ES2191309T3 - Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas. - Google Patents

Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas.

Info

Publication number
ES2191309T3
ES2191309T3 ES98925811T ES98925811T ES2191309T3 ES 2191309 T3 ES2191309 T3 ES 2191309T3 ES 98925811 T ES98925811 T ES 98925811T ES 98925811 T ES98925811 T ES 98925811T ES 2191309 T3 ES2191309 T3 ES 2191309T3
Authority
ES
Spain
Prior art keywords
molecules
heparin
compatibility
metal surfaces
free radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98925811T
Other languages
English (en)
Inventor
Yousef Samih Taktak
Kadem Gayad Al-Lamee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polybiomed Ltd
Original Assignee
Polybiomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomed Ltd filed Critical Polybiomed Ltd
Application granted granted Critical
Publication of ES2191309T3 publication Critical patent/ES2191309T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F13/00—Arrangements for modifying heat-transfer, e.g. increasing, decreasing
    • F28F13/18—Arrangements for modifying heat-transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflecting; by surface treatment, e.g. polishing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Chemically Coating (AREA)

Abstract

La invención se refiere a una superficie de metal, vidrio o cerámica tratada para mejorar su compatibilidad con materiales biológicos tales como sangre o productos relacionados con la sangre. El tratamiento implica una unión covalente de la superficie por medio de moléculas funcionalmente catalíticas, cada una de las cuales tiene al menos un grupo alcoxilano que puede formar al menos un primer enlace covalente mediante reacción con el óxido o hidróxido de dicha superficie y a menos otro grupo que pueda participar en una polimerización de radical libre. La polimerización por radical libre desde dicha molécula funcional se ve afectada entonces para construir cadenas de polímeros biocompatibles y/o hidrofílicos. La compatibilidad de la superficie metálica con materiales biológicos se puede mejorar además mediante enlaces con moléculas bioactivas tales como heparina o moléculas derivadas de la heparina con las cadenas de polímeros. Superficies metálicas adecuadas son aquellas de los dispositivos médicos tales como intercambiadores de calor, válvulas coronarias y periféricas y cables guía empleados en angioplastia.
ES98925811T 1997-06-03 1998-06-03 Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas. Expired - Lifetime ES2191309T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9711377A GB2325934A (en) 1997-06-03 1997-06-03 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics

Publications (1)

Publication Number Publication Date
ES2191309T3 true ES2191309T3 (es) 2003-09-01

Family

ID=10813448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98925811T Expired - Lifetime ES2191309T3 (es) 1997-06-03 1998-06-03 Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas.

Country Status (10)

