ES2194382T3 - Procedimiento de fabricacion de una ceramica apatitica, en particular para un uso biologico. - Google Patents

Procedimiento de fabricacion de una ceramica apatitica, en particular para un uso biologico.

Info

Publication number
ES2194382T3
ES2194382T3 ES98963593T ES98963593T ES2194382T3 ES 2194382 T3 ES2194382 T3 ES 2194382T3 ES 98963593 T ES98963593 T ES 98963593T ES 98963593 T ES98963593 T ES 98963593T ES 2194382 T3 ES2194382 T3 ES 2194382T3
Authority
ES
Spain
Prior art keywords
manufacturing
piece
h2po4
hpo4
apatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98963593T
Other languages
English (en)
Inventor
Joelle Carpena
Benoit Donazzon
Jean-Louis Lacout
Michele Freche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Application granted granted Critical
Publication of ES2194382T3 publication Critical patent/ES2194382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Dental Preparations (AREA)

Abstract

Procedimiento de fabricación de una pieza masiva de cerámica apatítica, que comprende las etapas siguientes: a) preparar una mezcla homogénea de polvos que comprenden al menos dos fosfatos de calcio escogidos entre: Ca(H2PO4)2, Ca(H2PO4)2 . H2O, Ca(HPO4), Ca(HPO4) . 2H2=, Ca3(PO4)2 de variedad alfa o beta y Ca4(PO4)2O, en cantidades tales que la mezcla corresponda a la obtención de una hidroxiapatita estequiométrica de fórmula Ca1O(PO4)6(OH)2 (II) o no estequiométrica de fórmula: Ca10-XVX(PO4)6-y(OH)2+y-2x (III) en la que V representa un espacio y x e y son tales que x < 1, y < 1 e y <= x, que tiene una relación atómica Ca/P inferior a 1, 667; b) compactar la mezcla de polvos obtenida en la etapa a) a temperatura ambiente, bajo una presión de 100 a 500 MPa, para obtener una pieza compactada; y c) someter la pieza compactada a un tratamiento hidrotérmico en un recinto hermético que contenga un medio acuoso, a una temperatura de 100 a 500ºC, durante un período de al menos 8 horas.
ES98963593T 1997-12-23 1998-12-22 Procedimiento de fabricacion de una ceramica apatitica, en particular para un uso biologico. Expired - Lifetime ES2194382T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9716357A FR2772746B1 (fr) 1997-12-23 1997-12-23 Procede de fabrication d'une ceramique apatitique, en particulier pour usage biologique

Publications (1)

Publication Number Publication Date
ES2194382T3 true ES2194382T3 (es) 2003-11-16

Family

ID=9514999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98963593T Expired - Lifetime ES2194382T3 (es) 1997-12-23 1998-12-22 Procedimiento de fabricacion de una ceramica apatitica, en particular para un uso biologico.

Country Status (8)

Country Link
US (1) US6338810B1 (es)
EP (1) EP1042252B1 (es)
JP (1) JP2001527020A (es)
KR (1) KR100573293B1 (es)
DE (1) DE69812709T2 (es)
ES (1) ES2194382T3 (es)
FR (1) FR2772746B1 (es)
WO (1) WO1999033766A1 (es)

