ES2195902T3 - Composicion que comprende esfingomielinasa alcalina para uso como preparacion dietetica, complemento alimenticio o producto farmaceutico. - Google Patents

Composicion que comprende esfingomielinasa alcalina para uso como preparacion dietetica, complemento alimenticio o producto farmaceutico.

Info

Publication number
ES2195902T3
ES2195902T3 ES00940741T ES00940741T ES2195902T3 ES 2195902 T3 ES2195902 T3 ES 2195902T3 ES 00940741 T ES00940741 T ES 00940741T ES 00940741 T ES00940741 T ES 00940741T ES 2195902 T3 ES2195902 T3 ES 2195902T3
Authority
ES
Spain
Prior art keywords
composition
pharmaceutical product
food supplement
includes alkaline
alkaline sphingomyelinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00940741T
Other languages
English (en)
Other versions
ES2195902T9 (es
ES2195902T5 (es
Inventor
Simone Claudio De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actial Farmaceutica Ltda
Original Assignee
Actial Farmaceutica Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11406823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2195902(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actial Farmaceutica Ltda filed Critical Actial Farmaceutica Ltda
Publication of ES2195902T3 publication Critical patent/ES2195902T3/es
Application granted granted Critical
Publication of ES2195902T5 publication Critical patent/ES2195902T5/es
Publication of ES2195902T9 publication Critical patent/ES2195902T9/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065—Microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/195—Proteins from microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)

Abstract

Composición dietética, nutritiva o farmacéutica, caracterizada porque comprende esfingomielinasa alcalina en una cantidad que es suficiente para ejercer un efecto dietético, nutricional o terapéutico en un individuo que lo necesite.
ES00940741T 1999-06-09 2000-06-07 Composicion que comprende esfingomielinasa alcalina de origen bacteriano para uso como preparacion dietetica, complemento alimenticio o producto farmaceutico. Expired - Lifetime ES2195902T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM99A0376 1999-06-09
IT1999RM000376A IT1311495B1 (it) 1999-06-09 1999-06-09 Composizione comprendente sfingomielinasi alcalina, utilizzabile qualeprodotto dietetico, integratore alimentare o medicamento.

Publications (3)

Publication Number Publication Date
ES2195902T3 true ES2195902T3 (es) 2003-12-16
ES2195902T5 ES2195902T5 (es) 2010-02-18
ES2195902T9 ES2195902T9 (es) 2011-03-01

Family

ID=11406823

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00940741T Expired - Lifetime ES2195902T5 (es) 1999-06-09 2000-06-07 Composicion que comprende esfingomielinasa alcalina de origen bacteriano para uso como preparacion dietetica, complemento alimenticio o producto farmaceutico.

Country Status (34)

