ES2185374T3 - Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos. - Google Patents

Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos.

Info

Publication number
ES2185374T3
ES2185374T3 ES99933705T ES99933705T ES2185374T3 ES 2185374 T3 ES2185374 T3 ES 2185374T3 ES 99933705 T ES99933705 T ES 99933705T ES 99933705 T ES99933705 T ES 99933705T ES 2185374 T3 ES2185374 T3 ES 2185374T3
Authority
ES
Spain
Prior art keywords
spectra
tissue
region
collected
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99933705T
Other languages
English (en)
Inventor
Joseph Chaiken
Charles M Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LighTouch Medical Inc
Original Assignee
LighTouch Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LighTouch Medical Inc filed Critical LighTouch Medical Inc
Application granted granted Critical
Publication of ES2185374T3 publication Critical patent/ES2185374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/655—Stimulated Raman

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Un método no invasor para determinar la concentración de un analito en sangre de un sujeto, que comprende: a) irradiar una región de tejido del sujeto con un manantial de luz; b) recoger los espectros de fluorescencia emitidos por la región de tejido, siendo la cantidad de espectros de fluorescencia indicadora del volumen de sangre; c) recoger los espectros de Raman emitidos por la región de tejido para un margen de longitudes de onda que corresponda al analito, siendo la cantidad de espectros de Raman indicadora de la cantidad de analito; y d) dividir los espectros de Raman recogidos por los espectros de fluorescencia recogidos, para obtener un número proporcional a la concentración de analito por unidad de volumen de sangre.
ES99933705T 1998-07-07 1999-07-07 Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos. Expired - Lifetime ES2185374T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9189998P 1998-07-07 1998-07-07

Publications (1)

Publication Number Publication Date
ES2185374T3 true ES2185374T3 (es) 2003-04-16

Family

ID=22230207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99933705T Expired - Lifetime ES2185374T3 (es) 1998-07-07 1999-07-07 Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos.

Country Status (9)

Country Link
US (1) US6289230B1 (es)
EP (1) EP1094746B1 (es)
JP (1) JP4486253B2 (es)
AT (1) ATE225142T1 (es)
AU (1) AU4970499A (es)
CA (1) CA2333565C (es)
DE (1) DE69903306T2 (es)
ES (1) ES2185374T3 (es)
WO (1) WO2000001295A1 (es)

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US6289230B1 (en) 2001-09-11
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