ES2191046T3 - Control de sistemas de soporte vital. - Google Patents
Control de sistemas de soporte vital.Info
- Publication number
- ES2191046T3 ES2191046T3 ES95911177T ES95911177T ES2191046T3 ES 2191046 T3 ES2191046 T3 ES 2191046T3 ES 95911177 T ES95911177 T ES 95911177T ES 95911177 T ES95911177 T ES 95911177T ES 2191046 T3 ES2191046 T3 ES 2191046T3
- Authority
- ES
- Spain
- Prior art keywords
- flow
- organ
- biological fluid
- control
- pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013060 biological fluid Substances 0.000 abstract 4
- 210000000056 organ Anatomy 0.000 abstract 4
- 230000003278 mimic effect Effects 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000000541 pulsatile effect Effects 0.000 abstract 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
- A61M16/026—Control means therefor including calculation means, e.g. using a processor specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/117—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/247—Positive displacement blood pumps
- A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
- A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
- A61M60/279—Peristaltic pumps, e.g. roller pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/31—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/37—Haemodialysis, haemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/515—Regulation using real-time patient data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/515—Regulation using real-time patient data
- A61M60/531—Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/562—Electronic control means, e.g. for feedback regulation for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/585—User interfaces
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Optics & Photonics (AREA)
- Human Computer Interaction (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Instructional Devices (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Electrotherapy Devices (AREA)
- Grinding Of Cylindrical And Plane Surfaces (AREA)
- Vehicle Body Suspensions (AREA)
- Paper (AREA)
Abstract
SE HACE UN CONTROL INFORMATICO DEL PASO DE UN FLUIDO BIOLOGICO HACIA UN ORGANO PARA QUE SE PUEDA SIMULAR LA VARIACION NATURAL DEL FLUJO. SE DESCRIBEN ESPECIFICAMENTE EL CONTROL DE UNA SALIDA DE FLUJO DE BOMBEO SANGUINEO DURANTE CPB HACIA UN FLUJO SANGUINEO PULSATIL MIMICO NORMAL DEL CORAZON Y EL CONTROL DE UNA SALIDA DE VENTILADOR HACIA LA RESPIRACION NORMAL MIMICA DE LOS PULMONES SANOS. SE ESTABLECE UN PATRON DE VARIACION EN EL TIEMPO DEL FLUJO INSTANTANEO DE UN FLUIDO BIOLOGICO A UN ORGANO DE ESPECIES DE MAMIFEROS, SE GENERA UN PARAMETRO DE CONTROL VARIABLE PARA LA REGULACION DEL PASO DEL FLUIDO BIOLOGICO HACIA EL ORGANO DE ACUERDO CON EL PATRON Y SE CONTROLA EL PASO DE FLUIDO BIOLOGICO HACIA EL ORGANO DE ACUERDO CON EL PARAMETRO DE CONTROL VARIABLE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9405002A GB9405002D0 (en) | 1994-03-15 | 1994-03-15 | Apparatus and method of use for pulsatile blood flow with return of in vivo variability of the pulse waveform |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2191046T3 true ES2191046T3 (es) | 2003-09-01 |
Family
ID=10751860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95911177T Expired - Lifetime ES2191046T3 (es) | 1994-03-15 | 1995-03-15 | Control de sistemas de soporte vital. |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6027498A (es) |
| EP (1) | EP0904116B1 (es) |
| JP (1) | JP3696241B2 (es) |
| AT (1) | ATE231012T1 (es) |
| AU (1) | AU1887395A (es) |
| CA (1) | CA2184992C (es) |
| DE (1) | DE69529425T2 (es) |
| ES (1) | ES2191046T3 (es) |
| GB (1) | GB9405002D0 (es) |
| WO (1) | WO1995024936A2 (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916191A (en) * | 1996-04-30 | 1999-06-29 | Medtronic, Inc. | Pulsatile flow generation in heart-lung machines |
| AUPP995999A0 (en) | 1999-04-23 | 1999-05-20 | University Of Technology, Sydney | Non-contact estimation and control system |