Country Link
US (2) US20020031507A1 (es)
EP (1) EP1181047B9 (es)
JP (2) JP4897167B2 (es)
KR (1) KR100812806B1 (es)
CN (3) CN101695374B (es)
AR (1) AR024564A1 (es)
AT (1) ATE237350T1 (es)
AU (1) AU778946B2 (es)
BR (1) BR0011447A (es)
CA (1) CA2376048C (es)
CZ (1) CZ296369B6 (es)
DE (1) DE60002194T3 (es)
DK (1) DK1181047T4 (es)
DZ (1) DZ3160A1 (es)
EA (1) EA005166B1 (es)
EE (1) EE05491B1 (es)
EG (1) EG24675A (es)
ES (1) ES2195902T5 (es)
HK (1) HK1046246A1 (es)
HU (1) HU228941B1 (es)
IL (2) IL146888A0 (es)
IS (1) IS2742B (es)
IT (1) IT1311495B1 (es)
MA (1) MA26792A1 (es)
MX (1) MXPA01012641A (es)
NO (1) NO327862B1 (es)
PL (1) PL214675B1 (es)
PT (1) PT1181047E (es)
SI (1) SI1181047T2 (es)
SK (1) SK285901B6 (es)
TR (1) TR200103566T2 (es)
UA (1) UA80799C2 (es)
WO (1) WO2000074712A2 (es)
ZA (1) ZA200200039B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1311495B1 (it) * 1999-06-09 2002-03-13 Mendes S U R L Composizione comprendente sfingomielinasi alcalina, utilizzabile qualeprodotto dietetico, integratore alimentare o medicamento.
IE20011100A1 (en) * 2001-12-21 2003-07-09 Vsl Pharma Ltd Analytical Method for Detecting Alkaline Sphingomyelinase and Kit for Use in Such Method
US9655932B2 (en) 2002-03-13 2017-05-23 Kibow Biotech, Inc. Composition and method for preventing or treating gout or hyperuricemia
US11103542B2 (en) 2002-03-13 2021-08-31 Kibow Biotech, Inc. Composition and method for maintaining healthy kidney function
US20050074442A1 (en) * 2002-03-13 2005-04-07 Natarajan Ranganathan Compositions and methods for augmenting kidney function
US9980988B2 (en) 2002-03-13 2018-05-29 Kibow Biotech, Inc. Compositions and methods for augmenting kidney function
KR100568036B1 (ko) * 2004-08-12 2006-04-07 하남주 장기능 활성화 및 면역기능 강화작용을 하는비피도박테리움 균주 및 이를 함유하는 생균제제
KR100610379B1 (ko) * 2004-08-26 2006-08-10 하남주 면역 증강 활성을 가지는 신규 유산균
TW200837194A (en) * 2007-03-06 2008-09-16 Microbio Company Ltd Taiwan Fermented panax notoginseng solution with anti-cancer effects and manufacture method thereof
KR100868777B1 (ko) * 2007-03-15 2008-11-17 재단법인서울대학교산학협력재단 Ｒｓ３ 유형의 저항 전분에 대해 분해능이 있는비피도박테리움 아도레스센티스를 유효성분으로 함유하는것을 특징으로 하는 식품 조성물
EP2270133B1 (en) 2008-04-22 2015-06-24 Corporación Alimentaria Peñasanta (Capsa) Method for obtaining a novel strain of bifidobacterium bifidum with activity against infection by helicobacter pylori
ES2395529B1 (es) 2011-06-08 2014-04-11 Pri, S.A. Combinación sinérgica para el tratamiento de la diabetes mellitus tipo 2.
KR101364695B1 (ko) * 2011-06-29 2014-02-19 가천대학교 산학협력단 헬리코박터 파이로리의 생육을 저해하는 타락 유래 젖산균
US20150284675A1 (en) * 2012-10-25 2015-10-08 Compagnie Gervais Danone Streptococcus thermophilus strains for treating helicobacter pylori infection
KR101479818B1 (ko) * 2012-12-17 2015-01-26 주식회사 알엔에이 유산균 파쇄물의 제조방법
TW201630596A (zh) * 2015-01-06 2016-09-01 Meiji Co Ltd 鞘脂質吸收促進劑
JP7088829B2 (ja) 2016-04-13 2022-06-21 株式会社明治 新生児向けの脳機能改善用組成物
WO2018125735A1 (en) 2016-12-29 2018-07-05 Kibow Biotech, Inc. Composition and method for maintaining healthy kidney function

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JPS55120787A (en) † 1979-03-09 1980-09-17 Teruhiko Beppu Preparation of sphingomyelinase
JPS60221084A (ja) * 1984-04-18 1985-11-05 Chiyoda Chem Eng & Constr Co Ltd スフインゴミエリナ−ゼの製造法
US5716615A (en) * 1992-02-10 1998-02-10 Renata Maria Anna Cavaliere Vesely Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
JP2676484B2 (ja) * 1994-03-28 1997-11-17 熊本県 ヨーグルト様乳酸発酵食品の製造方法
JP3122333B2 (ja) * 1995-02-28 2001-01-09 株式会社薬理学中央研究所 赤血球を原料とするスフィンゴミエリンおよびセラミドの新規製造方法とセラミド配合治療剤又は化粧品
JP4021951B2 (ja) * 1996-03-01 2007-12-12 わかもと製薬株式会社 乳酸菌を有効成分とする抗胃炎剤、抗潰瘍剤および醗酵食品
JP3530674B2 (ja) * 1996-03-04 2004-05-24 明治乳業株式会社 変異原性物質吸収阻害性食品
IT1288119B1 (it) * 1996-06-28 1998-09-10 Renata Maria Anna Ve Cavaliere Composizioni dietetiche da utilizzare nell'alimentazione per via enterica
IT1296148B1 (it) * 1996-11-22 1999-06-09 Renata Maria Anna Ve Cavaliere Uso di batteri lattici per accrescere il livello delle ceramidi della pelle e delle mucose, e composizioni dermatologiche e cosmetiche atte
JP3400282B2 (ja) * 1997-02-21 2003-04-28 株式会社ヤクルト本社 脂質代謝改善剤およびそれを含有する食品
IT1298918B1 (it) * 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
IT1311495B1 (it) * 1999-06-09 2002-03-13 Mendes S U R L Composizione comprendente sfingomielinasi alcalina, utilizzabile qualeprodotto dietetico, integratore alimentare o medicamento.

