ES2185709T3 - Aparato y metodo para realizar manipulaciones microfluidicas para analisis y sintesis quimicos. - Google Patents

Aparato y metodo para realizar manipulaciones microfluidicas para analisis y sintesis quimicos.

Info

Publication number
ES2185709T3
ES2185709T3 ES95927492T ES95927492T ES2185709T3 ES 2185709 T3 ES2185709 T3 ES 2185709T3 ES 95927492 T ES95927492 T ES 95927492T ES 95927492 T ES95927492 T ES 95927492T ES 2185709 T3 ES2185709 T3 ES 2185709T3
Authority
ES
Spain
Prior art keywords
microchip
synthesis
channels
substrate
chemical analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927492T
Other languages
English (en)
Inventor
J Michael Ramsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UT Battelle LLC
Original Assignee
UT Battelle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UT Battelle LLC filed Critical UT Battelle LLC
Application granted granted Critical
Publication of ES2185709T3 publication Critical patent/ES2185709T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00912—Separation by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00916—Separation by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00993—Design aspects
    • B01J2219/00995—Mathematical modeling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
    • B29C66/026—Chemical pre-treatments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/03—After-treatments in the joint area
    • B29C66/034—Thermal after-treatments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N2030/162—Injection electromigration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/383—Flow patterns flow switching in a single column by using auxiliary fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G01N2030/8435—Preparation of the fraction to be distributed adding modificating material for chemical reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/01—Micromixers: continuous laminar flow with laminar boundary mixing in the linear direction parallel to the fluid propagation with or without conduit geometry influences from the pathway

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Fluid Mechanics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Non-Electrical Variables (AREA)

Abstract

SE PRESENTA UN METODO Y UN SISTEMA DE LABORATORIO DE MICROCHIP (10) QUE SUMINISTRAN MANIPULACIONES FLUIDICAS PARA UNA VARIEDAD DE APLICACIONES, INCLUYENDO LA INYECCION DE MUESTRAS PARA SEPARACIONES QUIMICAS DE MICROCHIP. EL MICROCHIP SE FABRICA UTILIZANDO PROCEDIMIENTOS DE FOTOLITOGRAFIA COMUNES Y ATAQUE QUIMICO HUMEDO, CON EL SUBSTRATO Y LA PLACA DE CUBIERTA UNIDOS UTILIZANDO UNION DIRECTA. LA ELECTROCROMATOGRAFIA Y LA ELECTROFORESIS CAPILAR SE REALIZAN EN CANALES (26, 28, 30, 32, 34, 36, 38) FORMADOS EN EL SUBSTRATO. LOS SUJETOS DE ANALISIS SON CARGADOS EN UNA INTERSECCION DE CUATRO VIAS DE LOS CANALES BOMBEANDO ELECTROCINETICAMENTE EL SUJETO DE ANALISIS A TRAVES DE LA INTERSECCION (40), SIGUIENDO CON UNA CONMUTACION DE LOS POTENCIALES PARA OBLIGAR A QUE EL SUJETO DE ANALISIS SE OBTURE EN EL INTERIOR DEL CANAL DE SEPARACION.
ES95927492T 1994-08-01 1995-08-01 Aparato y metodo para realizar manipulaciones microfluidicas para analisis y sintesis quimicos. Expired - Lifetime ES2185709T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/283,769 US6001229A (en) 1994-08-01 1994-08-01 Apparatus and method for performing microfluidic manipulations for chemical analysis

Publications (1)

Publication Number Publication Date
ES2185709T3 true ES2185709T3 (es) 2003-05-01

Family

ID=23087469

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927492T Expired - Lifetime ES2185709T3 (es) 1994-08-01 1995-08-01 Aparato y metodo para realizar manipulaciones microfluidicas para analisis y sintesis quimicos.

Country Status (13)

Country Link
US (16) US6001229A (es)
EP (3) EP1382962A1 (es)
JP (1) JP4023819B2 (es)
KR (1) KR100369497B1 (es)
CN (1) CN1052301C (es)
AT (2) ATE374940T1 (es)
AU (1) AU701348B2 (es)
CA (1) CA2196429C (es)
DE (2) DE69535608T2 (es)
DK (1) DK0775306T3 (es)
ES (1) ES2185709T3 (es)
MX (1) MX9700845A (es)
WO (1) WO1996004547A1 (es)

