ES2180438B2 - PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS. - Google Patents

PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS.

Info

Publication number
ES2180438B2
ES2180438B2 ES200101362A ES200101362A ES2180438B2 ES 2180438 B2 ES2180438 B2 ES 2180438B2 ES 200101362 A ES200101362 A ES 200101362A ES 200101362 A ES200101362 A ES 200101362A ES 2180438 B2 ES2180438 B2 ES 2180438B2
Authority
ES
Spain
Prior art keywords
implant
plasma
implants
prosthesis
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200101362A
Other languages
Spanish (es)
Other versions
ES2180438A1 (en
Inventor
Eduardo Anitua Aldecoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200101362A priority Critical patent/ES2180438B2/en
Application filed by Individual filed Critical Individual
Priority to PT01969813T priority patent/PT1352665E/en
Priority to EA200200918A priority patent/EA003728B1/en
Priority to PL358223A priority patent/PL205705B1/en
Priority to PCT/ES2001/000348 priority patent/WO2002024243A1/en
Priority to CZ20022557A priority patent/CZ20022557A3/en
Priority to AT01969813T priority patent/ATE415982T1/en
Priority to DE60136852T priority patent/DE60136852D1/en
Priority to BR0107230-7A priority patent/BR0107230A/en
Priority to CA2402578A priority patent/CA2402578C/en
Priority to AU89950/01A priority patent/AU780317B2/en
Priority to ES01969813T priority patent/ES2317933T3/en
Priority to US10/203,426 priority patent/US7144428B2/en
Priority to ROA200201275A priority patent/RO121370B1/en
Priority to IL14970001A priority patent/IL149700A0/en
Priority to NZ52173701A priority patent/NZ521737A/en
Priority to EP01969813A priority patent/EP1352665B1/en
Priority to JP2002528312A priority patent/JP4430302B2/en
Priority to MXPA02007452A priority patent/MXPA02007452A/en
Priority to KR1020027006260A priority patent/KR100811765B1/en
Priority to CNB018027857A priority patent/CN1221294C/en
Priority to IL149700A priority patent/IL149700A/en
Priority to NO20022364A priority patent/NO326151B1/en
Priority to ARP020102216A priority patent/AR034479A1/en
Priority to MA26750A priority patent/MA25704A1/en
Priority to LT2002095A priority patent/LT5088B/en
Priority to LVP-02-162A priority patent/LV12911B/en
Publication of ES2180438A1 publication Critical patent/ES2180438A1/en
Application granted granted Critical
Publication of ES2180438B2 publication Critical patent/ES2180438B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Prostheses (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

"Disposición para constituir una superficie bioactiva en implantes o prótesis". Una disposición para mejorar la actividad superficial de un implante o prótesis realizado en titanio u otros materiales, consistente en poner en contacto dicha superficie con una capa superficial de un plasma rico en factores de crecimiento."Provision to constitute a bioactive surface in implants or prostheses". An arrangement to improve the surface activity of an implant or prosthesis made of titanium or other materials, consisting in contacting said surface with a surface layer of a plasma rich in growth factors.

Description

Disposición para constituir una superficie bioactiva en implantes o prótesis.Willingness to constitute a surface Bioactive in implants or prostheses.

La invención se refiere a una disposición para bioactivar la superficie de implantes o prótesis realizadas en cualquier tipo de material, por ejemplo titanio, elementos normalmente utilizados en tratamientos terapéuticos.The invention relates to an arrangement for bioactivate the surface of implants or prostheses performed in any type of material, for example titanium, elements normally used in therapeutic treatments.

Dentro de esta técnica, se conoce por la solicitud pendiente ES-P-200002267 un método para proporcionar una mayor actividad a la superficie de implantes o prótesis, en orden a la mejora de su eficacia práctica cuando tal implante o prótesis se coloca en un paciente.Within this technique, it is known by the pending application ES-P-200002267 a method to provide greater activity to the surface of implants or prostheses, in order to improve their practical effectiveness when such an implant or prosthesis is placed in a patient.

También dentro de este contexto, son conocidas, entre otras, por las referencias anteriores US-A-5.876.453 otras prácticas de activación de la superficie de este tipo de unidades.Also within this context, they are known, among others, by the previous references US-A-5,876,453 other practices of surface activation of this type of units.

