ES2192560T3 - Material viscoelastico sintetico para aplicaciones oftalmicas. - Google Patents

Material viscoelastico sintetico para aplicaciones oftalmicas.

Info

Publication number
ES2192560T3
ES2192560T3 ES94928700T ES94928700T ES2192560T3 ES 2192560 T3 ES2192560 T3 ES 2192560T3 ES 94928700 T ES94928700 T ES 94928700T ES 94928700 T ES94928700 T ES 94928700T ES 2192560 T3 ES2192560 T3 ES 2192560T3
Authority
ES
Spain
Prior art keywords
composition
viscoelastic material
ophthalmic applications
molecular weight
hydroxypropyl methylcellulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928700T
Other languages
English (en)
Inventor
Bradford C Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of ES2192560T3 publication Critical patent/ES2192560T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

UNA COMPOSICION VISCOELASTICA PARA INYECCION EN UN OJO HUMANO COMPUESTA DE ALREDEDOR DEL 2,0 AL 2,5 POR CIENTO DE CELULOSA DE HIDROXI PROPILMETILO DISUELTA EN UNA SOLUCION DE SAL FISIOLOGICA, TENIENDO LA COMPOSICION UNA VISCOSIDAD DE ALREDEDOR DE 15.000 A ALREDEDOR DE 40.000 CENTIPOISE Y LA CELULOSA DE HIDROXI PROPILMETILO TENIENDO UN PESO MOLECULAR DE ALREDEDOR DE 220.000 A MENOS DE ALREDEDOR DE 20.000 DALTONS, LA COMPOSICION ESTANDO LIBRE DE DESECHOS O GELES POR ENCIMA DE 0,5 {MI}M. TAMBIEN SE DESCRIBE UN PROCESO PARA PREPARAR LA COMPOSICION LIMPIA, DE CELULOSA DE HIDROXI PROPILMETILO DE ALTO PESO MOLECULAR.
ES94928700T 1993-04-30 1994-04-06 Material viscoelastico sintetico para aplicaciones oftalmicas. Expired - Lifetime ES2192560T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5582293A 1993-04-30 1993-04-30

Publications (1)

Publication Number Publication Date
ES2192560T3 true ES2192560T3 (es) 2003-10-16

Family

ID=22000374

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928700T Expired - Lifetime ES2192560T3 (es) 1993-04-30 1994-04-06 Material viscoelastico sintetico para aplicaciones oftalmicas.

Country Status (12)