Families Citing this family (823)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6652808B1 (en) * 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
DE69333601T2 (de) 1993-04-15 2005-09-15 Zeptosens Ag Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
DE19511603A1 (de) * 1995-03-30 1996-10-02 Norbert Dr Ing Schwesinger Vorrichtung zum Mischen kleiner Flüssigkeitsmengen
US6120665A (en) * 1995-06-07 2000-09-19 Chiang; William Yat Chung Electrokinetic pumping
AU6541596A (en) * 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
DE19536582A1 (de) * 1995-09-29 1997-04-03 Siemens Ag Verfahren und Vorrichtung zur Bereitstellung eines Volumens einer Substanz
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
EP0889751B1 (en) * 1996-04-03 1999-09-08 The Perkin-Elmer Corporation Device and method for multiple analyte detection
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
EP1726957A3 (en) 1996-04-25 2007-07-11 BioArray Solutions Ltd. Light-controlled electrokinetic assembly of particles near surfaces
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US5971158A (en) * 1996-06-14 1999-10-26 University Of Washington Absorption-enhanced differential extraction device
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
JP3361530B2 (ja) 1996-06-28 2003-01-07 カリパー・テクノロジーズ・コープ． 電子ピペッタおよび電気泳動バイアスのための補償手段
AU754363B2 (en) * 1996-06-28 2002-11-14 Caliper Life Sciences, Inc. Microfluidic device and method
AU2003213516C1 (en) * 1996-06-28 2006-04-27 Caliper Technologies Corporation High-throughput Screening Assay Systems in Microscale Fluidic Devices
AU729537B2 (en) * 1996-06-28 2001-02-01 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
AU743084B2 (en) * 1996-07-16 2002-01-17 Caliper Technologies Corporation Separation of fluid components in a microfluidic system
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5858187A (en) * 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
EP0938674B1 (de) 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
US6465257B1 (en) 1996-11-19 2002-10-15 Caliper Technologies Corp. Microfluidic systems
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
DE19648458C1 (de) 1996-11-22 1998-07-09 Evotec Biosystems Gmbh Mikromechanische Ejektionspumpe zum Heraustrennen kleinster Fluidvolumina aus einem strömenden Probenfluid
GB2319771B (en) * 1996-11-29 2001-09-26 Imperial College Process
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
EP1030733A1 (en) * 1997-02-05 2000-08-30 California Institute Of Technology Microfluidic sub-millisecond mixers
US6056859A (en) * 1997-02-12 2000-05-02 Lockheed Martin Energy Research Corporation Method and apparatus for staining immobilized nucleic acids
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US5964995A (en) 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
CA2284612A1 (en) 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
US7033474B1 (en) * 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
AU727083B2 (en) 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
US5976336A (en) * 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
AU747505B2 (en) * 1997-04-25 2002-05-16 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
JP2002503336A (ja) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US6524790B1 (en) * 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
US5882465A (en) * 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5900130A (en) * 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
CA2300203A1 (en) * 1997-09-02 1999-03-11 Caliper Technologies Corporation Microfluidic system with electrofluidic and electrothermal controls
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6012902A (en) * 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
EP1018012A4 (en) 1997-09-26 2002-10-09 Univ Washington Simultaneous particle separation and chemical reaction
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) * 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6143152A (en) * 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
JP2001523001A (ja) * 1997-11-12 2001-11-20 ピーイー コーポレイション （エヌワイ） 自己修正ベンドをもつ蛇行電気泳動チャネル
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6074725A (en) * 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
US5948227A (en) * 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6299747B1 (en) 1997-12-17 2001-10-09 Cetek Corporation Capillary electrophoretic methods to detect new biologically active compounds in complex biological material
EP1042668A1 (en) 1997-12-24 2000-10-11 Cetek Corporation Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
EP1044370B1 (en) 1997-12-30 2017-08-23 Caliper Life Sciences, Inc. Software for the display of chromatographic separation data
US6153076A (en) * 1998-01-12 2000-11-28 The Regents Of The University Of California Extended length microchannels for high density high throughput electrophoresis systems
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6857449B1 (en) 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6100541A (en) * 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
WO1999047255A1 (en) * 1998-03-17 1999-09-23 Cepheid Unitary chemical processing device
DE19980632B4 (de) * 1998-04-08 2005-07-07 Universität Heidelberg Verfahren zur Durchführung von Reaktionen zwischen mindestens zwei Reaktionspartnern in wässrigen Reaktionsgemischen
US6444474B1 (en) * 1998-04-22 2002-09-03 Eltron Research, Inc. Microfluidic system for measurement of total organic carbon
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
CA2320296A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6274089B1 (en) 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
CA2332919A1 (en) * 1998-06-08 1999-12-16 Caliper Technologies Corporation Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
AU4423399A (en) * 1998-06-09 1999-12-30 Caliper Technologies Corporation Fluorescent polarization detection in microfluidic systems
WO1999064851A1 (en) * 1998-06-11 1999-12-16 Arizona Board Of Regents Control of flow and materials for micro devices
US6890411B1 (en) 1998-06-11 2005-05-10 Arizona Board Of Regents Control of flow and materials for micro devices
KR20010052741A (ko) * 1998-06-12 2001-06-25 야마모토 카즈모토 분석 장치
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US6529835B1 (en) 1998-06-25 2003-03-04 Caliper Technologies Corp. High throughput methods, systems and apparatus for performing cell based screening assays
US6627446B1 (en) * 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6794197B1 (en) 1998-07-14 2004-09-21 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US20020049694A1 (en) 1998-07-27 2002-04-25 J. Wallace Parce Distributed database for analytical instruments
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
CN1275202A (zh) * 1998-08-19 2000-11-29 詹诺普蒂克股份公司 输送极少液量的装置及其制造方法
EP1876442A3 (en) 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integrated monolithic microfabricated liquid chromatography system and method
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
US20020192719A1 (en) * 1998-09-30 2002-12-19 Caliper Technologies Corp. Homogeneous assay methods
US6498005B1 (en) 1998-09-30 2002-12-24 Caliper Technologies Corp. Homogeneous assay methods
US6086243A (en) * 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6592696B1 (en) 1998-10-09 2003-07-15 Motorola, Inc. Method for fabricating a multilayered structure and the structures formed by the method
GB9822185D0 (en) 1998-10-13 1998-12-02 Zeneca Ltd Device
AU2003204460B2 (en) * 1998-10-14 2005-11-10 Caliper Life Sciences, Inc. Microfluidic controller and detector system with self-calibration
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
NL1010327C2 (nl) 1998-10-15 2000-04-18 Univ Twente Inrichting en werkwijze voor het besturen van een vloeistofstroom.
US6217731B1 (en) * 1998-10-21 2001-04-17 Spectrumedix Corporation Method and apparatus for monitoring and displaying the status of a parallel capillary electrophoresis device
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6062261A (en) * 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US6150119A (en) 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020019059A1 (en) * 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
CN1296703C (zh) * 1999-02-02 2007-01-24 卡钳生命科学股份有限公司 鉴定蛋白质的方法、装置和系统
US20050027111A1 (en) * 1999-02-02 2005-02-03 Caliper Life Sciences, Inc. Methods, devices and systems for characterizing proteins
US6913679B1 (en) 1999-02-11 2005-07-05 The Regents Of The University Of California Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
EP1174182A4 (en) 1999-02-18 2003-07-23 Toyo Kohan Co Ltd MICROCHIP FOR CHEMICAL REACTIONS
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6503359B2 (en) 1999-03-05 2003-01-07 Burstein Technologies, Inc. Monomolecular adhesion methods for manufacturing microfabricated multilaminate devices
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6148508A (en) * 1999-03-12 2000-11-21 Caliper Technologies Corp. Method of making a capillary for electrokinetic transport of materials
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
JP2000283960A (ja) * 1999-03-31 2000-10-13 Shimadzu Corp マイクロチップ電気泳動装置
AU3547200A (en) * 1999-04-02 2000-10-23 Morphometrix Technologies Inc. Electro-osmotic pumping system and method
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6375817B1 (en) * 1999-04-16 2002-04-23 Perseptive Biosystems, Inc. Apparatus and methods for sample analysis
US6605475B1 (en) 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US6270641B1 (en) * 1999-04-26 2001-08-07 Sandia Corporation Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
WO2000070080A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6287774B1 (en) * 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
AU5291600A (en) * 1999-06-01 2000-12-18 Caliper Technologies Corporation Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
US6406605B1 (en) 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
AU5405100A (en) * 1999-06-16 2001-01-02 Gesellschaft Zur Forderung Der Spektrochemie Und Angewandten Spektroskopie E.V. Device for preparing samples
DE19927535B4 (de) * 1999-06-16 2004-06-17 Merck Patent Gmbh Miniaturisiertes Analysensystem mit Vorrichtung zum Ausschleusen von Substanzen
DE19927534B4 (de) * 1999-06-16 2008-01-31 Merck Patent Gmbh Vorrichtung zur Probenaufgabe
JP2001004628A (ja) * 1999-06-18 2001-01-12 Kanagawa Acad Of Sci & Technol 免疫分析装置と免疫分析方法
GB2385014B (en) 1999-06-21 2003-10-15 Micro Chemical Systems Ltd Method of preparing a working solution
DE19964315B4 (de) * 1999-06-22 2005-01-13 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Analyseneinheit mit einem Schnittstellenelement und einem Labor-Mikrochip
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
WO2000078454A1 (en) * 1999-06-22 2000-12-28 Agilent Technologies, Inc. Apparatus for the operation of a microfluidic device
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
DE19964399B4 (de) * 1999-06-22 2005-06-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Einrichtung zum Betrieb eines Labor-Mikrochips mit einem mittels eines Bajonettverschlusses befestigbaren Schnittstellenelement
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
GB9915686D0 (en) * 1999-07-06 1999-09-01 Zeneca Ltd Device
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6395232B1 (en) * 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
US6660147B1 (en) 1999-07-16 2003-12-09 Applera Corporation High density electrophoresis device and method
DE19935433A1 (de) * 1999-08-01 2001-03-01 Febit Ferrarius Biotech Gmbh Mikrofluidischer Reaktionsträger
