ES2192554T3 - Subunidades (alfa-2-, alfa-3, alfa-5, alfa-6, beta-2) del receptor gaba-a y celulas sometidas a transfeccion que las expresan. - Google Patents

Subunidades (alfa-2-, alfa-3, alfa-5, alfa-6, beta-2) del receptor gaba-a y celulas sometidas a transfeccion que las expresan.

Info

Publication number
ES2192554T3
ES2192554T3 ES92911528T ES92911528T ES2192554T3 ES 2192554 T3 ES2192554 T3 ES 2192554T3 ES 92911528 T ES92911528 T ES 92911528T ES 92911528 T ES92911528 T ES 92911528T ES 2192554 T3 ES2192554 T3 ES 2192554T3
Authority
ES
Spain
Prior art keywords
alfa
receiver
gaba
beta
subunities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911528T
Other languages
English (en)
Inventor
Karen Louise Hadingham
Bourdelles Beatrice Le
Paul John Whiting
Peter Baxter Wingrove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2192554T3 publication Critical patent/ES2192554T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Semiconductor Memories (AREA)
  • Semiconductor Lasers (AREA)
  • Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)

Abstract

LA INVENCION SE REFIERE A UNA LINEA DE CELULAS EUCARIOTICAS, COTRANSFECTADAS, ESTABLES CAPACES DE EXPRESAR UN RECEPTOR DEL GABA-A, PARTICULARMENTE UN RECEPTOR DEL GABA-A HUMANO, DICHO RECEPTOR COMPRENDE AL MENOS UNA SUBUNIDAD ALTA, UNA BETA Y UNA GAMMA; ASIMISMO LA INVENCION SE REFIERE A LA CLONACION DE LAS NUEVAS SECUENCIAS DE CDNA QUE CODIFICAN LAS SUBUNIDADES 2, 3, 5, 6 Y (BETA)2 DEL RECEPTOR DEL GABA-A Y AL USO DE LAS LINEAS CELULARES EN EL DISEÑO Y DESARROLLO Y MEDICAMENTOS DE SUBTIPO SELECTIVO, DEL RECEPTOR DEL GABA-A.
ES92911528T 1991-06-11 1992-06-09 Subunidades (alfa-2-, alfa-3, alfa-5, alfa-6, beta-2) del receptor gaba-a y celulas sometidas a transfeccion que las expresan. Expired - Lifetime ES2192554T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919112504A GB9112504D0 (en) 1991-06-11 1991-06-11 Cell line

Publications (1)

Publication Number Publication Date
ES2192554T3 true ES2192554T3 (es) 2003-10-16

Family

ID=10696436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911528T Expired - Lifetime ES2192554T3 (es) 1991-06-11 1992-06-09 Subunidades (alfa-2-, alfa-3, alfa-5, alfa-6, beta-2) del receptor gaba-a y celulas sometidas a transfeccion que las expresan.

Country Status (10)

Country Link
EP (2) EP0589930B1 (es)
JP (1) JPH06508023A (es)
AT (1) ATE234355T1 (es)
AU (1) AU663090B2 (es)
CA (1) CA2109193C (es)
DE (1) DE69232953T2 (es)
DK (1) DK0589930T3 (es)
ES (1) ES2192554T3 (es)
GB (1) GB9112504D0 (es)
WO (1) WO1992022652A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333923T2 (de) * 1992-12-10 2006-08-03 Merck Sharp & Dohme Ltd., Hoddesdon Stabil transfizierte Zelllinien welche Gaba-A- Rezeptoren mit der Untereinheitenzusammensetzung alpha-3, beta-3 und gamma-2 exprimieren
GB9408064D0 (en) * 1994-04-22 1994-06-15 Merck Sharp & Dohme Nucleic acids
US5527703A (en) * 1994-05-25 1996-06-18 Merck & Co., Inc. DNA encoding glutamate gated chloride channels
GB9420010D0 (en) 1994-10-01 1994-11-16 Marck Sharp & Dohme Limited Nucleic acids
US5693492A (en) * 1995-05-05 1997-12-02 Merck & Co., Inc. DNA encoding glutamate gated chloride channels
GB9715164D0 (en) * 1997-07-19 1997-09-24 Medical Res Council Improvements in or relating to expression of nucleic acid sequences in cerebellar cells
US6358701B1 (en) 1997-08-11 2002-03-19 Merck & Co., Inc. DNA molecules encoding Ctenocephalides felis glutamate gated chloride channels
US20060141528A1 (en) * 2004-05-21 2006-06-29 Aebersold Rudolf H Compositions and methods for quantification of serum glycoproteins
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN106854207B (zh) 2015-12-08 2019-10-29 上海赛默罗生物科技有限公司 呔嗪类衍生物、其制备方法、药物组合物和用途
US11512089B2 (en) 2018-03-12 2022-11-29 Shanghai SIMR Biotechnology Co., Ltd Substituted [1,2,4]triazolo[3,4-a]phthalazines as modulators of GABAA receptor activity
CN112979655A (zh) 2019-12-16 2021-06-18 上海赛默罗生物科技有限公司 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途
AU2022327398A1 (en) 2021-08-12 2024-03-21 Shanghai SIMR Biotechnology Co., Ltd Substituted triazole derivative, preparation method therefor, pharmaceutical composition thereof, and use thereof
CN116854680A (zh) 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途

Also Published As

Publication number Publication date
GB9112504D0 (en) 1991-07-31
DK0589930T3 (da) 2003-04-22
WO1992022652A1 (en) 1992-12-23
DE69232953T2 (de) 2003-12-11
AU663090B2 (en) 1995-09-28
ATE234355T1 (de) 2003-03-15
EP0589930A1 (en) 1994-04-06
EP1258530A2 (en) 2002-11-20
AU1921192A (en) 1993-01-12
EP0589930B1 (en) 2003-03-12
EP1258530A3 (en) 2002-11-27
JPH06508023A (ja) 1994-09-14
CA2109193C (en) 2003-04-08
CA2109193A1 (en) 1992-12-12
DE69232953D1 (de) 2003-04-17

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