ES2187587T3 - Biosensor. - Google Patents

Biosensor.

Info

Publication number
ES2187587T3
ES2187587T3 ES96103842T ES96103842T ES2187587T3 ES 2187587 T3 ES2187587 T3 ES 2187587T3 ES 96103842 T ES96103842 T ES 96103842T ES 96103842 T ES96103842 T ES 96103842T ES 2187587 T3 ES2187587 T3 ES 2187587T3
Authority
ES
Spain
Prior art keywords
piezoelement
biosensor
sensor
space
contg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96103842T
Other languages
English (en)
Inventor
Paul Dr Meller
Norbert Dr Madry
Carsten Dr Schelp
Andrzej Dr Grzegorzewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2187587T3 publication Critical patent/ES2187587T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G01N2291/0257—Adsorption, desorption, surface mass change, e.g. on biosensors with a layer containing at least one organic compound

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Acoustics & Sound (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Holo Graphy (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

LA INVENCION SE REFIERE A UN BIOSENSOR (10) PARA LA MEDICION DE MODIFICACIONES DE VISCOSIDAD, DE DENSIDAD Y/O DE MASA EN UN FLUIDO A SER INVESTIGADO, POR EJEMPLO SENSOR DE COAGULACION DE LA SANGRE O IMMUNOASSAY. DE ACUERDO CON LA INVENCION LOS REACTIVOS NECESARIOS DE PRUEBA ESTAN CONTENIDOS EN UN CUERPO (13) SOPORTE, QUE SE APOYA SOBRE LA SUPERFICIE (18) DE MEDICION DE UN PIEZOELEMENTO (8). COMO SENSOR DE COAGULACION DE LA SANGRE PUEDE ACTUAR DE CUERDO CON LA INVENCION LA SUPERFICIE (18) DE MEDICION DE ACTIVACION PROPIA, ESTANDO CUBIERTAS TAMBIEN CON REACTIVOS DE ACTIVIDAD DE COAGULACION.
ES96103842T 1995-04-10 1996-03-12 Biosensor. Expired - Lifetime ES2187587T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19512710A DE19512710A1 (de) 1995-04-10 1995-04-10 Biosensor

Publications (1)

Publication Number Publication Date
ES2187587T3 true ES2187587T3 (es) 2003-06-16

Family

ID=7758833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96103842T Expired - Lifetime ES2187587T3 (es) 1995-04-10 1996-03-12 Biosensor.

Country Status (10)