US7517442B1 (en) 1999-08-09 2009-04-14 Life Technologies Corporation Facile method and apparatus for the analysis of biological macromolecules in two dimensions using common and familiar electrophoresis formats
KR20020021810A (ko) * 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
AU7101000A (en) 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
EP2343128A1 (en) 1999-09-17 2011-07-13 BioArray Solutions Ltd. Substrate and chip for conducting bioassays
US6210986B1 (en) 1999-09-23 2001-04-03 Sandia Corporation Microfluidic channel fabrication method
US20040023293A1 (en) * 1999-09-27 2004-02-05 Kreimer David I. Biochips for characterizing biological processes
US20020132371A1 (en) * 1999-09-27 2002-09-19 Kreimer David I. Amplification of analyte detection by substrates having particle structures with receptors
US20030232388A1 (en) * 1999-09-27 2003-12-18 Kreimer David I. Beads having identifiable Raman markers
US6468763B1 (en) 1999-09-29 2002-10-22 Caliper Technologies Corp. Optical detection of transmembrane potential changes
DE19947496C2 (de) * 1999-10-01 2003-05-22 Agilent Technologies Inc Mikrofluidischer Mikrochip
DE19964337B4 (de) * 1999-10-01 2004-09-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Mikrofluidischer Mikrochip mit abbiegbarem Ansaugrohr
WO2001027253A1 (en) 1999-10-08 2001-04-19 Caliper Technologies Corp. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
JP2001108619A (ja) 1999-10-12 2001-04-20 Minolta Co Ltd 分析装置、試料操作針および試料取り出し方法
DE19949551C2 (de) 1999-10-14 2001-12-13 Agilent Technologies Inc Mikrofluidischer Mikrochip, Energieversorgungseinrichtung und Verfahren zum Betrieb eines mikrofluidischen Mikrochips
US6878255B1 (en) 1999-11-05 2005-04-12 Arrowhead Center, Inc. Microfluidic devices with thick-film electrochemical detection
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6149815A (en) * 1999-11-23 2000-11-21 Sauter; Andrew D. Precise electrokinetic delivery of minute volumes of liquid(s)
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US6271038B1 (en) * 1999-12-15 2001-08-07 Glaxo Wellcome Inc. Methods for high throughout determination and ranking of formulations and solubility
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
WO2001051918A1 (en) * 2000-01-12 2001-07-19 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU777273B2 (en) * 2000-01-12 2004-10-07 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
EP1248949B1 (en) 2000-01-18 2013-05-22 Advion, Inc. Electrospray device with array of separation columns and method for separation of fluidic samples
US6556923B2 (en) * 2000-01-26 2003-04-29 Caliper Technologies Corp. Software for high throughput microfluidic systems
US6589729B2 (en) 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
DE10005844A1 (de) * 2000-02-10 2004-07-22 Andresen, Karin Anordnung zur Charakterisierung biochemischer Reaktionen und zur Analyse biologischer Proben
US6685813B2 (en) 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
AU3499701A (en) * 2000-02-11 2001-08-20 Aclara Biosciences Inc Microfluidic device with sample injector and method
EP1123739B1 (en) * 2000-02-11 2006-11-29 STMicroelectronics S.r.l. Integrated device for microfluid thermoregulation, and manufacturing process thereof
US20020189946A1 (en) * 2000-02-11 2002-12-19 Aclara Biosciences, Inc. Microfluidic injection and separation system and method
US20040108207A1 (en) * 2000-02-11 2004-06-10 Aclara Biosciences, Inc. Injection and separation system and method employing transient isotachophoretic stacking
DK173796B1 (da) 2000-02-16 2001-11-05 Nkt Res As Fremgangsmåde til styring af strømning i et strømingssystem
US6685810B2 (en) * 2000-02-22 2004-02-03 California Institute Of Technology Development of a gel-free molecular sieve based on self-assembled nano-arrays
US6681616B2 (en) * 2000-02-23 2004-01-27 Caliper Technologies Corp. Microfluidic viscometer
US7040144B2 (en) * 2000-02-23 2006-05-09 Caliper Life Sciences, Inc. Microfluidic viscometer
MXPA02008290A (es) 2000-02-23 2004-09-10 Caliper Technologies Inc Sistema de control de presion de multi-reserva-.
WO2001069226A1 (en) * 2000-03-10 2001-09-20 Dna Sciences, Inc. Cross channel device for serial sample injection
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US6749735B1 (en) 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
US7141152B2 (en) * 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
EP1265709A2 (en) * 2000-03-17 2002-12-18 Aclara BioSciences, Inc. Microfluidic device and system with additional peripheral channels
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
DE10017791A1 (de) * 2000-04-10 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Mikrodosierung kleinster Flüssigkeitsmengen für Biopolymerarrays
US6290909B1 (en) * 2000-04-13 2001-09-18 Sandia Corporation Sample injector for high pressure liquid chromatography
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
WO2001086249A2 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
AU6152301A (en) 2000-05-12 2001-11-26 Caliper Techn Corp Detection of nucleic acid hybridization by fluorescence polarization
US20040009614A1 (en) * 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
GB2362713A (en) * 2000-05-26 2001-11-28 Casect Ltd Sampling system for gas
WO2001095999A1 (en) * 2000-06-09 2001-12-20 University Of Delaware System and method for chemical analysis using laser ablation
GB2363809B (en) * 2000-06-21 2003-04-02 Schlumberger Holdings Chemical sensor for wellbore applications
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001271438A1 (en) * 2000-06-23 2002-01-08 Daniel Armstrong Method for separation, identification and evaluation of microbes and cells
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
EP1305615B1 (en) * 2000-07-21 2004-09-29 Aclara BioSciences, Inc. Method and devices for capillary electrophoresis with a norbornene based surface coating
US7049579B2 (en) * 2000-07-26 2006-05-23 The Regents Of The University Of California Manipulation of live cells and inorganic objects with optical micro beam arrays
WO2002010732A1 (en) * 2000-08-02 2002-02-07 Caliper Technologies Corp. High throughput separations based analysis systems
US20070119711A1 (en) * 2000-08-02 2007-05-31 Caliper Life Sciences, Inc. High throughput separations based analysis systems and methods
AU2001284700B2 (en) * 2000-08-03 2005-12-08 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
DE10041853C1 (de) * 2000-08-25 2002-02-28 Gmd Gmbh Konfigurierbares Mikroreaktornetzwerk
ATE448875T1 (de) * 2000-09-14 2009-12-15 Caliper Life Sciences Inc Mikrofluidische vorrichtungen und methoden um temperatur-vermittelte reaktionen durchzuführen
US7057704B2 (en) 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20020041831A1 (en) * 2000-09-18 2002-04-11 Battrell C. Frederick Externally controllable surface coatings for microfluidic devices
US6939451B2 (en) * 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
JP2002184775A (ja) * 2000-12-19 2002-06-28 Mitsubishi Electric Corp 柱状構造物を備えた構造体、その製造方法及びそれを用いたｄｎａ分離デバイス
US6706162B1 (en) * 2000-09-25 2004-03-16 Applera Corporation High speed, high resolution compositions, methods, and kits for capillary electrophoresis
US6994826B1 (en) 2000-09-26 2006-02-07 Sandia National Laboratories Method and apparatus for controlling cross contamination of microfluid channels
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
WO2002037091A1 (en) 2000-10-31 2002-05-10 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20030057092A1 (en) * 2000-10-31 2003-03-27 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20050011761A1 (en) * 2000-10-31 2005-01-20 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
WO2002037079A2 (en) * 2000-11-06 2002-05-10 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Sample delivery system with laminar mixing for microvolume biosensing
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US6744038B2 (en) 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US6784420B2 (en) * 2000-11-13 2004-08-31 Genoptix, Inc. Method of separating particles using an optical gradient
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6833542B2 (en) * 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
US6770182B1 (en) * 2000-11-14 2004-08-03 Sandia National Laboratories Method for producing a thin sample band in a microchannel device
AU2002230524A1 (en) * 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
AU2002227181A1 (en) 2000-11-16 2002-05-27 Burstein Technologies, Inc. Optical biodiscs with reflective layers
EP1345698A4 (en) * 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUID DEVICES FOR THE INTRODUCTION AND DISPOSAL OF FLUIDS FROM MICROFLUID SYSTEMS
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
EP1355858A2 (en) * 2000-11-17 2003-10-29 University Of Virginia Patent Foundation Method for orthogonal analyte stacking/injection systems in electrophoresis
JP2002214241A (ja) * 2000-11-20 2002-07-31 Minolta Co Ltd マイクロチップ
EP1410045A2 (en) * 2000-11-22 2004-04-21 Burstein Technologies, Inc. Apparatus and methods for separating agglutinants and disperse particles
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
GB0028647D0 (en) * 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
US6942778B1 (en) * 2000-11-28 2005-09-13 Nanogen, Inc. Microstructure apparatus and method for separating differently charged molecules using an applied electric field
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
JP3778041B2 (ja) * 2000-12-08 2006-05-24 コニカミノルタホールディングス株式会社 粒子分離機構及び粒子分離装置
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
JP2002236131A (ja) * 2000-12-08 2002-08-23 Minolta Co Ltd マイクロチップ
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
US20020110926A1 (en) * 2001-01-16 2002-08-15 Caliper Technologies Corp. Emulator device
US7070681B2 (en) * 2001-01-24 2006-07-04 The Board Of Trustees Of The Leland Stanford Junior University Electrokinetic instability micromixer
EP1355823A4 (en) * 2001-01-29 2005-04-20 Caliper Life Sciences Inc NON-MECHANICAL VALVES FOR FLUID SYSTEMS
US6707548B2 (en) 2001-02-08 2004-03-16 Array Bioscience Corporation Systems and methods for filter based spectrographic analysis
WO2002070118A2 (en) * 2001-02-09 2002-09-12 Microchem Solutions Apparatus and method for small-volume fluid manipulation and transportation
AU2002306486A1 (en) * 2001-02-09 2002-08-28 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
US6913697B2 (en) * 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
EP1360472B1 (en) * 2001-02-15 2009-12-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
US7670559B2 (en) * 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7016560B2 (en) * 2001-02-28 2006-03-21 Lightwave Microsystems Corporation Microfluidic control for waveguide optical switches, variable attenuators, and other optical devices
US6949176B2 (en) * 2001-02-28 2005-09-27 Lightwave Microsystems Corporation Microfluidic control using dielectric pumping
US7867776B2 (en) * 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US6870613B1 (en) * 2001-03-07 2005-03-22 Carolyn Tisone Simultaneous recording of multispectral fluorescence signatures
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US20020151041A1 (en) * 2001-03-15 2002-10-17 Kreimer David I. Enhancing surfaces for analyte detection
US7037417B2 (en) * 2001-03-19 2006-05-02 Ecole Polytechnique Federale De Lausanne Mechanical control of fluids in micro-analytical devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6575188B2 (en) * 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6989129B2 (en) * 2001-04-05 2006-01-24 The President And Fellows Of Harvard College Automated capillary liquid chromatography small volume analysis system
