ES2179843T3 - Metodo para la abertura selectiva de capilares de tejido cerebral anormal. - Google Patents
Metodo para la abertura selectiva de capilares de tejido cerebral anormal.Info
- Publication number
- ES2179843T3 ES2179843T3 ES94915822T ES94915822T ES2179843T3 ES 2179843 T3 ES2179843 T3 ES 2179843T3 ES 94915822 T ES94915822 T ES 94915822T ES 94915822 T ES94915822 T ES 94915822T ES 2179843 T3 ES2179843 T3 ES 2179843T3
- Authority
- ES
- Spain
- Prior art keywords
- abnormal brain
- brain tissue
- capillaries
- opening
- capables
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002159 abnormal effect Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 210000004556 brain Anatomy 0.000 title 1
- 239000004744 fabric Substances 0.000 title 1
- 210000005013 brain tissue Anatomy 0.000 abstract 4
- 101800004538 Bradykinin Proteins 0.000 abstract 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 2
- 102100035792 Kininogen-1 Human genes 0.000 abstract 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 2
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000004781 brain capillary Anatomy 0.000 abstract 1
- 210000001715 carotid artery Anatomy 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/043—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
METODO PARA ABRIR SELECTIVAMENTE LOS CAPILARES ANORMALES DEL TEJIDO CEREBRAL DE UN MAMIFERO CON EL FIN DE PERMITIR EL PASO SELECTIVO DE AGENTES NEUROFARMACEUTICOS TANTO DE ALTO COMO DE BAJO PESO MOLECULAR AL TEJIDO CEREBRAL ANORMAL. EL METODO UTILIZA LA INFUSION DIRECTA DE BRADIQUININA EN LA ARTERIA CAROTIDA. LA DOSIS DE BRADIQUININA SE MANTIENE A NIVELES QUE PERMITEN LA APERTURA DE LOS CAPILARES DEL CEREBRO ANORMALES SIN ABRIR LOS CAPILARES NORMALES DEL CEREBRO. EL METODO ES UTIL PARA INTRODUCIR UNA AMPLIA VARIEDAD DE AGENTES NEUROFARMACEUTICOS DE FORMA SELECTIVA EN LOS TUMORES CEREBRALES Y OTROS TEJIDOS CEREBRALES ANORMALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/059,623 US5434137A (en) | 1993-05-10 | 1993-05-10 | Method for selective opening of abnormal brain tissue capillaries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2179843T3 true ES2179843T3 (es) | 2003-02-01 |
Family
ID=22024161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94915822T Expired - Lifetime ES2179843T3 (es) | 1993-05-10 | 1994-04-19 | Metodo para la abertura selectiva de capilares de tejido cerebral anormal. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5434137A (es) |
| EP (1) | EP0698203B1 (es) |
| JP (1) | JPH08509978A (es) |
| AT (1) | ATE220329T1 (es) |
| AU (1) | AU679530B2 (es) |
| CA (1) | CA2162055A1 (es) |
| DE (1) | DE69430951T2 (es) |
| ES (1) | ES2179843T3 (es) |
| WO (1) | WO1994027133A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5827819A (en) | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
| WO1998022132A1 (en) * | 1996-11-20 | 1998-05-28 | Yissum Res Dev Co | A method and composition for enabling passage through the blood-brain barrier |
| US6043223A (en) * | 1997-11-12 | 2000-03-28 | The Regents Of The University Of California | Enhanced opening of abnormal brain tissue capillaries |
| US6774119B1 (en) * | 1999-04-26 | 2004-08-10 | Cedars-Sinai Medical Center | Herpes simplex virus type 1 (hsv-1)-derived vector for selectively inhibiting malignant cells and methods for its use to treat cancers and to express desired traits in malignant and non-malignant mammalian cells |
| US20050153940A1 (en) * | 2000-01-26 | 2005-07-14 | Cedars-Sinai Medical Center | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| US7018979B1 (en) | 2000-01-26 | 2006-03-28 | Cedars-Sinai Medical Center | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| AU2002247127A1 (en) * | 2001-02-14 | 2002-08-28 | Duke University | Therapy for cerebral vasospasm |
