ES2192128B1 - Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia. - Google Patents

Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia.

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Publication number
ES2192128B1
ES2192128B1 ES200100997A ES200100997A ES2192128B1 ES 2192128 B1 ES2192128 B1 ES 2192128B1 ES 200100997 A ES200100997 A ES 200100997A ES 200100997 A ES200100997 A ES 200100997A ES 2192128 B1 ES2192128 B1 ES 2192128B1
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ES
Spain
Prior art keywords
human
monoclonal antibody
molecule
therapy
specifically recognizes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200100997A
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English (en)
Other versions
ES2192128A1 (es
Inventor
Africa Gonzalez Fernandez
Monica Valladares Andrade
Ana Molina Ocaña
Francisco Gambon Deza
Susana Magadan Mompo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Vigo
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Universidade de Vigo
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Publication date
Application filed by Universidade de Vigo filed Critical Universidade de Vigo
Priority to ES200100997A priority Critical patent/ES2192128B1/es
Publication of ES2192128A1 publication Critical patent/ES2192128A1/es
Application granted granted Critical
Publication of ES2192128B1 publication Critical patent/ES2192128B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Anticuerpo monoclonal humano haIM-29 que reconoce la molécula humana CD69, y su uso en terapia humana. Un nuevo hibridoma, designado H69, productor de un anticuerpo monoclonal humano hAIM- 29 (de isotipo IgM / lambda). El anticuerpo reconoce de forma específica a la molécula humana CD69, que es un antígeno de activación muy temprano linfocitario. El hibridoma H69 se generó por fusión de células del mieloma murino NSO con células de bazo de un ratón transgénico portador de secuencias de inmunoglobulinas humanas que había sido inmunizado con una suspensión de células de rata transfectadas con la molécula humana CD69. El clon fue seleccionado por su patrón de reconocimiento celular por inmunofluorescencia indirecta frente a las células de rata transfectadas y frente a linfocitos activados humanos. La presente invención podría utilizarse para tratamiento de patologías humanas que conlleve gran activación linfocitaria (enfermedades autoinmunes como la artritis reumatoide u otras patologías de tipo inflamatorio).
ES200100997A 2001-04-27 2001-04-27 Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia. Expired - Fee Related ES2192128B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200100997A ES2192128B1 (es) 2001-04-27 2001-04-27 Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200100997A ES2192128B1 (es) 2001-04-27 2001-04-27 Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia.

Publications (2)

Publication Number Publication Date
ES2192128A1 ES2192128A1 (es) 2003-09-16
ES2192128B1 true ES2192128B1 (es) 2005-01-01

Family

ID=28051947

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200100997A Expired - Fee Related ES2192128B1 (es) 2001-04-27 2001-04-27 Anticuerpo monoclonal humano que reconoce especificamente la molecula humana cd69, y su uso en terapia.

Country Status (1)

Country Link
ES (1) ES2192128B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2347767A3 (en) 2003-01-31 2013-06-12 Albor Biologics, Inc. Immune regulation based on the targeting of early activation molecules
ES2244270A1 (es) * 2003-01-31 2005-12-01 Pilar Universidad Autonoma De Madrid Nueva estrategia de regulacion inmune fundamentada en la molecula inducible durante la activacion leucocitaria cd69.
PT2119452T (pt) * 2006-12-26 2020-05-08 Ct Inmunologia Molecular Composição farmacêutica que compreende um anticorpo monoclonal anti-cd6 utilizado no diagnóstico e tratamento de artrite reumatoide
EA201001467A1 (ru) 2008-03-14 2011-06-30 Биокон Лимитед Моноклональное антитело и способ его использования
CA2920368C (en) 2013-07-23 2023-03-21 Centro De Inmunologia Molecular Use of a cd6 binding partner and method based thereon
PL3529274T3 (pl) 2016-10-21 2024-09-09 Biocon Limited Przeciwciało monoklonalne i sposób jego stosowania w leczeniu tocznia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033735A1 (en) * 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1999045962A1 (en) * 1998-03-13 1999-09-16 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033735A1 (en) * 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1999045962A1 (en) * 1998-03-13 1999-09-16 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SANCHO D. et al. Functional Analysis of Ligand-Binding and Signal Transduction Domains of CD69 and CD23 C-Type Lectin Leukocyte Receptors. J. Immunol., Octubre 2000, Vol. 165, Nº 7, páginas 3868-3875. *

Also Published As

Publication number Publication date
ES2192128A1 (es) 2003-09-16

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