JP5162074B2 (ja) 2001-04-06 2013-03-13 フルイディグム コーポレイション ポリマー表面修飾
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
JP4362987B2 (ja) * 2001-04-09 2009-11-11 株式会社島津製作所 マイクロチップ電気泳動におけるサンプル導入方法
EP1377693A2 (en) * 2001-04-12 2004-01-07 AstraZeneca AB Micro-engineered reactors
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US20040009540A1 (en) * 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
DE60221240T2 (de) * 2001-05-02 2007-10-31 Applera Corp., Foster City Konzentration und reinigung von analyten mit elektrischen feldern
AU2002302937A1 (en) * 2001-05-07 2002-11-18 Nanolab Ltd. Method and apparatus for propelling a fluid
KR100442680B1 (ko) * 2001-05-10 2004-08-02 주식회사 디지탈바이오테크놀러지 미세 혼합 채널 장치
KR100442681B1 (ko) * 2001-05-10 2004-08-02 주식회사 디지탈바이오테크놀러지 채널 유닛 및 이 유닛을 이용한 혼합 채널 장치
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
US7211442B2 (en) * 2001-06-20 2007-05-01 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7179423B2 (en) 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US20020195343A1 (en) * 2001-06-20 2002-12-26 Coventor, Inc. Microfabricated separation device employing a virtual wall for interfacing fluids
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
US20030015425A1 (en) * 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US20020197733A1 (en) * 2001-06-20 2002-12-26 Coventor, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
AU2002326314A1 (en) * 2001-06-20 2003-01-08 Teragenics, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
EP1493487A1 (de) * 2001-06-28 2005-01-05 Agilent Technologies, Inc. Mikrofluid-System mit ESI-Reststromregelung
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
WO2003006133A2 (en) * 2001-07-13 2003-01-23 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
KR100455661B1 (ko) * 2001-07-20 2004-11-12 학교법인 포항공과대학교 아민 화합물 분석용 랩온어칩
US20060062696A1 (en) 2001-07-27 2006-03-23 Caliper Life Sciences, Inc. Optimized high throughput analytical systems
US7060171B1 (en) * 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
US6890409B2 (en) * 2001-08-24 2005-05-10 Applera Corporation Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US20030072682A1 (en) * 2001-10-11 2003-04-17 Dan Kikinis Method and apparatus for performing biochemical testing in a microenvironment
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US6966880B2 (en) * 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
US6783647B2 (en) 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
CA2463420A1 (en) * 2001-10-24 2003-05-01 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
WO2003038424A1 (en) * 2001-11-02 2003-05-08 Imperial College Innovations Limited Capillary electrophoresis microchip, system and method
US20030086333A1 (en) * 2001-11-05 2003-05-08 Constantinos Tsouris Electrohydrodynamic mixing on microfabricated devices
WO2003040411A1 (en) * 2001-11-05 2003-05-15 Transgenomic, Inc. Methods, systems, and kits for analysis of polynucleotides
US20040028559A1 (en) * 2001-11-06 2004-02-12 Peter Schuck Sample delivery system with laminar mixing for microvolume biosensing
US6750661B2 (en) 2001-11-13 2004-06-15 Caliper Life Sciences, Inc. Method and apparatus for controllably effecting samples using two signals
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
CN1164939C (zh) 2001-11-30 2004-09-01 清华大学 检测核苷酸和单核苷酸多态性用的毛细管电泳芯片装置
EP1463796B1 (en) 2001-11-30 2013-01-09 Fluidigm Corporation Microfluidic device and methods of using same
WO2003050035A2 (en) * 2001-12-06 2003-06-19 Nanostream, Inc. Adhesiveless microfluidic device fabrication
AU2002353107A1 (en) * 2001-12-11 2003-07-09 Sau Lan Tang Staats Microfluidic devices and methods for two-dimensional separations
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US7105810B2 (en) 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
WO2003066514A2 (en) * 2002-02-08 2003-08-14 University Of Louisville Research Foundation, Inc.Belknap Campus A capillary electrophoresis-electrochemical detection microchip device and supporting circuits
US6814859B2 (en) * 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US6958119B2 (en) * 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
EP2497564B1 (en) 2002-03-05 2014-05-14 Caliper Life Sciences, Inc. Electrophoretic separation in a microfluidic channel network
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US7195986B1 (en) * 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
GB0206117D0 (en) 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
EP1499706A4 (en) * 2002-04-01 2010-11-03 Fluidigm Corp MICROFLUIDIC PARTICLE ANALYSIS SYSTEMS
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7419784B2 (en) * 2002-04-02 2008-09-02 Dubrow Robert S Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
US6976590B2 (en) * 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6808075B2 (en) 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US8241883B2 (en) 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US6794734B2 (en) * 2002-05-03 2004-09-21 Mia-Com Heterojunction P-I-N diode and method of making the same
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP1508044B1 (en) * 2002-05-09 2010-09-01 The University of Chicago Device and method for pressure-driven plug transport and reaction
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
DE10223127C1 (de) * 2002-05-24 2003-10-02 Fraunhofer Ges Forschung Elektrisches Mikrofluidik-Multiplex-System und dessen Verwendung
US20030229672A1 (en) * 2002-06-05 2003-12-11 Kohn Daniel Mark Enforceable spam identification and reduction system, and method thereof
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
US7361313B2 (en) * 2003-02-18 2008-04-22 Intel Corporation Methods for uniform metal impregnation into a nanoporous material
US20030230524A1 (en) * 2002-06-18 2003-12-18 Naohiro Soga Chromatographic chip and method of fabrication thereof
GB0213979D0 (en) * 2002-06-18 2002-07-31 Sec Dep Of The Home Department Improvements in and relating to analysis
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US20060086309A1 (en) * 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
GB0216077D0 (en) * 2002-07-11 2002-08-21 Univ Cranfield Reconfigurable microfluidic device
DE10232849A1 (de) * 2002-07-19 2004-02-12 Abb Patent Gmbh Gasanalyseeinrichtung zur Qualitätsüberwachung eines gasförmigen Stoffes oder Stoffgemisches, insbesondere Luft
JP4225972B2 (ja) * 2002-07-26 2009-02-18 アプレラ コーポレイション 過剰な希釈剤を有する精製カラムを備える微小流体デバイスおよび方法
US7244961B2 (en) * 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
ATE358533T1 (de) * 2002-08-02 2007-04-15 Ge Healthcare Sv Corp Integriertes mikrochip-design
KR100480338B1 (ko) * 2002-08-08 2005-03-30 한국전자통신연구원 극소량의 유체제어를 위한 미세 유체제어소자
US7381317B2 (en) * 2002-08-12 2008-06-03 Beckman Coulter, Inc. Methods and compositions for capillary electrophoresis (CE)
BR0313618A (pt) 2002-08-21 2005-06-21 Shell Int Research Método para análise quìmica de fluidos de poço
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US20040053209A1 (en) * 2002-09-12 2004-03-18 Genoptix, Inc Detection and evaluation of topoisomerase inhibitors using optophoretic analysis
ITTO20020809A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Micropompa, in particolare per un dispositivo integrato di analisi del dna.
ITTO20020808A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
CA2500283A1 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
EP1569510B1 (en) 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
US20040067167A1 (en) * 2002-10-08 2004-04-08 Genoptix, Inc. Methods and apparatus for optophoretic diagnosis of cells and particles
GB2395006A (en) * 2002-10-29 2004-05-12 Micro Chemical Systems Ltd Apparatus and method for performing an assay
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7108775B2 (en) * 2002-11-08 2006-09-19 Applera Corporation Apparatus and method for confining eluted samples in electrophoresis systems
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
EP1565737A4 (en) * 2002-11-20 2007-02-14 Univ Virginia SEPARATION OF SPERM CELLS FROM OTHER BIOLOGICAL SUBSTANCES USING MICRO-PRODUCED EQUIPMENT, AND RELATED METHODS
US7189578B1 (en) * 2002-12-02 2007-03-13 Cfd Research Corporation Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems
AU2003293399A1 (en) * 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
WO2004055492A2 (en) * 2002-12-13 2004-07-01 Aclara Biosciences, Inc. Closed-loop control of electrokinetic processes in microfludic devices based on optical readings
AU2003291249A1 (en) * 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
DE10260308B3 (de) * 2002-12-20 2004-05-06 Siemens Ag Mikrostrukturierte Anordnung zur Behandlung mindestens eines Fluids
DE10260310B3 (de) * 2002-12-20 2004-05-06 Siemens Ag Mikrostrukturierte Anordnung zur Behandlung eines Fluids
US20060113190A1 (en) * 2002-12-27 2006-06-01 Kurnik Ronald T Microfluidic device and method for improved sample handling
JP2006512092A (ja) 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
KR100506185B1 (ko) * 2003-01-03 2005-08-04 주식회사 옵트론-텍 뇌혈관 질환 진단 시스템의 실험실 칩.
US6833068B2 (en) * 2003-01-13 2004-12-21 Sandia National Laboratories Passive injection control for microfluidic systems
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
US7355010B2 (en) 2003-01-30 2008-04-08 Bellbrook Labs, Llc Assay method for group transfer reactions
EP1592813B1 (en) * 2003-01-30 2012-12-26 BellBrook Labs, LLC Assay method for group transfer reactions
US8088897B2 (en) * 2003-01-30 2012-01-03 BellBrook Labs, Inc. Assay method for group transfer reactions
CN100389321C (zh) * 2003-02-19 2008-05-21 浙江大学 微分析芯片贮液池内的液位稳定装置及其使用方法
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7147764B2 (en) * 2003-03-28 2006-12-12 Applera Corporation Dual electrode injection of analyte into a capillary electrophoretic device
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
DE10315514B3 (de) * 2003-04-04 2004-09-30 Siemens Ag Mikrofluidische Einrichtung zur gesteuerten Einleitung eines Fluids in einen Kanal
US20040195099A1 (en) * 2003-04-04 2004-10-07 Jacobson Stephen C. Sample filtration, concentration and separation on microfluidic devices
JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー．エス． ジェノミクス， インコーポレイテッド マイクロチャネルにおけるポリマーの操作
US7820030B2 (en) * 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
DE10318864B3 (de) * 2003-04-25 2004-09-23 Siemens Ag Mikrofluidische Einrichtung zur gesteuerten Einleitung eines Fluids in einen Kanal
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7344681B1 (en) 2003-06-06 2008-03-18 Sandia Corporation Planar micromixer
US7373255B2 (en) 2003-06-06 2008-05-13 Biacore Ab Method and system for determination of molecular interaction parameters
SE0301639D0 (sv) 2003-06-06 2003-06-06 Biacore Ab Method and apparatus for characterization of intercations
AU2004250131A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US20050103713A1 (en) * 2003-07-30 2005-05-19 Ramsey J. M. Devices with small-scale channels and the fabrication thereof by etching
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
US7745221B2 (en) * 2003-08-28 2010-06-29 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
CA2537091A1 (en) * 2003-09-01 2005-03-10 Inverness Medical Switzerland Gmbh Sampling device with capillary action
KR100852297B1 (ko) * 2003-09-05 2008-08-14 칼리퍼 라이프 사이언시즈, 인크. 분석물 주입 시스템
US7316320B2 (en) * 2003-09-18 2008-01-08 Intel Corporation Sorting charged particles
