ES2184332T3 - Dispositivo de gradiente magnetico elevado y metodo para la separacion o purificacion celular. - Google Patents

Dispositivo de gradiente magnetico elevado y metodo para la separacion o purificacion celular.

Info

Publication number
ES2184332T3
ES2184332T3 ES98955422T ES98955422T ES2184332T3 ES 2184332 T3 ES2184332 T3 ES 2184332T3 ES 98955422 T ES98955422 T ES 98955422T ES 98955422 T ES98955422 T ES 98955422T ES 2184332 T3 ES2184332 T3 ES 2184332T3
Authority
ES
Spain
Prior art keywords
channel
purification
magnetic gradient
elevated magnetic
cellular separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98955422T
Other languages
English (en)
Inventor
Donald David Briggs
Shang-Chih Jen
Richard Merrill Schwartz
Srikanth Ranga Chary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2184332T3 publication Critical patent/ES2184332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/888—Shaping or removal of materials, e.g. etching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure

Landscapes

  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)

Abstract

Dispositivo de separación para separar sustancias marcadas magnéticamente de un medio que comprende: un recipiente que tiene un canal interior, teniendo además el recipiente una entrada y una salida separadas; y un medio que produce un campo magnético de gradiente elevado que comprende extremidades polares magnéticas en los lados opuestos o sustancialmente opuestos del canal, en el que en funcionamiento, las extremidades polares crean un gradiente magnético continuo a través del canal, de manera que no exista en el canal un campo magnético cero.
ES98955422T 1997-10-10 1998-10-09 Dispositivo de gradiente magnetico elevado y metodo para la separacion o purificacion celular. Expired - Lifetime ES2184332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/948,357 US6241894B1 (en) 1997-10-10 1997-10-10 High gradient magnetic device and method for cell separation or purification

Publications (1)

Publication Number Publication Date
ES2184332T3 true ES2184332T3 (es) 2003-04-01

Family

ID=25487708

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98955422T Expired - Lifetime ES2184332T3 (es) 1997-10-10 1998-10-09 Dispositivo de gradiente magnetico elevado y metodo para la separacion o purificacion celular.

Country Status (9)

Country Link
US (1) US6241894B1 (es)
EP (1) EP1019195B1 (es)
AT (1) ATE223759T1 (es)
AU (1) AU1226999A (es)
DE (1) DE69807905T2 (es)
DK (1) DK1019195T3 (es)
ES (1) ES2184332T3 (es)
PT (1) PT1019195E (es)
WO (1) WO1999019071A1 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
DE10127069A1 (de) * 2001-05-23 2002-11-28 Bio Medical Apherese Systeme G Magnetfilter zur Abtrennung von strömenden magnetischen Objekten
EP1331035A1 (en) * 2002-01-23 2003-07-30 F. Hoffmann-La Roche AG Apparatus for retaining magnetic particles within a flow-through cell
US7318902B2 (en) * 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
AU2003277153A1 (en) 2002-09-27 2004-04-19 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
USD490531S1 (en) 2002-11-22 2004-05-25 Stemcell Technologies Inc. Magnetic separator housing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2532414C (en) 2003-07-12 2017-03-14 Accelr8 Technology Corporation Sensitive and rapid biodetection
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
DE102008047855A1 (de) * 2008-09-18 2010-04-22 Siemens Aktiengesellschaft Trenneinrichtung zur Trennung von in einer durch einen Trennkanal strömenden Suspension transportierten magnetisierbaren und nichtmagnetisierbaren Teilchen
US9156037B2 (en) 2009-01-15 2015-10-13 Children's Medical Center Corporation Microfluidic device and uses thereof
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
TWI362964B (en) 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
TWI407101B (zh) 2011-04-11 2013-09-01 Ind Tech Res Inst 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法
EP2701850B1 (en) 2011-04-27 2018-08-15 Becton Dickinson and Company Devices and methods for separating magnetically labeled moieties in a sample
WO2014066553A1 (en) * 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN105264127B (zh) 2013-03-15 2019-04-09 Gpb科学有限责任公司 颗粒的片上微流体处理
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
US9884326B2 (en) * 2013-06-28 2018-02-06 National Institute Of Advanced Industrial Science And Technology Matrix for magnetic separator and magnetic separator
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
GB201519668D0 (en) * 2015-11-06 2015-12-23 Ge Healthcare Bio Sciences Ab Method and chromatography media
US10625272B2 (en) 2015-11-18 2020-04-21 Industrial Technology Research Institute Magnetic separator
WO2018024819A1 (en) * 2016-08-05 2018-02-08 Haute Ecole D'ingenierie Et De Gestion Du Canton De Vaud (Heig-Vd) Device for removing particles from a material in movement
BR102016022548B1 (pt) * 2016-09-28 2022-03-22 José Pancrácio Ribeiro Matriz magnética ondulada para separador magnético de alta intensidade
US10844353B2 (en) 2017-09-01 2020-11-24 Gpb Scientific, Inc. Methods for preparing therapeutically active cells using microfluidics
WO2020058136A1 (en) * 2018-09-20 2020-03-26 Hemotune Ag Assembly for magnetic separation-based body fluid purification
WO2021161221A1 (en) * 2020-02-11 2021-08-19 Khalifa University of Science and Technology Systems and methods for enhancing the efficiency of separation processes
US11529636B2 (en) 2020-10-09 2022-12-20 Cláudio Henrique Teixeira Ribeiro Magnetic matrices and methods of using the same
CN112553043A (zh) * 2020-12-09 2021-03-26 深圳先进技术研究院 用于胎儿有核红细胞分离纯化的微流控芯片
CN118834752B (zh) * 2023-04-24 2025-09-19 深圳赛桥生物创新技术有限公司 磁分选装置及方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB236808A (en) * 1924-12-02 1925-07-16 Krupp Fried Grusonwerk Ag Improvements in or relating to zone poles for magnetic separators
US4212651A (en) * 1979-05-30 1980-07-15 The United States Of America As Represented By The United States Department Of Energy High gradient magnetic beneficiation of dry pulverized coal via upwardly directed recirculating fluidization
US4387286A (en) 1980-03-26 1983-06-07 Inoue-Japax Research Incorporated Apparatus for controlling splashes and purification of a machining liquid
US4560484A (en) * 1980-04-25 1985-12-24 Purdue Research Foundation Method and apparatus for magnetically separating particles from a liquid
US4743364A (en) 1984-03-16 1988-05-10 Kyrazis Demos T Magnetic separation of electrically conducting particles from non-conducting material
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5512332A (en) * 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
EP0339980B1 (en) * 1988-04-26 1994-07-20 Nippon Telegraph And Telephone Corporation Magnetic micro-particles, method and apparatus for collecting specimens for use in labelling immune reactions, and method and device for preparing specimens
US5536475A (en) 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
WO1990007380A2 (en) * 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5385707A (en) 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
WO1994011078A1 (en) * 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
GB9106284D0 (en) * 1991-03-25 1991-05-08 Cryogenic Consult Improvements in and relating to magnetic separators
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
EP0589636B1 (en) 1992-09-24 2000-08-02 Amersham Pharmacia Biotech UK Limited Magnetic separation method and apparatus therefor
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5520158A (en) * 1995-01-12 1996-05-28 Gasmaster International, Inc. Magnetic field fuel treatment device
EP0819250B1 (en) * 1995-04-06 2006-09-20 Miltenyi Biotec Inc. Multiparameter cell separation using releasable colloidal magnetic particles
AU7483596A (en) 1995-11-03 1997-05-22 David Sarnoff Research Center, Inc. Magnet

