ES2190067T3 - Iminas polidentadas y sus complejos metalicos. - Google Patents

Iminas polidentadas y sus complejos metalicos.

Info

Publication number
ES2190067T3
ES2190067T3 ES98910837T ES98910837T ES2190067T3 ES 2190067 T3 ES2190067 T3 ES 2190067T3 ES 98910837 T ES98910837 T ES 98910837T ES 98910837 T ES98910837 T ES 98910837T ES 2190067 T3 ES2190067 T3 ES 2190067T3
Authority
ES
Spain
Prior art keywords
polidented
iminas
metal complexes
cis
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98910837T
Other languages
English (en)
Inventor
Martin Schroder
Daniel Martin John Doble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham PLC filed Critical Amersham PLC
Application granted granted Critical
Publication of ES2190067T3 publication Critical patent/ES2190067T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/06—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C07C251/08—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton being acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Un ligando de fórmula: en la que: A es N, CR1, P, P=O, ciclohexano cis,cis,cis-1,3,5- trisustituido o un anillo macrocíclico triaza de 9 a 14 miembros N, N'', N"-trisustituido; L1, L2 y L3 son grupos de unión que se eligen independientemente entre alquileno C1-4, cicloalquileno C4- 6 u o-arileno C4-6; Y1, Y2 e Y3 se eligen independientemente entre -NH2, - B(=O)OZ, -N=CR-B(=O)OZ, NR-CR2-B(=O)OZ, N[CR2-B(=O)Q]2 y O- CR2-B(=O)OZ, donde B es C o PR2, cada Q es independientemente -OZ o -NR2 y Z es H o un contraión; cada grupo R y R1 se elige independientemente entre H, alquilo C1-5, alcoxialquilo C1-5, hidroxialquilo C1-5, aminoalquilo C1-5, arilo C5-10 o fluoroalquilo C1-6; R2 es OH, alquilo C1-6, alcoxialquilo C1-6, fluoroalquilo C1-6, alcoxi C1-10 o arilo C5-10; con la condición de que al menos uno de Y1, Y2 y Y3 sea - N=CR-B(=O)OZ.
ES98910837T 1997-03-07 1998-03-06 Iminas polidentadas y sus complejos metalicos. Expired - Lifetime ES2190067T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97301548 1997-03-07

Publications (1)

Publication Number Publication Date
ES2190067T3 true ES2190067T3 (es) 2003-07-16

Family

ID=8229239

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98910837T Expired - Lifetime ES2190067T3 (es) 1997-03-07 1998-03-06 Iminas polidentadas y sus complejos metalicos.

Country Status (6)

Country Link
US (1) US6153775A (es)
JP (1) JP4056088B2 (es)
DE (1) DE69810492T2 (es)
DK (1) DK1015419T3 (es)
ES (1) ES2190067T3 (es)
NO (1) NO313187B1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055112A2 (en) * 2001-01-09 2002-07-18 Bristol Myers Squibb Co Polypodal chelants for metallopharmaceuticals
US7928278B2 (en) * 2001-06-12 2011-04-19 University Of Florida Research Foundation, Inc. Method and apparatus for producing near-infrared radiation
US7632924B2 (en) 2004-06-18 2009-12-15 Ambrx, Inc. Antigen-binding polypeptides and their uses
JP4930943B2 (ja) * 2007-05-11 2012-05-16 国立大学法人群馬大学 酸素濃度測定試薬および酸素濃度測定方法
EP2348052A3 (en) 2007-09-17 2011-10-26 The Regents of The University of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
AU2012229156A1 (en) 2011-03-11 2013-10-31 Board Of Regents Of The University Of Nebraska Biomarker for coronary artery disease
PT3383920T (pt) 2015-11-30 2024-04-15 Univ California Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
CN116419747B (zh) 2020-08-07 2025-10-17 福蒂斯治疗公司 靶向cd46的免疫偶联物及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071965A (en) * 1988-07-19 1991-12-10 Mallinckrodt Medical, Inc. Novel tc-99m complexes
FR2670113A1 (fr) * 1990-12-06 1992-06-12 Medgenix Group Sa Agent de contraste constitue par un complexe neutre d'un cation paramagnetique et ligand pour former un complexe.
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
DE4406465A1 (de) * 1994-02-23 1995-08-24 Univ Leipzig Kontrastmittel für die Kernspintomographie

Also Published As

Publication number Publication date
US6153775A (en) 2000-11-28
JP2001514624A (ja) 2001-09-11
DK1015419T3 (da) 2003-04-22
NO994265L (no) 1999-11-05
DE69810492T2 (de) 2003-11-20
DE69810492D1 (de) 2003-02-06
JP4056088B2 (ja) 2008-03-05
NO994265D0 (no) 1999-09-02
NO313187B1 (no) 2002-08-26

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