PT1664722E (pt) 2003-09-22 2011-12-28 Bioarray Solutions Ltd Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
US20050232817A1 (en) * 2003-09-26 2005-10-20 The University Of Cincinnati Functional on-chip pressure generator using solid chemical propellant
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
WO2005047882A2 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007725B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having valve system
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
DE112004002254T5 (de) 2003-11-21 2007-08-16 Ebara Corp. Mikrofluidikvorrichtung
US7329391B2 (en) * 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
US20050161327A1 (en) * 2003-12-23 2005-07-28 Michele Palmieri Microfluidic device and method for transporting electrically charged substances through a microchannel of a microfluidic device
AU2004313572B2 (en) * 2003-12-23 2008-07-03 Caliper Life Sciences, Inc. Analyte injection system
JP2005227745A (ja) * 2004-01-14 2005-08-25 Seiko Epson Corp 液晶表示装置及び電子機器
WO2005072793A1 (en) 2004-01-29 2005-08-11 The Charles Stark Draper Laboratory, Inc. Implantable drug delivery apparatus
EP1713571B1 (en) * 2004-01-29 2008-04-09 Agilent Technologies, Inc. Mixing of fluids
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
ATE463584T1 (de) 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
CN100431679C (zh) * 2004-03-23 2008-11-12 独立行政法人科学技术振兴机构 微小液滴的生成方法及装置
US20050224350A1 (en) * 2004-03-30 2005-10-13 Intel Corporation Counter electroseparation device with integral pump and sidearms for improved control and separation
CN100585393C (zh) * 2004-04-28 2010-01-27 爱科来株式会社 电泳芯片和具有该电泳芯片的电泳装置
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US7273590B2 (en) * 2004-04-29 2007-09-25 Industrial Technology Research Institute gravity-driven apparatus and method for control of microfluidic devices
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (en) 2004-05-03 2016-12-07 Handylab, Inc. A microfluidic device for processing polynucleotide-containing samples
EP1747453B1 (en) * 2004-05-13 2009-09-02 Agilent Technologies, Inc. Controlling sample loading of a specimen
CA2567537A1 (en) 2004-05-21 2005-12-01 Caliper Life Sciences, Inc. Automated system for handling microfluidic devices
EP1766090B1 (en) 2004-05-25 2011-04-27 Helicos Biosciences Corporation Methods for nucleic acid immobilisation
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
WO2006085905A1 (en) 2004-05-28 2006-08-17 Board Of Regents, The University Of Texas System Programmable fluidic processors
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US20090008253A1 (en) * 2004-06-04 2009-01-08 Crystal Vision Microsystems Llc Device and Process for Continuous On-Chip Flow Injection Analysis
TWI291025B (en) * 2004-06-29 2007-12-11 Univ Nat Cheng Kung An integral micro-dialysis electrophoresis chip having on-line labeling function and the analysis method thereof
DE602004030678D1 (de) * 2004-07-19 2011-02-03 St Microelectronics Srl Vorrichtung zur Detektion von biologischen Molekülen mit erhöhter Detektionsgeschwindigkeit und Verfahren zur schnellen Detektion von Biomolekülen
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
US7618524B1 (en) 2004-08-10 2009-11-17 Sandia Corporation Polymeric salt bridges for conducting electric current in microfluidic devices
WO2006032044A2 (en) 2004-09-15 2006-03-23 Microchip Biotechnologies, Inc. Microfluidic devices
US20060060769A1 (en) 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7524672B2 (en) * 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
WO2006036592A1 (en) 2004-09-23 2006-04-06 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US7591883B2 (en) 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
EP1805500A4 (en) * 2004-09-28 2008-05-07 Singulex Inc SYSTEM AND METHOD FOR THE SPECTROSCOPIC ANALYSIS OF INDIVIDUAL PARTICLES
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US20060065532A1 (en) * 2004-09-30 2006-03-30 Matthias Stiene Microfluidic analytical system with accessible electrically conductive contact pads
US7534097B2 (en) * 2004-10-15 2009-05-19 Nanyang Technological University Method and apparatus for controlling multi-fluid flow in a micro channel
US8133703B2 (en) 2004-10-27 2012-03-13 Ceoheid Closed-system multi-stage nucleic acid amplification reactions
KR100571845B1 (ko) * 2004-10-28 2006-04-17 삼성전자주식회사 유체의 혼합방법 및 그 방법을 이용한 혼합장치
US20060094004A1 (en) * 2004-10-28 2006-05-04 Akihisa Nakajima Micro-reactor, biological material inspection device, and microanalysis system
US20060205061A1 (en) * 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
CA2595840C (en) * 2005-01-25 2013-12-10 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
CA2594483C (en) 2005-01-28 2014-08-26 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US20070017812A1 (en) * 2005-03-30 2007-01-25 Luc Bousse Optimized Sample Injection Structures in Microfluidic Separations
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
WO2006113727A2 (en) 2005-04-19 2006-10-26 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
US20070031819A1 (en) * 2005-04-26 2007-02-08 University Of Washington Microfluidic systems for biological and molecular analysis and methods thereof
MX2007013985A (es) 2005-05-09 2008-02-22 Theranos Inc Sistemas de fluidos de punto de cuidado y usos de los mismos.
JP2006317357A (ja) * 2005-05-13 2006-11-24 Shimadzu Corp マイクロチップ電気泳動方法及び装置
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
FR2887241B1 (fr) * 2005-06-15 2008-01-11 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ou chimique, et son utilisation
WO2006134274A1 (fr) * 2005-06-15 2006-12-21 Rhodia Operations Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ou chimique, et son utilisation
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1754536B1 (en) * 2005-08-16 2008-12-24 Agilent Technologies, Inc. Fluid injection system
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
ATE455302T1 (de) * 2005-09-02 2010-01-15 Wako Pure Chem Ind Ltd Komplexformierungs- und -trennungsverfahren
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US7988839B2 (en) 2005-09-20 2011-08-02 University Of Louisville Research Foundation, Inc. Capillary electrophoresis systems and methods
CN1319848C (zh) * 2005-09-22 2007-06-06 上海交通大学 阵列式多腔压电驱动微混合器
EP1931979B1 (en) * 2005-10-04 2015-11-18 Headway Technologies, Inc. Microfluidic detection of analytes
US20070199821A1 (en) * 2005-10-05 2007-08-30 Chow Andrea W Automated two-dimensional gel electrophoresis
US7727371B2 (en) * 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US8007267B2 (en) 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
DE102005055866A1 (de) * 2005-11-23 2007-05-24 Hte Ag The High Throughput Experimentation Company Verfahren zur Herstellung von Aryl-Aryl gekoppelter Verbindungen
US8355136B2 (en) 2005-12-16 2013-01-15 Indiana University Research And Technology Corporation Sub-micron surface plasmon resonance sensor systems
WO2007075444A2 (en) * 2005-12-16 2007-07-05 Indiana University Research & Technology Corporation Sub-micron surface plasmon resonance sensor systems
WO2007075919A2 (en) * 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer system
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US7641778B2 (en) * 2006-03-23 2010-01-05 Protea Biosciences, Inc. Gel electroelution and sample separation devices and associated processes
US7528368B2 (en) * 2006-03-23 2009-05-05 Protea Biosciences, Inc. Electrospray ionization process and add-on device with sample injection tip
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3156799B1 (en) 2006-04-04 2024-01-24 Novilux, LLC Analyzer and method for highly sensitive detection of analytes
AU2007233320B2 (en) 2006-04-04 2013-12-12 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US7641860B2 (en) * 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
WO2007146677A2 (en) * 2006-06-06 2007-12-21 Daniel Armstrong Electrokinetic sterility testing device
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US7854902B2 (en) * 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
US8366897B2 (en) * 2006-10-04 2013-02-05 National Institute Of Standards And Technology Gradient elution electrophoresis and detectorless electrophoresis apparatus
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US7600413B2 (en) * 2006-11-29 2009-10-13 Schlumberger Technology Corporation Gas chromatography system architecture
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2677309B9 (en) 2006-12-14 2014-11-19 Life Technologies Corporation Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range
WO2008085991A2 (en) 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
EP2104568A1 (en) 2007-01-17 2009-09-30 Agilent Technologies, Inc. Microfluidic chip with lateral opening for fluid introduction
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US9046192B2 (en) 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
KR20100028526A (ko) * 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
EP3626345A1 (en) 2007-04-04 2020-03-25 ANDE Corporation Systems for rapid multiplexed amplification of target nucleic acids
EP2148193A4 (en) * 2007-04-27 2010-08-18 Nat Inst Of Advanced Ind Scien ELECTROPHORESIS CHIP, ELECTROPHORESIS DEVICE, AND METHOD FOR ANALYZING SAMPLES THROUGH CAPILLARY ELECTROPHORESIS
EP2149050A2 (en) 2007-04-27 2010-02-03 The Regents Of The University Of California Device and methods for detection of airborne agents
KR100902093B1 (ko) * 2007-05-23 2009-06-09 인하대학교 산학협력단 미세채널 내에서 가시광선의 투과도 측정을 이용한 액체의Ｄｒｏｐｌｅｔ／Ｐｌｕｇ 및 미세입자 크기와 개수측정장치 및 측정방법
WO2008147530A1 (en) * 2007-05-24 2008-12-04 The Regents Of The University Of California Integrated fluidics devices with magnetic sorting
TWI322032B (en) * 2007-06-20 2010-03-21 Nat Univ Chung Cheng Microfluid mixer
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
WO2009012112A1 (en) 2007-07-13 2009-01-22 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
WO2009015296A1 (en) 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
WO2009021233A2 (en) * 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
CN104307581B (zh) * 2007-08-09 2017-04-12 诺思可有限公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
KR100894547B1 (ko) * 2007-08-10 2009-04-24 재단법인서울대학교산학협력재단 입자 포커싱 장치 및 이를 이용한 입자 포커싱 방법
WO2009026566A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US7946155B2 (en) * 2007-09-19 2011-05-24 Albion Laboratories, Inc. Method for quantitatively determining unbound metal in formulations containing chelates
US8029743B2 (en) 2007-09-19 2011-10-04 General Electric Company Microfluidic device with vertical injection aperture
DE602007007927D1 (de) 2007-11-05 2010-09-02 Agilent Technologies Inc Einfrierung eines mikrofluidischen Chips
EP2212437A4 (en) * 2007-11-07 2011-09-28 Univ British Columbia MICROFLUIDIC DEVICE AND METHOD OF USING THE DEVICE
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US7740747B2 (en) * 2007-12-28 2010-06-22 General Electric Company Injection method for microfluidic chips
EP2234916A4 (en) 2008-01-22 2016-08-10 Integenx Inc UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM
CN102016552A (zh) * 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
US20110127222A1 (en) * 2008-03-19 2011-06-02 Cynvenio Biosystems, Inc. Trapping magnetic cell sorting system
CN101960313A (zh) * 2008-03-24 2011-01-26 日本电气株式会社 微芯片的流路控制机构
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
WO2009129415A1 (en) * 2008-04-16 2009-10-22 Cynvenio Biosystems, Llc Magnetic separation system with pre and post processing modules
WO2009147554A1 (en) * 2008-05-27 2009-12-10 Koninklijke Philips Electronics N. V. Isoelectric focusing biochip