Also Published As

Publication number Publication date
HU228941B1 (en) 2013-07-29
PL214675B1 (pl) 2013-09-30
NO327862B1 (no) 2009-10-05
CA2376048A1 (en) 2000-12-14
KR20020016826A (ko) 2002-03-06
AU778946B2 (en) 2004-12-23
BR0011447A (pt) 2002-03-19
US20020031507A1 (en) 2002-03-14
NO20016004D0 (no) 2001-12-07
JP4897167B2 (ja) 2012-03-14
AR024564A1 (es) 2002-10-16
EE05491B1 (et) 2011-12-15
EP1181047A2 (en) 2002-02-27
SK285901B6 (sk) 2007-10-04
ES2195902T9 (es) 2011-03-01
ZA200200039B (en) 2002-12-24
HUP0201631A2 (hu) 2005-12-28
MXPA01012641A (es) 2004-03-19
CN101695374B (zh) 2015-08-19
TR200103566T2 (tr) 2002-05-21
EA005166B1 (ru) 2004-12-30
KR100812806B1 (ko) 2008-03-12
JP2012040015A (ja) 2012-03-01
PT1181047E (pt) 2003-09-30
IT1311495B1 (it) 2002-03-13
SK17162001A3 (sk) 2002-03-05
CZ296369B6 (cs) 2006-02-15
IS6178A (is) 2001-11-27
HK1046246A1 (zh) 2003-01-03
ITRM990376A1 (it) 2000-12-09
UA80799C2 (uk) 2007-11-12
EE200100661A (et) 2003-04-15
US20050084486A1 (en) 2005-04-21
HUP0201631A3 (en) 2006-02-28
CN1354672A (zh) 2002-06-19
CA2376048C (en) 2014-12-09
PL364729A1 (en) 2004-12-13
EA200200019A1 (ru) 2002-06-27
IL146888A0 (en) 2002-08-14
DK1181047T4 (da) 2010-03-15
EP1181047B1 (en) 2003-04-16
DE60002194T3 (de) 2010-02-25
DZ3160A1 (fr) 2000-12-14
WO2000074712A2 (en) 2000-12-14
SI1181047T1 (en) 2003-10-31
EG24675A (en) 2010-04-27
EP1181047B9 (en) 2010-08-25
ITRM990376A0 (it) 1999-06-09
ATE237350T1 (de) 2003-05-15
MA26792A1 (fr) 2004-12-20
DE60002194D1 (de) 2003-05-22
CN101695374A (zh) 2010-04-21
NO20016004L (no) 2002-02-06
CZ20014219A3 (cs) 2002-04-17
DK1181047T3 (da) 2003-08-11
DE60002194T2 (de) 2004-01-29
IL146888A (en) 2012-02-29
WO2000074712A3 (en) 2001-05-03
ES2195902T5 (es) 2010-02-18
CN101352234A (zh) 2009-01-28
JP2003501399A (ja) 2003-01-14
EP1181047B2 (en) 2009-10-28
IS2742B (is) 2011-06-15
AU5563900A (en) 2000-12-28
SI1181047T2 (sl) 2010-02-26

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