| WO2001068162A2 (en) * | 2000-03-16 | 2001-09-20 | Biovar Life Support Inc. | Control of life support systems |
| US6454697B1 (en) | 2000-07-18 | 2002-09-24 | Dai-Yuan Wang | Cardiac support device and method |
| US8641715B2 (en) | 2002-05-31 | 2014-02-04 | Vidacare Corporation | Manual intraosseous device |
| IL165224A0 (en) | 2002-05-31 | 2005-12-18 | Vidacare Corp | Apparatus and method to access bone marrow |
| US11337728B2 (en) | 2002-05-31 | 2022-05-24 | Teleflex Life Sciences Limited | Powered drivers, intraosseous devices and methods to access bone marrow |
| US10973545B2 (en) | 2002-05-31 | 2021-04-13 | Teleflex Life Sciences Limited | Powered drivers, intraosseous devices and methods to access bone marrow |
| US8668698B2 (en) | 2002-05-31 | 2014-03-11 | Vidacare Corporation | Assembly for coupling powered driver with intraosseous device |
| US8672858B2 (en) | 2002-08-30 | 2014-03-18 | University Of Florida Research Foundation, Inc. | Method and apparatus for predicting work of breathing |
| JP4836453B2 (ja) | 2002-08-30 | 2011-12-14 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 呼吸仕事量を予測するための方法および装置 |
| AU2003265729B2 (en) * | 2002-09-30 | 2007-10-18 | Thoratec Corporation | Physiological demand responsive control system |
| AU2002951685A0 (en) * | 2002-09-30 | 2002-10-17 | Ventrassist Pty Ltd | Physiological demand responsive control system |
| US9504477B2 (en) | 2003-05-30 | 2016-11-29 | Vidacare LLC | Powered driver |
| AU2003903726A0 (en) * | 2003-07-18 | 2003-07-31 | Ventracor Limited | A device for detecting heart pumping state |
| AU2003904032A0 (en) * | 2003-08-04 | 2003-08-14 | Ventracor Limited | Improved Transcutaneous Power and Data Transceiver System |
| WO2005032620A1 (en) * | 2003-10-09 | 2005-04-14 | Ventracor Limited | Impeller |
| US20060083642A1 (en) | 2004-10-18 | 2006-04-20 | Cook Martin C | Rotor stability of a rotary pump |
| US7513875B2 (en) * | 2004-10-20 | 2009-04-07 | Deepbreeze Ltd. | Method and system for managing mechanical respiratory ventilation |
| US20070142923A1 (en) * | 2005-11-04 | 2007-06-21 | Ayre Peter J | Control systems for rotary blood pumps |
| WO2007070932A1 (en) * | 2005-12-19 | 2007-06-28 | Ventrassist Pty Ltd | Improvements to tuning dc brushless motors |
| US20070179334A1 (en) * | 2006-01-30 | 2007-08-02 | Groves Laurie L | Sleep aid |
| AU2007201127B2 (en) * | 2006-03-23 | 2012-02-09 | Thoratec Corporation | System For Preventing Diastolic Heart Failure |
| US7850594B2 (en) | 2006-05-09 | 2010-12-14 | Thoratec Corporation | Pulsatile control system for a rotary blood pump |
| US8944069B2 (en) | 2006-09-12 | 2015-02-03 | Vidacare Corporation | Assemblies for coupling intraosseous (IO) devices to powered drivers |
| US7963905B2 (en) * | 2006-10-11 | 2011-06-21 | Thoratec Corporation | Control system for a blood pump |
| US20080133006A1 (en) * | 2006-10-27 | 2008-06-05 | Ventrassist Pty Ltd | Blood Pump With An Ultrasonic Transducer |
| DE102008060799B3 (de) * | 2008-11-27 | 2010-04-15 | Technische Universität Dresden | Kontroller für Beatmungsgeräte zur Regelung einer variablen Druckunterstützungsbeatmung |
| US20100222633A1 (en) * | 2009-02-27 | 2010-09-02 | Victor Poirier | Blood pump system with controlled weaning |
| US20100222635A1 (en) * | 2009-02-27 | 2010-09-02 | Thoratec Corporation | Maximizing blood pump flow while avoiding left ventricle collapse |
| US8562507B2 (en) | 2009-02-27 | 2013-10-22 | Thoratec Corporation | Prevention of aortic valve fusion |
| US8449444B2 (en) * | 2009-02-27 | 2013-05-28 | Thoratec Corporation | Blood flow meter |
| US20100222878A1 (en) * | 2009-02-27 | 2010-09-02 | Thoratec Corporation | Blood pump system with arterial pressure monitoring |
| US9320269B2 (en) | 2009-09-25 | 2016-04-26 | John Brassil | Organ preservation system |
| US9089635B2 (en) | 2010-06-22 | 2015-07-28 | Thoratec Corporation | Apparatus and method for modifying pressure-flow characteristics of a pump |
| TW201212959A (en) | 2010-06-22 | 2012-04-01 | Thoratec Corp | Fluid delivery system and method for monitoring fluid delivery system |
