ES2190771B2 - Procedimiento para la produccion de resveratrol en cultivos celulares. - Google Patents

Procedimiento para la produccion de resveratrol en cultivos celulares.

Info

Publication number
ES2190771B2
ES2190771B2 ES200200162A ES200200162A ES2190771B2 ES 2190771 B2 ES2190771 B2 ES 2190771B2 ES 200200162 A ES200200162 A ES 200200162A ES 200200162 A ES200200162 A ES 200200162A ES 2190771 B2 ES2190771 B2 ES 2190771B2
Authority
ES
Spain
Prior art keywords
resveratrol
procedure
production
cell cultures
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200200162A
Other languages
English (en)
Other versions
ES2190771A1 (es
Inventor
Martinez Roque Bru
Garcia M Angeles Pedreno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Murcia
Original Assignee
University of Alicante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200200162A priority Critical patent/ES2190771B2/es
Application filed by University of Alicante filed Critical University of Alicante
Priority to EP03704713A priority patent/EP1471141A1/en
Priority to US10/501,339 priority patent/US7309591B2/en
Priority to CA002486588A priority patent/CA2486588A1/en
Priority to PCT/ES2003/000026 priority patent/WO2003062406A1/es
Priority to JP2003562274A priority patent/JP4444659B2/ja
Priority to AU2003206973A priority patent/AU2003206973B2/en
Publication of ES2190771A1 publication Critical patent/ES2190771A1/es
Application granted granted Critical
Publication of ES2190771B2 publication Critical patent/ES2190771B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Procedimiento para la producción de resveratrol en cultivos celulares. El procedimiento comprende incubar un cultivo de células productoras de resveratrol de forma natural, en suspensión, en presencia de una {be}-ciclodextrina metilada aleatoriamente (BCDMA) con un grado de sustitución comprendido entre 11 y 13 bajo condiciones que permiten la síntesis de resveratrol y su excreción al medio de cultivo, y, si se desea, aislar el resveratrol producido del medio de cultivo. El resveratrol puede ser utilizado en la elaboración de productos farmacéuticos o nutracéuticos.
ES200200162A 2002-01-24 2002-01-24 Procedimiento para la produccion de resveratrol en cultivos celulares. Expired - Fee Related ES2190771B2 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES200200162A ES2190771B2 (es) 2002-01-24 2002-01-24 Procedimiento para la produccion de resveratrol en cultivos celulares.
US10/501,339 US7309591B2 (en) 2002-01-24 2003-01-21 Method for the production of resveratrol in cell cultures
CA002486588A CA2486588A1 (en) 2002-01-24 2003-01-21 Method for the production of resveratrol in cell cultures
PCT/ES2003/000026 WO2003062406A1 (es) 2002-01-24 2003-01-21 Procedimiento para la produccion de resveratrol en cultivos celulares
EP03704713A EP1471141A1 (en) 2002-01-24 2003-01-21 Method for the production of resveratrol in cell cultures
JP2003562274A JP4444659B2 (ja) 2002-01-24 2003-01-21 細胞培養中でレスベラトロールを産生する方法
AU2003206973A AU2003206973B2 (en) 2002-01-24 2003-01-21 Method for the production of resveratrol in cell cultures

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200200162A ES2190771B2 (es) 2002-01-24 2002-01-24 Procedimiento para la produccion de resveratrol en cultivos celulares.

Publications (2)

Publication Number Publication Date
ES2190771A1 ES2190771A1 (es) 2003-08-01
ES2190771B2 true ES2190771B2 (es) 2004-03-01

Family

ID=27589315

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200200162A Expired - Fee Related ES2190771B2 (es) 2002-01-24 2002-01-24 Procedimiento para la produccion de resveratrol en cultivos celulares.

Country Status (7)

Country Link
US (1) US7309591B2 (es)
EP (1) EP1471141A1 (es)
JP (1) JP4444659B2 (es)
AU (1) AU2003206973B2 (es)
CA (1) CA2486588A1 (es)
ES (1) ES2190771B2 (es)
WO (1) WO2003062406A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2609549A1 (en) * 2005-05-25 2006-11-30 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
US7666677B2 (en) 2006-07-05 2010-02-23 Luis Fabricio Medina-Bolivar Production of stilbenes in plant hairy root cultures
CN101500549A (zh) 2006-08-09 2009-08-05 帝斯曼知识产权资产管理有限公司 酪蛋白复合物
ES2328002B2 (es) * 2008-02-29 2010-03-29 Universidad De Alicante Uso combinado de metil-jasmonato y ciclodextrinas para la produccion de resveratrol.
ES2344775B2 (es) * 2008-10-31 2011-06-07 Universidad De Murcia Uso de las ciclodextrinas para la produccion y extraccion de fitoesteroles en cultivos celulares.
CN102382862A (zh) * 2010-09-01 2012-03-21 中国科学院大连化学物理研究所 利用悬浮培养葡萄细胞生产13c标记反式白藜芦醇的方法
US9598707B2 (en) 2012-11-26 2017-03-21 Arkansas State University-Jonesboro Method to increase the yield of products in plant material
JP2015181362A (ja) * 2014-03-20 2015-10-22 一般財団法人バイオダイナミックス研究所 高機能性食用油とその製造法
KR102858341B1 (ko) * 2021-09-14 2025-09-12 주식회사 아이엔지알 포도 캘러스 배양액을 유효성분으로 함유하는 항균 및 항산화용 조성물
CN116135965B (zh) * 2023-02-09 2024-02-27 大连工业大学 一株生物合成白藜芦醇的巨大芽孢杆菌ph3及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1103372C (zh) * 2000-08-30 2003-03-19 尉亚辉 含有白藜芦醇细胞的生产方法

Also Published As

Publication number Publication date
EP1471141A1 (en) 2004-10-27
CA2486588A1 (en) 2003-07-31
JP4444659B2 (ja) 2010-03-31
US20060205049A1 (en) 2006-09-14
JP2005514945A (ja) 2005-05-26
ES2190771A1 (es) 2003-08-01
AU2003206973B2 (en) 2008-09-04
US7309591B2 (en) 2007-12-18
AU2003206973A1 (en) 2003-09-02
WO2003062406A1 (es) 2003-07-31

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