ES2192265T3 - PHARMACEUTICAL DOSAGE FORM THAT MASKS FLAVOR AND IS RELEASED QUICKLY. - Google Patents

PHARMACEUTICAL DOSAGE FORM THAT MASKS FLAVOR AND IS RELEASED QUICKLY.

Info

Publication number
ES2192265T3
ES2192265T3 ES97911402T ES97911402T ES2192265T3 ES 2192265 T3 ES2192265 T3 ES 2192265T3 ES 97911402 T ES97911402 T ES 97911402T ES 97911402 T ES97911402 T ES 97911402T ES 2192265 T3 ES2192265 T3 ES 2192265T3
Authority
ES
Spain
Prior art keywords
flavor
dosage form
pharmaceutical dosage
masks
released quickly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97911402T
Other languages
Spanish (es)
Inventor
Akinori Itoh
Toshiyuki Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2192265T3 publication Critical patent/ES2192265T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SUMINISTRA UNA FORMA DE DOSIFICACION FARMACEUTICA DE LIBERACION RAPIDA Y CON ENMASCARAMIENTO DEL SABOR QUE COMPRENDE UN NUCLEO QUE CONTIENE UN INGREDIENTE FARMACOLOGICAMENTE ACTIVO, CELULOSA DE HIDROXIPROPILO DE BAJA SUSTITUCION Y CELULOSA MICROCRISTALINA, LA CANTIDAD DE CELULOSA MICROCRISTALINA ES DE AL MENOS UN 26,0% DEL PESO EN BASE AL PESO TOTAL DEL NUCLEO; UNA CAPAZ DE REVESTIMIENTO INTERNA FORMADA SOBRE EL NUCLEO Y QUE CONTIENE UN POLIMERO SOLUBLE EN AGUA; Y UNA CAPA DE REVESTIMIENTO EXTERNA FORMADA SOBRE LA CAPA DE REVESTIMIENTO INTERNA Y QUE CONTIENE UN POLIMERO INSOLUBLE EN LAS SALIVA. TAMBIEN SE PRESENTA UN PROCEDIMIENTO PARA PREPARAR LA FORMA DE DOSIFICACION ORAL.THE INVENTION PROVIDES A FORM OF PHARMACEUTICAL DOSAGE OF QUICK RELEASE AND WITH MASK OF THE FLAVOR THAT INCLUDES A NUCLEUS THAT CONTAINS A PHARMACOLOGICALLY ACTIVE, CELLULOSE HYDROXIPROPYL LOW REPLACEMENT AND MICROSCRYSTALLY MICRO-CELLULAR MICRO-CELLULAR. % OF WEIGHT BASED ON TOTAL WEIGHT OF NUCLEO; A COAT OF INTERNAL COATING FORMED ON THE NUCLEUS AND CONTAINING A WATER SOLUBLE POLYMER; AND AN EXTERNAL COATING LAYER FORMED ON THE INTERNAL COATING LAYER AND CONTAINING AN INSOLUBLE POLYMER IN THE SALIVA. A PROCEDURE IS ALSO PRESENTED TO PREPARE THE ORAL DOSAGE FORM.

ES97911402T 1997-01-06 1997-11-20 PHARMACEUTICAL DOSAGE FORM THAT MASKS FLAVOR AND IS RELEASED QUICKLY. Expired - Lifetime ES2192265T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9700003 1997-01-06

Publications (1)

Publication Number Publication Date
ES2192265T3 true ES2192265T3 (en) 2003-10-01

Family

ID=11004515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97911402T Expired - Lifetime ES2192265T3 (en) 1997-01-06 1997-11-20 PHARMACEUTICAL DOSAGE FORM THAT MASKS FLAVOR AND IS RELEASED QUICKLY.