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CN102047104B (zh) * 2008-07-22 2014-09-03 爱科来株式会社 利用毛细管电泳法的分析装置及分析方法
US8436990B2 (en) 2008-07-22 2013-05-07 Arkray, Inc. Microchip and analyzing apparatus
DE102008038114B4 (de) * 2008-08-18 2018-08-02 Karlsruher Institut für Technologie Verfahren zur räumlichen Trennung und zum gesonderten Nachweis von Kationen und Anionen, die sich in einem Analyten befinden
EP2163305A1 (en) * 2008-09-05 2010-03-17 INSTITUT FÜR MIKROTECHNIK MAINZ GmbH Device and process for rapid isolation of a compound in a sample
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
US8377277B2 (en) 2008-10-22 2013-02-19 General Electric Company System and method for performing microfluidic manipulation
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) * 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US7740748B2 (en) 2008-10-27 2010-06-22 General Electric Company Electrophoresis system and method
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
EP2364368B1 (en) 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US7927476B2 (en) 2008-12-22 2011-04-19 General Electric Company Injection method for microfluidic chips
FR2940450B1 (fr) * 2008-12-22 2011-02-18 Centre Nat Rech Scient Dispositif et procede pour etudier une zone d'etude par onde acoustique
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
ES2568509T3 (es) 2009-01-15 2016-04-29 Adaptive Biotechnologies Corporation Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
US8354080B2 (en) 2009-04-10 2013-01-15 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
WO2010135382A1 (en) * 2009-05-18 2010-11-25 Brigham Young University Integrated microfluidic device for serum biomarker quantitation using either standard addition or a calibration curve
EP2433143B1 (en) * 2009-05-19 2016-03-02 The Regents of The University of California Multi-directional microfluidic devices and methods
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
RU2559541C2 (ru) 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
WO2010144358A1 (en) * 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
CN102713640B (zh) * 2009-06-10 2015-09-16 辛温尼奥生物系统公司 鞘流装置和方法
US9550985B2 (en) 2009-06-15 2017-01-24 Netbio, Inc. Methods for forensic DNA quantitation
CA2765949C (en) 2009-06-25 2016-03-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
CA2766795C (en) 2009-06-26 2017-10-03 President And Fellows Of Harvard College Fluid injection
US20150160171A1 (en) * 2009-09-23 2015-06-11 Abt Molecular Imaging, Inc. Automated Quality Control System for Radiopharmaceuticals
US12235250B2 (en) * 2009-09-23 2025-02-25 Best Abt, Inc. Radiopharmaceutical production system and quality control system utilizing high performance liquid chromatography
US20110114190A1 (en) * 2009-11-16 2011-05-19 The Hong Kong University Of Science And Technology Microfluidic droplet generation and/or manipulation with electrorheological fluid
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
WO2011085258A2 (en) 2010-01-07 2011-07-14 Life Technologies Corporation Fluidics interface system
WO2011106098A2 (en) 2010-02-25 2011-09-01 Advanced Microlabs, Llc Microfluidic interface for a microchip
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
KR101744339B1 (ko) * 2010-05-03 2017-06-08 삼성전자주식회사 타겟 생체분자의 분리요소를 포함하는 표면탄성파 센서 디바이스
JP2013525820A (ja) 2010-05-06 2013-06-20 シングレクス、インコーポレイテッド 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8432149B2 (en) 2010-06-30 2013-04-30 Life Technologies Corporation Array column integrator
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
WO2012024500A1 (en) 2010-08-18 2012-02-23 Life Technologies Corporation Chemical coating of microwell for electrochemical detection device
US20120045786A1 (en) * 2010-08-19 2012-02-23 Stith Curtis W Opto-fluidic microscope diagnostic system
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
EP2643695A4 (en) 2010-11-23 2016-03-09 Univ California MULTIDIRECTIONAL MICROFLUIDIC DEVICES WITH A PAN CAPTURE BINDING REGION AND METHOD OF USE THEREOF
JP6067572B2 (ja) 2010-12-03 2017-01-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア タンパク質再生マイクロ流体デバイス、及びそれを製造して使用する方法
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
EP2658999B1 (en) 2010-12-30 2019-03-13 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012106501A1 (en) 2011-02-02 2012-08-09 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
EP2490005A1 (en) * 2011-02-18 2012-08-22 Koninklijke Philips Electronics N.V. Microfluidic resistance network and microfluidic device
EP2490020A1 (en) * 2011-02-18 2012-08-22 Koninklijke Philips Electronics N.V. Measurement chip, microfluidic device and method of measurement chip manufacture
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
US9459239B2 (en) 2011-07-08 2016-10-04 Agilent Technologies, Inc. Intake monitoring for accurate proportioning
US11053535B2 (en) 2011-09-12 2021-07-06 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
DK2761305T3 (da) 2011-09-30 2017-11-20 Becton Dickinson Co Forenet reagensstrimmel
WO2013089887A2 (en) * 2011-09-30 2013-06-20 The Regents Of The University Of California Microfluidic devices and methods for assaying a fluid sample using the same
HK1201565A1 (en) 2011-10-21 2015-09-04 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
EP3388535B1 (en) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
EP2812708B1 (en) 2012-02-10 2019-09-04 The University of North Carolina At Chapel Hill Method of analysing an analyte with fluidic nanofunnels
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
PT2831276T (pt) 2012-05-08 2016-07-26 Adaptive Biotechnologies Corp Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9502225B2 (en) * 2012-06-20 2016-11-22 The University Of North Carolina At Chapel Hill Integrated sample processing for electrospray ionization devices
EP2904111B1 (en) 2012-10-01 2017-12-06 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
JP2015532978A (ja) * 2012-10-25 2015-11-16 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 液体検知用の方法および装置
US9304334B2 (en) * 2013-01-21 2016-04-05 Photronics, Inc. Microfluidic thermoptic energy processor
US10261065B2 (en) 2013-02-28 2019-04-16 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
BR112015020651A2 (pt) * 2013-02-28 2017-07-18 Ricoh Co Ltd dispositivo de fluido e método de fabricação do mesmo, e meio de transferência térmica para fabricação do dispositivo de fluido
CA2903481A1 (en) 2013-03-13 2014-10-09 The University Of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US9671368B2 (en) 2013-05-10 2017-06-06 The Regents Of The University Of California Two-dimensional microfluidic devices and methods of using the same
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
EP2833136A1 (en) * 2013-07-31 2015-02-04 University College Cork Opto-fluidic microsystem and method
JP6532456B2 (ja) 2013-10-04 2019-06-19 ライフ テクノロジーズ コーポレーション 終止化学を用いる配列決定における整相効果（ｐｈａｓｉｎｇ ｅｆｆｅｃｔｓ）をモデル化するための方法及びシステム
GB201320146D0 (en) * 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
KR101536164B1 (ko) * 2013-12-18 2015-07-13 한국기초과학지원연구원 유도체화 반응 기체 크로마토그래피 칩
WO2015112635A1 (en) 2014-01-21 2015-07-30 The Board Of Trustees Of The University Of Illinois Wettability patterned substrates for pumpless liquid transport and drainage
CA2941612A1 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
EP3204519B1 (en) 2014-10-10 2020-04-29 Quantapore Inc. Nanopore-based polymer analysis with mutually-quenching fluorescent labels
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
EP3209410B1 (en) 2014-10-22 2024-12-25 IntegenX Inc. Electrophoresis cartridge and corresponding method for sample preparation, processing and analysis
CN104297327B (zh) * 2014-10-29 2017-01-18 广东国盛医学科技股份有限公司 一种采用微流控芯片分析血清脂蛋白亚型精细亚组分的方法
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US9255905B1 (en) 2015-05-11 2016-02-09 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
WO2016182811A1 (en) 2015-05-11 2016-11-17 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US10035887B2 (en) * 2015-08-19 2018-07-31 Shimadzu Corporation Manufacturing method for nanoparticle
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
US10564121B2 (en) * 2015-11-26 2020-02-18 Vladislav Dolnik Device and method for separation and analysis of trace and ultra-trace ionogenic compounds by isotachophoresis and zone electrophoresis on chip
CN121253411A (zh) 2015-11-30 2026-01-02 因塔生物有限责任公司 用于样品表征的装置和方法
US10639634B2 (en) 2016-06-01 2020-05-05 Government Of The United States Of America, As Represented By The Secretary Of Commerce Vacuum compatible fluid sampler
CN106345543B (zh) * 2016-09-13 2018-07-06 哈尔滨工业大学 一种基于固定电势的感应电荷电渗的微混合芯片
PL3538665T3 (pl) 2016-11-14 2024-05-06 PPB Technology Pty Ltd Cząsteczki czujnika proteazy
DE102016015171B4 (de) 2016-12-20 2021-04-01 Albert-Ludwigs-Universität Freiburg Analysevorrichtung mit funktionalisierten Kryogelen
DE102017108120A1 (de) * 2017-04-13 2018-10-18 Laser-Laboratorium Göttingen e.V. Analysevorrichtung
PL3665481T3 (pl) 2017-08-08 2024-02-05 PPB Technology Pty Ltd Czujniki węglowodanów
CN111356528A (zh) * 2017-11-22 2020-06-30 惠普发展公司，有限责任合伙企业 多区域微流体装置
CA3089842A1 (en) 2018-01-29 2019-08-01 Intabio, Inc. Devices, methods and kits for sample characterization
EP3811397B1 (en) 2018-05-31 2024-09-18 Intabio, Llc Methods for interfacing microfluidic systems with mass spectrometry
EP3797279A4 (en) * 2018-07-11 2022-08-03 The University of Hong Kong AUTOMATIC MICROFLUIDIC SYSTEM FOR CONTINUOUS AND QUANTITATIVE COLLECTION OF DROPLETS
JP7430701B2 (ja) 2018-07-23 2024-02-13 ディーエヌエー スクリプト 核酸鎖の大規模並列酵素合成
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
US12428668B2 (en) 2019-01-03 2025-09-30 Dna Script One pot synthesis of sets of oligonucleotides
DE102019202174A1 (de) * 2019-02-19 2020-08-20 Robert Bosch Gmbh Vorrichtung zur Untersuchung einer biologischen Probe
CN110044680B (zh) * 2019-04-28 2024-02-23 宁波大学 一种毛细管电泳的样品浓缩装置和方法
GB2606810A (en) 2019-08-05 2022-11-23 Seer Inc Systems and methods for sample preparation, data generation, and protein corona analysis
US12594557B2 (en) 2019-08-12 2026-04-07 Intabio, Llc Isoelectric focusing devices and fixtures
US11285484B2 (en) 2019-08-12 2022-03-29 Intabio, Llc Multichannel isoelectric focusing devices and high voltage power supplies
CN110567790B (zh) * 2019-09-11 2021-11-05 南京信息工程大学 带电小颗粒在线浓缩与检测的微电泳芯片及检测方法
CN111610247B (zh) * 2020-05-27 2021-03-16 中国科学院地质与地球物理研究所 一种从地质样品中快速分离出高纯度w的方法
GB2598113B (en) 2020-08-18 2024-11-20 Agilent Technologies Inc Fluidically coupling with elastic structure deformable by sealing element
US12576400B2 (en) 2021-01-08 2026-03-17 Cellanome, Inc. Methods for incubating and analyzing a cell in a compartment of a fluidic device
US12576399B2 (en) 2021-01-08 2026-03-17 Cellanome, Inc. Methods for imaging and analyzing a cell in a compartment of a fluidic device
MX2023007842A (es) 2021-01-08 2023-09-19 Cellanome Inc Dispositivos y metodos para analizar muestras biologicas.
US12661647B2 (en) 2022-03-22 2026-06-23 Cellanome, Inc. Methods for enclosing and analyzing a cell in a fluidic device
TWI822221B (zh) 2022-08-02 2023-11-11 友達光電股份有限公司 微流體檢測裝置
WO2024225888A1 (en) * 2023-04-28 2024-10-31 Vulcan Photonics Sdn. Bhd. Millifluidic chromatography plate
WO2025188593A1 (en) * 2024-03-04 2025-09-12 Trustees Of Tufts College Wick-based analytical device for multiplexed quantification of biomarkers using carbon dots integrated with molecularly imprinted polymer
US20250389715A1 (en) 2024-06-24 2025-12-25 Amplifidx, Inc. Point-of-care bioassay systems and methods of making and using the same

