ES2186876T3 - Derivados de 8-azabiciclo(3.2.1)octano, su preparacion y su uso como insecticidas. - Google Patents

Derivados de 8-azabiciclo(3.2.1)octano, su preparacion y su uso como insecticidas.

Info

Publication number
ES2186876T3
ES2186876T3 ES97910543T ES97910543T ES2186876T3 ES 2186876 T3 ES2186876 T3 ES 2186876T3 ES 97910543 T ES97910543 T ES 97910543T ES 97910543 T ES97910543 T ES 97910543T ES 2186876 T3 ES2186876 T3 ES 2186876T3
Authority
ES
Spain
Prior art keywords
optionally
ring
carbamyl
alkoxycarbonyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97910543T
Other languages
English (en)
Inventor
Christopher John Urch
Terence Lewis
Raymond Leo Sunley
Roger Salmon
Christopher Richard Ay Godfrey
Christopher Ian Brightwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Ltd filed Critical Syngenta Ltd
Application granted granted Critical
Publication of ES2186876T3 publication Critical patent/ES2186876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE AR ES FENILO OPCIONALMENTE SUSTITUIDO O UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS, QUE CONTIENE DE 1 A 3 HETEROATOMOS SELECCIONADOS INDIVIDUALMENTE A PARTIR DE ATOMOS DE NITROGENO, OXIGENO Y AZUFRE, Y AL MENOS UNA INSATURACION (DOBLE ENLACE) ENTRE ATOMOS ADYACENTES EN EL ANILLO, ESTANDO FUSIONADO OPCIONALMENTE DICHO ANILLO HETEROCICLICO A UN ANILLO DE BENCENO. LOS SUSTITUYENTES, SI ESTAN PRESENTES, SE SELECCIONAN A PARTIR DE ATOMOS DE HALOGENO, GRUPOS CIANO, ALQUILO, ALQUENILO, ALQUINILO, ALCOXI, HALOALQUILO, HALOALQUENILO, ALQUILTIO Y ALQUILAMINO; R REPRESENTA HIDROGENO O CIANO, O UN GRUPO SELECCIONADO A PARTIR DE ALQUILO, ARILO, HETEROARILO, ARALQUILO, HETEROARILALQUILO, ALQUENILO, ARALQUENILO, ALQUINILO, ALCOXICARBONILO, ALCANOSULFONILO, ARENOSULFONILO, ALQUENILOXICARBONILO, ARALQUILOXICARBONILO, ARILOXICARBONILO, HETEROCICLILALQUILO, CARBAMILO, DITIOCARBOXILO O XR 3 (DONDE X REPRESENTA OXIGENO O UN GRUPO NR 4 ), CON LA CONDICION DE QUE, CUANDO R ES ALQUENILO, ARALQUENILO O ALQUINILO, DICHO GRUPO NO TIENE UN ATOMO DE CARBONO INSATURADO UNIDO DIRECTAMENTE AL NITROGENO DEL ANILLO DE LA FORMULA (I); R 3 Y R 4 SON, INDEPENDIENTEMENTE, HIDRO GENO, ALQUILO, ARILO, HETEROARILO, ARALQUILO, HETEROARILALQUILO, ALQUENILO, ARALQUENILO, ALQUINILO, HETEROCICLILALQUILO, ALCOXICARBONILO O ACILO