ES2185459A1 - Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo. - Google Patents

Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.

Info

Publication number
ES2185459A1
ES2185459A1 ES200002370A ES200002370A ES2185459A1 ES 2185459 A1 ES2185459 A1 ES 2185459A1 ES 200002370 A ES200002370 A ES 200002370A ES 200002370 A ES200002370 A ES 200002370A ES 2185459 A1 ES2185459 A1 ES 2185459A1
Authority
ES
Spain
Prior art keywords
preparation
pantoprazole
intermediates therefor
intermediate compounds
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002370A
Other languages
English (en)
Other versions
ES2185459B1 (es
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma Francis SRL
Original Assignee
Dinamite Dipharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200002370A priority Critical patent/ES2185459B1/es
Application filed by Dinamite Dipharma SpA filed Critical Dinamite Dipharma SpA
Priority to ES01974316T priority patent/ES2227276T3/es
Priority to AU2001293856A priority patent/AU2001293856A1/en
Priority to US10/381,978 priority patent/US7060839B2/en
Priority to CA002424278A priority patent/CA2424278A1/en
Priority to KR10-2003-7004671A priority patent/KR20030060901A/ko
Priority to AT01974316T priority patent/ATE275561T1/de
Priority to MXPA03002908A priority patent/MXPA03002908A/es
Priority to IL15518101A priority patent/IL155181A0/xx
Priority to JP2002561459A priority patent/JP2004517944A/ja
Priority to TR2004/02547T priority patent/TR200402547T4/xx
Priority to DE60105441T priority patent/DE60105441T2/de
Priority to DK01974316T priority patent/DK1335913T3/da
Priority to PCT/EP2001/011327 priority patent/WO2002028852A1/en
Priority to EP01974316A priority patent/EP1335913B1/en
Priority to IL155181A priority patent/IL155181A/en
Publication of ES2185459A1 publication Critical patent/ES2185459A1/es
Application granted granted Critical
Publication of ES2185459B1 publication Critical patent/ES2185459B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la obtención de pantoprazol y compuestos intermedios para el mismo. Se describe un nuevo procedimiento para la obtención del principio activo pantoprazol que se basa en el empleo de nuevos compuestos intermedios de fórmula general (I), **FIGURA** en la que X representa un átomo de halógeno y n es 0 ó 1, de manera que cuando n es 1, los compuestos intermedios se someten a una reacción de metoxilación, y cuando n es 0 dichos compuestos intermedios se oxidan en primer lugar hasta que n sea 1 y posteriormente se someten a la reacción de metoxilación. Se describen también los nuevos intermedios, así como su procedimiento de obtención.
ES200002370A 2000-10-02 2000-10-02 Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo. Expired - Fee Related ES2185459B1 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES200002370A ES2185459B1 (es) 2000-10-02 2000-10-02 Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
TR2004/02547T TR200402547T4 (tr) 2000-10-02 2001-10-01 Pantoprazol ve ara maddelerini hazırlamak için bir işlem.
US10/381,978 US7060839B2 (en) 2000-10-02 2001-10-01 Process for the preparation of pantoprazole and intermediates therefor
CA002424278A CA2424278A1 (en) 2000-10-02 2001-10-01 A process for the preparation of pantoprazole and intermediates therefor
KR10-2003-7004671A KR20030060901A (ko) 2000-10-02 2001-10-01 팬토프라졸 및 그 중간체의 제조방법
AT01974316T ATE275561T1 (de) 2000-10-02 2001-10-01 Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
MXPA03002908A MXPA03002908A (es) 2000-10-02 2001-10-01 Procedimientos para la preparacion de pantoprazol e intermedios del mismo.
IL15518101A IL155181A0 (en) 2000-10-02 2001-10-01 A process for the preparation of pantoprazole and intermediates therefor
ES01974316T ES2227276T3 (es) 2000-10-02 2001-10-01 Porocedimiento de preparacion de pantoprazol e intermediarios del mismo.
AU2001293856A AU2001293856A1 (en) 2000-10-02 2001-10-01 A process for the preparation of pantoprazole and intermediates therefor
DE60105441T DE60105441T2 (de) 2000-10-02 2001-10-01 Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
DK01974316T DK1335913T3 (da) 2000-10-02 2001-10-01 Fremgangsmåde til fremstilling af pantoprazol og intermediære deraf
PCT/EP2001/011327 WO2002028852A1 (en) 2000-10-02 2001-10-01 A process for the preparation of pantoprazole and intermediates therefor
EP01974316A EP1335913B1 (en) 2000-10-02 2001-10-01 A process for the preparation of pantoprazole and intermediates therefor
JP2002561459A JP2004517944A (ja) 2000-10-02 2001-10-01 パントプラゾールおよびその中間体を調製する方法
IL155181A IL155181A (en) 2000-10-02 2003-04-01 Process for making pantoprazole and its intermediates and processes for making them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002370A ES2185459B1 (es) 2000-10-02 2000-10-02 Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.