Country Status (36)

Country Link
EP (1) EP0941075B1 (en)
JP (1) JP3350059B2 (en)
KR (1) KR20000069899A (en)
CN (1) CN1244119A (en)
AP (1) AP802A (en)
AR (1) AR008553A1 (en)
AT (1) ATE238776T1 (en)
AU (1) AU715867B2 (en)
BG (1) BG103541A (en)
BR (1) BR9714253A (en)
CA (1) CA2277017C (en)
CO (1) CO4650099A1 (en)
DE (1) DE69721559T2 (en)
DK (1) DK0941075T3 (en)
EA (1) EA199900521A1 (en)
ES (1) ES2192265T3 (en)
HN (1) HN1997000151A (en)
HR (1) HRP980005A2 (en)
HU (1) HUP0002744A3 (en)
ID (1) ID21806A (en)
IL (1) IL130582A0 (en)
IS (1) IS5095A (en)
MA (1) MA26464A1 (en)
NO (1) NO993315L (en)
NZ (1) NZ336251A (en)
OA (1) OA11072A (en)
PA (1) PA8443301A1 (en)
PE (1) PE27999A1 (en)
PL (1) PL334439A1 (en)
SK (1) SK89599A3 (en)
TN (1) TNSN98002A1 (en)
TR (1) TR199901564T2 (en)
UY (1) UY24835A1 (en)
WO (1) WO1998030209A1 (en)
YU (1) YU31599A (en)
ZA (1) ZA9829B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200591B1 (en) * 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
DE19834507A1 (en) * 1998-07-31 2000-02-03 Hexal Ag Pharmaceutical, water-soluble tablet formulation for the use of sildenafil
DE19834506A1 (en) * 1998-07-31 2000-02-03 Hexal Ag Transmucosal therapeutic system for the use of sildenafil
UA67802C2 (en) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION
EP2260836B1 (en) * 1998-11-25 2016-08-10 Cima Labs Inc. Rapid release tablet with coated drug-containing core and surrounding taste masking layer
FR2795962B1 (en) * 1999-07-08 2003-05-09 Prographarm Laboratoires PROCESS FOR THE MANUFACTURE OF MASK TASTE COATED GRANULES AND IMMEDIATE RELEASE OF THE ACTIVE INGREDIENT
ATE552013T1 (en) 2000-09-06 2012-04-15 Mitsubishi Tanabe Pharma Corp PREPARATIONS FOR ORAL USE
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
AR034813A1 (en) * 2001-07-20 2004-03-17 Novartis Ag PHARMACEUTICAL COMPOSITIONS AND USE OF THE SAME
GB2380936B (en) * 2001-10-18 2003-07-09 Reckitt Benckiser Healthcare Improvements in or relating to compositions
SE0202365D0 (en) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
MXPA06010908A (en) 2004-03-25 2006-12-15 Astellas Pharma Inc Composition for solid pharmaceutical preparation of solifenacin or salt thereof.
BG66010B1 (en) * 2004-12-08 2010-10-29 "Софарма" Ад Medicamentous form of sildenafil
DE602006020642D1 (en) * 2005-01-06 2011-04-21 Cima Labs Inc Taste suppressant system for non-plasticized medicines
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
WO2007010930A1 (en) * 2005-07-20 2007-01-25 Astellas Pharma Inc. Drug-containing coated fine particle for intrabuccally disintegrating preparation and method of producing the same
JP2007031407A (en) 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd Low-substituted cellulose ether-containing coating composition and film coating preparation with unpleasant taste masked
US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
JP4602949B2 (en) * 2006-08-02 2010-12-22 和光堂株式会社 Coated particle-containing composition and method for producing the same
ES2441999T5 (en) * 2006-11-14 2018-01-23 Sunstar Inc. Oral composition containing crystalline cellulose treated on its surface with a water soluble substance
JP5777273B2 (en) * 2008-07-10 2015-09-09 大正製薬株式会社 Formulation particles containing drug with unpleasant taste
JP4706785B2 (en) * 2008-09-30 2011-06-22 アステラス製薬株式会社 Particulate pharmaceutical composition for oral administration
EP2374460A4 (en) 2008-12-12 2013-08-21 Rhein Siegfried Sa De Cv Pulsed-release sildenafil composition and method for preparing said composition
DE102009016584A1 (en) 2009-04-06 2010-10-07 Ratiopharm Gmbh Orodispersible tablet containing a sildenafil salt
JP5933268B2 (en) * 2009-12-28 2016-06-08 ニプロ株式会社 Oral preparation with improved quality
JP5226732B2 (en) * 2010-05-20 2013-07-03 エスエス製薬株式会社 Compression molding for hypnosis
TWI462739B (en) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Preparation and medical use of Sildenafil-homologous quaternary ammonium piperazine salt
GB201119985D0 (en) * 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
CN103271940B (en) * 2013-05-03 2014-03-12 湖北新济药业有限公司 Compound metal ion replenisher and preparation method thereof
EP3421032A4 (en) * 2016-02-23 2019-10-23 Nipro Corporation PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DELIBERATE PREPARATION COMPRISING THE SAME, AND PROCESS FOR PRODUCING THE PARTICLES OF THE PHARMACEUTICAL COMPOSITION
JP7837673B2 (en) * 2018-08-28 2026-03-31 東和薬品株式会社 drug-containing particles
CN113559070B (en) * 2021-08-18 2022-12-06 广州中冠动物药业有限公司 Preparation method of medicine suitable for pet cough
CN116139088B (en) * 2023-01-31 2024-04-16 南京海纳医药科技股份有限公司 Sildenafil citrate-containing dry suspension and preparation method thereof