CARBOXILICO; LAS FRACCIONES ALQUILO DE R, R 3 Y R 4 COMPRENDEN DE 1 A 15 ATOMOS DE CARBONO Y ESTAN SUSTITUIDAS OPCIONALMENTE POR UNO O MAS SUSTITUYENTES SELECCIONADOS A PARTIR DE HALOGENOS, GRUPOS CIANO, CARBOXILO, ACILO CARBOXILICO, CARBAMILO, ALCOXICARBONILO, ALCOXI, ALQUILENDIOXI, HIDROXILO, NITRO, AMINO, ACILAMINO, IMIDATO Y FOSFONATO; LAS FRACCIONES ARILO, HETEROARILO, ARALQUILO, HETEROARILALQUILO, ALQUENILO, ARALQUENILO, ALQUINILO, ALCOXICARBONILO, ALCANOSULFONILO, ARENOSULFONILO, ALCANILOXICARBONILO, ARALQUILOXICARBONILO, ARILOXICARBONILO, HETEROCICLILALQUILO, CARBAMILO O DITIOCARBOXILO DE R, R 3 Y R 4 COMPRENDEN DE 1 A 15 ATOM OSDE CARBONO, Y ESTAN OPCIONALMENTE SUSTITUIDDAS POR UNO O MAS SUSTITUYENTES SELECCIONADOS A PARTIR DE HALOGENO, GRUPOS CIANO, CARBOXILO, ACILO CARBOXILICO, CARBAMILO, ALCOXICARBONILO, ALCOXI, ALQUILENDIOXI, HIDROXILO, NITRO, HALOALQUILO, ALQUILO, AMINO, ACILAMINO, IMIDATO Y FOSFONATO; R 1 REPRESENTA HIDROGENO, HIDROXILO, ALQUILO, ALCOXI, AMINO, NITRO, ISOCIANATO, ACILAMINO, HIDROXIALQUILO, HETEROARILO OPCIONALMENTE SUSTITUIDO, ALCOXIALQUILO, HALOALQUILO, HALOHIDROXIALQUILO, ARALQUILOXIALQUILO, ACILOXIALQUILO, AMIDOXIMIDO, SULFONILOXIALQUILO, AMINOALQUILO, ALCOXICARBONILAMINO, ACILAMINOALQUILO, CIANOALQUILO, IMINO, FORMILO, ACILO O ACIDO CARBOXILICO O UN ESTER O AMIDA DE LOS MISMOS, O ALQUENILO O ALQUINILO, CUALQUIERA DE LOS CUALES ESTA OPCIONALMENTE SUSTITUIDO POR HALOGENO, GRUPO ALCOXI, CICLOALQUILO, ARILO OPCIONALMENTE SUSTITUIDO, HETEROARILO O CIANO OPCIONALMENTE SUSTITUIDO; O UNA SAL DE ADICION, SAL DE AMONIO CUATERNARIA O N - OXIDO DERIVADO DE DICHA SAL. LA INVENCION SE REFIERE ASIMISMOA UNA COMPOSICION INSECTICIDA, ACARICIDA O MEMATICIDA QUE COMPRENDE UN COMPUESTO DE FORMULA (I) Y UN PORTADOR ADECUADO O DILUYENTE PARA LA MISMA, ASI COMO A UN PROCEDIMIENTO PARA COMBATIR Y CONTROLAR PLAGAS DE INSECTOS, ACAROS O NEMATODOS EN UN EMPLAZAMIENTO, POR TRATAMIENTO CON UNA CANTIDAD EFECTIVA DE UN COMPUESTO DE FORMULA (I) O UNA COMPOSICION DESCRITA ANTERIORMENTE.
ES97910543T 1996-11-26 1997-10-30 Derivados de 8-azabiciclo(3.2.1)octano, su preparacion y su uso como insecticidas. Expired - Lifetime ES2186876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9624611.1A GB9624611D0 (en) 1996-11-26 1996-11-26 Bicyclic amine compounds