| EP3117845B1 (en) | 2010-09-24 | 2018-10-31 | Tc1 Llc | Generating artificial pulse |
| AU2011305243A1 (en) | 2010-09-24 | 2013-04-04 | Thoratec Corporation | Control of circulatory assist systems |
| CN102012971B (zh) * | 2010-12-03 | 2012-12-26 | 深圳市理邦精密仪器股份有限公司 | 一种打印胎心率曲线的方法及装置 |
| US8788236B2 (en) | 2011-01-31 | 2014-07-22 | Covidien Lp | Systems and methods for medical device testing |
| US8676529B2 (en) | 2011-01-31 | 2014-03-18 | Covidien Lp | Systems and methods for simulation and software testing |
| EP4194039B1 (en) * | 2011-12-05 | 2025-09-24 | Thornhill Scientific Inc. | A system to attain a targeted end tidal partial pressure of a gas |
| US10165966B2 (en) | 2013-03-14 | 2019-01-01 | University Of Florida Research Foundation, Incorporated | Methods and systems for monitoring resistance and work of breathing for ventilator-dependent patients |
| CN110101927B (zh) | 2014-04-15 | 2021-10-08 | Tc1有限责任公司 | 用于控制血泵的方法和系统 |
| DE102014107980A1 (de) * | 2014-06-05 | 2015-12-17 | Hamilton Medical Ag | Beatmungssystem mit maschineller Beatmung und extrakorporalem Blutgasaustausch |
| DE102017000940A1 (de) | 2017-02-02 | 2018-08-02 | Xenios Ag | Anordnung mit einer Blutpumpe, einer Steuereinheit und einem Gerät zur Übermittlung der Messwerte |
| US20250185648A1 (en) * | 2023-12-08 | 2025-06-12 | Alexandre Ivachtchenko | Method, device, and cardioplegic solution for the preservation of a donor heart |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001700A (en) * | 1974-04-16 | 1977-01-04 | Sutter Hospitals Medical Research Foundation | Digital waveform generator for automatic respiratory ventilators |
| US4231354A (en) * | 1978-07-14 | 1980-11-04 | Howmedica, Incorporated | Pulsatile blood pumping apparatus and method |
| US4448192A (en) * | 1982-03-05 | 1984-05-15 | Hewlett Packard Company | Medical ventilator device parametrically controlled for patient ventilation |
| US4584996A (en) * | 1984-03-12 | 1986-04-29 | Blum Alvin S | Apparatus for conservative supplemental oxygen therapy |
| FR2624744B1 (fr) * | 1987-12-18 | 1993-09-17 | Inst Nat Sante Rech Med | Procede de regulation d'un dispositif de ventilation artificielle et un tel dispositif |
| US5186431A (en) * | 1989-09-22 | 1993-02-16 | Yehuda Tamari | Pressure sensitive valves for extracorporeal circuits |
| JP2582010B2 (ja) * | 1991-07-05 | 1997-02-19 | 芳嗣 山田 | 呼吸筋活動のモニタ装置 |
| GB9125467D0 (en) * | 1991-11-29 | 1992-01-29 | Mockridge Jeffrey N A | Neo-natal ventilation apparatus |
-
1994
- 1994-03-15 GB GB9405002A patent/GB9405002D0/en active Pending
-
1995
- 1995-03-15 US US08/714,116 patent/US6027498A/en not_active Expired - Lifetime
- 1995-03-15 CA CA002184992A patent/CA2184992C/en not_active Expired - Lifetime
- 1995-03-15 DE DE69529425T patent/DE69529425T2/de not_active Expired - Lifetime
- 1995-03-15 EP EP95911177A patent/EP0904116B1/en not_active Expired - Lifetime
- 1995-03-15 AT AT95911177T patent/ATE231012T1/de not_active IP Right Cessation
- 1995-03-15 WO PCT/CA1995/000144 patent/WO1995024936A2/en not_active Ceased
- 1995-03-15 JP JP52375495A patent/JP3696241B2/ja not_active Expired - Lifetime
- 1995-03-15 AU AU18873/95A patent/AU1887395A/en not_active Abandoned
- 1995-03-15 ES ES95911177T patent/ES2191046T3/es not_active Expired - Lifetime
- 1995-03-15 US US08/404,464 patent/US5647350A/en not_active Expired - Lifetime
-
1997
- 1997-04-15 US US08/834,205 patent/US5941841A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1887395A (en) | 1995-10-03 |
| US6027498A (en) | 2000-02-22 |
| EP0904116A2 (en) | 1999-03-31 |
| WO1995024936A3 (en) | 1995-12-07 |
| JPH09510126A (ja) | 1997-10-14 |
| JP3696241B2 (ja) | 2005-09-14 |
| US5647350A (en) | 1997-07-15 |
| CA2184992C (en) | 2004-11-23 |
| EP0904116B1 (en) | 2003-01-15 |
| US5941841A (en) | 1999-08-24 |
| ATE231012T1 (de) | 2003-02-15 |
| DE69529425T2 (de) | 2004-03-04 |
| GB9405002D0 (en) | 1994-04-27 |
| WO1995024936A2 (en) | 1995-09-21 |
| DE69529425D1 (de) | 2003-02-20 |
| CA2184992A1 (en) | 1995-09-21 |
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