Asimismo, por la WO-A-00/44314, es conocido un plasma y su método de obtención, a partir de la extracción -in situ- de sangre del propio paciente, para la elaboración de dicho plasma, en orden a la obtención de mayor rapidez en la regeneración ósea cuando dicho plasma es utilizado.Also, by WO-A-00/44314, a plasma and its method of obtaining it are known, from the extraction - in situ - of blood from the patient himself, for the preparation of said plasma, in order to obtain faster in bone regeneration when said plasma is used.

Cada uno de los dos componentes. tanto implante activado superficialmente como plasma, procuran de forma positiva una aceleración en la actividad de la regeneración ósea cuando cada uno de ellos, separadamente, son utilizados en la práctica.Each of the two components. both implant superficially activated as plasma, they procure positively an acceleration in the activity of bone regeneration when each one of them, separately, are used in practice.

Ambas técnicas tienen demostrada su eficacia a través de las innumerables aplicaciones prácticas llevadas a cabo, de las cuales se ha destacado que con ellas se disminuye notablemente el tiempo necesario habitualmente para la regeneración ósea, cuando se aplican separadamente.Both techniques have proven effective at through the innumerable practical applications carried out, of which it has been highlighted that with them it decreases notably the time usually required for regeneration bone, when applied separately.

De forma sorprendente, se ha encontrado que ambas técnicas pueden llegar a ser complementarias y no se presentan inconvenientes para tal complementariedad, sino grandes ventajas reales, por cuanto la combinación de ambas técnicas, en la forma apropiada, conduce a la creación de una bioactividad sensiblemente aumentada, hasta tal punto que la actividad y velocidad de eficacia en la regeneración ósea del paciente, puede llegar a duplicarse.Surprisingly, it has been found that both techniques can become complementary and do not occur inconveniences for such complementarity, but great advantages real, because the combination of both techniques, in the form appropriate, leads to the creation of a bioactivity noticeably increased, to such an extent that activity and speed of effectiveness in bone regeneration of the patient, it can double.

Así, se ha encontrado que poniendo en contacto la superficie normalmente activada de un implante o una prótesis, tanto de titanio como de otro tipo de materiales, con una capa o recubrimiento de plasma rico en factores de crecimiento, obtenido a partir de la sangre del receptor e inmediatamente antes de su aplicación, la potencialidad superficial del conjunto se multiplica por dos, es decir, se puede llegar a reducir a la mitad el tiempo de tratamiento para la integración ósea, todo ello con mayor y mejor aposición ósea, es decir, un mayor contacto del implante o prótesis con el hueso.Thus, it has been found that by contacting the normally activated surface of an implant or a prosthesis, both of titanium as of other materials, with a layer or plasma coating rich in growth factors, obtained at from the recipient's blood and immediately before its application, the surface potentiality of the set is multiplied by two, that is, the time of treatment for bone integration, all with greater and better bone apposition, that is, greater contact of the implant or prosthesis with the bone

No se ha podido determinar con total certeza la causa real de este cambio tan sorprendente de la actividad superficial del implante o prótesis. Se piensa que es como consecuencia de la presencia de puentes de fibrina creados por el plasma y de la concentración de factores de crecimiento, pero es un hecho incuestionable que la mejora se produce y que esta mejora es perfectamente verificable en la práctica.Unable to determine with total certainty the real cause of this amazing change in activity superficial implant or prosthesis. It is thought to be like consequence of the presence of fibrin bridges created by the plasma and growth factor concentration, but it is a unquestionable fact that the improvement occurs and that this improvement is perfectly verifiable in practice.

La puesta en ejecución para esta bioactivación, puede llevarse a cabo simplemente poniendo en contacto físico la superficie del implante, por inmersión en el plasma para su posterior inclusión en el alvéolo u oquedad de que se trate.The implementation for this bioactivation, it can be carried out simply by putting the physical contact surface of the implant, by immersion in the plasma for subsequent inclusion in the socket or cavity in question.

La creación de la capa superficial es posible también que sea obtenida por alojamiento del plasma en el interior del alvéolo, plasma que con la posterior incorporación del implante, toma contacto con él.The creation of the surface layer is possible also to be obtained by housing the plasma inside of the socket, plasma that with the subsequent incorporation of the implant, Make contact with him.

Obviamente, la combinación de ambos supuestos, lograría los mismos efectos tal y como es fácilmente deducible.Obviously, the combination of both assumptions, it would achieve the same effects as it is easily deductible.

Resumiendo por tanto el espíritu de la invención, se resalta de nuevo la base de la reivindicación de la misma, la que se sustenta en la siguiente y repetida exposición.Summarizing therefore the spirit of the invention, the basis of the claim thereof is highlighted again, which It is based on the following and repeated exposure.

