ES2180988T3 - Sintesis enzimatica de acidos hidroxamicos opticamente activos y su conversion en aminas primarias opticamente activas por transposicion de lossen. - Google Patents

Sintesis enzimatica de acidos hidroxamicos opticamente activos y su conversion en aminas primarias opticamente activas por transposicion de lossen.

Info

Publication number
ES2180988T3
ES2180988T3 ES97923056T ES97923056T ES2180988T3 ES 2180988 T3 ES2180988 T3 ES 2180988T3 ES 97923056 T ES97923056 T ES 97923056T ES 97923056 T ES97923056 T ES 97923056T ES 2180988 T3 ES2180988 T3 ES 2180988T3
Authority
ES
Spain
Prior art keywords
optically active
lossen
transposition
acids
primary amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97923056T
Other languages
English (en)
Inventor
Beate Hirrlinger
Andreas Stolz
Hans-Joachim Knackmuss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19634446A external-priority patent/DE19634446A1/de
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Application granted granted Critical
Publication of ES2180988T3 publication Critical patent/ES2180988T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENER ACIDOS HIDROXANICOS OPTICAMENTE ACTIVOS DE LA FORMULA GENERAL (I) EN DONDE R 1 , R 2 Y R 3 SON DIFERENTES Y REPRESENTAN UN RADICAL HIDROCARBONADO CICLICO O LINEAL, ALIFATICO O AROMATICO, SUSTITUIDO O NO SUSTITUIDO, QUE PUEDE CONTENER HETERO-ATOMOS, CARACTERIZADO PORQUE UN RACEMATO DE AMIDAS QUIRALES, ESTERES DE ACIDO CARBOXILICO O ACIDOS CARBOXILICOS DE LA FORMULA GENERAL (II) EN DONDE R 1 , R 2 Y R SUP,3 SE DEFINEN COMO ANTERIORMENTE Y X ES -NH 2 , -OR O -OH, SIENDO R CUALQUIER RADICAL ORGANICO, REACCIONANDOSE CON AMINA DE HIDROXILO NH 2 OH EN LA PRESENCIA DE UNA TRANSFERA SA DE ACILO Y EL ACIDO HIDROXANICO OPTICAMENTE ACTIVO (I) ASI OBTENIDO SE SEPARA DEL ENANTIOMERO NO REACCIONADO DE LA FORMULA GENERAL (II). EL ACIDOS HIDROXANICO OPTICAMENTE ACTIVOS ASI OBTENIDO PUEDE CONVERTIRSE EN LAS CORRESPONDIENTES AMINAS PRIMARIAS OPTICAMENTE ACTIVAS MEDIANTE LA TRANSPOSICION DE LOSSEN.
ES97923056T 1996-05-20 1997-05-12 Sintesis enzimatica de acidos hidroxamicos opticamente activos y su conversion en aminas primarias opticamente activas por transposicion de lossen. Expired - Lifetime ES2180988T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19620189 1996-05-20
DE19634446A DE19634446A1 (de) 1996-05-20 1996-08-26 Enzymatische Synthese optisch aktiver Hydroxamsäuren und ihre Umsetzung zu optisch aktiven primären Aminen durch Lossen-Umlagerung

Publications (1)

Publication Number Publication Date
ES2180988T3 true ES2180988T3 (es) 2003-02-16

Family

ID=26025840

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97923056T Expired - Lifetime ES2180988T3 (es) 1996-05-20 1997-05-12 Sintesis enzimatica de acidos hidroxamicos opticamente activos y su conversion en aminas primarias opticamente activas por transposicion de lossen.

Country Status (7)

Country Link
US (1) US6281003B1 (es)
EP (1) EP0935669B1 (es)
JP (1) JP2000511047A (es)
AT (1) ATE221577T1 (es)
CA (1) CA2253866A1 (es)
ES (1) ES2180988T3 (es)
WO (1) WO1997044480A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4329893B2 (ja) * 2002-07-15 2009-09-09 株式会社リコー デジタルカメラ装置
EP3390345B1 (en) * 2015-12-17 2021-03-24 Vito NV Process for the separation of organic compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43408B (en) 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
YU43290B (en) 1986-11-13 1989-06-30 Lek Tovarna Farmacevtskih Process for preparing inclusioned complex of ibuproxane with beta-cyclodextrine
JP2640958B2 (ja) * 1988-03-09 1997-08-13 花王株式会社 ヒドロキサム酸加水分解酵素
JPH01242560A (ja) * 1988-03-25 1989-09-27 Fuji Photo Film Co Ltd ｏ−アミノフエノール類の製造方法
NL9100038A (nl) 1991-01-11 1992-08-03 Stamicarbon Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren.
WO1995002574A1 (en) 1993-07-14 1995-01-26 Smithkline Beecham Corporation Synthesis of acid addition salts of hydroxylamines

Also Published As

Publication number Publication date
EP0935669B1 (de) 2002-07-31
EP0935669A1 (de) 1999-08-18
ATE221577T1 (de) 2002-08-15
WO1997044480A1 (de) 1997-11-27
JP2000511047A (ja) 2000-08-29
US6281003B1 (en) 2001-08-28
CA2253866A1 (en) 1997-11-27

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