ES2180456B1 - Isoxazoles sustituidos y su utilizacion como antibioticos. - Google Patents

Isoxazoles sustituidos y su utilizacion como antibioticos.

Info

Publication number
ES2180456B1
ES2180456B1 ES200101793A ES200101793A ES2180456B1 ES 2180456 B1 ES2180456 B1 ES 2180456B1 ES 200101793 A ES200101793 A ES 200101793A ES 200101793 A ES200101793 A ES 200101793A ES 2180456 B1 ES2180456 B1 ES 2180456B1
Authority
ES
Spain
Prior art keywords
antibiotics
substituted
isoxazols
carbon
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200101793A
Other languages
English (en)
Other versions
ES2180456A1 (es
Inventor
Carles Farrerons Gallemi
Carmen Lagunas Arnal
Anna Fernandez Serrat
Juan Lorenzo Catena Ruiz
Ignacio Jose MIQUEL BONO
Dolors Balsa Lopez
Carolina Salcedo Roca
Natividad Toledo Mesa
Andres Fernandez Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Salvat SA
Original Assignee
Laboratorios Salvat SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200101793A priority Critical patent/ES2180456B1/es
Application filed by Laboratorios Salvat SA filed Critical Laboratorios Salvat SA
Priority to AU2002319320A priority patent/AU2002319320B2/en
Priority to KR1020047001066A priority patent/KR100882377B1/ko
Priority to DE60221870T priority patent/DE60221870T2/de
Priority to SI200230622T priority patent/SI1437349T1/sl
Priority to CA002453846A priority patent/CA2453846A1/en
Priority to CNA02818517XA priority patent/CN1556797A/zh
Priority to ES02748888T priority patent/ES2291481T3/es
Priority to PCT/ES2002/000358 priority patent/WO2003008395A1/es
Priority to EP02748888A priority patent/EP1437349B9/en
Priority to JP2003513955A priority patent/JP2005502634A/ja
Priority to US10/484,027 priority patent/US20050014806A1/en
Priority to DK02748888T priority patent/DK1437349T3/da
Priority to BR0211588-3A priority patent/BR0211588A/pt
Priority to PT02748888T priority patent/PT1437349E/pt
Priority to AT02748888T priority patent/ATE370129T1/de
Publication of ES2180456A1 publication Critical patent/ES2180456A1/es
Application granted granted Critical
Publication of ES2180456B1 publication Critical patent/ES2180456B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Isoxazoles sustituidos y su utilización como antibióticos. Los compuestos de fórmula (I), donde X es O, NH, OCO, NH-CO, NH-COO, NH-CO-NH, NH-CS o NH-CS-NH; R4 es H, (C1-C3)-alquilo opcionalmente sustituido por halógeno, o un radical heterocíclico de carbono seleccionado entre varias posibilidades; R1 y R3 son H o F; y R2 es un radical heterocíclico de nitrógeno o carbono, son útiles para el tratamiento de infecciones microbianas en el cuerpo humano o animal.
ES200101793A 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos. Expired - Lifetime ES2180456B1 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES200101793A ES2180456B1 (es) 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos.
JP2003513955A JP2005502634A (ja) 2001-07-20 2002-07-17 置換イソオキサゾールおよびその抗生物質としての使用
DE60221870T DE60221870T2 (de) 2001-07-20 2002-07-17 Substituierte isoxazole und deren verwendung als antibiotika
SI200230622T SI1437349T1 (sl) 2001-07-20 2002-07-17 Substituirani izoksazoli in njihova uporaba kot antibiotiki
CA002453846A CA2453846A1 (en) 2001-07-20 2002-07-17 Substituted isoxazoles and the use thereof as antibiotics
CNA02818517XA CN1556797A (zh) 2001-07-20 2002-07-17 取代的异噁唑化合物及其作为抗生素的应用
ES02748888T ES2291481T3 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos.
PCT/ES2002/000358 WO2003008395A1 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos
AU2002319320A AU2002319320B2 (en) 2001-07-20 2002-07-17 Substituted isoxazoles and the use thereof as antibiotics
KR1020047001066A KR100882377B1 (ko) 2001-07-20 2002-07-17 치환된 이속사졸 및 항생제로서의 이들의 용도
US10/484,027 US20050014806A1 (en) 2001-07-20 2002-07-17 Substituted isoxazoles and their use as antibiotics
DK02748888T DK1437349T3 (da) 2001-07-20 2002-07-17 Substituerede isoxazoler og anvendelse deraf som antibiotika
BR0211588-3A BR0211588A (pt) 2001-07-20 2002-07-17 Isoxazóis substituìdos e o uso deles como antibióticos
PT02748888T PT1437349E (pt) 2001-07-20 2002-07-17 Isoxazóis substituídos e sua utilização como antibióticos
AT02748888T ATE370129T1 (de) 2001-07-20 2002-07-17 Substituierte isoxazole und deren verwendung als antibiotika
EP02748888A EP1437349B9 (en) 2001-07-20 2002-07-17 Substituted isoxazoles and the use thereof as antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101793A ES2180456B1 (es) 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos.

