ES2189285T3 - Nuevas piranonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen - Google Patents

Nuevas piranonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen

Info

Publication number
ES2189285T3
ES2189285T3 ES98965668T ES98965668T ES2189285T3 ES 2189285 T3 ES2189285 T3 ES 2189285T3 ES 98965668 T ES98965668 T ES 98965668T ES 98965668 T ES98965668 T ES 98965668T ES 2189285 T3 ES2189285 T3 ES 2189285T3
Authority
ES
Spain
Prior art keywords
atoms
moiety
alkoxy
piranonas
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98965668T
Other languages
English (en)
Inventor
Shyam Sunder Chatterjee
Hermann Hauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Application granted granted Critical
Publication of ES2189285T3 publication Critical patent/ES2189285T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2H-1-piran-2-onas de fórmula general I en la que R1 es un resto alquilo de 2 a 5 átomos de C, un resto cicloalquilo de 4 a 6 átomos de C, un resto cicloalquil-alquilo de 4 a 8 átomos de C o un resto alcoxi-alquilo con un total de 3 a 5 átomos de C, y R2 es un resto 2-fenil-etenilo sustituido en el anillo de benceno en las posiciones 3, 4 y 5 por R3, R4 y R5, siendo independientemente entre sí R3 y R5 metoxilo o etoxilo, y R4 un resto alcoxilo de cadena lineal o ramificado de 1 a 5 átomos de C, un resto alquenil-oxilo de 3 a 5 átomos de C, un resto cicloalcoxilo de 4 a 6 átomos de C, un resto cicloalquil-alcoxilo de 4 a 8 átomos de C o un resto alcoxi-alcoxilo con un total de 3 a 5 átomos de C.
ES98965668T 1997-11-14 1998-11-12 Nuevas piranonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen Expired - Lifetime ES2189285T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19750623A DE19750623A1 (de) 1997-11-14 1997-11-14 Pyranone, Verfahren zu ihrer Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ES2189285T3 true ES2189285T3 (es) 2003-07-01

Family

ID=7848824

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98965668T Expired - Lifetime ES2189285T3 (es) 1997-11-14 1998-11-12 Nuevas piranonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen

Country Status (9)

Country Link
US (1) US6288109B1 (es)
EP (1) EP1032572B1 (es)
JP (1) JP2001523682A (es)
AT (1) ATE229526T1 (es)
AU (1) AU750666B2 (es)
CA (1) CA2310244A1 (es)
DE (2) DE19750623A1 (es)
ES (1) ES2189285T3 (es)
WO (1) WO1999025716A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608105B2 (en) * 2000-12-18 2003-08-19 Meiji Dairies Corporation TNF-α production inhibitor comprising kavalactone as an active ingredient
US7037524B2 (en) 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US20050053678A1 (en) * 2001-10-03 2005-03-10 Gow Robert T. Methods and compositions for betel nut chewing gum
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
US7105185B2 (en) * 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US20030118761A1 (en) * 2001-12-21 2003-06-26 Kimberly-Clark Worldwide, Inc. Elastomeric articles having improved chemical resistance
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
US7052642B2 (en) 2003-06-11 2006-05-30 Kimberly-Clark Worldwide, Inc. Composition for forming an elastomeric article
CN1917892A (zh) * 2003-10-24 2007-02-21 草本制药科学有限责任公司 包含冬青的方法和组合物
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
CN103145666B (zh) * 2013-03-27 2015-04-22 山东省科学院生物研究所 4-取代α-吡喃酮衍生物及其制备方法与应用
CN112353791B (zh) 2013-11-11 2025-02-25 夸利蒂赫布丘蒂克斯公司 卡瓦衍生的治疗性化合物及其使用方法
CN110551090B (zh) * 2019-10-21 2021-06-18 扬州工业职业技术学院 一种超声波提取中药狗脊中抗肿瘤活性成分的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1279683B (de) 1963-11-29 1968-10-10 Spezialchemie Gmbh & Co Verfahren zur Herstellung von substituierten ª‡-Pyronen
DE1277263B (de) * 1963-11-29 1968-09-12 Spezialchemie Gmbh & Co Verfahren zur Herstellung von Dihydromethysticin oder Dihydrokawain
GB1061847A (en) 1964-03-23 1967-03-15 Mobil Oil Corp Method for preparing highly siliceous zeolite type materials and the products thereof

Also Published As

Publication number Publication date
DE59806655D1 (de) 2003-01-23
JP2001523682A (ja) 2001-11-27
EP1032572A2 (de) 2000-09-06
EP1032572B1 (de) 2002-12-11
WO1999025716A2 (de) 1999-05-27
CA2310244A1 (en) 1999-05-27
ATE229526T1 (de) 2002-12-15
US6288109B1 (en) 2001-09-11
WO1999025716A9 (de) 1999-09-02
WO1999025716A3 (de) 1999-07-15
AU750666B2 (en) 2002-07-25
DE19750623A1 (de) 1999-05-20
AU2152899A (en) 1999-06-07

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