ES2175925T3 - Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1. - Google Patents
Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1.Info
- Publication number
- ES2175925T3 ES2175925T3 ES99900012T ES99900012T ES2175925T3 ES 2175925 T3 ES2175925 T3 ES 2175925T3 ES 99900012 T ES99900012 T ES 99900012T ES 99900012 T ES99900012 T ES 99900012T ES 2175925 T3 ES2175925 T3 ES 2175925T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- heterocyclic
- amino
- independently selected
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
5 1. Un compuesto con la siguiente Fórmula: **fórmula** o las sales farmacéuticamente aceptables del mismo, en la que R 1 y R 2 son independientemente alquilo C1-C4; o R 1 y R 2 , junto con el átomo de carbono al que están unidos forman un grupo mono-, bi-, trio espirocíclico que tiene entre 6 y 13 átomos de carbono, en el que el grupo cíclico está opcionalmente sustituido con uno a cinco sustituyentes independientemente seleccionados entre alquilo C1-C4, alquileno C2-C4, alcoxi C1-C4, hidroxi, oxo, =CH2 y =CH-alquilo C1-C4; R 3 es alquilo C1-C7, alquenilo C2-C5, alquinilo C2-C5, fenil-alquilo-C1-C5, fenilo opcionalmente sustituido con uno a tres sustituyentes independientemente seleccionados entre úor, alquilo C1-C3 y alcoxi C1-C3, o un grupo heteroarilo seleccionado entre furilo, tienilo, pirrolilo y piridilo, en el que dicho grupo heteroarilo está opcionalmente sustituido con uno a tres sustituyentes independientemente seleccionados entre halógeno, alquilo C1-C3 y alcoxiC1-C3, con la condición de que cuando ambos R 1 y R 2 son alquilo C1-C4, entonces R 3 es distinto a alquilo C1-C7, alquenilo C2-C5 y alquinilo C2-C5; R 4 se selecciona entre: 1) hidrógeno, 2) alquilo (C1-C8), cicloalquilo (C3-C7), alquenilo (C2-C8), alquinilo (C2-C8), alquilo (C1-C6)-Z-, alquilo (C1-C6)-Z-alquilo (C1-C6), cicloalquilo (C3-C7)-Z-alquilo (C1-C6), alquenilo (C2-C6)-Z-alquilo (C1-C6) o alquinilo (C2-C6)-Z-alquilo (C1-C6), opcionalmente mono o disustituido donde Z se selecciona entre O, S, SO, SO2, CO,CO2, OCO, NR, CONR y NRCO, donde R es hidrógeno o alquilo (C1-C6) y los sustituyentes a unirse al radical alquilo, alquenilo, alquinilo o cicloalquilo se seleccionan independientemente entre halógeno, hidroxi, carboxi, amino, monoo di-(alquil C1-C4)amino, hidrazino, azido, ureido, amidino y guanidino; o 3) arilo, heterocíclico, arilalquilo (C1-C5), heterocíclico alquilo (C1-C5), heterocíclico-heterocíclico alquilo (C1-C5); arilheterocíclico alquilo (C1-C5); heterocíclico-Z-alquilo (C1-C5), aril-Z-alquilo (C1C5), arilalquilo (C1-C5)-Z-alquilo (C1-C5) oheterocíclico alquilo (C1-C5)-Z-alquilo (C1-C5), opcionalmente mono o disustituido, en el que el grupo arilo se selecciona entre fenilo, naftilo, indanilo, (1,2,3,4)-tetrahidronaftilo, indenilo e isoindenilo; el grupo heterocíclico se selecciona entre piperidino, hexametilenimino, morfolino, tiamorfolino, pirrolidino, pirazolino, pirazolidino, pirazorilo, piperazinilo, furilo, tienilo, oxazolilo, tetrazolilo, tiazolilo, imidazolilo, imidazolinilo, pirazolilo, piridilo, pirimidinilo, pirrolilo, pirrolidinilo, quinolilo, tiofenilo, pirazinilo, piridazinilo, aziridinilo y azetidinilo; en el que Z se selecciona entre O, S, SO, SO2, CO,CO2, OCO, NR, CONR y NRCO, en el que R es hidrógeno o alquilo (C1-C6) y los sustituyentes a los que se une el radical arilo o heterocíclico se seleccionan independientemente entre