Publications (1)

Publication Number Publication Date
ES2186876T3 true ES2186876T3 (es) 2003-05-16

Family

ID=10803532

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97910543T Expired - Lifetime ES2186876T3 (es) 1996-11-26 1997-10-30 Derivados de 8-azabiciclo(3.2.1)octano, su preparacion y su uso como insecticidas.

Country Status (17)

Country Link
US (2) US6093726A (es)
EP (1) EP0946553B1 (es)
JP (1) JP2001506988A (es)
KR (1) KR20000069095A (es)
CN (1) CN1245498A (es)
AT (1) ATE231860T1 (es)
AU (1) AU4789097A (es)
BR (1) BR9713429A (es)
CA (1) CA2272076A1 (es)
DE (1) DE69718816T2 (es)
ES (1) ES2186876T3 (es)
GB (1) GB9624611D0 (es)
ID (1) ID21772A (es)
IL (1) IL130059A0 (es)
SV (1) SV1997000097A (es)
TR (1) TR199901170T2 (es)
WO (1) WO1998025923A1 (es)

Families Citing this family (70)

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JP2004018506A (ja) * 2002-06-20 2004-01-22 Bayer Ag 殺虫性フタラミド誘導体
DE10238725A1 (de) * 2002-08-23 2004-03-04 Bayer Cropscience Ag Substituierte Heterocyclypyrimidine
DE10246959A1 (de) * 2002-10-09 2004-04-22 Bayer Cropscience Ag Thiazolylbiphenylamide
DE10249055A1 (de) * 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
DE10257080A1 (de) * 2002-12-06 2004-06-24 Bayer Cropscience Ag Substituierte Pyrazolincarboxanilide
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DE10303589A1 (de) * 2003-01-29 2004-08-12 Bayer Cropscience Ag Pyrazolylcarboxanilide
JP4722829B2 (ja) 2003-02-14 2011-07-13 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト オキサチンカルボキサミド
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DE10337496A1 (de) 2003-08-14 2005-04-14 Bayer Cropscience Ag 4-Biphenylsubstituierte-4-substituierte-pyrazolidin-3,5-dione
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DE10349502A1 (de) 2003-10-23 2005-05-25 Bayer Cropscience Ag 1,3-Dimethylbutylcarboxanilide
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MXPA06004308A (es) 2003-10-23 2006-06-05 Bayer Cropscience Ag Isopentilcarboxanilidas para la lucha contra los microorganismos indeseables.
IN2004DE01799A (es) * 2003-10-23 2007-01-12 Bayer Cropscience Ag
DE10354607A1 (de) 2003-11-21 2005-06-16 Bayer Cropscience Ag Siylierte Carboxamide
DE10357568A1 (de) * 2003-12-10 2005-07-07 Bayer Cropscience Ag Pyrazolopyrimidine
DE102004003493A1 (de) * 2004-01-23 2005-08-11 Bayer Cropscience Ag 5-Phenylpyrimidine
DE102004005786A1 (de) 2004-02-06 2005-08-25 Bayer Cropscience Ag Haloalkylcarboxamide
DE102004005785A1 (de) 2004-02-06 2005-08-25 Bayer Cropscience Ag 2-Halogenfuryl/thienyl-3-carboxamide
DE102004006324A1 (de) * 2004-02-10 2005-08-25 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden Eigenschaften
DE102004007076A1 (de) * 2004-02-13 2005-08-25 Bayer Cropscience Ag Imidazolopyrimidine
DE102004008807A1 (de) * 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
JP2006076990A (ja) 2004-03-12 2006-03-23 Bayer Cropscience Ag 殺虫性ベンゼンジカルボキサミド類
DE102004012901A1 (de) 2004-03-17 2005-10-06 Bayer Cropscience Ag Silylierte Carboxamide
DE102004014620A1 (de) 2004-03-25 2005-10-06 Bayer Cropscience Ag 2,4,6-phenylsubstituierte cyclische Ketoenole
US7485727B2 (en) * 2004-03-31 2009-02-03 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
DE102004032418A1 (de) * 2004-04-07 2005-10-27 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden Eigenschaften
DE102004020840A1 (de) 2004-04-27 2005-11-24 Bayer Cropscience Ag Verwendung von Alkylcarbonsäureamiden als Penetrationsförderer
DE102004022897A1 (de) * 2004-05-10 2005-12-08 Bayer Cropscience Ag Azinyl-imidazoazine
DE102004030753A1 (de) 2004-06-25 2006-01-19 Bayer Cropscience Ag 3'-Alkoxy spirocyclische Tetram- und Tretronsäuren
DE102004041530A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
DE102004059725A1 (de) 2004-12-11 2006-06-22 Bayer Cropscience Ag 2-Alkyl-cycloalk(en)yl-carboxamide
DE102004062513A1 (de) 2004-12-24 2006-07-06 Bayer Cropscience Ag Insektizide auf Basis von Neonicotinoiden und ausgewählten Strobilurinen
DE102004062512A1 (de) 2004-12-24 2006-07-06 Bayer Cropscience Ag Synergistische Mischungen mit insektizider und fungizider Wirkung
DE102005022147A1 (de) 2005-04-28 2006-11-02 Bayer Cropscience Ag Wirkstoffkombinationen
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
US8338607B2 (en) 2005-10-06 2012-12-25 Nippon Soda Co., Ltd. Cyclic amine compounds and agents for pest control
DE102005057837A1 (de) 2005-12-03 2007-06-06 Bayer Cropscience Ag Fungizide Wirkstoffkombination
DE102005058838A1 (de) 2005-12-09 2007-06-14 Bayer Cropscience Ag Fungizide Wirkstoffkombination
DE102005059891A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag 3'-Alkoxy-spirocyclopentyl substituierte Tetram- und Tetronsäuren
DE102005060462A1 (de) 2005-12-17 2007-06-28 Bayer Cropscience Ag Biphenylcarboxamide
DE102005060466A1 (de) 2005-12-17 2007-06-28 Bayer Cropscience Ag Carboxamide
DE102005060467A1 (de) 2005-12-17 2007-06-21 Bayer Cropscience Ag Carboxamide
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
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CN1245498A (zh) 2000-02-23
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EP0946553A1 (en) 1999-10-06
BR9713429A (pt) 2000-02-01
DE69718816D1 (de) 2003-03-06
US6174894B1 (en) 2001-01-16
GB9624611D0 (en) 1997-01-15
SV1997000097A (es) 1998-10-15
KR20000069095A (ko) 2000-11-25
IL130059A0 (en) 2000-02-29
CA2272076A1 (en) 1998-06-18
ATE231860T1 (de) 2003-02-15
WO1998025923A1 (en) 1998-06-18
AU4789097A (en) 1998-07-03
EP0946553B1 (en) 2003-01-29
TR199901170T2 (xx) 1999-07-21

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