ES2186845T3 - Agentes protectores de radiacion adecuados para usar con productos radiofarmaceuticos que comprenden ingredientes activos reducibles. - Google Patents
Agentes protectores de radiacion adecuados para usar con productos radiofarmaceuticos que comprenden ingredientes activos reducibles.Info
- Publication number
- ES2186845T3 ES2186845T3 ES97307255T ES97307255T ES2186845T3 ES 2186845 T3 ES2186845 T3 ES 2186845T3 ES 97307255 T ES97307255 T ES 97307255T ES 97307255 T ES97307255 T ES 97307255T ES 2186845 T3 ES2186845 T3 ES 2186845T3
- Authority
- ES
- Spain
- Prior art keywords
- active ingredient
- radiation
- reducable
- radiopharmaceuticals
- active ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
EN LA PRESENTE INVENCION SE PRESENTA UN AGENTE DE PROTECCION CONTRA LAS RADIACIONES QUE PROTEGE AL INGREDIENTE ACTIVO DE SUSTANCIAS RADIOFARMACEUTICAS CONTRA LA RADIOLISIS CAUSADA POR UNA REACCION DEL INGREDIENTE ACTIVO CON RADIALES DE AGUA FORMADA POR LA RADIOLISIS DEL AGUA, SIN QUE SE DESCOMPONGA EL INGREDIENTE ACTIVO TAL COMO UN INGREDIENTE ACTIVO FACILMENTE REDUCIBLE. EL AGENTE DE PROTECCION CONTRA LAS RADIACIONES DE LA PRESENTE INVENCION SE CARACTERIZA PORQUE CONTIENE UN COMPUESTO ORGANICO QUE SE PUEDE UTILIZAR EN FARMACOS MEDICOS Y PORQUE TIENE UNA ALTA ACEPTABILIDAD FISIOLOGICA Y PROTEGE AL INGREDIENTE ACTIVO RADIOETIQUETADO DE LAS SUSTANCIAS FARMACEUTICAS CONTRA LA ACCION DE LAS RADIACIONES. LA CONSTANTE DE LA VELOCIDAD DE REACCION DE DICHO COMPUESTO ORGANICO CON UN RADICAL OH, UN RADICAL H O UN ELECTRON HIDRATADO DEBE SER DE 1X10 SUP,8} A 5X10 SUP,10}M SUP,1}S SUP,-1} Y, CUANDO SE AÑADE A SUSTANCIAS RADIOFARMACEUTICAS, LA CONCENTRACION MOLAR DEL COMPUESTO ORGANICO DEBE SER AL MENOS50 VECES TAN ALTA COMO LA CONCENTRACION MOLAR DEL INGREDIENTE ACTIVO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26792996 | 1996-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2186845T3 true ES2186845T3 (es) | 2003-05-16 |
Family
ID=17451579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97307255T Expired - Lifetime ES2186845T3 (es) | 1996-09-18 | 1997-09-18 | Agentes protectores de radiacion adecuados para usar con productos radiofarmaceuticos que comprenden ingredientes activos reducibles. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6027710A (es) |
| EP (1) | EP0832654B1 (es) |
| JP (1) | JP4989555B2 (es) |
| AT (1) | ATE231005T1 (es) |
| DE (1) | DE69718406T2 (es) |
| DK (1) | DK0832654T3 (es) |
| ES (1) | ES2186845T3 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953360B1 (en) * | 1998-03-24 | 2004-05-26 | Council of Scientific and Industrial Research | Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester |
| US6315979B1 (en) * | 1998-06-02 | 2001-11-13 | The Dow Chemical Company | Radioiodinated sulfonated phenols for brachytherapy |
| US6567492B2 (en) | 2001-06-11 | 2003-05-20 | Eastern Isotopes, Inc. | Process and apparatus for production of F-18 fluoride |
| US20030198593A1 (en) * | 2002-04-15 | 2003-10-23 | Frank R. Keith | Radioprotectants for radiopharmaceutical formulations |
| JP2006505610A (ja) | 2002-11-05 | 2006-02-16 | イヨン ベアム アプリカスィヨン エッス.アー. | 18−f標識放射性製剤の安定化 |
