ES2196262T3 - Compuestos de benzotiofeno, intermedios, procedimientos y usos. - Google Patents

Compuestos de benzotiofeno, intermedios, procedimientos y usos.

Info

Publication number
ES2196262T3
ES2196262T3 ES97304458T ES97304458T ES2196262T3 ES 2196262 T3 ES2196262 T3 ES 2196262T3 ES 97304458 T ES97304458 T ES 97304458T ES 97304458 T ES97304458 T ES 97304458T ES 2196262 T3 ES2196262 T3 ES 2196262T3
Authority
ES
Spain
Prior art keywords
benzotiophene
compounds
intermediates
procedures
pirrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97304458T
Other languages
English (en)
Inventor
George Joseph Cullinan
Kennan Joseph Fahey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2196262T3 publication Critical patent/ES2196262T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA NUEVOS COMPUESTOS DE BENZOTIOFENO DE FORMULA EN LA QUE: R1 ES C1 TITUIDO, TE SUSTITUIDO, O H, OPCIONALMENTE SUSTITUIDO, ENILO OPCIONALMENTE SUSTITUIDO, SON CADA UNO DE ELLOS INDEPENDIENTEMENTE ALQUILO C1 COMBINAN FORMANDO, CON EL NITROGENO AL CUAL ESTAN UNIDOS, PIPERIDINILO, PIRROLIDINILO, METILPIRROLIDINILO, DIMETILPIRROLIDINILO O HEXAMETILENIMINO; CON LA CONDICION DE QUE CUANDO N ES 3, ENTONCES NI R1 NI R2 PUEDEN SER O UNA SAL O SOLVATO FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS.
ES97304458T 1996-07-02 1997-06-25 Compuestos de benzotiofeno, intermedios, procedimientos y usos. Expired - Lifetime ES2196262T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2102696P 1996-07-02 1996-07-02

Publications (1)

Publication Number Publication Date
ES2196262T3 true ES2196262T3 (es) 2003-12-16

Family

ID=21801903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97304458T Expired - Lifetime ES2196262T3 (es) 1996-07-02 1997-06-25 Compuestos de benzotiofeno, intermedios, procedimientos y usos.

Country Status (7)

Country Link
US (1) US6432983B1 (es)
EP (1) EP0816360B1 (es)
JP (1) JPH1067776A (es)
AT (1) ATE236152T1 (es)
CA (1) CA2206752A1 (es)
DE (1) DE69720326T2 (es)
ES (1) ES2196262T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
ES2259376T3 (es) 2001-05-22 2006-10-01 Eli Lilly And Company 1,2,3,4-tetrahidroquinolinas 2-sustituidas y sus derivados, composiciones y procedimientos.
ES2236536T3 (es) 2001-05-22 2005-07-16 Eli Lilly And Company Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
US9962362B2 (en) 2012-03-29 2018-05-08 Children's Hospital Medical Center Use of small molecule inhibitors targeting EYA tyrosine phosphatase
US9725430B2 (en) 2013-01-16 2017-08-08 Children's Hospital Medical Center Use of small molecule inhibitors targeting EYA tyrosine phosphatase

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300575B (de) 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3394125A (en) 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en) 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65404A0 (en) * 1981-04-03 1982-07-30 Lilly Co Eli Benzothiophene compounds and process for preparing them
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4358593A (en) 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
WO1989002893A1 (en) 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
US5395842A (en) 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
WO1995017095A1 (en) * 1993-12-21 1995-06-29 Eli Lilly And Company Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
AU1339795A (en) * 1993-12-21 1995-07-10 Eli Lilly And Company Non-peptide tachykinin receptor antagonists
US5492921A (en) * 1994-09-20 1996-02-20 Eli Lilly And Company Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation
IL115582A0 (en) * 1994-10-14 1996-01-19 Lilly Co Eli Methods for treating resistant tumors
US5663192A (en) * 1994-10-20 1997-09-02 Eli Lilly And Company Heterocyclic neuropeptide Y receptor antagonists
WO1996012488A1 (en) * 1994-10-20 1996-05-02 Eli Lilly And Company Bicyclic bradykinin receptor antagonists
IL115613A0 (en) * 1994-10-20 1996-01-19 Lilly Co Eli Bicyclic neuropeptide y receptor antagonists
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis

Also Published As

Publication number Publication date
EP0816360A1 (en) 1998-01-07
US6432983B1 (en) 2002-08-13
DE69720326D1 (de) 2003-05-08
ATE236152T1 (de) 2003-04-15
DE69720326T2 (de) 2003-11-27
JPH1067776A (ja) 1998-03-10
EP0816360B1 (en) 2003-04-02
CA2206752A1 (en) 1998-01-02

Similar Documents

Publication Publication Date Title
SV2002000195A (es) Compuestos farmaceuticamente activos ref. pcs10342 afae/bb
EA199700117A1 (ru) Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
ES2196344T3 (es) Derivados de sulfonamida y su uso en el tratamiento de trastornos de snc.
ES2195970T3 (es) L-ribavirina y usos de la misma.
ATE200279T1 (de) Herstellung von 3,4,4-trisubstituiertem piperidinyl-n-alkylcarboxylaten und zwischenverbindungen, verwendbar als opioid antagonisten
GT199900067A (es) Nuevas 4-fenilpiperidinas para el tratamiento dedermatosis prurìtica.
ECSP941135A (es) Antagonistas triciclicos de vasopresina de benzacepina
ES2162198T3 (es) Agentes estrogenos.
ES2184762T3 (es) Allquil bencilaminoquinuclidinas sustituidas con heteroatomos como antagonista de la sustancia p'.
DE69429524D1 (de) Aminocyclohexylester und ihre anwendung
IT1098168B (it) Procedimento per l'unione di cuori di scambi ferroviari, cuori che sono costituiti da acciaio fuso duro al manganese,con rotaie costituite da acciaie al carbonio
ES2168613T3 (es) Empleo de copolimeros hidrosolubles como principios activos en formulaciones cosmeticas.
DE69903333D1 (de) Crf rezeptor-antagonisten und darauf bezogene methoden
DE68902784D1 (de) Auswechselbarer quenchgas-injektionsring.
CO4970722A1 (es) Derivados de eritromicina con puente en 6, 9
TR200200263T2 (tr) Yeni seçiçi retinoid agonistleri
CR6741A (es) Compuestos de eter difenilico utiles en terapia
DE69229339D1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
ES2171911T3 (es) Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos.
ES2110260T3 (es) Androstenonas.
FI974434L (fi) Trisyklisiä 5,6-dihydro-9H-pyratsolo(3,4-c)-1,2,4,-triatsolo(4,3-alfapidiinejä
ES2158077T3 (es) Carboxanilidas oxidiacinicas artropodicidas.
ES2196262T3 (es) Compuestos de benzotiofeno, intermedios, procedimientos y usos.
ES2195089T3 (es) Benzotiofenos amorfos, procedimientos de preparacion y uso.
UA41350C2 (uk) Похідна морфоліну або її фармацевтично прийнятна сіль та фармацевтична композиція на її основі