ES2187834T3 - Conjugados fluorescentes no agregados y su procedimiento de obtencion. - Google Patents

Conjugados fluorescentes no agregados y su procedimiento de obtencion.

Info

Publication number
ES2187834T3
ES2187834T3 ES97951325T ES97951325T ES2187834T3 ES 2187834 T3 ES2187834 T3 ES 2187834T3 ES 97951325 T ES97951325 T ES 97951325T ES 97951325 T ES97951325 T ES 97951325T ES 2187834 T3 ES2187834 T3 ES 2187834T3
Authority
ES
Spain
Prior art keywords
added
fluorescent conjugates
obtaining procedure
carboxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951325T
Other languages
English (en)
Inventor
Daniel Aspe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of ES2187834T3 publication Critical patent/ES2187834T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electroluminescent Light Sources (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE OBTENCION DE UN CONJUGADO FLUORESCENTE ENTRE UNA MOLECULA PORTADORA QUE TIENE AL MENOS UN GRUPO AMINO, HIDROXI, CARBOXI Y/O SULFIDRILO Y UN REACTIVO FLUOROFORO QUE TIENE AL MENOS UN GRUPO FUNCIONAL SUSCEPTIBLE DE REACCIONAR CON DICHO(S) GRUPO(S) AMINO, HIDROXI, CARBOXI Y/O SULFIDRILO QUE CONSISTE EN PONER EN PRESENCIA DICHA MOLECULA PORTADORA Y DICHO REACTIVO CON UNA SOLUCION ACUOSA DE UN MACROCICLO SOLUBLE EN AGUA. LA INVENCION SE REFIERE TAMBIEN A LOS CONJUGADOS OBTENIDOS POR ESTE PROCEDIMIENTO Y SU UTILIZACION.
ES97951325T 1996-12-12 1997-12-12 Conjugados fluorescentes no agregados y su procedimiento de obtencion. Expired - Lifetime ES2187834T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615261A FR2757162B1 (fr) 1996-12-12 1996-12-12 Conjugues fluorescents non agreges

Publications (1)

Publication Number Publication Date
ES2187834T3 true ES2187834T3 (es) 2003-06-16

Family

ID=9498586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951325T Expired - Lifetime ES2187834T3 (es) 1996-12-12 1997-12-12 Conjugados fluorescentes no agregados y su procedimiento de obtencion.

Country Status (9)

Country Link
EP (1) EP0946870B1 (es)
JP (1) JP3955638B2 (es)
AT (1) ATE228656T1 (es)
AU (1) AU5489498A (es)
CA (1) CA2272890C (es)
DE (1) DE69717490T2 (es)
ES (1) ES2187834T3 (es)
FR (1) FR2757162B1 (es)
WO (1) WO1998026287A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731741A1 (de) * 1997-07-23 1999-01-28 Deutsches Krebsforsch Konjugat zur Unterscheidung von krankhaftem und gesundem Gewebe
EP0934986A1 (de) * 1997-12-17 1999-08-11 Roche Diagnostics GmbH Farbstoff-Polyaccharid- bzw. Cyclosaccharid-Konjugate und deren Verwendung als Diagnostikum
US6242430B1 (en) 1998-04-30 2001-06-05 Laboratory Of Molecular Biophotonics Cyclodextrin-based rotaxane dyes, labeling agent using the dye, and a method for labeling
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
DE10026623A1 (de) * 2000-05-29 2001-12-06 Heinz Langhals Perylenfarbstoffe mit persistenter Fluoreszenz durch sterische Aggregationshinderung
WO2003029383A1 (en) 2001-09-28 2003-04-10 Canon Kabushiki Kaisha Organic luminescence device
FR2840611B1 (fr) * 2002-06-06 2005-09-09 Cis Bio Int Entite fluorescente comportant un fluorophore lie de maniere covalente a au moins un oligonucleotide et comportant au moins un groupe fonctionnel et ses utilisations
FR2878853B1 (fr) * 2004-12-07 2007-03-16 Biocydex Soc Par Actions Simpl Procede d'obtention d'un complexe fluorescent, complexe obtenu et utilisation
JP2009506188A (ja) * 2005-08-30 2009-02-12 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチ 絡み合った蛍光ポリマーおよび両親媒性分子を含んだ水溶性蛍光粒子
FR3045053B1 (fr) * 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
WO1991002040A1 (en) * 1989-08-04 1991-02-21 Kosak Kenneth M Cyclodextrin labels for nucleic acid and biochemical analysis
WO1991005605A1 (en) * 1989-10-10 1991-05-02 Kosak Kenneth M Cyclodextrin labels for immunoassay and biochemical analysis
EP0708837B1 (en) * 1993-07-13 2006-03-08 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates

Also Published As

Publication number Publication date
WO1998026287A1 (fr) 1998-06-18
JP3955638B2 (ja) 2007-08-08
DE69717490T2 (de) 2003-09-04
CA2272890C (en) 2004-11-30
AU5489498A (en) 1998-07-03
EP0946870B1 (fr) 2002-11-27
DE69717490D1 (de) 2003-01-09
EP0946870A1 (fr) 1999-10-06
JP2001506002A (ja) 2001-05-08
ATE228656T1 (de) 2002-12-15
CA2272890A1 (en) 1998-06-18
FR2757162A1 (fr) 1998-06-19
FR2757162B1 (fr) 1999-03-26

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