ES2192630T3 - Procedimiento para aislar el acido 2-ceto-l-gulonico. - Google Patents

Procedimiento para aislar el acido 2-ceto-l-gulonico.

Info

Publication number
ES2192630T3
ES2192630T3 ES97106678T ES97106678T ES2192630T3 ES 2192630 T3 ES2192630 T3 ES 2192630T3 ES 97106678 T ES97106678 T ES 97106678T ES 97106678 T ES97106678 T ES 97106678T ES 2192630 T3 ES2192630 T3 ES 2192630T3
Authority
ES
Spain
Prior art keywords
acid
keto
stage
gulonic
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97106678T
Other languages
English (en)
Inventor
Ralf Dumpelmann
Tomislav Keglevic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2192630T3 publication Critical patent/ES2192630T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

METODO PARA LA TRANSFORMACION DE UNA SAL SODICA DEL ACIDO 2 CETO ACUOSA EN UNA SOLUCION ALCOHOLICA DEL ACIDO LIBRE Y SI SE DESEA EN UN ESTER ALQUILICO DEL ACIDO, CONSISTENTE EN A) OBTENER EL 2 CETO MENTACION ACUOSA MEDIANTE EVAPORACION, ENFRIAMIENTO O CRISTALIZACION FORZADA Y TRITURADO DE LOS CRISTALES OBTENIDOS, B1) SUSPENDER EL 2 ENTE TRITURADO OBTENIDO EN LA ETAPA A) EN UN ALCOHOL DE BAJO PESO MOLECULAR, DEJAR HINCHARSE LOS CRISTALES Y AÑADIR DESPUES UN ACIDO CON BAJO CONTENIDO DE AGUA, DE FORMA QUE EL PH SEA SUPERIOR A 1,5, O B2) AÑADIR EL 2 ONOHIDRATO EVENTUALMENTE TRITURADO OBTENIDO EN LA ETAPA A) A UNA CANTIDAD APROXIMADAMENTE ESTEOQUIOMETRICA DE UN ACIDO CON BAJO CONTENIDO DE AGUA, UTILIZANDO UN SISTEMA DE MOLTURACION HUMEDA EN UN ALCOHOL DE BAJO PESO MOLECULAR, DE FORMA QUE EL PH SEA SUPERIOR A 1,5, O B3) UNA COMBINACION TECNICA DE LAS ETAPAS B1) Y B2) INCLUIDA LA RETROALIMENTACION DE LAS CORRIENTES DE SUSTANCIAS, Y C) SEPARAR LA SAL FORMADA EN LA ETAPA B1), B2) Y B3) DEL ACIDO AÑADIDO OBTENIENDO ASI UNA SOLUCION ALCOHOLICA DE ACIDO 2 OLUCION ALCOHOLICA DE ACIDO 2 LA ETAPA C) CON UNA CANTIDAD CATALITICA DE UN ACIDO O CON UN CAMBIADOR CATIONICO ACIDO PARA ESTERIFICAR EL ACIDO 2 ALQUILICO DE BAJO PESO MOLECULAR DEL ACIDO 2 CO.
ES97106678T 1996-04-30 1997-04-23 Procedimiento para aislar el acido 2-ceto-l-gulonico. Expired - Lifetime ES2192630T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96106829 1996-04-30
EP97102766 1997-02-20

Publications (1)

Publication Number Publication Date
ES2192630T3 true ES2192630T3 (es) 2003-10-16

Family

ID=26141900

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97106678T Expired - Lifetime ES2192630T3 (es) 1996-04-30 1997-04-23 Procedimiento para aislar el acido 2-ceto-l-gulonico.

Country Status (10)