Country Link
US (1) US6599558B1 (es)
EP (1) EP0988071B1 (es)
JP (1) JP4357005B2 (es)
AT (1) ATE233110T1 (es)
AU (1) AU740161B2 (es)
CA (1) CA2293266C (es)
DE (1) DE69811666T2 (es)
ES (1) ES2191309T3 (es)
GB (1) GB2325934A (es)
WO (1) WO1998055162A2 (es)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7220276B1 (en) * 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
FR2827799A1 (fr) * 2001-07-27 2003-01-31 Sofradim Production Endoprothese vasculaire recouverte d'un derive fonctionnalise de dextrane et son procede de preparation
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
GB0122393D0 (en) * 2001-09-17 2001-11-07 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US20030195610A1 (en) * 2002-04-04 2003-10-16 Herrmann Robert A. Processes for producing polymer coatings through surface polymerization
EP1656165B1 (en) * 2003-08-19 2008-12-17 PolyBioMed Limited Polymeric drug release system for medical devices
CN101693031A (zh) 2003-11-18 2010-04-14 诺瓦提斯公司 Kit突变形式的抑制剂
JP2007530173A (ja) * 2004-03-26 2007-11-01 サーモディクス，インコーポレイティド 生体適合性表面のための方法およびシステム
US7550444B2 (en) * 2004-03-26 2009-06-23 Surmodics, Inc. Composition and method for preparing biocompatible surfaces
US20050234545A1 (en) * 2004-04-19 2005-10-20 Yea-Yang Su Amorphous oxide surface film for metallic implantable devices and method for production thereof
US20060013853A1 (en) * 2004-07-19 2006-01-19 Richard Robert E Medical devices having conductive substrate and covalently bonded coating layer
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
US8431226B2 (en) * 2005-03-30 2013-04-30 Biomet Manufacturing Corp. Coated medical device
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
KR20080084808A (ko) 2005-11-17 2008-09-19 바이오미메틱 세라퓨틱스, 인크. ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP2054537A2 (en) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
GB0617644D0 (en) 2006-09-07 2006-10-18 Polybiomed Ltd Hydrophilic surfaces for medical devices
ATE508708T1 (de) 2006-09-14 2011-05-15 Boston Scient Ltd Medizinprodukte mit wirkstofffreisetzender beschichtung
EP2959925B1 (en) 2006-09-15 2018-08-29 Boston Scientific Limited Medical devices and methods of making the same
EP2121068B1 (en) 2006-09-15 2010-12-08 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
CA2663250A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503494A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生分解性内部人工器官およびその製造方法
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
WO2008073628A2 (en) 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US7981150B2 (en) * 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
CA2674195A1 (en) 2006-12-28 2008-07-10 Boston Scientific Limited Bioerodible endoprostheses and methods of making same
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7935143B2 (en) * 2008-01-02 2011-05-03 Abbott Cardiovascular Systems Inc. Stent formed from polymer-bioceramic composite with radiopaque bioceramic particles
AU2009212151C1 (en) 2008-02-07 2015-09-17 Stryker Corporation Compositions and methods for distraction osteogenesis
EP2271380B1 (en) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
BR122020000059B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US7819914B2 (en) * 2008-12-16 2010-10-26 Cordis Corporation Adhesion promoting primer for coated surfaces
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
KR101107223B1 (ko) * 2009-11-10 2012-01-25 한국과학기술연구원 금속 기판에 대한 고분자의 코팅 접착력을 향상시키기 위한 나노 커플링
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10647829B2 (en) 2013-06-20 2020-05-12 Sumitomo Rubber Industries, Ltd. Surface modification method and surface modification body
JP6157429B2 (ja) * 2013-10-21 2017-07-05 住友ゴム工業株式会社 潤滑性、低タンパク質吸着性および／または低細胞吸着性を有する金属医療用具及びその製造方法
JP6371165B2 (ja) 2014-09-02 2018-08-08 住友ゴム工業株式会社 金属医療用具
JP6613692B2 (ja) 2015-08-03 2019-12-04 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
DE102018110591B4 (de) * 2018-05-03 2022-11-03 Acandis Gmbh Medizinische Vorrichtung mit Fibrinbeschichtung, System und Set mit einer derartigen Vorrichtung sowie Herstellverfahren
EP3860669B1 (en) * 2018-10-01 2024-04-03 MicroVention, Inc. Medical devices
CN116410510A (zh) * 2021-12-31 2023-07-11 江苏百赛飞生物科技有限公司 一种材料表面改性的方法和基于该方法得到的表面改性的材料

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE306597B (es) 1964-12-17 1968-12-02 Incentive Ab
US5112640A (en) * 1990-05-04 1992-05-12 The Research Foundation Of State University Of New York University At Buffalo Silicone elastomer lined prosthetic devices and methods of manufacture
US5356433A (en) * 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5336518A (en) * 1992-12-11 1994-08-09 Cordis Corporation Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
US5443455A (en) * 1993-07-27 1995-08-22 Target Therapeutics, Inc. Guidewire and method of pretreating metal surfaces for subsequent polymer coating
US5625083A (en) * 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5679659A (en) * 1995-08-22 1997-10-21 Medtronic, Inc. Method for making heparinized biomaterials
US5607475A (en) * 1995-08-22 1997-03-04 Medtronic, Inc. Biocompatible medical article and method
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6013855A (en) * 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces

Also Published As

Publication number Publication date
CA2293266A1 (en) 1998-12-10
JP2002502286A (ja) 2002-01-22
DE69811666T2 (de) 2003-12-18
EP0988071B1 (en) 2003-02-26
GB9711377D0 (en) 1997-07-30
JP4357005B2 (ja) 2009-11-04
WO1998055162A3 (en) 1999-03-04
DE69811666D1 (de) 2003-04-03
AU7778998A (en) 1998-12-21
ATE233110T1 (de) 2003-03-15
US6599558B1 (en) 2003-07-29
WO1998055162A2 (en) 1998-12-10
AU740161B2 (en) 2001-11-01
GB2325934A (en) 1998-12-09
EP0988071A2 (en) 2000-03-29
CA2293266C (en) 2008-08-12

Similar Documents

Publication Publication Date Title
ES2191309T3 (es) Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas.
DE69912951T2 (de) Biokompatible rissbeständige beschichtungszusammensetzungen enthaltend funktionelle silikonpolymere
ES2056641T3 (es) Moleculas estrella de poli(oxido de etileno) inmovilizadas para aplicaciones biologicas.
ATE507501T1 (de) Hochsicheres silikonhaltiges material für eine okularlinse und herstellungsprozess dafür
ES2069686T3 (es) Reticulacion de prepolimeros de siloxano con funciones (met)acriloxialquenileno.
BR8706333A (pt) Cateter para remover material biologico por energia laser,construcao de cateter flexivel,processo para tratar o lumen de um vaso sanguineo,combinacao de cateter e dispositivos de fibra optica,processo para ministrar energia laser a material biologico numa posicao selecionada no interior de um paciente
BR9911754A (pt) Copolìmero linear de ciclodextrina, composição terapêutica, composição de ciclodextrina, processos de preparo de um copolìmero linear de ciclodextrina, e de um copolìmero linear de ciclodextrina oxidada, processo para produzir um polìmero reticulado de ciclodextrina, e, processo de tratamento
ATE339535T1 (de) Durch ein sol-gel verfahren hergestellte bioaktive silicafasern und zugehörige verfahren und anwendungen
PL325338A1 (en) Methods of and compositions for selectivel;y modifying nucleic acids
ES8405624A1 (es) Procedimiento para proporcionar una capa superficial biocompatible a articulos dotados de al menos una superficie de vidrio, silicio, aluminio, o caucho silicona.
DE60301929D1 (de) Struktursysteme für Gewebebehandlungszusammensetzungen
ES8606903A1 (es) Un metodo para entregar un agente seleccionado a un lugar biologico caracterizado por la presencia de una secuencia de adn seleccionada.
NO885275D0 (no) VaskulŸre antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav.
ATE301478T1 (de) Strahlungsundurchlässiges kollagenbiomaterial für implantierbare vorrichtungen
BR9406410A (pt) Membrana modificada na superfície e processo de preparação de membranas poliméricas modificadas na superfície com grupos funcionais para imobilização de moléculas bioativas
DE69637642D1 (de) Und kombinierte zusammensetzungen und deren verwendung
ES2136297T3 (es) Arquitectura laminar de microcomponentes.
BR0315810A (pt) Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c
ES2124345T3 (es) Oligomeros que se ligan a acidos nucleicos con ramificacion en n para tratamiento y diagnostico.
EP1064308A4 (en) METHODS FOR IDENTIFYING INDUCERS AND INHIBITORS OF PROTEOLYTIC ANTIBODIES, AND COMPOSITIONS AND USES THEREOF
ES2194029T3 (es) Variantes del virus hiv-2.
BR9904412A (pt) Hidrogéis oticamente transparentes e processos para suas produções
BR0106969A (pt) Método de fabricação de um substrato multicelular e substrato multicelular
ES2187630T3 (es) Poliorganosiloxanos perfluorados polifuncionales y sus procedimientos de obtencion.
ES2088432T3 (es) Fragmentos de acidos nucleicos derivados de un genoma de micobacteria apropiada, sus aplicaciones en el diagnostico de infecciones por micobacterias y plasmidos que contienen dichos fragmentos.