ES2196034T3 - Aparato y procedimiento de deteccion de un ligando blanco. - Google Patents

Aparato y procedimiento de deteccion de un ligando blanco.

Info

Publication number
ES2196034T3
ES2196034T3 ES94930509T ES94930509T ES2196034T3 ES 2196034 T3 ES2196034 T3 ES 2196034T3 ES 94930509 T ES94930509 T ES 94930509T ES 94930509 T ES94930509 T ES 94930509T ES 2196034 T3 ES2196034 T3 ES 2196034T3
Authority
ES
Spain
Prior art keywords
reaction
chamber
detection
detection chamber
detection unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930509T
Other languages
English (en)
Inventor
Julian Gordon
John J Kotlarik
Donald I Stimpson
Joanell V Hoijer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196034T3 publication Critical patent/ES2196034T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Image Processing (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Fire Alarms (AREA)

Abstract

SE PROPORCIONAN METODOS, DISPOSITIVOS, APARATOS Y KITS PARA AMPLIFICAR Y DETECTAR LIGANDOS COMO ACIDOS NUCLEICOS. EL APARATO PUEDE SER UN DISPOSITIVO DE CICLO TERMICO DE DOS FILAS QUE PUEDE OPERAR EN CONJUNCION CON UNA UNIDAD DE REACCION/DETECCION HERMETICA. UNA MUESTRA SE CARGA EN UNA CAMARA DE REACCION DEL DISPOSITIVO QUE A CONTINUACION ES ACOPLADA CON UNA CAMARA DE DETECCION PARA FORMAR LA UNIDAD DE REACCION/DETECCION. LA MEZCLA DE REACCION PUEDE TRANSFERIRSE A LA CAMARA DE DETECCION MEDIANTE UN ELEMENTO DE CALENTAMIENTO Y EXPANSION DE UN FLUIDO. EL LIGANDO DIANA SE INMOVILIZA EN UNA DISPOSICION PREDETERMINADA SOBRE UNA BASE EN LA CAMARA DE DETECCION. UN SISTEMA DE ADQUISICION DE IMAGENES DE VIDEO ASOCIADO AL APARATO DETECTA Y ANALIZA EL LIGANDO INMOVILIZADO. LAS IMAGENES SE CAPTURAN, DIGITALIZAN Y SE SOMETEN A UN ANALISIS ESTADISTICO PARA MEJORAR LA PRECISION DEL METODO DE ADQUISICION DE IMAGENES.
ES94930509T 1993-10-21 1994-09-28 Aparato y procedimiento de deteccion de un ligando blanco. Expired - Lifetime ES2196034T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14038393A 1993-10-21 1993-10-21

Publications (1)

Publication Number Publication Date
ES2196034T3 true ES2196034T3 (es) 2003-12-16

Family

ID=22490987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930509T Expired - Lifetime ES2196034T3 (es) 1993-10-21 1994-09-28 Aparato y procedimiento de deteccion de un ligando blanco.

Country Status (8)

