ES2178382T3 - Compuestos de benciloxiprodigiosina. - Google Patents

Compuestos de benciloxiprodigiosina.

Info

Publication number
ES2178382T3
ES2178382T3 ES99903671T ES99903671T ES2178382T3 ES 2178382 T3 ES2178382 T3 ES 2178382T3 ES 99903671 T ES99903671 T ES 99903671T ES 99903671 T ES99903671 T ES 99903671T ES 2178382 T3 ES2178382 T3 ES 2178382T3
Authority
ES
Spain
Prior art keywords
pyrrole
benciloxiprodigiosine
compounds
alkyl
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99903671T
Other languages
English (en)
Inventor
Alessio Roberto D
Ermes Vanotti
Alberto Bargiotti
Marcellino Tibolla
Mario Ferrari
Anna Maria Isetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of ES2178382T3 publication Critical patent/ES2178382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

El compuesto que es un 2-{(}1H-pirrol-2-ilo{-5{[}{(}2H-pirrol-2- iliden{metil{]}-1H-pirrol de fórmula (I) en el que R1 es hidrógeno o alquilo C{sub,1-5} y R2 es un alquilo C{sub,1-5} o una sal farmacéuticamente aceptable de éste, es útil como agente inmunomodulador y para tratamiento de leucemia/ linfoma de las células T de adulto.
ES99903671T 1998-02-09 1999-01-21 Compuestos de benciloxiprodigiosina. Expired - Lifetime ES2178382T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9802745.1A GB9802745D0 (en) 1998-02-09 1998-02-09 Benzyloxy prodigiosine compounds

Publications (1)

Publication Number Publication Date
ES2178382T3 true ES2178382T3 (es) 2002-12-16

Family

ID=10826711

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99903671T Expired - Lifetime ES2178382T3 (es) 1998-02-09 1999-01-21 Compuestos de benciloxiprodigiosina.

Country Status (8)

Country Link
US (1) US6369096B1 (es)
EP (1) EP0975592B1 (es)
JP (1) JP2001520680A (es)
CA (1) CA2286174A1 (es)
DE (1) DE69901659T2 (es)
ES (1) ES2178382T3 (es)
GB (1) GB9802745D0 (es)
WO (1) WO1999040069A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014987A1 (en) * 2000-01-26 2004-01-22 Gemin X Biotechnologies Inc. Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases
US6407244B1 (en) 2000-01-26 2002-06-18 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
KR20010081515A (ko) * 2000-02-15 2001-08-29 복성해 프로디지오신의 당뇨병 예방 및 치료용 조성물
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
ATE378329T1 (de) 2001-07-18 2007-11-15 Gemin X Biotechnologies Inc Verbindungen vom pyrroltyp, zusammensetzungen und verfahren zur behandlung von krebs, zur behandlung von virenerkrankungen und zur unterdrückung der immunreaktion
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
ES2454551T3 (es) * 2004-12-28 2014-04-10 Gemin X Pharmaceuticals Canada Inc. Compuestos dipirrólicos, composiciones, y métodos para el tratamiento del cáncer o enfermedades virales
KR100674222B1 (ko) * 2005-07-11 2007-01-24 한국생명공학연구원 세라시아 마르세센스 ｂ-1231 ｋｃｔｃ 0386ｂｐ로부터분리한 프로디지오신을 유효성분으로 포함한 급성이식편대숙주병의 예방 및 치료용 조성물
ES2615077B1 (es) * 2015-12-02 2018-03-14 Universidad De Burgos Una nueva familia de compuestos, procedimiento de obtención de los mismos y sus usos en el tratamiento y/o profilaxis de enfermedades

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326284D0 (en) * 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation
GB9603212D0 (en) 1996-02-15 1996-04-17 Pharmacia Spa Process for the preparation of 2,2'-bipyrrolyl-pyrromethane derivatives

Also Published As

Publication number Publication date
DE69901659T2 (de) 2002-12-19
JP2001520680A (ja) 2001-10-30
US20020049248A1 (en) 2002-04-25
WO1999040069A1 (en) 1999-08-12
DE69901659D1 (de) 2002-07-11
CA2286174A1 (en) 1999-08-12
GB9802745D0 (en) 1998-04-08
EP0975592A1 (en) 2000-02-02
EP0975592B1 (en) 2002-06-05
US6369096B1 (en) 2002-04-09

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