| US7018614B2 (en) * | 2002-11-05 | 2006-03-28 | Eastern Isotopes, Inc. | Stabilization of radiopharmaceuticals labeled with 18-F |
| JP5139678B2 (ja) * | 2003-07-24 | 2013-02-06 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 安定な放射性医薬品組成物およびその製法 |
| JP5112062B2 (ja) * | 2005-06-14 | 2013-01-09 | 日本メジフィジックス株式会社 | 放射性画像診断剤 |
| PT2106808T (pt) * | 2006-12-21 | 2018-03-26 | Nihon Mediphysics Co Ltd | Agente de imagiologia de diagnóstico radioativo compreendendo ácido 1-amino-3-[18f]fluoro-ciclobutanocarboxílico |
| JP5258583B2 (ja) | 2007-02-13 | 2013-08-07 | 日本メジフィジックス株式会社 | 放射性画像診断剤の製造方法 |
| KR20160030589A (ko) * | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA761944B (en) * | 1975-04-30 | 1977-03-30 | Procter & Gamble | Stable radiographic scanning agents |
| US4364920A (en) * | 1975-04-30 | 1982-12-21 | Medi-Physics, Inc. | Stable diagnostic reagents |
| JPS5736894A (ja) * | 1980-08-13 | 1982-02-27 | Matsushita Electric Works Ltd | Insatsuhaisenban |
| JPS5896031A (ja) * | 1981-12-03 | 1983-06-07 | Nippon Mejifuijitsukusu Kk | 放射性診断剤およびその製造用組成物 |
| JPS59199636A (ja) * | 1983-04-26 | 1984-11-12 | Nippon Mejifuijitsukusu Kk | 放射性診断剤 |
| US5393512A (en) * | 1985-01-14 | 1995-02-28 | Vanderheyden; Jean-Luc | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| DE3780820D1 (es) * | 1987-10-30 | 1992-09-03 | Sorin Biomedica S.P.A., Saluggia, Vercelli, It | |
| US4848538A (en) * | 1988-07-07 | 1989-07-18 | Gerber Garment Technology, Inc. | Carrier and variable position carrier body |
| US4880615A (en) * | 1988-11-25 | 1989-11-14 | Merck & Co., Inc. | Stabilized radiopharmaceutical compositions |
| US5219556A (en) * | 1990-07-09 | 1993-06-15 | Mallinckrodt Medical, Inc. | Stabilized therapeutic radiopharmaceutical complexes |
| US5306482A (en) * | 1991-04-09 | 1994-04-26 | Merck Frosst Canada, Inc. | Radiopharmaceutical bacteriostats |
| WO1993002652A2 (en) * | 1991-08-01 | 1993-02-18 | Hybritech Incorporated | Modified haptens useful as imaging and therapeutic agents |
| DK0600992T3 (da) * | 1991-08-29 | 2000-10-09 | Mallinckrodt Medical Inc | Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner |
-
1997
- 1997-09-16 US US08/923,002 patent/US6027710A/en not_active Expired - Lifetime
- 1997-09-18 ES ES97307255T patent/ES2186845T3/es not_active Expired - Lifetime
- 1997-09-18 AT AT97307255T patent/ATE231005T1/de not_active IP Right Cessation
- 1997-09-18 DK DK97307255T patent/DK0832654T3/da active
- 1997-09-18 EP EP97307255A patent/EP0832654B1/en not_active Expired - Lifetime
- 1997-09-18 DE DE69718406T patent/DE69718406T2/de not_active Expired - Fee Related
-
2008
- 2008-05-26 JP JP2008136705A patent/JP4989555B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0832654B1 (en) | 2003-01-15 |
| DE69718406T2 (de) | 2003-11-20 |
| DE69718406D1 (de) | 2003-02-20 |
| JP4989555B2 (ja) | 2012-08-01 |
| ATE231005T1 (de) | 2003-02-15 |
| US6027710A (en) | 2000-02-22 |
| EP0832654A2 (en) | 1998-04-01 |
| DK0832654T3 (da) | 2003-03-31 |
| EP0832654A3 (en) | 1999-03-17 |
| JP2008222723A (ja) | 2008-09-25 |
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