halógeno, hidroxi, carboxi, alquilo (C1-C4), halo alquilo (C1-C4), alcoxi (C1-C4), alquilo (C1-C4)-CO-, alquil (C1-C4) amino-CO-, fenilo, bencilo, amino, monoo di(alquil C1-C4)amino, hidrazino, azido, ureido, amidino y guanidino; R 5 se selecciona independientemente entre halógeno, alquilo C1-C3, alcoxi C1-C3, alquil(C1-C3) sulfonilo, CF3, carboxi, hidroxi, amino, alquilamino, acilamino, arilcarbonilo, alquilcarbonilo e hidroxialquilo y n es 0,1, 2, 3ó 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB9800069 | 1998-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2175925T3 true ES2175925T3 (es) | 2002-11-16 |
Family
ID=11004651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99900012T Expired - Lifetime ES2175925T3 (es) | 1998-01-19 | 1999-01-08 | Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6423725B1 (es) |
| EP (1) | EP1049689B1 (es) |
| JP (1) | JP3342478B2 (es) |
| CN (1) | CN1288464A (es) |
| AP (1) | AP9901442A0 (es) |
| AR (1) | AR014421A1 (es) |
| AT (1) | ATE219772T1 (es) |
| AU (1) | AU1679099A (es) |
| BG (1) | BG104670A (es) |
| BR (1) | BR9907104A (es) |
| CA (1) | CA2317462C (es) |
| CO (1) | CO4990962A1 (es) |
| DE (1) | DE69901934T2 (es) |
| DK (1) | DK1049689T3 (es) |
| EA (1) | EA200000683A1 (es) |
| ES (1) | ES2175925T3 (es) |
| GT (1) | GT199900008A (es) |
| IL (1) | IL137149A0 (es) |
| IS (1) | IS5539A (es) |
| MA (1) | MA26598A1 (es) |
| NO (1) | NO20003671L (es) |
| OA (1) | OA11445A (es) |
| PA (1) | PA8467101A1 (es) |
| PE (1) | PE20000166A1 (es) |
| PL (1) | PL342046A1 (es) |
| PT (1) | PT1049689E (es) |
| TN (1) | TNSN99006A1 (es) |
| TR (1) | TR200002090T2 (es) |
| WO (1) | WO1999036421A1 (es) |
| ZA (1) | ZA99314B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| EP0997464B1 (en) * | 1998-10-23 | 2005-02-16 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists |
| AU1185300A (en) * | 1998-11-20 | 2000-06-13 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivatives |
| SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| ES2223588T3 (es) | 1999-10-13 | 2005-03-01 | Banyu Pharmaceutical Co., Ltd. | Derivados de imidazolidinona sustituidos. |
| JP2003524634A (ja) | 1999-12-06 | 2003-08-19 | ユーロ−セルティーク，エス．エイ． | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
| JP3989247B2 (ja) | 1999-12-06 | 2007-10-10 | ユーロ−セルティーク エス．エイ． | ノシセプチン受容体親和性を有するトリアゾスピロ化合物 |
| HK1049799A1 (zh) | 1999-12-06 | 2003-05-30 | Euro-Celtique, S.A. | 具有类鸦片受体亲和力的三级氨基化合物 |
| GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
| GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB0005642D0 (en) | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
| US6969712B2 (en) | 2000-11-15 | 2005-11-29 | Banyu Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
| CN1516584A (zh) | 2001-04-18 | 2004-07-28 | ŷ�����ǹɷ�����˾ | 螺吡唑化合物 |
| ATE410165T1 (de) | 2001-04-18 | 2008-10-15 | Euro Celtique Sa | Nociceptin-analoga |
| ATE403431T1 (de) | 2001-04-18 | 2008-08-15 | Euro Celtique Sa | Benzimidazolon-verbindungen |
| EP2033644A1 (en) | 2001-04-18 | 2009-03-11 | Euro-Celtique S.A. | Spiroindene and spiroindane compounds |
| RU2268883C2 (ru) | 2001-04-18 | 2006-01-27 | Эро-Селтик, С.А. | Аналоги ноницептина и фармацевтическая композиция на их основе |
| DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| JP3896309B2 (ja) | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| US7566728B2 (en) | 2002-03-29 | 2009-07-28 | Mitsubishi Tanabe Pharma Corporation | Remedy for sleep disturbance |
