ES2180975T3 - Derivados de cicloalquilaminometilpirrolidina. - Google Patents
Derivados de cicloalquilaminometilpirrolidina.Info
- Publication number
- ES2180975T3 ES2180975T3 ES97919690T ES97919690T ES2180975T3 ES 2180975 T3 ES2180975 T3 ES 2180975T3 ES 97919690 T ES97919690 T ES 97919690T ES 97919690 T ES97919690 T ES 97919690T ES 2180975 T3 ES2180975 T3 ES 2180975T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- alkyl
- hydrogen atom
- halogenomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 acetoxymethyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003248 quinolines Chemical group 0.000 abstract 1
- 150000007660 quinolones Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cosmetics (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Silicon Compounds (AREA)
- Liquid Crystal (AREA)
Abstract
UN DERIVADO DE LA QUINOLONA REPRESENTADO POR LA FORMULA (I): EN LA QUE R 1 REPRESENTA UN GRUPO CICLOALQUILO; R SUP ,2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO AMINO, UN GRUPO HIDROXILO, UN GRUPO TIOL, UN GRUPO HALOGENOMETILO, UN GRUPO ALQUILO, UN GRUPO ALQUENILO, UN GRUPO ALQUINILO O UN GRUPO ALCOXI. R 3 REPRESENTA UN GRUPO AMINO, UN GRUPO HALOGENOMETILO, UN GRUPO HALOGENOMETOXILO, UN GRUPO ALQUILO, UN GRUPO ALQUENILO, UN GRUPO ALQUINILO O UN GRUPO ALCOXI; R 4 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO; R 5 REPRESENTA UN GRUPO ALQUILO QUE TIENE DE 3 A 6 ATOMOS DE CARBONO; LOS ANTERIORES R 1 A R 5 PUEDEN SER SUSTITUIDOS; X REPRESENTA UN ATOMO DE HALOGENO O UN ATOMO DE HIDROGENO; E Y REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO FENILO, UN GRUPO ACETOXIMETILO, UN GRUPO PIVALOILOXIMETILO, UN GRUPO ETOXICARBONILO, UN GRUPO COLINA, UN GRUPO DIMETILAMINOETILO, UN GRUPO 5 - INDANILO, UN GRUPO FTALILDINILO, UN GRUPO 5 ALQUIL - 2 - OXO - 1,3 - DIOXOL - 4 - ILMETILO, UN GRUPO 3 - ACETOXI - 2 - OXOBUTILO, UN GRUPO ALQUILO CON 1 A 6 ATOMOS DE CARBONO, UN GRUPO ALCOXIMETIL QUE TIENE DE 2 A 7 ATOMOS DE CARBONO, O UN GRUPO FENILALQUILO CON 1 A 6 ATOMOS DE CARBONO EN SU MITAD ALQUILO, O UNA SAL DEL MISMO. EL COMPUESTO MUESTRA UNA AMPLIA Y POTENTE ACTIVIDAD ANTIMICROBIANA CONTRA DIVERSAS BACTERIAS, INCLUIDAS LAS RESISTENTES A LOS FARMACOS, ASI COMO UNA NOTABLE SEGURIDAD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10233496 | 1996-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2180975T3 true ES2180975T3 (es) | 2003-02-16 |
Family
ID=14324624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97919690T Expired - Lifetime ES2180975T3 (es) | 1996-04-24 | 1997-04-24 | Derivados de cicloalquilaminometilpirrolidina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6194434B1 (es) |
| EP (1) | EP0900793B1 (es) |
| JP (1) | JP4127322B2 (es) |
| KR (1) | KR100458146B1 (es) |
| CN (1) | CN1116295C (es) |
| AT (1) | ATE221063T1 (es) |
| AU (1) | AU726378B2 (es) |
| BR (1) | BR9708824A (es) |
| CA (1) | CA2251927C (es) |
| DE (1) | DE69714249T2 (es) |
| DK (1) | DK0900793T3 (es) |
| EA (1) | EA000878B1 (es) |
| ES (1) | ES2180975T3 (es) |
| ID (1) | ID16655A (es) |
| PT (1) | PT900793E (es) |
| TW (1) | TW425394B (es) |
| WO (1) | WO1997040037A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1044476B (zh) | 1999-03-17 | 2010-09-17 | 第一制药株式会社 | 药物组合物 |
| US7153851B2 (en) | 2002-03-18 | 2006-12-26 | Kyorin Pharmaceutical Co., Ltd. | 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium |
| PL1666477T3 (pl) * | 2003-09-10 | 2013-11-29 | Kyorin Seiyaku Kk | Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| JP5322927B2 (ja) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| MX380385B (es) | 2015-03-13 | 2025-03-12 | Kyorin Seiyaku Kk | Agente para el tratamiento de infeccion respiratoria. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| US4657913A (en) | 1985-04-18 | 1987-04-14 | Warner-Lambert Company | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
| JPH0696572B2 (ja) | 1985-07-17 | 1994-11-30 | 大日本製薬株式会社 | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| US4771055A (en) | 1986-07-28 | 1988-09-13 | Warner-Lambert Company | 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids |
| US4965273A (en) * | 1986-10-08 | 1990-10-23 | Bristol-Myers Company | Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents |
| US4954507A (en) * | 1986-10-08 | 1990-09-04 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents |
| ZA877471B (en) * | 1986-10-08 | 1988-04-05 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents |
| US4780468A (en) | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| DE3814517A1 (de) | 1988-02-05 | 1989-08-17 | Bayer Ag | Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| US5173484A (en) * | 1988-02-05 | 1992-12-22 | Bayer Aktiengesellschaft | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them |
| IL90062A (en) | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them |
-
1997
- 1997-04-23 TW TW086105396A patent/TW425394B/zh not_active IP Right Cessation
- 1997-04-23 ID IDP971346A patent/ID16655A/id unknown
- 1997-04-24 PT PT97919690T patent/PT900793E/pt unknown
- 1997-04-24 WO PCT/JP1997/001446 patent/WO1997040037A1/ja not_active Ceased
- 1997-04-24 EP EP97919690A patent/EP0900793B1/en not_active Expired - Lifetime
- 1997-04-24 AT AT97919690T patent/ATE221063T1/de not_active IP Right Cessation
- 1997-04-24 KR KR10-1998-0708448A patent/KR100458146B1/ko not_active Expired - Fee Related
- 1997-04-24 DK DK97919690T patent/DK0900793T3/da active
- 1997-04-24 JP JP53793597A patent/JP4127322B2/ja not_active Expired - Fee Related
- 1997-04-24 US US09/171,637 patent/US6194434B1/en not_active Expired - Fee Related
- 1997-04-24 EA EA199800952A patent/EA000878B1/ru not_active IP Right Cessation
- 1997-04-24 AU AU24072/97A patent/AU726378B2/en not_active Ceased
- 1997-04-24 ES ES97919690T patent/ES2180975T3/es not_active Expired - Lifetime
- 1997-04-24 BR BR9708824A patent/BR9708824A/pt not_active IP Right Cessation
- 1997-04-24 CN CN97195563A patent/CN1116295C/zh not_active Expired - Fee Related
- 1997-04-24 DE DE69714249T patent/DE69714249T2/de not_active Expired - Fee Related
- 1997-04-24 CA CA002251927A patent/CA2251927C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69714249T2 (de) | 2003-03-27 |
| ATE221063T1 (de) | 2002-08-15 |
| CA2251927C (en) | 2005-02-15 |
| JP4127322B2 (ja) | 2008-07-30 |
| EA199800952A1 (ru) | 1999-04-29 |
| TW425394B (en) | 2001-03-11 |
| DK0900793T3 (da) | 2002-10-14 |
| EA000878B1 (ru) | 2000-06-26 |
| PT900793E (pt) | 2002-11-29 |
| DE69714249D1 (en) | 2002-08-29 |
| KR100458146B1 (ko) | 2005-06-13 |
| AU726378B2 (en) | 2000-11-02 |
| WO1997040037A1 (en) | 1997-10-30 |
| ID16655A (id) | 1997-10-30 |
| KR20000010578A (ko) | 2000-02-15 |
| EP0900793A1 (en) | 1999-03-10 |
| EP0900793B1 (en) | 2002-07-24 |
| US6194434B1 (en) | 2001-02-27 |
| CN1116295C (zh) | 2003-07-30 |
| BR9708824A (pt) | 1999-08-03 |
| CN1222151A (zh) | 1999-07-07 |
| AU2407297A (en) | 1997-11-12 |
| CA2251927A1 (en) | 1997-10-30 |
| HK1018786A1 (en) | 2000-01-07 |
| EP0900793A4 (en) | 1999-07-07 |
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