Country Link
US (1) US5892144A (es)
EP (1) EP0737853B1 (es)
JP (1) JP3955646B2 (es)
KR (1) KR960038388A (es)
AT (1) ATE229175T1 (es)
AU (1) AU706858B2 (es)
CA (1) CA2173706A1 (es)
DE (2) DE19512710A1 (es)
ES (1) ES2187587T3 (es)
MX (1) MX9601324A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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US6407557B1 (en) * 1998-08-27 2002-06-18 Canon Kabushiki Kaisha Process for measuring the electrical resistance of a resistive body for example for checking the conformity of a liquid product and devices for carrying out such a process
US6200532B1 (en) * 1998-11-20 2001-03-13 Akzo Nobel Nv Devices and method for performing blood coagulation assays by piezoelectric sensing
EP2042610A1 (fr) * 1999-02-23 2009-04-01 Asulab S.A. Système électrochimique pour la détermination d'un temps de coagulation du sang
GB9921982D0 (en) * 1999-09-16 1999-11-17 Secretary Trade Ind Brit Cavitation sensor
EP1350103B1 (en) * 2000-01-19 2010-01-06 Given Imaging Ltd. A system for detecting substances
ATE389871T1 (de) 2001-01-16 2008-04-15 Given Imaging Ltd System zur bestimmung der in-vivo-zustände in körperlumina
DE60332944D1 (de) * 2002-08-13 2010-07-22 Given Imaging Ltd System für die probenahme und analyse in vivo
JP2007521477A (ja) * 2003-06-26 2007-08-02 ギブン・イメージング・リミテツド 生体内検出用の方法、装置、およびシステム
JP3757960B2 (ja) * 2003-07-11 2006-03-22 セイコーエプソン株式会社 液滴吐出装置、電気光学装置の製造方法、電子機器の製造方法
US7460896B2 (en) * 2003-07-29 2008-12-02 Given Imaging Ltd. In vivo device and method for collecting oximetry data
US7399609B2 (en) * 2003-12-30 2008-07-15 3M Innovative Properties Company Staphylococcus detection
CN1914512A (zh) * 2003-12-30 2007-02-14 3M创新有限公司 增强细胞的细胞壁组分的信号检测的方法
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US8738106B2 (en) * 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
IL174531A0 (en) * 2005-04-06 2006-08-20 Given Imaging Ltd System and method for performing capsule endoscopy diagnosis in remote sites
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7263874B2 (en) * 2005-06-08 2007-09-04 Bioscale, Inc. Methods and apparatus for determining properties of a fluid
JP2007010523A (ja) * 2005-06-30 2007-01-18 Kyocera Kinseki Corp 微少質量測定用センサー
JP2009532168A (ja) * 2006-04-03 2009-09-10 ギブン イメージング リミテッド 生体内分析のための装置、システムおよび方法
US20100120016A1 (en) * 2006-09-01 2010-05-13 Yanbin Li Methods and systems for detection of contaminants
US20080114549A1 (en) * 2006-11-09 2008-05-15 Mark Evan Schafer Rapid response blood analyzer
JP4899820B2 (ja) * 2006-11-24 2012-03-21 株式会社日立製作所 凝固センサ
WO2008081181A1 (en) * 2006-12-28 2008-07-10 Highland Biosciences Limited Biosensor
GB0716542D0 (en) * 2007-08-24 2007-10-03 Highland Biosciences Ltd Endotoxin biosensor
US8515507B2 (en) * 2008-06-16 2013-08-20 Given Imaging Ltd. Device and method for detecting in-vivo pathology
US8424370B2 (en) * 2009-01-16 2013-04-23 Matrix Sensors, Inc. Liquid analysis using capacitative micromachined ultrasound transducers
US20120275959A1 (en) * 2009-09-09 2012-11-01 Andreas Hettich Gmbh & Co. Kg Apparatus for performing haemostasis tests
DE102009040879B4 (de) * 2009-09-09 2012-12-06 Andreas Hettich Gmbh & Co. Kg Verfahren zur Bestimmung der Gerinnungszeit
US8633711B2 (en) * 2009-10-09 2014-01-21 Micropoint Bioscience, Inc. Inductive coagulation sensors and devices
WO2011049601A2 (en) * 2009-10-21 2011-04-28 Micropoint Bioscience Inc. Piezoelectric coagulation sensors
HRP20230171T1 (hr) 2014-09-09 2023-03-31 Perosphere Technologies Inc. Univerzalni test koagulacije na bazi mikrofluidnog čipa
DE202015104762U1 (de) * 2015-09-08 2016-12-09 Jürgen Schulz Kartusche für eine Koagulationsmessung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236893A (en) * 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
DE3435843A1 (de) * 1984-09-29 1986-04-03 Gödecke AG, 1000 Berlin Antirheumatisch wirksame suppositorien
US4558589A (en) * 1984-10-09 1985-12-17 Miles Laboratories, Inc. Ultrasonic coagulation monitor and method
US4695956A (en) * 1984-11-01 1987-09-22 Leveen Eric G Apparatus and method of quantifying hemostasis using oscillations from a transducer immersed in the blood sample
US4735906A (en) * 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4847193A (en) * 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
US5211054A (en) * 1987-08-19 1993-05-18 Seiko Instruments Inc. Method and system for analyzing a gelation reaction by utilizing a piezoelectric resonator
US4999284A (en) * 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
DE69010506T2 (de) * 1989-10-04 1994-12-22 Du Pont Bestimmungsverfahren für biologische zielkomplexe auf der oberfläche eines biosensors.
US5179028A (en) * 1990-04-20 1993-01-12 Hughes Aircraft Company Antibody coated crystal chemical sensor
DE4334834A1 (de) * 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen

Also Published As

Publication number Publication date
US5892144A (en) 1999-04-06
EP0737853A1 (de) 1996-10-16
MX9601324A (es) 1997-04-30
AU706858B2 (en) 1999-06-24
DE19512710A1 (de) 1996-10-17
AU5054196A (en) 1996-10-24
JP3955646B2 (ja) 2007-08-08
JPH08285756A (ja) 1996-11-01
CA2173706A1 (en) 1996-10-11
DE59609933D1 (de) 2003-01-16
KR960038388A (ko) 1996-11-21
EP0737853B1 (de) 2002-12-04
ATE229175T1 (de) 2002-12-15

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