| JP2005289816A (ja) * | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
| GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| ATE457299T1 (de) * | 2002-11-12 | 2010-02-15 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ |
| SA04250305B1 (ar) * | 2003-09-25 | 2008-06-02 | سولفاي فارماسوتيكالز بي . في | مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية |
| AR045843A1 (es) * | 2003-10-03 | 2005-11-16 | Solvay Pharm Bv | Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos |
| GB0328243D0 (en) | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
| AR054816A1 (es) * | 2005-07-13 | 2007-07-18 | Banyu Pharma Co Ltd | Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos |
| US7300947B2 (en) * | 2005-07-13 | 2007-11-27 | Banyu Pharmaceutical Co., Ltd. | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives |
| US20090111778A1 (en) * | 2005-11-18 | 2009-04-30 | Richard Apodaca | 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase |
| JP2009525269A (ja) | 2006-01-30 | 2009-07-09 | ユーロ−セルティーク エス．エイ． | カルシウムチャネルブロッカーとしての環状尿素化合物 |
| GB0605786D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| GB0605784D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| CA2666630C (en) * | 2006-10-16 | 2012-01-24 | Mitsubishi Tanabe Pharma Corporation | Agent for prophylaxis or treatment of alcohol dependence or drug dependence |
| EP2397477B1 (en) * | 2007-01-16 | 2014-03-05 | Purdue Pharma LP | Heterocyclic-substituted piperidine compounds and the uses thereof |
| CN101622241B (zh) | 2007-03-01 | 2013-05-22 | 田边三菱制药株式会社 | 苯并咪唑化合物及其医药用途 |
| WO2009027820A2 (en) | 2007-08-31 | 2009-03-05 | Purdue Pharma L.P. | Substituted-quinoxaline-type-piperidine compounds and the uses thereof |
| US8119661B2 (en) | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| JP2013532149A (ja) * | 2010-06-17 | 2013-08-15 | ノバルティス アーゲー | ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体 |
| EP2976077A4 (en) | 2013-03-22 | 2016-11-30 | Scripps Research Inst | SUBSTITUTED BENZIMIDAZOLE AS NOCICEPTIN RECEPTOR MODULATORS |
| BR112019010719A2 (pt) * | 2016-11-28 | 2019-10-01 | Mitsubishi Tanabe Pharma Corp | composição farmacêutica para tratar a dependência de cocaína ou prevenir a recaída da dependência de cocaína, métodos para tratar a dependência e para prevenir a recaída da dependência de cocaína de cocaína, uso de (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo, e, (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo. |
| WO2019141803A1 (en) | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
| CN116496270B (zh) * | 2022-01-27 | 2024-09-24 | 四川大学华西医院 | 一类4-氨基哌啶衍生物及其制备方法和用途 |
| AU2025206007A1 (en) * | 2024-01-05 | 2026-04-16 | Yichang Humanwell Pharmaceutical Co., Ltd. | Cyclohexyl-substituted piperidine derivative, pharmaceutical composition comprising same, and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3161645A (en) | 1962-12-18 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds |
| US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| AT388731B (de) | 1987-12-15 | 1989-08-25 | Gerot Pharmazeutika | Neue derivate von benzimidazol, ihre herstellung und verwendung |
| AU7478396A (en) | 1995-10-31 | 1997-05-22 | Merck & Co., Inc. | Muscarine agonists |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| DE69736776T2 (de) | 1996-04-19 | 2007-01-18 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität |
| CA2291094C (en) | 1997-05-30 | 2008-02-26 | Banyu Pharmaceutical Co., Ltd. | 2-oxoimidazole derivative |
-
1999
- 1999-01-08 PL PL99342046A patent/PL342046A1/xx not_active Application Discontinuation
- 1999-01-08 DE DE69901934T patent/DE69901934T2/de not_active Expired - Fee Related
- 1999-01-08 TR TR2000/02090T patent/TR200002090T2/xx unknown
- 1999-01-08 ES ES99900012T patent/ES2175925T3/es not_active Expired - Lifetime
- 1999-01-08 IL IL13714999A patent/IL137149A0/xx unknown
- 1999-01-08 PT PT99900012T patent/PT1049689E/pt unknown
- 1999-01-08 AU AU16790/99A patent/AU1679099A/en not_active Abandoned
- 1999-01-08 JP JP2000540137A patent/JP3342478B2/ja not_active Expired - Fee Related
- 1999-01-08 CA CA002317462A patent/CA2317462C/en not_active Expired - Fee Related
- 1999-01-08 US US09/403,408 patent/US6423725B1/en not_active Expired - Fee Related
- 1999-01-08 WO PCT/IB1999/000012 patent/WO1999036421A1/en not_active Ceased
- 1999-01-08 BR BR9907104-5A patent/BR9907104A/pt not_active Application Discontinuation
- 1999-01-08 DK DK99900012T patent/DK1049689T3/da active
- 1999-01-08 CN CN99802227A patent/CN1288464A/zh active Pending
- 1999-01-08 EA EA200000683A patent/EA200000683A1/ru unknown
- 1999-01-08 AT AT99900012T patent/ATE219772T1/de not_active IP Right Cessation
- 1999-01-08 EP EP99900012A patent/EP1049689B1/en not_active Expired - Lifetime
- 1999-01-14 AP APAP/P/1999/001442A patent/AP9901442A0/en unknown
- 1999-01-15 PA PA19998467101A patent/PA8467101A1/es unknown
- 1999-01-15 MA MA25432A patent/MA26598A1/fr unknown
- 1999-01-15 TN TNTNSN99006A patent/TNSN99006A1/fr unknown
- 1999-01-18 AR ARP990100184A patent/AR014421A1/es unknown
- 1999-01-18 PE PE1999000041A patent/PE20000166A1/es not_active Application Discontinuation
- 1999-01-18 ZA ZA9900314A patent/ZA99314B/xx unknown
- 1999-01-19 GT GT199900008A patent/GT199900008A/es unknown
- 1999-01-19 CO CO99002592A patent/CO4990962A1/es unknown
-
2000
- 2000-06-16 IS IS5539A patent/IS5539A/is unknown
- 2000-07-07 OA OA1200000203A patent/OA11445A/en unknown
- 2000-07-18 NO NO20003671A patent/NO20003671L/no not_active Application Discontinuation
- 2000-08-07 BG BG104670A patent/BG104670A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69901934T2 (de) | 2002-11-07 |
| AP9901442A0 (en) | 1999-03-31 |
| TNSN99006A1 (fr) | 2005-11-10 |
| OA11445A (en) | 2004-04-30 |
| MA26598A1 (fr) | 2004-12-20 |
| CA2317462C (en) | 2005-09-13 |
| DK1049689T3 (da) | 2002-07-22 |
| PL342046A1 (en) | 2001-05-21 |
| BR9907104A (pt) | 2000-10-24 |
| IL137149A0 (en) | 2001-07-24 |
| PE20000166A1 (es) | 2000-03-07 |
| ATE219772T1 (de) | 2002-07-15 |
| EP1049689B1 (en) | 2002-06-26 |
| NO20003671D0 (no) | 2000-07-18 |
| PA8467101A1 (es) | 2000-09-29 |
| EA200000683A1 (ru) | 2000-12-25 |
| JP3342478B2 (ja) | 2002-11-11 |
| CA2317462A1 (en) | 1999-07-22 |
| CN1288464A (zh) | 2001-03-21 |
| PT1049689E (pt) | 2002-09-30 |
| DE69901934D1 (de) | 2002-08-01 |
| GT199900008A (es) | 2000-07-12 |
| ZA99314B (en) | 2000-07-18 |
| BG104670A (en) | 2001-05-31 |
| NO20003671L (no) | 2000-09-18 |
| WO1999036421A1 (en) | 1999-07-22 |
| TR200002090T2 (tr) | 2000-11-21 |
| CO4990962A1 (es) | 2000-12-26 |
| IS5539A (is) | 2000-06-16 |
| AR014421A1 (es) | 2001-02-28 |
| EP1049689A1 (en) | 2000-11-08 |
| AU1679099A (en) | 1999-08-02 |
| US6423725B1 (en) | 2002-07-23 |
| JP2002509148A (ja) | 2002-03-26 |
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