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JPS63258809A (en) * 1987-04-16 1988-10-26 Towa Yakuhin Kk Fine granule having excellent releasing property of medicinally active ingredient and masked bitterness
EP0458751A1 (en) * 1990-05-25 1991-11-27 Warner-Lambert Company Delivery system for cyclic amino acids with improved taste, texture and compressibility
JP2576927B2 (en) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 Fine grain nucleus
CZ289804B6 (en) * 1994-07-08 2002-04-17 Astrazeneca Ab Multiple units tableted dosage form

Also Published As

Publication number Publication date
AU4880897A (en) 1998-08-03
BG103541A (en) 2000-03-31
CO4650099A1 (en) 1998-09-03
IL130582A0 (en) 2000-06-01
BR9714253A (en) 2000-04-18
DE69721559T2 (en) 2003-11-27
HRP980005A2 (en) 1998-10-31
CN1244119A (en) 2000-02-09
HUP0002744A3 (en) 2001-01-29
PA8443301A1 (en) 2000-05-24
NO993315D0 (en) 1999-07-05
HUP0002744A2 (en) 2000-12-28
AR008553A1 (en) 2000-01-19
ZA9829B (en) 1999-07-05
OA11072A (en) 2002-02-27
CA2277017C (en) 2002-11-26
YU31599A (en) 2000-03-21
EA199900521A1 (en) 1999-12-29
ATE238776T1 (en) 2003-05-15
KR20000069899A (en) 2000-11-25
EP0941075B1 (en) 2003-05-02
AU715867B2 (en) 2000-02-10
ID21806A (en) 1999-07-29
EP0941075A1 (en) 1999-09-15
JP2000514830A (en) 2000-11-07
NO993315L (en) 1999-07-05
DE69721559D1 (en) 2003-06-05
SK89599A3 (en) 2000-12-11
JP3350059B2 (en) 2002-11-25
AP9801173A0 (en) 1998-01-31
UY24835A1 (en) 2000-09-29
HN1997000151A (en) 1997-12-20
WO1998030209A1 (en) 1998-07-16
AP802A (en) 2000-01-21
TR199901564T2 (en) 1999-09-21
CA2277017A1 (en) 1998-07-16
MA26464A1 (en) 2004-12-20
PE27999A1 (en) 1999-03-12
TNSN98002A1 (en) 2005-03-15
PL334439A1 (en) 2000-02-28
DK0941075T3 (en) 2003-07-14
IS5095A (en) 1999-06-25
NZ336251A (en) 2001-01-26

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