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5120228A (en) * 1974-07-23 1976-02-18 Dainippon Toryo Kk Boseihifukusoseibutsu
US4370382A (en) * 1980-06-19 1983-01-25 Union Carbide Corporation Modified zinc-rich coatings
US4390403A (en) * 1981-07-24 1983-06-28 Batchelder J Samuel Method and apparatus for dielectrophoretic manipulation of chemical species
US5230781A (en) * 1984-03-29 1993-07-27 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes
US5207880A (en) * 1984-03-29 1993-05-04 The Board Of Regents Of The University Of Nebraska DNA sequencing
US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US4680201A (en) * 1985-10-30 1987-07-14 Stellan Hjerten Coating for electrophoresis tube
GB2191110B (en) * 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4865706A (en) * 1986-10-21 1989-09-12 Northeastern University High performance microcapillary gel electrophoresis
US5112460A (en) * 1986-10-21 1992-05-12 Northeastern University High performance microcapillary gel electrophoresis
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
US4997536A (en) * 1988-07-06 1991-03-05 Beckman Instruments, Inc. Control of electrokinetic potential by treatment with redox agents
EP0356160A3 (en) * 1988-08-24 1991-09-11 The Board Of Trustees Of The Leland Stanford Junior University Capillary device
US4909919A (en) * 1988-11-22 1990-03-20 The Regents Of The University Of Michigan Velocity modulated capillary electrophoresis analysis system
US5089111A (en) * 1989-01-27 1992-02-18 Bio-Rad Laboratories, Inc. Electrophoretic sieving in gel-free media with dissolved polymers
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US4996880A (en) * 1989-03-23 1991-03-05 Electric Power Research Institute, Inc. Operating turbine resonant blade monitor
US5096554A (en) * 1989-08-07 1992-03-17 Applied Biosystems, Inc. Nucleic acid fractionation by counter-migration capillary electrophoresis
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5073239A (en) * 1990-01-24 1991-12-17 Bio-Rad Laboratories, Inc. Fluid introduction into a capillary by electroendosmosis
US5092973A (en) * 1990-01-26 1992-03-03 The Board Of Trustees Of The Leland Stanford Junior University Rectangular capillaries for capillary electrophoresis
US5141621A (en) * 1990-01-26 1992-08-25 The Board Of Trustees Of The Leland Stanford Junior University Capillary electrophoresis injection device and method
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5110431A (en) * 1990-02-28 1992-05-05 Applied Biosystems, Inc. On-capillary gap junction for fluorescence detection in capillary electrophoresis
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5307148A (en) * 1990-04-05 1994-04-26 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5122248A (en) * 1990-05-18 1992-06-16 Northeastern University Pulsed field capillary electrophoresis
US5325170A (en) * 1990-05-31 1994-06-28 Thermo Instrument Systems Inc. Laser-based refractive index detector using backscatter
EP0484278B1 (de) * 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
EP0497077B1 (de) * 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
JPH04318181A (ja) * 1991-04-17 1992-11-09 Nippon Paint Co Ltd アルミニウム又はその合金用処理液
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
EP0544969B1 (de) * 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
US5288463A (en) * 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
US5338427A (en) * 1993-02-26 1994-08-16 Biometric Imaging Inc. Single use separation cartridge for a capillary electrophoresis instrument
US5410030A (en) * 1993-04-05 1995-04-25 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes containing pyridinium moieties
DE69333601T2 (de) * 1993-04-15 2005-09-15 Zeptosens Ag Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
US5571680A (en) * 1994-01-21 1996-11-05 Beckman Instruments, Inc. Homogeneous immunoassays and enzyme based assays of analytes using capillary electrophoresis
US5543026A (en) * 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5900130A (en) * 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
KR100650118B1 (ko) * 1999-07-19 2006-11-27 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 레이저 피닝에 의한 금속의 외형 형성

