ES2190672T3 - Amido-lactamas 3-(tio-sustituidas), utiles como inhibidores de metaloproteinasa matricial. - Google Patents

Amido-lactamas 3-(tio-sustituidas), utiles como inhibidores de metaloproteinasa matricial.

Info

Publication number
ES2190672T3
ES2190672T3 ES99962921T ES99962921T ES2190672T3 ES 2190672 T3 ES2190672 T3 ES 2190672T3 ES 99962921 T ES99962921 T ES 99962921T ES 99962921 T ES99962921 T ES 99962921T ES 2190672 T3 ES2190672 T3 ES 2190672T3
Authority
ES
Spain
Prior art keywords
group
hydrogen
alkyl
formula
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99962921T
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English (en)
Inventor
Alan Warshawsky
Michael J Janusz
Gary A Flynn
Joseph P Burkhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2190672T3 publication Critical patent/ES2190672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la fórmula **(Fórmula)** en donde q es 1 o 2; A se selecciona entre el grupo consistente en -OH y -NRR¿; en donde R y R¿ se seleccionan independientemente entre el grupo consistente en hidrógeno y alquilo C1-C6 o R y R¿ introducidos junto con el átomo de nitrógeno al que están unidos, forman un N-morfolino, N-piperidino, N-pirrolidino o N-isoindolilo; R1 se selecciona entre el grupo consistente en hidrógeno, alquilo C1-C6, -(CH2)a-CO2R5, -(CH2)aC(O)NH2, -(CH2)4NH2, -(CH2)3-NH-C(NH)NH2, -(CH2)2-S(O)b-CH3, -CH2-OH, -CH(OH)CH3, -CH2SH, -(CH2)d-Ar1 y -CH2-Ar2; en donde a es 1 o 2; b es 0, 1 o 2; d es un número entero de 0 a 4; R5 se selecciona entre el grupo consistente en hidrógeno, alquilo C1-C4 y bencilo; Ar1 es un radical seleccionado entre el grupo consistente en **(Fórmula)** en donde R6 representa 1 a 2 sustituyentes seleccionados independientemente entre el grupo consistente en hidrógeno, halógeno, alquilo C1-C4, hidroxi y alcoxi C1-C4; R7 se selecciona entre el grupo consistente en hidrógeno, halógeno, alquilo C1-C4 y alcoxi C1-C4; Ar2 es un radical seleccionado entre el grupo consistente en **(Fórmula)** R2 se selecciona entre el grupo consistente en alquilo C1-C6, -(CH2)g-Ar1, y -(CH2)-Ar2, ; en donde g en un número entero de 1 a 4; Ar1, es un radical seleccionado entre el grupo consistente en **(Fórmula)** en donde R6, representa 1 a 2 sustituyentes seleccionados independientemente entre el grupo consistente en hidrógeno, halógeno, alquilo C1-C4, hidroxi y alcoxi C1-C4; R7V se selecciona entre el grupo consistente en hidrógeno, halógeno, alquilo C1-C4 y alcoxi C1-C4; Ar2, es un radical seleccionado entre el grupo consistente en **(Fórmula)** R3 se selecciona entre el grupo consistente en alquilo C1-C6, -(CH2)m-W, -(CH2)p-Ar3, -(CH2)k45 CO2R9, -(CH2)m-NR8''SO2-Y1 y -(CH2)m-Z-Q en donde m es un número entero de 2 a 8; p es un número entero de 0-10; k es un número entero de 1 a 9; W es ftalimido; Ar3 se selecciona entre el grupo consistente en **(Fórmula)** en donde R23 representa 1 a 2 sustituyentes seleccionados independientemente del grupo consistente en hidrógeno, halógeno, alquilo C1-C4 y alcoxi C1-C4; R8, es hidrógeno o alquilo C1-C6; R9 es hidrógeno o alquilo C1-C6; Y1 se selecciona entre el grupo consistente en hidrógeno, -(CH2)j-Ar4 y -N(R24)2 en donde j es 0 o 1; R24 representa cada uno independientemente hidrógeno o alquilo C1-C6 o se introducen junto con nitrógeno al que están unidos para formar N-morfolino, N-piperidino, N-pirrolidino o N-isoindolilo; Ar4 es **(Fórmula)** en donde R25 representa 1 a 3 sustituyentes seleccionados independientemente del grupo consistente en hidrógeno, halógeno, alquilo C1-C4 y alcoxi C1-C4; Z se selecciona entre el grupo consistente en -O-, -NR8-, -C(O)NR8-, -NR8C(O)-, -NR8C(O)NH-, -NR8C(O)O- y -OC(O)NH-; en donde R8 es hidrógeno o alquilo C1-C6; Q se selecciona entre el grupo consistente en hidrógeno, -(CH2)n-Y2 y -(CH2)xY3; en donde n es un número entero de 0 a 4; Y2 se selecciona entre el grupoconsistente en hidrógeno, -(CH2)h-Ar5 y -(CH2)t-C(O)OR27
ES99962921T 1998-12-31 1999-11-30 Amido-lactamas 3-(tio-sustituidas), utiles como inhibidores de metaloproteinasa matricial. Expired - Lifetime ES2190672T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22394198A 1998-12-31 1998-12-31

Publications (1)

Publication Number Publication Date
ES2190672T3 true ES2190672T3 (es) 2003-08-01

Family

ID=22838632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99962921T Expired - Lifetime ES2190672T3 (es) 1998-12-31 1999-11-30 Amido-lactamas 3-(tio-sustituidas), utiles como inhibidores de metaloproteinasa matricial.

Country Status (11)

Country Link
EP (1) EP1150976B1 (es)
JP (1) JP2002534425A (es)
AR (1) AR033642A1 (es)
AT (1) ATE233259T1 (es)
AU (1) AU1926700A (es)
CA (1) CA2358939A1 (es)
DE (1) DE69905621T2 (es)
DK (1) DK1150976T3 (es)
ES (1) ES2190672T3 (es)
PT (1) PT1150976E (es)
WO (1) WO2000040578A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114005D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527795A (en) * 1990-10-18 1996-06-18 Merrell Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
DE69516128T2 (de) * 1994-02-14 2000-12-21 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
CZ288436B6 (en) * 1994-10-05 2001-06-13 Darwin Discovery Ltd Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
GB9624562D0 (en) * 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides

Also Published As

Publication number Publication date
DE69905621T2 (de) 2003-11-27
DE69905621D1 (de) 2003-04-03
JP2002534425A (ja) 2002-10-15
WO2000040578A1 (en) 2000-07-13
AR033642A1 (es) 2004-01-07
PT1150976E (pt) 2003-07-31
DK1150976T3 (da) 2003-06-02
EP1150976B1 (en) 2003-02-26
CA2358939A1 (en) 2000-07-13
EP1150976A1 (en) 2001-11-07
ATE233259T1 (de) 2003-03-15
AU1926700A (en) 2000-07-24

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