| US7211561B2 (en) * | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
| US7045543B2 (en) | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20050074506A1 (en) * | 2003-10-02 | 2005-04-07 | Brainsgate Ltd. | Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders |
| US20050095196A1 (en) * | 2003-10-29 | 2005-05-05 | Black Keith L. | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| EP1828111A2 (en) * | 2004-11-12 | 2007-09-05 | Neurochem (International) Limited | Methods and fluorinated compositions for treating amyloid-related diseases |
| CN101103018A (zh) * | 2004-11-16 | 2008-01-09 | 神经化学（国际）有限公司 | 治疗cns和淀粉样蛋白-相关疾病的化合物 |
| BRPI0519243A2 (pt) * | 2004-12-22 | 2009-01-06 | Neurochem Int Ltd | mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide |
| EP1850852A4 (en) * | 2005-02-22 | 2009-11-18 | Cedars Sinai Medical Center | USE OF SILDENAFIL, VARDENAFIL AND OTHER 5-PHOSPHODIESTERASE INHIBITORS TO INCREASE THE PERMEABILITY OF THE ABNORMAL BLOOD-BRAIN DISEASE |
| US20070232556A1 (en) * | 2006-03-31 | 2007-10-04 | Montine Thomas J | Methods and compositions for the treatment of neurological diseases and disorders |
| US20100316626A1 (en) * | 2006-08-11 | 2010-12-16 | The Government Of The United States Of America As Represented By The Secretary | Methods for treatment and diagnosis of psychiatric disorders |
| DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
| WO2008139480A2 (en) * | 2007-05-16 | 2008-11-20 | Yeda Research And Development Co. Ltd. | Assessment of blood-brain barrier disruption |
| US20110178024A1 (en) | 2008-09-29 | 2011-07-21 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
| CA2772023A1 (en) | 2009-08-18 | 2011-02-24 | Ben Gurion University Of The Negev Research And Development Authority | System and method for analyzing imaging data |
| US10275680B2 (en) | 2011-10-19 | 2019-04-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
| US10809323B2 (en) | 2013-04-24 | 2020-10-20 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
| EP3634978A1 (en) | 2017-06-07 | 2020-04-15 | Adrx, Inc. | Tau aggregation inhibitors |
| EP3668886A2 (en) | 2017-08-18 | 2020-06-24 | Adrx, Inc. | Tau aggregation peptide inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112596A (en) * | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| US5268164A (en) * | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
-
1993
- 1993-05-10 US US08/059,623 patent/US5434137A/en not_active Expired - Lifetime
-
1994
- 1994-04-19 AU AU67701/94A patent/AU679530B2/en not_active Ceased
- 1994-04-19 CA CA002162055A patent/CA2162055A1/en not_active Abandoned
- 1994-04-19 EP EP94915822A patent/EP0698203B1/en not_active Expired - Lifetime
- 1994-04-19 WO PCT/US1994/004269 patent/WO1994027133A1/en not_active Ceased
- 1994-04-19 JP JP6525442A patent/JPH08509978A/ja active Pending
- 1994-04-19 DE DE69430951T patent/DE69430951T2/de not_active Expired - Fee Related
- 1994-04-19 AT AT94915822T patent/ATE220329T1/de not_active IP Right Cessation
- 1994-04-19 ES ES94915822T patent/ES2179843T3/es not_active Expired - Lifetime
-
1995
- 1995-02-16 US US08/389,347 patent/US5527778A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69430951D1 (de) | 2002-08-14 |
| EP0698203A4 (en) | 1997-02-26 |
| AU679530B2 (en) | 1997-07-03 |
| EP0698203B1 (en) | 2002-07-10 |
| AU6770194A (en) | 1994-12-12 |
| US5434137A (en) | 1995-07-18 |
| CA2162055A1 (en) | 1994-11-24 |
| US5527778A (en) | 1996-06-18 |
| JPH08509978A (ja) | 1996-10-22 |
| WO1994027133A1 (en) | 1994-11-24 |
| DE69430951T2 (de) | 2003-03-27 |
| EP0698203A1 (en) | 1996-02-28 |
| ATE220329T1 (de) | 2002-07-15 |
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