Publications (2)

Publication Number Publication Date
ES2180456A1 ES2180456A1 (es) 2003-02-01
ES2180456B1 true ES2180456B1 (es) 2004-05-01

Family

ID=8498579

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200101793A Expired - Lifetime ES2180456B1 (es) 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos.
ES02748888T Expired - Lifetime ES2291481T3 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02748888T Expired - Lifetime ES2291481T3 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos.

Country Status (14)

Country Link
US (1) US20050014806A1 (es)
EP (1) EP1437349B9 (es)
JP (1) JP2005502634A (es)
KR (1) KR100882377B1 (es)
CN (1) CN1556797A (es)
AT (1) ATE370129T1 (es)
AU (1) AU2002319320B2 (es)
BR (1) BR0211588A (es)
CA (1) CA2453846A1 (es)
DE (1) DE60221870T2 (es)
DK (1) DK1437349T3 (es)
ES (2) ES2180456B1 (es)
PT (1) PT1437349E (es)
WO (1) WO2003008395A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
MXPA04012393A (es) 2002-06-12 2005-06-17 Chemocentryx Derivados de piperazina 1-aril-4-substituidos para utilizar como antagonistas ccr1 para tratamiento de inflamacion y desordenes inmunes.
HRP20050092A2 (en) * 2002-06-29 2005-02-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
CN100542534C (zh) * 2003-12-09 2009-09-23 凯莫森特里克斯股份有限公司 取代的哌嗪
WO2005082892A2 (en) * 2004-02-17 2005-09-09 Dr. Reddy's Laboratories Ltd. Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
CN1950082B (zh) 2004-03-03 2013-02-06 凯莫森特里克斯股份有限公司 双环和桥连的含氮杂环化物
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
JP5020073B2 (ja) 2004-06-18 2012-09-05 ミレニアム ファーマシューティカルズ インク． 第Ｘａ因子阻害剤
US7696352B2 (en) 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
JP2009523764A (ja) * 2006-01-19 2009-06-25 ラボラトリオス・サルバト・ソシエダッド・アノニマ 抗菌活性を有するジカルボニル化合物
EA015942B1 (ru) 2006-05-05 2011-12-30 Милленниум Фамэсьютикэлс, Инк. Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови
WO2007134457A1 (en) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
CN101220000B (zh) * 2007-12-28 2010-12-22 天津药物研究院 酰氯和磺酰氯类衍生物及其用途
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
WO2011075602A1 (en) 2009-12-17 2011-06-23 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
WO2011084652A2 (en) 2009-12-17 2011-07-14 Millennium Pharmaceuticals, Inc. Salts and crystalline forms of a factor xa inhibitor
CN101798303B (zh) * 2010-03-10 2011-09-07 天津药物研究院 一类氮唑的衍生物、其制备方法和用途
CN101781294B (zh) * 2010-03-10 2012-02-01 天津药物研究院 一类咪唑的衍生物、其制备方法和用途
GEP20156370B (en) 2011-03-07 2015-09-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
EP2694488B1 (en) * 2011-04-08 2014-11-12 Pfizer Inc Isoxazole derivatives useful as antibacterial agents
EP2694481B1 (en) 2011-04-08 2015-12-30 Pfizer Inc Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
KR101369584B1 (ko) * 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
WO2013055793A1 (en) 2011-10-12 2013-04-18 University Of Pittsburg-Of The Commonwealth System Of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
US9920039B2 (en) 2013-03-15 2018-03-20 Università Degli Studi Di Milano—Bicocca 1,2,4-Oxadiazol compounds active against gram-positive pathogens
CN103172584A (zh) * 2013-03-15 2013-06-26 吉林大学 双异噁唑甲醚衍生物及制备方法
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
EP3046561B1 (en) * 2013-09-20 2023-02-22 University of Pittsburgh - Of the Commonwealth System of Higher Education Compounds for treating prostate cancer
US10518196B2 (en) * 2014-01-29 2019-12-31 General Electric Company Devices for separation of particulates, associated methods and systems
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
CN109369553B (zh) * 2018-10-22 2023-04-11 上海凌凯医药科技有限公司 一种合成n-3-异恶唑氨基甲酸叔丁酯的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1054874T3 (da) * 1998-02-13 2002-12-30 Upjohn Co Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
GB9928568D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
DE60221870T2 (de) 2008-05-08
BR0211588A (pt) 2004-07-13
US20050014806A1 (en) 2005-01-20
KR100882377B1 (ko) 2009-02-05
KR20040043164A (ko) 2004-05-22
CA2453846A1 (en) 2003-01-30
DE60221870D1 (de) 2007-09-27
EP1437349B9 (en) 2008-09-10
ES2291481T3 (es) 2008-03-01
WO2003008395A1 (es) 2003-01-30
AU2002319320B2 (en) 2008-03-06
EP1437349B1 (en) 2007-08-15
EP1437349A1 (en) 2004-07-14
PT1437349E (pt) 2007-11-19
CN1556797A (zh) 2004-12-22
DK1437349T3 (da) 2007-12-03
JP2005502634A (ja) 2005-01-27
ATE370129T1 (de) 2007-09-15
ES2180456A1 (es) 2003-02-01

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