Also Published As

Publication number Publication date
CN1168720A (zh) 1997-12-24
US20040009517A1 (en) 2004-01-15
MX9700845A (es) 1997-09-30
US6010607A (en) 2000-01-04
US20030226755A1 (en) 2003-12-11
US20020008030A1 (en) 2002-01-24
AU701348B2 (en) 1999-01-28
US20040137445A1 (en) 2004-07-15
JPH10507516A (ja) 1998-07-21
EP1162455B1 (en) 2007-10-03
CA2196429A1 (en) 1996-02-15
US6342142B1 (en) 2002-01-29
US5858195A (en) 1999-01-12
EP0775306A1 (en) 1997-05-28
US20030150733A1 (en) 2003-08-14
KR100369497B1 (ko) 2003-04-11
JP4023819B2 (ja) 2007-12-19
DE69528705D1 (de) 2002-12-05
US20030205469A1 (en) 2003-11-06
US6010608A (en) 2000-01-04
AU3150895A (en) 1996-03-04
DE69535608D1 (de) 2007-11-15
US20040007464A1 (en) 2004-01-15
WO1996004547A1 (en) 1996-02-15
US20030205470A1 (en) 2003-11-06
EP1382962A1 (en) 2004-01-21
CN1052301C (zh) 2000-05-10
US6033546A (en) 2000-03-07
EP0775306B1 (en) 2002-10-30
EP0775306A4 (en) 1997-10-22
US6001229A (en) 1999-12-14
DK0775306T3 (da) 2002-11-25
ATE374940T1 (de) 2007-10-15
US6475363B1 (en) 2002-11-05
KR970705020A (ko) 1997-09-06
US20030226753A1 (en) 2003-12-11
DE69535608T2 (de) 2008-07-10
ATE227023T1 (de) 2002-11-15
EP1162455A1 (en) 2001-12-12
CA2196429C (en) 2001-05-08
DE69528705T2 (de) 2003-07-03

Similar Documents

Publication Publication Date Title
AU3150895A (en) Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Chen et al. A prototype two-dimensional capillary electrophoresis system fabricated in poly (dimethylsiloxane)
Kopp et al. Developments in technology and applications of microsystems
US6251343B1 (en) Microfluidic devices and systems incorporating cover layers
US5770029A (en) Integrated electrophoretic microdevices
US9039973B2 (en) Hybrid digital and channel microfluidic devices and methods of use thereof
US5599432A (en) Device and a method for the electrophoretic separation of fluid substance mixtures
US20070017812A1 (en) Optimized Sample Injection Structures in Microfluidic Separations
US20020025576A1 (en) Integrated sample analysis device
Shackman et al. Gradient elution moving boundary electrophoresis for high-throughput multiplexed microfluidic devices
US7037417B2 (en) Mechanical control of fluids in micro-analytical devices
US7294247B1 (en) Electrophoretic separating device and method for using the device
Guijt et al. Use of bioaffinity interactions in electrokinetically controlled assays on microfabricated devices
WO2001053794A1 (en) Parallel sample loading and injection device for multichannel microfluidic devices
US20030057092A1 (en) Microfluidic methods, devices and systems for in situ material concentration
JP4619728B2 (ja) 試料分析装置
KR100442412B1 (ko) 모세관으로 연결된 랩온어칩 시스템
Blasco et al. Electrochemical detection in capillary electrophoresis on microchips
Jiang Plastic microfluidic devices for high throughput drug screening and proteome analysis
Kopf-Sill et al. Creating a lab-on-a-chip with microfluidic technologies
Li et al. Lab on a chip for point-of-care analysis of drugs in body fluids
US20170052146A1 (en) Methods and apparatus for introducing a sample into a separation channel for electrophoresis
Kler et al. Column--coupling strategies for multidimensional electrophoretic separations
Liu et al. Comparison of Different Strategies of Chemiluminescence Detection for Microchip System Fabricated in Poly (Dimethylsiloxane)
MICROCHIP Koutarou Idegami¹, Masaaki Kobayashi¹, Yuzuru Takamura and Eiichi Tamiya²