ES2196800T3 - Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica. - Google Patents

Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica.

Info

Publication number
ES2196800T3
ES2196800T3 ES99919290T ES99919290T ES2196800T3 ES 2196800 T3 ES2196800 T3 ES 2196800T3 ES 99919290 T ES99919290 T ES 99919290T ES 99919290 T ES99919290 T ES 99919290T ES 2196800 T3 ES2196800 T3 ES 2196800T3
Authority
ES
Spain
Prior art keywords
inflammation
treatment
derivatives
oheteroaril
nurogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99919290T
Other languages
English (en)
Inventor
Ramon Merce-Vidal
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Application granted granted Critical
Publication of ES2196800T3 publication Critical patent/ES2196800T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los derivados de aril(o heteroaril)azolilcarbinol de fórmula general (I), donde R1 es un átomo de hidrógeno o un grupo alquilo inferior; R2 es un radical dialquilaminoalquilo o azaheterociclilalquilo; Ar es un radical fenilo o tienilo, opcionalmente sustituidos; y Het es un heterocido aromático nitrogenado de 5 miembros que contiene de uno a tres átomos de nitrógeno, opcionalmente sustituido; son adecuados para el tratamiento de la inflamación neurogénica, presente en diferentes procesos, tales como diabetes, asma, cistitis, gingivitis, migraña, dermatitis, rinitis, psoriasis, inflamación de nervios ciático y lumbares, procesos gastrointestinales, inflamación ocular, etc., en mamíferos, incluido el hombre.
ES99919290T 1998-05-18 1999-05-18 Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica. Expired - Lifetime ES2196800T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009801021A ES2137136B1 (es) 1998-05-18 1998-05-18 Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
PCT/ES1999/000142 WO1999059524A2 (es) 1998-05-18 1999-05-18 Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica

Publications (1)

Publication Number Publication Date
ES2196800T3 true ES2196800T3 (es) 2003-12-16

Family

ID=8303801

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801021A Expired - Fee Related ES2137136B1 (es) 1998-05-18 1998-05-18 Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
ES99919290T Expired - Lifetime ES2196800T3 (es) 1998-05-18 1999-05-18 Usos de derivados de aril (oheteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion nueurogenica.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES009801021A Expired - Fee Related ES2137136B1 (es) 1998-05-18 1998-05-18 Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.

Country Status (24)

Country Link
EP (1) EP1086682B1 (es)
JP (1) JP2002515409A (es)
KR (1) KR100572416B1 (es)
CN (1) CN1221257C (es)
AR (1) AR019555A1 (es)
AT (1) ATE237328T1 (es)
AU (1) AU759229B2 (es)
BR (1) BR9910587A (es)
CA (1) CA2332711A1 (es)
CZ (1) CZ291593B6 (es)
DE (1) DE69906969T2 (es)
DK (1) DK1086682T3 (es)
ES (2) ES2137136B1 (es)
HU (1) HUP0102112A3 (es)
IL (2) IL139744A0 (es)
NO (1) NO20005837L (es)
NZ (1) NZ508316A (es)
PL (1) PL344742A1 (es)
PT (1) PT1086682E (es)
RU (1) RU2212237C2 (es)
TR (1) TR200003434T2 (es)
TW (1) TW570796B (es)
WO (1) WO1999059524A2 (es)
ZA (1) ZA200006732B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2174756B2 (es) * 2001-04-06 2003-11-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias.
ES2180449B1 (es) * 2001-07-06 2004-01-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
EA008744B1 (ru) * 2002-08-12 2007-08-31 Актавис Груп Хф. Применение соединений антагонистов кальцитонин генсвязанного пептида (cgrp) для лечения псориаза
WO2006010627A1 (en) * 2004-07-30 2006-02-02 Laboratorios Del Dr. Esteve, S.A. Aryl (or heteroaryl) azolylcarbinols
EP1632227A1 (en) * 2004-09-07 2006-03-08 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction
EP1820502A1 (en) * 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321158A1 (de) * 1983-06-11 1984-12-13 Bayer Ag, 5090 Leverkusen Azolylmethyl-thienyl-carbinol-derivate
FR2613720B1 (fr) * 1987-04-10 1990-01-19 Esteve Labor Dr Derives d'aryl-heteroaryl carbinols avec activite analgesique
FR2681322B1 (fr) * 1991-09-12 1993-12-17 Laboratorios Dr Esteve Sa Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments .
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

Also Published As

Publication number Publication date
TW570796B (en) 2004-01-11
PL344742A1 (en) 2001-11-19
RU2212237C2 (ru) 2003-09-20
KR100572416B1 (ko) 2006-04-18
CZ291593B6 (cs) 2003-04-16
AU759229B2 (en) 2003-04-10
DE69906969T2 (de) 2003-12-11
BR9910587A (pt) 2001-01-30
IL139744A (en) 2007-08-19
CZ20004282A3 (en) 2001-05-16
AR019555A1 (es) 2002-02-27
NO20005837D0 (no) 2000-11-17
AU3711899A (en) 1999-12-06
KR20010034868A (ko) 2001-04-25
CN1306424A (zh) 2001-08-01
NZ508316A (en) 2002-02-01
WO1999059524A3 (es) 2000-03-09
EP1086682A2 (en) 2001-03-28
JP2002515409A (ja) 2002-05-28
ES2137136B1 (es) 2000-07-01
ZA200006732B (en) 2002-08-16
CA2332711A1 (en) 1999-11-25
ES2137136A1 (es) 1999-12-01
TR200003434T2 (tr) 2001-04-20
HUP0102112A2 (hu) 2002-03-28
DE69906969D1 (de) 2003-05-22
ATE237328T1 (de) 2003-05-15
HUP0102112A3 (en) 2002-06-28
CN1221257C (zh) 2005-10-05
DK1086682T3 (da) 2003-06-23
NO20005837L (no) 2001-01-08
WO1999059524A2 (es) 1999-11-25
PT1086682E (pt) 2003-07-31
IL139744A0 (en) 2002-03-10
EP1086682B1 (en) 2003-04-16

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