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AU1064800A (en) * 1998-11-12 2000-06-05 Nycomed Amersham Plc Products and methods
DE19938704C1 (de) * 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Verfahren zur Herstellung von Reaktionssystemen zur Implantation in den menschlichen und tierischen Körper als Knochenersatz, die u.a. Calcium und Phosphor enthalten
DE10032220A1 (de) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
JP2003052804A (ja) * 2001-08-09 2003-02-25 Ichiro Ono インプラントの製造方法およびインプラント
US7273523B2 (en) * 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
DE10225420A1 (de) * 2002-06-07 2003-12-24 Sanatis Gmbh Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon
KR100465985B1 (ko) * 2002-07-30 2005-01-15 재단법인서울대학교산학협력재단 인공골용 생체활성 복합 세라믹스 조성물 및 그의 제조방법
US6905723B2 (en) * 2003-05-30 2005-06-14 Depuy Products, Inc. Strontium-substituted apatite coating
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
US20040250729A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Fast-setting carbonated hydroxyapatite compositions and uses
CN1988923B (zh) 2004-04-27 2012-10-03 凯丰有限责任公司 骨替代组合物及其使用方法
KR100759718B1 (ko) 2004-12-21 2007-10-04 요업기술원 수열 열간 가압법을 이용한 인산칼슘계 다공체 및 그 제조방법
US7651701B2 (en) 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
ITMI20051966A1 (it) * 2005-10-18 2007-04-19 C N R Consiglio Naz Delle Ri C Una idrossiapatite plurisostituita ed il relativo composito con un polimero naturale e-o sintetico loro preparazione e usi
EP3517137A1 (en) * 2005-11-14 2019-07-31 Biomet 3I, LLC Deposition of discrete nanoparticles on an implant surface
KR100788494B1 (ko) 2006-02-09 2007-12-24 세종대학교산학협력단 수산화 아파타이트 소결체의 제조 방법
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
US20080075788A1 (en) * 2006-09-21 2008-03-27 Samuel Lee Diammonium phosphate and other ammonium salts and their use in preventing clotting
WO2008073190A2 (en) * 2006-11-03 2008-06-19 Kyphon Sarl Materials and methods and systems for delivering localized medical treatments
BRPI0811035B8 (pt) * 2007-04-23 2021-05-25 Baxter Healthcare Sa composições de fibrina contendo compostos de estrôncio
US20080317807A1 (en) * 2007-06-22 2008-12-25 The University Of Hong Kong Strontium fortified calcium nano-and microparticle compositions and methods of making and using thereof
ES2545781T3 (es) * 2008-01-28 2015-09-15 Biomet 3I, Llc Implante superficial con mayor hidrofilia
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
EP2358651A2 (en) 2008-11-12 2011-08-24 Engqvist, Håkan Hydraulic cements, methods and products
JP5871822B2 (ja) 2010-03-10 2016-03-01 オスディーサイン アーベー 組織欠損を補正するためのインプラントおよび方法
US8641418B2 (en) * 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
KR101311979B1 (ko) * 2010-06-30 2013-09-26 김대수 수산화인회석/산화지르코늄 복합물 코팅을 이용한 바이오재료의 제조방법 및 이로 제조되는 바이오재료
JP5875034B2 (ja) * 2011-02-02 2016-03-02 学校法人日本大学 多孔質立体構造体及びその利用
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
US20130066327A1 (en) 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
US8591645B2 (en) 2011-09-09 2013-11-26 Ossdsign Ab Hydraulic cements with optimized grain size distribution, methods, articles and kits
US9775862B2 (en) * 2012-01-30 2017-10-03 Warsaw Orthopedic, Inc. Modification of reactivity of bone constructs
WO2013142118A1 (en) 2012-03-20 2013-09-26 Biomet 3I, Llc Surface treatment for an implant surface
US9913931B2 (en) 2012-12-14 2018-03-13 Ossdsign Ab Cement-forming compositions, monetite cements, implants and methods for correcting bone defects
EP2956088A2 (en) 2013-02-12 2015-12-23 OssDsign AB Mosaic implants, kits and methods for correcting bone defects
NL2011195C2 (en) 2013-07-18 2015-01-21 Xpand Biotechnology B V Method for producing an osteoinductive calcium phosphate and products thus obtained.
CZ305232B6 (cs) * 2013-08-28 2015-06-24 Vysoké Učení Technické V Brně Způsob přípravy a použití stroncium samaritého cementu
JP6312128B2 (ja) * 2014-01-22 2018-04-18 国立大学法人茨城大学 骨形成促進物質含有リン酸塩型セラミック薄膜の製造方法及び該薄膜を表面層として有する骨組織インプラントの製造方法
WO2016024248A1 (en) 2014-08-14 2016-02-18 Ossdsign Ab Bone implants for correcting bone defects
KR101997974B1 (ko) * 2017-08-24 2019-07-08 한국과학기술원 하이드록시아파타이트 소결체 및 이의 제조방법
EP3866711B8 (en) 2018-10-16 2024-11-06 OssDsign AB Implants for filling bore holes in bone

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GB2189815B (en) * 1986-03-24 1990-10-10 Permelec Electrode Ltd Titanium composite materials coated with calcium phosphate compound and process for production thereof
DE3711426A1 (de) * 1987-04-04 1988-10-13 Mtu Muenchen Gmbh Implantat mit bioaktivem ueberzug
JP3198125B2 (ja) * 1991-06-18 2001-08-13 株式会社アドバンス インプラントの製造方法
US5763092A (en) * 1993-09-15 1998-06-09 Etex Corporation Hydroxyapatite coatings and a method of their manufacture
DE19816858A1 (de) * 1998-04-16 1999-10-21 Merck Patent Gmbh Tricalciumphosphathaltige Biozementpasten mit Kohäsionspromotoren

Also Published As

Publication number Publication date
EP1042252A1 (fr) 2000-10-11
FR2772746A1 (fr) 1999-06-25
WO1999033766A1 (fr) 1999-07-08
KR20010033495A (ko) 2001-04-25
KR100573293B1 (ko) 2006-04-24
US6338810B1 (en) 2002-01-15
FR2772746B1 (fr) 2000-01-28
JP2001527020A (ja) 2001-12-25
DE69812709D1 (de) 2003-04-30
DE69812709T2 (de) 2004-03-25
EP1042252B1 (fr) 2003-03-26

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