Un implante, o prótesis activado superficialmente según la técnica de tratamiento con ataque físico, químico, o físico-químico, presenta una actividad mejorada con respecto a otros desactivados por su carácter rugoso y humectante.An implant, or superficially activated prosthesis according to the treatment technique with physical, chemical attack, or physicochemical, it has an improved activity with compared to others deactivated by its rugged nature and moisturizer

Sin embargo, un implante o prótesis, previamente activado según la técnica anterior, es bioactivada con una capacidad efectiva, si la superficie de dicho implante o prótesis es recubierta con una película de un plasma rico en factores de crecimiento.However, an implant or prosthesis, previously activated according to the prior art, it is bioactivated with a capacity effective, if the surface of said implant or prosthesis is coated with a plasma film rich in factors of increase.

El tiempo necesario para la integración ósea es reducido a la mitad y la aposición ósea es mejorada y ampliada.The time needed for bone integration is halved and bone apposition is improved and enlarged.

Claims (4)

1. Disposición para constituir una superficie bioactiva en implantes o prótesis que se alojan en una cavidad, siendo esta cavidad por ejemplo un alvéolo, presentando estos implantes o prótesis una superficie rugosa y humectante tras un tratamiento con ataque físico, químico o físico-químico, y estando esta superficie libre de residuos químicos contaminantes tras un lavado en fases sucesivas, estando dicha disposición caracterizada en que la superficie rugosa del elemento de que se trate, implante o prótesis, está recubierta por una capa de un plasma rico en factores de crecimiento, plasma obtenido de la propia sangre del paciente.1. Willingness to constitute a surface bioactive in implants or prostheses that are housed in a cavity, this cavity being for example an alveolus, presenting these implants or prostheses a rough and moisturizing surface after a treatment with physical, chemical or physicochemical, and this surface being free of chemical contaminant residues after washing in successive phases, said arrangement being characterized in that the rough surface of the element in question, implant or prosthesis, is coated for a layer of a plasma rich in growth factors, plasma obtained from the patient's own blood. 2. Disposición para constituir una superficie bioactiva en implantes o prótesis, según la 1ª reivindicación, caracterizada en que la capa de plasma está dispuesta sobre la superficie rugosa del implante o prótesis con carácter previo a su ubicación en la cavidad de que se trate.2. Arrangement for constituting a bioactive surface in implants or prostheses, according to the first claim, characterized in that the plasma layer is disposed on the rough surface of the implant or prosthesis prior to its location in the cavity in question. 3. Disposición para constituir una superficie bioactiva en implantes o prótesis, según la 1ª reivindicación, caracterizada en que la superficie rugosa del implante o prótesis es recubierta con plasma, estando este plasma ocupando la cavidad, inicialmente.3. Arrangement to constitute a bioactive surface in implants or prostheses, according to the first claim, characterized in that the rough surface of the implant or prosthesis is coated with plasma, this plasma being initially occupying the cavity. 4. Disposición para constituir una superficie bioactiva en implantes o prótesis, según la 1ª reivindicación, caracterizada en que la capa de plasma se sitúa sobre el implante o prótesis tanto después de la introducción del implante o prótesis en la cavidad, estando la cavidad rellena con plasma, como antes de la introducción del implante o prótesis en la cavidad.4. Arrangement to constitute a bioactive surface in implants or prostheses, according to the 1st claim, characterized in that the plasma layer is placed on the implant or prosthesis both after the introduction of the implant or prosthesis into the cavity, the cavity being filled with plasma, as before the introduction of the implant or prosthesis into the cavity.
ES200101362A 2000-09-19 2001-06-13 PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS. Expired - Lifetime ES2180438B2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
ES200101362A ES2180438B2 (en) 2001-06-13 2001-06-13 PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS.
NZ52173701A NZ521737A (en) 2000-09-19 2001-09-14 The surface treatment of implants and prosthesis in titanium and other materials
PL358223A PL205705B1 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
PCT/ES2001/000348 WO2002024243A1 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
CZ20022557A CZ20022557A3 (en) 2000-09-19 2001-09-14 Surface treatment process of implants made of titanium or other materials
AT01969813T ATE415982T1 (en) 2000-09-19 2001-09-14 METHOD FOR SURFACE TREATMENT OF IMPLANTS OR PROStheses MADE OF TITANIUM
DE60136852T DE60136852D1 (en) 2000-09-19 2001-09-14 METHOD FOR THE SURFACE TREATMENT OF IMPLANTS OR TITANIUM PROSTHESES
BR0107230-7A BR0107230A (en) 2000-09-19 2001-09-14 Surface treatment method of implants or prostheses made of titanium or other materials
CA2402578A CA2402578C (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
AU89950/01A AU780317B2 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
ES01969813T ES2317933T3 (en) 2000-09-19 2001-09-14 METHOD OF SURFACE TREATMENT OF IMPLANTS OR PROTESIS PERFORMED IN TITANIUM.
US10/203,426 US7144428B2 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
ROA200201275A RO121370B1 (en) 2000-09-19 2001-09-14 Process for surface treatment of implants and prostheses made of titanium and other materials
IL14970001A IL149700A0 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
PT01969813T PT1352665E (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium
KR1020027006260A KR100811765B1 (en) 2000-09-19 2001-09-14 Surface treatment of implants or prostheses of titanium or other materials
EA200200918A EA003728B1 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials
MXPA02007452A MXPA02007452A (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium or other materials.
JP2002528312A JP4430302B2 (en) 2000-09-19 2001-09-14 Surface treatment of titanium and other implants and prostheses
CNB018027857A CN1221294C (en) 2000-09-19 2001-09-14 Surface treatment of implants and prostheses made of titanium and other materials
EP01969813A EP1352665B1 (en) 2000-09-19 2001-09-14 Method for surface treatment of implants or prosthesis made of titanium
IL149700A IL149700A (en) 2000-09-19 2002-05-16 Method for surface treatment of implants or prosthesis made of titanium or other materials
NO20022364A NO326151B1 (en) 2000-09-19 2002-05-16 Method for surface treatment of titanium implants or prostheses and such implants or dentures.
ARP020102216A AR034479A1 (en) 2001-06-13 2002-06-12 METHOD OF SURFACE TREATMENT OF IMPLANTS OR PROTESIS PERFORMED IN TITANIUM OR OTHER MATERIALS
MA26750A MA25704A1 (en) 2000-09-19 2002-07-29 THE SURFACE TREATMENT OF TITANIUM IMPLANTS AND PROSTHESES AND OTHER PRODUCTS.
LT2002095A LT5088B (en) 2000-09-19 2002-08-28 The surface treatment of implants and prostheses in titanium and other materials
LVP-02-162A LV12911B (en) 2000-09-19 2002-09-03 Method for surface treatment of implants or prosthesis made of titanium or other materials