Publications (2)

Publication Number Publication Date
ES2185459A1 true ES2185459A1 (es) 2003-04-16
ES2185459B1 ES2185459B1 (es) 2003-12-16

Family

ID=8495120

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002370A Expired - Fee Related ES2185459B1 (es) 2000-10-02 2000-10-02 Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
ES01974316T Expired - Lifetime ES2227276T3 (es) 2000-10-02 2001-10-01 Porocedimiento de preparacion de pantoprazol e intermediarios del mismo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01974316T Expired - Lifetime ES2227276T3 (es) 2000-10-02 2001-10-01 Porocedimiento de preparacion de pantoprazol e intermediarios del mismo.

Country Status (14)

Country Link
US (1) US7060839B2 (es)
EP (1) EP1335913B1 (es)
JP (1) JP2004517944A (es)
KR (1) KR20030060901A (es)
AT (1) ATE275561T1 (es)
AU (1) AU2001293856A1 (es)
CA (1) CA2424278A1 (es)
DE (1) DE60105441T2 (es)
DK (1) DK1335913T3 (es)
ES (2) ES2185459B1 (es)
IL (2) IL155181A0 (es)
MX (1) MXPA03002908A (es)
TR (1) TR200402547T4 (es)
WO (1) WO2002028852A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2163372B1 (es) * 2000-03-13 2003-05-01 Esteve Quimica Sa Procedimiento de oxidacion de un grupo tioeter a sulfoxido.
CA2510849A1 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
CA2518999A1 (en) * 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd Crystalline and amorphous solids of pantoprazole and processes for their preparation
WO2004111029A2 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
ITMI20031813A1 (it) * 2003-09-23 2005-03-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di pantoprazolo e suoi sali.
WO2005054228A1 (en) * 2003-12-05 2005-06-16 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
ZA200706613B (en) * 2004-12-16 2009-03-25 Cipla Ltd Process
ES2264362B1 (es) * 2004-12-22 2007-11-01 Laboratorios Viñas S.A. "procedimiento para la obtencion de derivados de 2-(2-piridinilmetilsufinil-1h-benzimidazoles".
ES2273564B1 (es) * 2005-03-22 2008-04-01 Quimica Sintetica, S.A. Procedimiento para la preparacion de pantoprazol.
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
CN103242297A (zh) * 2013-05-20 2013-08-14 湖北宜恒茶油产业科技有限责任公司 一种5-二氟甲氧基-2-[[(4-氯-3-甲氧基-2-吡啶基)甲基]硫代]-1h-苯并咪唑一水合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8705875A1 (es) * 1984-06-16 1987-06-01 Byk Gulden Lomberg Chem Fab Procedimiento para preparar dialcoxipiridinas
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
WO2001004109A1 (en) * 1999-07-14 2001-01-18 Quimica Sintetica, S.A. Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT394368B (de) * 1990-08-07 1992-03-25 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von 3,4-dialkoxypyridinen
RU2060541C1 (ru) 1992-06-03 1996-05-20 Проектное бюро "ЭЛСАР тоо" Устройство для вычисления азимутальной корреляционной функции
ES2171116B1 (es) * 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8705875A1 (es) * 1984-06-16 1987-06-01 Byk Gulden Lomberg Chem Fab Procedimiento para preparar dialcoxipiridinas
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
WO2001004109A1 (en) * 1999-07-14 2001-01-18 Quimica Sintetica, S.A. Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles

Also Published As

Publication number Publication date
US20040049044A1 (en) 2004-03-11
TR200402547T4 (tr) 2004-12-21
DK1335913T3 (da) 2005-01-10
DE60105441T2 (de) 2005-01-20
IL155181A0 (en) 2003-11-23
EP1335913A1 (en) 2003-08-20
CA2424278A1 (en) 2002-04-11
AU2001293856A1 (en) 2002-04-15
ES2227276T3 (es) 2005-04-01
US7060839B2 (en) 2006-06-13
MXPA03002908A (es) 2004-12-03
KR20030060901A (ko) 2003-07-16
DE60105441D1 (de) 2004-10-14
ATE275561T1 (de) 2004-09-15
JP2004517944A (ja) 2004-06-17
WO2002028852A1 (en) 2002-04-11
IL155181A (en) 2008-11-03
EP1335913B1 (en) 2004-09-08
ES2185459B1 (es) 2003-12-16

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