ES2196574T3 - Procedimiento para la preparacion de soluciones estables de acido acetilsalicilico. - Google Patents

Procedimiento para la preparacion de soluciones estables de acido acetilsalicilico.

Info

Publication number
ES2196574T3
ES2196574T3 ES98931817T ES98931817T ES2196574T3 ES 2196574 T3 ES2196574 T3 ES 2196574T3 ES 98931817 T ES98931817 T ES 98931817T ES 98931817 T ES98931817 T ES 98931817T ES 2196574 T3 ES2196574 T3 ES 2196574T3
Authority
ES
Spain
Prior art keywords
weight
preparation
stable solutions
acid
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98931817T
Other languages
English (en)
Inventor
Walter Burghart
Kurt Dr Burghart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2196574T3 publication Critical patent/ES2196574T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para la preparación de soluciones estables de ácido acetilsalicílico con disolventes orgánicos, no acuosos y farmacéuticamente tolerables tales como dimetilisosorbida, propilenglicol o éter monoetílico de dietilenglicol, caracterizado porque a la solución se añaden 0, 005, 2% en peso de una imida ácida cíclica y/o 0, 005, 2% en peso de un ácido sulfamínico, así como, preferentemente, 1, 40% en peso, referido al peso de la solución, de un compuesto de la fórmula general en la que R1 significa H, CH3 o C2H5, n = 0 ó 1 y R2 significa H o uno o múltiples restos alquilo inferior, alquiloxi inferior o alquenilo inferior, con 1 hasta 5 átomos de C.
ES98931817T 1997-07-15 1998-07-15 Procedimiento para la preparacion de soluciones estables de acido acetilsalicilico. Expired - Lifetime ES2196574T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT120697 1997-07-15

Publications (1)

Publication Number Publication Date
ES2196574T3 true ES2196574T3 (es) 2003-12-16

Family

ID=3508919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98931817T Expired - Lifetime ES2196574T3 (es) 1997-07-15 1998-07-15 Procedimiento para la preparacion de soluciones estables de acido acetilsalicilico.

Country Status (7)

Country Link
US (1) US6306843B1 (es)
EP (1) EP1009410B1 (es)
AU (1) AU736539B2 (es)
CA (1) CA2298464A1 (es)
DE (1) DE59807484D1 (es)
ES (1) ES2196574T3 (es)
WO (1) WO1999003474A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129987D0 (en) * 2001-12-14 2002-02-06 Zylepsis Ltd Skin compositions
US7374772B2 (en) * 2002-11-07 2008-05-20 Bommarito Alexander A Topical antifungal treatment
CA2629979A1 (en) * 2008-04-25 2009-10-25 Pharmascience Inc. Novel resveratrol compositions
WO2011076401A1 (de) 2009-12-23 2011-06-30 Holger Schankin Acetylsalicylsäure-haltige, im wesentlichen wasserfreie pharmazeutische zusammensetzungen
PH12013500477A1 (en) 2010-09-13 2018-01-17 Bev Rx Inc Aqueous drug delivery system comprising off-flavor masking agent
GB2533669B (en) * 2014-12-23 2016-12-14 Innovate Pharmaceuticals Ltd Salicylate compound composition
US11096949B2 (en) 2017-05-30 2021-08-24 Rhoshan Pharmaceuticals, Inc. In-vial deposition of a stable, sterile and crystalline O-acetyl salicylic acid
IT202000014578A1 (it) * 2020-06-18 2021-12-18 Poli Md S R L Dispositivo medicale comprendente acido acetil salicilico
WO2025114578A1 (en) * 2023-11-29 2025-06-05 Auxesis Pharma Holding Ab (Publ) A composition and use thereof as a medicament

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3316150A (en) * 1964-02-26 1967-04-25 Faeges Marvin Stable suspensions of acetyl salicylic acid
DE2501548A1 (de) 1974-01-25 1975-07-31 Procter & Gamble Mundbehandlungsmittel
US4228162A (en) * 1979-07-09 1980-10-14 Research Corporation Dimethyl isosorbide in liquid formulation of aspirin
FR2496459A1 (fr) * 1980-12-19 1982-06-25 Astier Laboratoires Docteur P Composition pharmaceutique sous forme d'un gel contenant de l'acide acetylsalicylique
CS227456B1 (cs) * 1982-05-17 1984-04-16 Valenta Vladimir Externí přípravek pro prevenci a/nebo léčení dermatóz
FI931934L (fi) * 1990-10-31 1993-05-31 Procter & Gamble Dextrometorfaninnehaollande hostmedicinkompositioner
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
US5723453A (en) 1995-11-13 1998-03-03 Health Corporation Stabilized, water-soluble aspirin composition
US5900416A (en) * 1996-02-01 1999-05-04 Anthea Enterprises Incorporated Aqueous caffeine dosage forms

Also Published As

Publication number Publication date
AU736539B2 (en) 2001-08-02
CA2298464A1 (en) 1999-01-28
DE59807484D1 (de) 2003-04-17
US6306843B1 (en) 2001-10-23
WO1999003474A1 (de) 1999-01-28
AU8198598A (en) 1999-02-10
EP1009410B1 (de) 2003-03-12
EP1009410A1 (de) 2000-06-21

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