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101362A ES2180438B2 (en) 2001-06-13 2001-06-13 PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS.

Publications (2)

Publication Number Publication Date
ES2180438A1 ES2180438A1 (en) 2003-02-01
ES2180438B2 true ES2180438B2 (en) 2004-11-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101362A Expired - Lifetime ES2180438B2 (en) 2000-09-19 2001-06-13 PROVISION TO CONSTITUTE A BIOACTIVE SURFACE IN IMPLANTS OR PROTESIS.

Country Status (2)

Country Link
AR (1) AR034479A1 (en)
ES (1) ES2180438B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009016451A2 (en) 2007-08-02 2009-02-05 Biotechnology Institute, I Mas D, S.L. Method and compound for the treatment of articular diseases or articular pain, or for the treatment of skin for aesthetic or other purposes, and the method of preparation of the compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464440A (en) * 1992-01-13 1995-11-07 Lucocer Aktiebolag Porous implant with two sets of pores
US5691305A (en) * 1991-09-13 1997-11-25 Baylink; David J. Bone implant composition comprising a porous matrix, bone growth promoter proteins, and phosphotyrosyl protein phosphatase inhibitor
WO2000044314A1 (en) * 1999-01-26 2000-08-03 Eduardo Anitua Aldecoa Bone tissue regenerating composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691305A (en) * 1991-09-13 1997-11-25 Baylink; David J. Bone implant composition comprising a porous matrix, bone growth promoter proteins, and phosphotyrosyl protein phosphatase inhibitor
US5464440A (en) * 1992-01-13 1995-11-07 Lucocer Aktiebolag Porous implant with two sets of pores
WO2000044314A1 (en) * 1999-01-26 2000-08-03 Eduardo Anitua Aldecoa Bone tissue regenerating composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009016451A2 (en) 2007-08-02 2009-02-05 Biotechnology Institute, I Mas D, S.L. Method and compound for the treatment of articular diseases or articular pain, or for the treatment of skin for aesthetic or other purposes, and the method of preparation of the compound

Also Published As

Publication number Publication date
ES2180438A1 (en) 2003-02-01
AR034479A1 (en) 2004-02-25

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