ES2182349T3 - Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2. - Google Patents

Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.

Info

Publication number
ES2182349T3
ES2182349T3 ES98936398T ES98936398T ES2182349T3 ES 2182349 T3 ES2182349 T3 ES 2182349T3 ES 98936398 T ES98936398 T ES 98936398T ES 98936398 T ES98936398 T ES 98936398T ES 2182349 T3 ES2182349 T3 ES 2182349T3
Authority
ES
Spain
Prior art keywords
synthesis
orto
benches
tetrazol
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98936398T
Other languages
English (en)
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2182349T3 publication Critical patent/ES2182349T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un proceso de metilación directa de feniltetrazoles útil para la preparación de compuestos de fórmula (II) intermedios para la síntesis de antagonistas de angiotensina II.
ES98936398T 1997-06-30 1998-06-29 Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2. Expired - Lifetime ES2182349T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Publications (1)

Publication Number Publication Date
ES2182349T3 true ES2182349T3 (es) 2003-03-01

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98936398T Expired - Lifetime ES2182349T3 (es) 1997-06-30 1998-06-29 Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.

Country Status (12)

Country Link
US (1) US6271375B1 (es)
EP (1) EP0994881B1 (es)
JP (1) JP4128633B2 (es)
AT (1) ATE224395T1 (es)
CA (1) CA2294609C (es)
CZ (1) CZ293277B6 (es)
DE (1) DE69808093T2 (es)
ES (1) ES2182349T3 (es)
HU (1) HU226471B1 (es)
IL (1) IL133249A (es)
IT (1) IT1292437B1 (es)
WO (1) WO1999001459A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066161A1 (en) 1999-04-28 2000-11-09 Takeda Chemical Industries, Ltd. Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy
WO2004014259A1 (en) 2002-07-26 2004-02-19 Pharmacia Groningen Bv Method and device for manipulation of an intraocular lens
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
EP1511739B1 (en) * 2003-03-17 2008-04-30 Teva Pharmaceutical Industries Ltd. Polymorphs of valsartan
US7378531B2 (en) * 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
EP1556363A2 (en) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Process for the preparation of valsartan and intermediates thereof
CA2534892A1 (en) * 2003-08-08 2005-02-17 Dipharma S.P.A. A process for the preparation of phenyltetrazole derivatives
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
WO2006067216A2 (en) * 2004-12-22 2006-06-29 Enantia, S. L. Intermediate compounds for the preparation of an angiotensin ii receptor and process for the preparation of valsartan
EP1833801B9 (en) * 2004-12-22 2009-02-25 Algry Quimica, S.L Intermediate compounds for the preparation of angiotensin ii receptor antagonists
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
EP2043607A2 (en) * 2006-06-23 2009-04-08 Usv Limited Process for the preparation of micronized valsartan
US7943794B2 (en) * 2008-02-13 2011-05-17 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
US8492577B2 (en) * 2008-04-07 2013-07-23 Hetero Research Foundation Process for preparation of valsartan intermediate
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US12365654B2 (en) 2019-12-02 2025-07-22 Harman Finochem Limited Process for the preparation of highly pure valsartan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
TW226375B (es) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5310929A (en) 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
WO1996040684A1 (en) * 1995-06-07 1996-12-19 American Home Products Corporation Process for preparation of biphenyl derivatives

Also Published As

Publication number Publication date
ITMI971544A1 (it) 1998-12-30
CA2294609C (en) 2008-08-19
US6271375B1 (en) 2001-08-07
DE69808093D1 (de) 2002-10-24
HUP0004227A2 (hu) 2001-06-28
CA2294609A1 (en) 1999-01-14
CZ477499A3 (cs) 2000-07-12
IL133249A (en) 2003-12-10
JP4128633B2 (ja) 2008-07-30
DE69808093T2 (de) 2003-06-05
EP0994881A1 (en) 2000-04-26
WO1999001459A1 (en) 1999-01-14
CZ293277B6 (cs) 2004-03-17
HUP0004227A3 (en) 2003-03-28
JP2002510314A (ja) 2002-04-02
ATE224395T1 (de) 2002-10-15
HU226471B1 (en) 2008-12-29
IL133249A0 (en) 2001-04-30
IT1292437B1 (it) 1999-02-08
EP0994881B1 (en) 2002-09-18
ITMI971544A0 (es) 1997-06-30

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