ES2191343T3 - Derivado de ribonucleoxido y su procedimiento de preparacion. - Google Patents

Derivado de ribonucleoxido y su procedimiento de preparacion.

Info

Publication number
ES2191343T3
ES2191343T3 ES98948841T ES98948841T ES2191343T3 ES 2191343 T3 ES2191343 T3 ES 2191343T3 ES 98948841 T ES98948841 T ES 98948841T ES 98948841 T ES98948841 T ES 98948841T ES 2191343 T3 ES2191343 T3 ES 2191343T3
Authority
ES
Spain
Prior art keywords
derivative
ribonucleoxide
preparation procedure
base
proton
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98948841T
Other languages
English (en)
Inventor
Stefan Pitsch
Patrick A Weiss
Luzi Jenny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen AG
Original Assignee
Qiagen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen AG filed Critical Qiagen AG
Application granted granted Critical
Publication of ES2191343T3 publication Critical patent/ES2191343T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un derivado de ribonucleósido que comprende una unidad de D- o L-ribosa y tiene la siguiente fórmula estructural general: **(Fórmula)** en la que R1 es una base de la familia de purina o pirimidina o un derivado de tal base, R2 es un protón o un derivado sustituido de ácido fosfónico, R3 es un protón o un grupo de protección adecuado, y R4, R5 y R6 son tres sustituyentes arilo o alquilo que conjuntamente comprenden de seis a 30 átomos de C.
ES98948841T 1997-08-18 1998-08-17 Derivado de ribonucleoxido y su procedimiento de preparacion. Expired - Lifetime ES2191343T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH193197 1997-08-18

Publications (1)

Publication Number Publication Date
ES2191343T3 true ES2191343T3 (es) 2003-09-01

Family

ID=4221948

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98948841T Expired - Lifetime ES2191343T3 (es) 1997-08-18 1998-08-17 Derivado de ribonucleoxido y su procedimiento de preparacion.

Country Status (8)

Country Link
US (1) US5986084A (es)
EP (1) EP1005478B1 (es)
JP (1) JP4473445B2 (es)
AT (1) ATE231518T1 (es)
AU (1) AU9532198A (es)
DE (1) DE69810934T2 (es)
ES (1) ES2191343T3 (es)
WO (1) WO1999009044A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867294B1 (en) 1998-07-14 2005-03-15 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
AU1656601A (en) * 1999-11-12 2001-06-12 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
GB0227352D0 (en) * 2002-11-22 2002-12-31 Novartis Ag Organic compounds
US7560231B2 (en) 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
JP4613160B2 (ja) * 2004-03-23 2011-01-12 潤 藤田 軽度の低温により遺伝子の発現を促進させる配列
CA2513340A1 (en) 2004-08-25 2006-02-25 F. Hoffmann-La Roche Ag Reusable substrate for dna microarray production
DE602004032245D1 (de) 2004-11-16 2011-05-26 Qiagen Gmbh Genabschaltung (Gene silencing) durch hybride Sens-DNA und Antisens-RNA Konstrukte, gekoppelt an ein Peptid zur erleichterten Aufnahme in Zellen
US20060234973A1 (en) * 2005-04-14 2006-10-19 Kevin Fitzgerald Transcription factor RNA interference reagents and methods of use thereof
JPWO2007029641A1 (ja) * 2005-09-05 2009-03-19 藤田　潤 軽度の低温により遺伝子の発現を促進させる配列
US7759471B2 (en) 2005-10-31 2010-07-20 Agilent Technologies, Inc. Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
US20090203897A1 (en) * 2008-02-08 2009-08-13 Operon Biotechnologies, Inc. Method of Using Polymer Embedded Solid Supports for Small Scale Oligonucleotide Synthesis
US9399655B2 (en) 2012-06-06 2016-07-26 University of Pittsburgh—of the Commonwealth System of Higher Education Catalytic glycosylation with designer thioglycoside and novel protecting groups for same and for synthesis of oligosaccharides
PL221806B1 (pl) 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
CN104447848B (zh) * 2014-12-15 2017-01-18 扬州三友合成化工有限公司 一种（异丙氧基硅）氯甲烷的制备方法
EP4441066A1 (en) 2021-11-29 2024-10-09 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides
WO2025229953A1 (ja) 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法
WO2026048956A1 (ja) * 2024-08-29 2026-03-05 住友化学株式会社 核酸オリゴマーの製造方法

Also Published As

Publication number Publication date
AU9532198A (en) 1999-03-08
US5986084A (en) 1999-11-16
EP1005478A1 (en) 2000-06-07
ATE231518T1 (de) 2003-02-15
JP2001515087A (ja) 2001-09-18
EP1005478B1 (en) 2003-01-22
WO1999009044A1 (en) 1999-02-25
DE69810934T2 (de) 2003-11-27
DE69810934D1 (de) 2003-02-27
JP4473445B2 (ja) 2010-06-02

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