Country Link
US (2) US5422376A (es)
EP (1) EP0732913B1 (es)
JP (1) JP2976350B2 (es)
KR (1) KR100246016B1 (es)
AT (1) ATE233083T1 (es)
AU (1) AU681146B2 (es)
CA (1) CA2161774C (es)
DE (1) DE69432188T2 (es)
DK (1) DK0732913T3 (es)
ES (1) ES2192560T3 (es)
RU (1) RU2145882C1 (es)
WO (1) WO1994025004A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
EP1267894B1 (en) 2000-03-14 2010-05-05 Alcon Inc. Viscoelastics for use in middle ear surgery
US20030086899A1 (en) * 2000-03-14 2003-05-08 Jafari Masoud R. Chondroitin sulfate containing viscoelastics for use in treating joints
RU2200519C2 (ru) * 2000-05-15 2003-03-20 Ченчик Александр Дмитриевич Способ газовой тампонады при проведении офтальмологических полостных операций
WO2002022139A1 (en) * 2000-09-14 2002-03-21 Robert Theiler Intraarticular agent for the treatment of osteoarthritis
BR0115154A (pt) * 2000-11-06 2006-06-06 Alcon Inc material viscoelástico transicional não-aspirante para uso em cirurgia
US6756363B1 (en) * 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
JP4169596B2 (ja) * 2000-12-20 2008-10-22 アルコン、インコーポレイテッド 白内障を液化破壊により取り除くための溶液
WO2003011257A1 (en) * 2001-08-01 2003-02-13 Jasjit Singh Composition and process the manufacture of soluble containers with improved gel-strength
US7820194B2 (en) 2001-12-21 2010-10-26 Alcon, Inc. Combinations of viscoelastics for use during surgery
US20040101561A1 (en) * 2002-11-13 2004-05-27 Jafari Masoud R. Combinations of viscoelastics for use during surgery
US20120283232A9 (en) * 2003-11-12 2012-11-08 Zhengjun Wang Process for making a pharmaceutical composition
US20050215515A1 (en) * 2004-03-29 2005-09-29 Claudio Bucolo Viscoelastic composition, method of use and package
US20060159651A1 (en) * 2005-01-14 2006-07-20 Michael Colvard Gradient molecular weight viscoelastic solutions
RU2310327C1 (ru) * 2006-03-24 2007-11-20 Владимир Николаевич Канюков Способ консервации донорских тканей для офтальмохирургии
RU2600863C2 (ru) * 2007-12-10 2016-10-27 Сентисс Фарма Прайвит Лимитед Офтальмическая композиция, включающая фенилэфрин
DE102009037514A1 (de) 2009-08-17 2011-03-10 Dirk-Henning Dr. Menz Wasserlösliche Polysaccharidether und ihre Verwendung
US8845624B2 (en) * 2010-06-25 2014-09-30 Alcon LexSx, Inc. Adaptive patient interface
EP2922919B1 (en) 2012-11-21 2020-03-25 University Of Louisville Research Foundation, Inc. Compositions and methods for reducing oxidative damage
RU2015128609A (ru) * 2012-12-19 2017-01-25 КАШИВ ФАРМА, ЭлЭлСи Перенасыщенные стабилизированные наночастицы для слаборастворимых лекарственных средств
DE102014103512A1 (de) 2014-03-14 2015-09-17 Carl Zeiss Meditec Ag Injektor zur Injektion eines Operations-Hilfsfluids in ein Auge sowie Verfahren zum Erzeugen eines Operations-Hilfsfluids
EP3256136A4 (en) 2015-02-09 2018-11-21 University Of Louisville Research Foundation, Inc. Ophthalmic compositions and methods for reducing oxidative damage to an eye lens
WO2022172089A1 (en) * 2021-02-12 2022-08-18 I Optima Ltd. Compound, method and system for ophthalmic surgery

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL188266C (nl) * 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
DE3416777C2 (de) * 1984-05-07 1986-11-20 Gödecke AG, 1000 Berlin Pharmazeutische topische Zubereitungen
JPS62122671A (ja) * 1985-11-23 1987-06-03 千寿製薬株式会社 眼内手術用高粘性液の製造法
JPH0657245B2 (ja) * 1986-05-14 1994-08-03 ト−メ−産業株式会社 眼科手術用粘弾性溶液
US4819617A (en) * 1986-09-04 1989-04-11 University Of Florida Viscoelastic material for ophthalmic surgery
CA1317226C (en) * 1987-05-04 1993-05-04 Phillip E. Pennell Viscoelastic fluid for ophthalmic surgery and method of using same
US4853374A (en) * 1987-06-09 1989-08-01 M.D.R. Group, Inc. Viscoelastic vitreous substitute with UV blocker
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution
US5218107A (en) * 1991-12-30 1993-06-08 The Dow Chemical Company Removal of undesirable material from water-soluble cellulose ether aqueous solutions

Also Published As

Publication number Publication date
EP0732913B1 (en) 2003-02-26
JP2976350B2 (ja) 1999-11-10
CA2161774C (en) 2000-01-04
ATE233083T1 (de) 2003-03-15
CA2161774A1 (en) 1994-11-10
US5422376A (en) 1995-06-06
AU6700894A (en) 1994-11-21
USRE42243E1 (en) 2011-03-22
KR100246016B1 (ko) 2000-04-01
DE69432188T2 (de) 2004-01-22
DK0732913T3 (da) 2003-06-16
AU681146B2 (en) 1997-08-21
EP0732913A1 (en) 1996-09-25
RU2145882C1 (ru) 2000-02-27
DE69432188D1 (de) 2003-04-03
JPH09507469A (ja) 1997-07-29
HK1019005A1 (en) 2000-01-14
WO1994025004A1 (en) 1994-11-10

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