
FR (1) FR2736834B1 (es)
PT (1) PT839059E (es)
WO (1) WO1997003705A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289660B1 (it) * 1996-10-03 1998-10-16 Sorin Biomedica Diagnost Spa Procedimento per la riduzione di composti ossigenati del renio o del tecnezio
DE19860289C2 (de) * 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
FR2797769B1 (fr) * 1999-09-01 2003-07-25 Cis Bio Int Produits radiopharmaceutiques et leur procede de preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340899C (en) * 1988-03-09 2000-02-15 Andre Bardy Procede de preparation de complexes nitruro 99m tc, 186 re ou 188 re utilisables comme produits radiopharmaceutiques
JP3015970B2 (ja) * 1988-11-25 2000-03-06 セ・イ・エス・ビオ・アンテルナショナル・ソシエテ・アノニム 遷移金属の窒化物錯体を含んでいる、心臓への向性を特に有する放射性医薬製品およびその製造方法
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
AU9172191A (en) * 1990-12-12 1992-07-08 Mallinckrodt Medical, Inc. Method of radioactive labelling of blood cells and kit therefor
FR2679452B1 (fr) * 1991-07-22 1993-11-12 Cis Bio International Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.
FR2698272B1 (fr) * 1992-11-20 1994-12-30 Cis Bio Int Procédé de marquage cellulaire au moyen de complexes nitruro-bis (dithiocarbamato)Tc-99m et trousse pour la mise en Óoeuvre de ce procédé.

Also Published As

Publication number Publication date
FR2736834B1 (fr) 1997-08-29
US6071492A (en) 2000-06-06
PT839059E (pt) 2002-09-30
AU6617896A (en) 1997-02-18
EP0839059B1 (fr) 2002-04-17
WO1997003705A1 (fr) 1997-02-06
DE69620762T2 (de) 2002-11-07
JPH11509224A (ja) 1999-08-17
ATE216267T1 (de) 2002-05-15
EP0839059A1 (fr) 1998-05-06
AU705807B2 (en) 1999-06-03
DK0839059T3 (da) 2002-08-12
DE69620762D1 (de) 2002-05-23
FR2736834A1 (fr) 1997-01-24
CA2227038A1 (fr) 1997-02-06

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