ES2185655T3 - Fracciones de acido aurintricarboxilico y analogos con actividad anti-angiogenica y metodos de uso. - Google Patents

Fracciones de acido aurintricarboxilico y analogos con actividad anti-angiogenica y metodos de uso.

Info

Publication number
ES2185655T3
ES2185655T3 ES94919200T ES94919200T ES2185655T3 ES 2185655 T3 ES2185655 T3 ES 2185655T3 ES 94919200 T ES94919200 T ES 94919200T ES 94919200 T ES94919200 T ES 94919200T ES 2185655 T3 ES2185655 T3 ES 2185655T3
Authority
ES
Spain
Prior art keywords
aurintricarboxilic
acid
analogs
fractions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94919200T
Other languages
English (en)
Inventor
Delwood Collins
Antonio Gagliardi
Anjan Bhattacharyya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Application granted granted Critical
Publication of ES2185655T3 publication Critical patent/ES2185655T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

EL ACIDO AURINTRICARBOXILICO TIENE UNA POTENTE ACTIVIDAD ANTIANGIOGENICA Y PUDE USARSE PARA NUEVAS COMPOSICIONES TERAPEUTICAS PARA ENFERMEDADES DE NEOVASCULARIZACION INCLUYENDO EL TRATAMIENTO DE TUMORES SOLIDOS, LA RETINOPATIA DIABETICA Y LA RINITIS, ENTRE OTRAS ENFERMEDADES.
ES94919200T 1993-05-17 1994-05-17 Fracciones de acido aurintricarboxilico y analogos con actividad anti-angiogenica y metodos de uso. Expired - Lifetime ES2185655T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/061,477 US5434185A (en) 1993-05-17 1993-05-17 Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts

Publications (1)

Publication Number Publication Date
ES2185655T3 true ES2185655T3 (es) 2003-05-01

Family

ID=22036048

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94919200T Expired - Lifetime ES2185655T3 (es) 1993-05-17 1994-05-17 Fracciones de acido aurintricarboxilico y analogos con actividad anti-angiogenica y metodos de uso.

Country Status (9)

Country Link
US (1) US5434185A (es)
EP (1) EP0699070B1 (es)
AU (1) AU678307B2 (es)
CA (1) CA2163118C (es)
DE (1) DE69431349T2 (es)
ES (1) ES2185655T3 (es)
NZ (1) NZ267802A (es)
PT (1) PT699070E (es)
WO (1) WO1994026278A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2438297A (en) * 1996-05-09 1997-11-26 Alcon Laboratories, Inc. Combinations of angiostatic compounds
US6537554B1 (en) 1998-09-10 2003-03-25 Curagen Corporation Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
WO2000030632A1 (en) * 1998-11-23 2000-06-02 Eisai Co., Ltd. Aryl and heteroaryl compounds useful as fibroblast growth factor antagonists
US6371980B1 (en) * 1999-08-30 2002-04-16 Cardiovasc, Inc. Composite expandable device with impervious polymeric covering and bioactive coating thereon, delivery apparatus and method
US6538028B1 (en) 2000-02-01 2003-03-25 Vanderbilt University Method for inhibiting complement activation
US20030104573A1 (en) * 2000-09-11 2003-06-05 Shimkets Richard A. Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
DK1663197T3 (da) 2003-09-09 2008-01-07 Fumapharm Ag Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astma
WO2005123965A1 (en) * 2004-06-15 2005-12-29 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Potent and selective inhibition by aurintricarboxylic acid
SI1799196T1 (sl) 2004-10-08 2016-10-28 Forward Pharma A/S Farmacevtski sestavki z nadzorovanim sproščanjem, obsegajoči ester fumarne kisline
US10966945B2 (en) 2011-08-01 2021-04-06 Aurin Biotech Inc. Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic synthetic complex
US10588879B2 (en) 2011-08-01 2020-03-17 Aurin Biotech Inc. Treatment of age-related macular degeneration
EP2581080A1 (en) 2011-10-13 2013-04-17 Helmholtz-Zentrum für Infektionsforschung GmbH Inhibitor of colonisation of mucosa
JP2015522060A (ja) * 2012-07-13 2015-08-03 アウリン バイオテック インコーポレイテッド アウリントリカルボン酸合成複合体の低分子量成分による、補体の膜侵襲複合体およびｃ３転換酵素の選択的阻害
US8877808B2 (en) 2012-12-06 2014-11-04 Aurin Biotech Inc. Protection against skin diseases by aurin tricarboxylic acid and its derivatives
WO2015154057A1 (en) * 2014-04-04 2015-10-08 Nhan Tran Methods for treating cancer
US10004707B2 (en) 2014-04-15 2018-06-26 Aurin Biotech Inc. Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007270A (en) * 1975-11-18 1977-02-08 American Cyanamid Company Complement inhibitors
GB1560880A (en) * 1975-12-29 1980-02-13 Ici Ltd Diphenylmethane derivatives and pharmaceutical compositions containing them
US4749647A (en) * 1984-06-22 1988-06-07 Genetic Systems Corporation Polymerization-induced separation assay using recognition pairs
NO162160C (no) * 1987-01-09 1989-11-15 Medi Cult As Serumfritt vekstmedium, samt anvendelse derav.
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis

Also Published As

Publication number Publication date
WO1994026278A1 (en) 1994-11-24
EP0699070B1 (en) 2002-09-11
DE69431349T2 (de) 2003-07-31
PT699070E (pt) 2003-01-31
AU678307B2 (en) 1997-05-22
CA2163118A1 (en) 1994-11-24
EP0699070A1 (en) 1996-03-06
CA2163118C (en) 1999-10-26
DE69431349D1 (de) 2002-10-17
AU8050294A (en) 1994-12-12
EP0699070A4 (en) 1997-11-12
US5434185A (en) 1995-07-18
NZ267802A (en) 1997-04-24

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