Also Published As

Publication number Publication date
US6241894B1 (en) 2001-06-05
ATE223759T1 (de) 2002-09-15
AU1226999A (en) 1999-05-03
DE69807905D1 (de) 2002-10-17
PT1019195E (pt) 2003-01-31
EP1019195B1 (en) 2002-09-11
EP1019195A1 (en) 2000-07-19
DE69807905T2 (de) 2003-05-22
WO1999019071A1 (en) 1999-04-22
DK1019195T3 (da) 2002-12-30

Similar Documents

Publication Publication Date Title
ES2184332T3 (es) Dispositivo de gradiente magnetico elevado y metodo para la separacion o purificacion celular.
NO20004163L (no) System, apparat og fremgangsmÕte for kontinuerlig magnetseparasjon av bestanddeler fra en blanding, og fremgangsmÕte for fremstilling av apparatet
ES2098127T3 (es) Procedimiento para la purificacion de taxoides.
IL160482A0 (en) Device and method for concentration and detection of pathogenic germs from blood products and/or their derivatives
ES8500573A1 (es) Metodo para separar particulas en un campo gravitarorio.
ES2180539T3 (es) Metodos para expandir selectivamente celulas madre.
AP9901607A0 (en) Method and apparatus for continuous flow isoelectric focusing for
NO20030023L (no) Apparat og fremgangsmåte for fluidseparasjon
FI20000618A0 (fi) Menetelmä ja laitteisto autojen kuljettamiseksi
ATE364448T1 (de) Hochgradienten-magnetfilter und verfahren zum abtrennen von schwach magnetisierbaren partikeln aus flüssigen medien
DE69233634D1 (de) Gasplasma behandeltes, poröses Medium und Trennungsmethode unter Verwendung des Mediums
MX9204733A (es) Aparato y metodo para procesar pelicula de chatarra.
BR9814215A (pt) Dispositivo e método para resfriar correias de fundição contìnua
DK1533880T3 (da) Indretning og fremgangsmåde til differentialbeskyttelse samt elektrisk apparat, der omfatter en sådan indretning
FI970804A0 (fi) Menetelmä ja laite putkilinjojen, erityisesti viemäriputkijärjestelmien tiiviyden valvomiseksi
EA200400347A1 (ru) Водоотделитель для масла
DE59506819D1 (de) Membranverfahren zur Trennung fluider Gemische
NO20030203D0 (no) Fremgangsmåte og apparat for aritmetisk operasjon og registreringsmedium for operasjonsfremgangsmåten
FI20010234A0 (fi) Laitteisto sekä menetelmä kaasun erottamiseksi virtaavista nesteistä
BR9900117A (pt) Dispositivo para a determinação de fluxo contìnuo de massa de um meio gasoso.
HUP9802208A1 (hu) Eljárás és szerkezet folyadékok vegyi segédanyagok és sűrített levegő nélküli lehűtésére
BR0100753A (pt) Separador magnético de baixa intensidade
MX9207625A (es) Aparato y metodo para reducir contaminantes en el flujo de gas efluente.
ES2127638T3 (es) Procedimiento y dispositivo para la separacion de un medio en una parte componente que contiene materias solidas y en una parte componente liquida.
FR2775615B1 (fr) Procede et installation pour traiter par des elements de separation, un milieu liquide notamment pollue, tout en assurant le non colmatage desdits elements