Country Link
US (1) US5852211A (es)
EP (1) EP0805210B1 (es)
JP (1) JP3976832B2 (es)
CN (1) CN1155554C (es)
AT (1) ATE234931T1 (es)
BR (1) BR9701962A (es)
DE (1) DE59709535D1 (es)
DK (1) DK0805210T3 (es)
ES (1) ES2192630T3 (es)
ID (1) ID16816A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153791A (en) * 1999-08-02 2000-11-28 Archer-Daniels-Midland Company Process for purifying 2-keto-L-gulonic acid
BR0012953A (pt) * 1999-08-03 2002-09-24 Archer Daniels Midland Co Processo para a recupepação de ácidos organicos
US6902917B1 (en) 1999-08-03 2005-06-07 Archer-Daniels-Midland Company Process for recovery of organic acids from fermentration broths
US6670505B1 (en) 2000-03-07 2003-12-30 Eastman Chemical Company Process for the recovery of organic acids from aqueous solutions
US7137711B1 (en) 2000-03-21 2006-11-21 Leonard Reiffel Multi-user retro reflector data input
CN1190752C (zh) 2000-05-03 2005-02-23 伦纳德·赖费尔 双模式数据成像产品
US6320061B1 (en) 2000-06-05 2001-11-20 Eastman Chemical Company Solvent exchange process
EP1325397B1 (en) * 2000-08-18 2008-07-09 Leonard Reiffel Annotating imaged data product
US7034803B1 (en) 2000-08-18 2006-04-25 Leonard Reiffel Cursor display privacy product
AU2002235191A1 (en) * 2000-12-15 2002-06-24 Leonard Reiffel Imaged coded data source transducer product
AU2002228950A1 (en) * 2000-12-15 2002-06-24 Leonard Reiffel Imaged coded data source tracking product
EP1354471A4 (en) * 2000-12-15 2006-02-08 Leonard Reiffel DATA ENTRY PRODUCT OF MULTI-SOURCE MULTI-IMAGEUR MULTI-SOURCE CODE DATA SOURCE
US20040195327A1 (en) * 2001-04-19 2004-10-07 Leonard Reiffel Combined imaging coded data source data acquisition
GB0119864D0 (en) * 2001-08-15 2001-10-10 Cerestar Holding Bv Process for the manufacture of 2-keto-L-gulonic acid
DE10149869A1 (de) * 2001-10-10 2003-04-24 Basf Ag Verfahren zur Isolierung von Salzen von organischen Säuren aus einer Fermentationsbrühe und zur Freisetzung der organischen Säure
US20060291797A1 (en) * 2003-05-27 2006-12-28 Leonard Reiffel Multi-imager multi-source multi-use coded data source data input product
CN100353158C (zh) * 2004-08-24 2007-12-05 天津理工大学 一种2－酮基－l－古龙酸含量的分析方法
CN102242178A (zh) * 2011-06-21 2011-11-16 安徽丰原发酵技术工程研究有限公司 一种2-酮基-l-古龙酸的制备方法
KR101900256B1 (ko) * 2012-02-08 2018-09-20 푸락 바이오켐 비.브이. 카복실레이트 산성화
CN111943836A (zh) * 2019-05-16 2020-11-17 帝斯曼知识产权资产管理有限公司 回收2-酮-l-古洛糖酸的改进方法
CN119528719B (zh) * 2024-11-07 2025-10-24 浙江工业大学 一种盐析萃取耦合结晶分离纯化发酵液中古龙酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3381027A (en) * 1964-04-22 1968-04-30 Hoffmann La Roche Preparation and recovery of methyl 2-ketogluconate
JPS5266684A (en) * 1975-12-01 1977-06-02 Shionogi & Co Ltd Purification and separation of 2-keto-l-glonic acid
JPS58177986A (ja) * 1982-04-09 1983-10-18 Shionogi & Co Ltd Ｌ−アスコルビン酸の製造方法
DE3831070A1 (de) * 1988-09-13 1990-03-22 Basf Ag Verfahren zur isolierung von 2-keto-polyhdroxy-c(pfeil abwaerts)6(pfeil abwaerts)-carbonsaeuren, insbesondere von 2-keto-l-gulonsaeure aus waessrigen fermentationsaustraegen
FR2636343B1 (es) * 1988-09-13 1994-11-25 Rhone Poulenc Sante
FR2648136B1 (fr) * 1989-06-12 1994-06-17 Rhone Poulenc Sante Procede de preparation de l'acide ascorbique
CH678057A5 (de) * 1989-06-26 1991-07-31 Enco Eng Ag Verfahren zur herstellung von natrium- oder kalium-l-ascorbat.
CN1122802A (zh) * 1994-12-28 1996-05-22 华东理工大学 古龙酸钠定量地转化制取抗坏血酸的方法

Also Published As

Publication number Publication date
JP3976832B2 (ja) 2007-09-19
US5852211A (en) 1998-12-22
EP0805210B1 (de) 2003-03-19
EP0805210A2 (de) 1997-11-05
CN1155554C (zh) 2004-06-30
ATE234931T1 (de) 2003-04-15
EP0805210A3 (de) 1999-07-14
DE59709535D1 (de) 2003-04-24
DK0805210T3 (da) 2003-07-14
BR9701962A (pt) 1998-09-15
ID16816A (id) 1997-11-13
CN1169978A (zh) 1998-01-14
JPH1053556A (ja) 1998-02-24

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