Country Link
EP (1) EP0724725B1 (es)
JP (1) JP3457322B2 (es)
AT (1) ATE236400T1 (es)
AU (1) AU7960494A (es)
CA (1) CA2174330C (es)
DE (1) DE69432424T2 (es)
ES (1) ES2196034T3 (es)
WO (1) WO1995011454A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700695A (en) * 1994-06-30 1997-12-23 Zia Yassinzadeh Sample collection and manipulation method
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6723290B1 (en) 1998-03-07 2004-04-20 Levine Robert A Container for holding biologic fluid for analysis
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
DE69940647D1 (de) 1998-05-01 2009-05-07 Gen Probe Inc Automatische diagnostische Analysevorrichtung
US6845913B2 (en) * 1999-02-11 2005-01-25 Flir Systems, Inc. Method and apparatus for barcode selection of themographic survey images
JP3957118B2 (ja) * 1999-05-18 2007-08-15 富士フイルム株式会社 試験片およびこの試験片からの画像情報読取装置
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
EP1513948B1 (en) * 2002-05-29 2009-04-15 Autogenomics, Inc. Integrated micro array system and methods therefor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7946984B2 (en) 2004-07-13 2011-05-24 Dexcom, Inc. Transcutaneous analyte sensor
US7794659B2 (en) 2005-03-10 2010-09-14 Gen-Probe Incorporated Signal measuring system having a movable signal measuring device
JP4854334B2 (ja) 2006-03-06 2012-01-18 三洋電機株式会社 核酸増幅生成物のリアルタイム検出装置
CN1888902B (zh) * 2006-08-11 2011-05-18 杭州优思达生物技术有限公司 全封闭式靶核酸扩增物快速检测装置
EP2252196A4 (en) 2008-02-21 2013-05-15 Dexcom Inc SYSTEMS AND METHOD FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA
CA2752715C (en) 2009-04-14 2018-05-01 Arie R. Van Doorn Hifu induced cavitation with reduced power threshold
BRPI1012522B1 (pt) 2009-04-15 2019-11-26 Biocartis N V sistema ótico de multiplexação e método para detectar componentes de amostra em pelo menos duas câmaras de amostra diferentes
WO2010118542A1 (en) 2009-04-15 2010-10-21 Biocartis Sa Protection of bioanalytical sample chambers
EP2427270B1 (en) 2009-05-06 2015-04-01 Biocartis NV Device for cutting a sample carrier
WO2011003039A2 (en) 2009-07-02 2011-01-06 Dexcom, Inc. Analyte sensors and methods of manufacturing same
US9351677B2 (en) 2009-07-02 2016-05-31 Dexcom, Inc. Analyte sensor with increased reference capacity
US9579651B2 (en) 2009-12-18 2017-02-28 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US9199233B2 (en) 2010-03-31 2015-12-01 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with deflecting top panel
KR20130029128A (ko) 2010-07-23 2013-03-21 베크만 컬터, 인코포레이티드 실시간 pcr용 용기
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
ES2533839T3 (es) 2010-12-30 2015-04-15 Abbott Point Of Care, Inc. Cartucho de análisis de fluido biológico con porción de manipulación de muestra y porción de cámara de análisis
EP2678664B1 (en) 2011-02-24 2019-08-07 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US9910054B2 (en) 2011-11-07 2018-03-06 Beckman Coulter, Inc. System and method for processing samples
EP3373015A1 (en) 2011-11-07 2018-09-12 Beckman Coulter Inc. Aliquotter system and workflow
WO2013070755A2 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Centrifuge system and workflow
KR20140091033A (ko) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 검체 컨테이너 검출
US8973736B2 (en) 2011-11-07 2015-03-10 Beckman Coulter, Inc. Magnetic damping for specimen transport system
CN104040352B (zh) 2011-11-07 2016-09-07 贝克曼考尔特公司 机械臂
CN110573884B (zh) * 2017-04-28 2023-04-28 以兹迪亚技术公司 使用大磁性颗粒复合物的自动免疫分析装置和方法
CN110869745B (zh) 2017-08-17 2023-08-11 雅培医护站股份有限公司 用于执行光学测定的设备、系统和方法
CN110892247B (zh) 2017-08-17 2023-08-25 雅培医护站股份有限公司 用于执行光学和电化学测定的设备、系统和方法
WO2019035082A1 (en) 2017-08-17 2019-02-21 Abbott Point Of Care Inc. TECHNIQUES FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS WITH UNIVERSAL CIRCUITS
DE102018106601A1 (de) * 2018-03-21 2019-09-26 Fragol Ag Vorrichtung und Verfahren zur thermischen Lagerung von Proben
US11061045B2 (en) 2019-03-12 2021-07-13 Picodya Technologies Ltd. Sample analysis system and method
JP7779903B2 (ja) * 2021-03-24 2025-12-03 富士フイルム株式会社 イムノクロマトグラフ検査装置
DE102021110828A1 (de) * 2021-04-28 2022-11-03 Innovative Sensor Technology Ist Ag System, Verfahren und Verbrauchsprodukt für ein chemisches, bio- oder immunchemisches Nachweisverfahren

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636875B2 (en) * 1989-03-17 1993-05-13 Abbott Laboratories Method and device for improved reaction kinetics in nucleic acid hybridizations
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5244815A (en) * 1990-01-19 1993-09-14 Lamina Ltd. Fingerprint test pad and method for fingerprinting using particle based immunoassay
DE69132905T2 (de) * 1990-12-06 2002-08-01 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Detektion von Nukleinsäuresequenzen
WO1992020824A1 (en) * 1991-05-24 1992-11-26 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
WO1992022879A1 (en) * 1991-06-13 1992-12-23 Abbott Laboratories Optical imaging for positioning and cell counting
WO1993020227A1 (en) * 1992-03-31 1993-10-14 Abbott Laboratories Method of multiplex ligase chain reaction

Also Published As

Publication number Publication date
AU7960494A (en) 1995-05-08
EP0724725B1 (en) 2003-04-02
JPH09504610A (ja) 1997-05-06
CA2174330A1 (en) 1995-04-27
EP0724725A1 (en) 1996-08-07
DE69432424D1 (de) 2003-05-08
ATE236400T1 (de) 2003-04-15
DE69432424T2 (de) 2004-03-18
JP3457322B2 (ja) 2003-10-14
CA2174330C (en) 2003-09-23
WO1995011454A1 (en) 1995-04-27

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