ES2197500T3 - Uso de cloruro de n,n-bis(fenilcarbamoilmetil)dimetilamonio y sus usos derivados en el tratamiento del dolor cronico. - Google Patents
Uso de cloruro de n,n-bis(fenilcarbamoilmetil)dimetilamonio y sus usos derivados en el tratamiento del dolor cronico.Info
- Publication number
- ES2197500T3 ES2197500T3 ES98941201T ES98941201T ES2197500T3 ES 2197500 T3 ES2197500 T3 ES 2197500T3 ES 98941201 T ES98941201 T ES 98941201T ES 98941201 T ES98941201 T ES 98941201T ES 2197500 T3 ES2197500 T3 ES 2197500T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- dimethylamon
- carbamoilmetil
- phenyl
- chronic pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002193 Pain Diseases 0.000 title abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
- 208000000094 Chronic Pain Diseases 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- YGCONRRHHMKQRL-UHFFFAOYSA-N bis(2-anilino-2-oxoethyl)-dimethylazanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1NC(=O)C[N+](C)(C)CC(=O)NC1=CC=CC=C1 YGCONRRHHMKQRL-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Uso de un compuesto para la preparación de un medicamento para el tratamiento o prevención del dolor crónico/no agudo en animales de sangre caliente incluyendo seres humanos, teniendo el compuesto la fórmula siguiente: en la que R1, R2, R3, R6, R7 y R8 se seleccionan independientemente de bromo, cloro, flúor, carboxi, hidrógeno, hidroxi, hidroximetilo, metanosulfonamido, nitro, sulfamilo, trifluorometilo, alcanoiloxi C2-C7, alquilo C1-C6, alcoxi C1-C6, alcoxicarbonilo C2-C7, N(R9, R10), fenilo y tioalquilo C1-C6; y donde R9 y R10 son independientemente hidrógeno, acetilo, metanosulfonilo o alquilo C1-C6; R4 y R5 se han seleccionado independientemente a partir de hidrógeno, alquilo C1-C8, alcoxialquilo C3-C8 y aralquilo C7-C12; X es el anión de la sal farmacéuticamente aceptable; o de sus isómeros enantioméricos, diastoméricos y geométricos aislados, o sus mezclas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5631297P | 1997-09-03 | 1997-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2197500T3 true ES2197500T3 (es) | 2004-01-01 |
Family
ID=22003584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98941201T Expired - Lifetime ES2197500T3 (es) | 1997-09-03 | 1998-09-03 | Uso de cloruro de n,n-bis(fenilcarbamoilmetil)dimetilamonio y sus usos derivados en el tratamiento del dolor cronico. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1009397B1 (es) |
| JP (1) | JP2001514216A (es) |
| CN (1) | CN1276722A (es) |
| AT (1) | ATE238047T1 (es) |
| AU (1) | AU8970198A (es) |
| BR (1) | BR9812182A (es) |
| CA (1) | CA2303815A1 (es) |
| DE (1) | DE69813839T2 (es) |
| ES (1) | ES2197500T3 (es) |
| TW (1) | TW536401B (es) |
| WO (1) | WO1999011252A2 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217918C (zh) | 1998-04-01 | 2005-09-07 | 卡迪欧梅制药公司 | 氨基环己基醚化合物和其用途 |
| CA2334481A1 (en) * | 1998-06-09 | 1999-12-16 | Nortran Pharmaceuticals Inc. | Compositions and methods for treatment of cough |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| DE60305200T2 (de) | 2003-05-02 | 2007-05-10 | Cardiome Pharma Corp. | Aminocyclohexylether-verbindungen und deren verwendung |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| JP5583325B2 (ja) | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
| KR20090082507A (ko) | 2006-11-20 | 2009-07-30 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 통증 및 소양증 치료용 방법, 조성물 및 키트 |
| WO2011006073A1 (en) | 2009-07-10 | 2011-01-13 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| US11021443B2 (en) | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CA3129089A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Ester substituted ion channel blockers and methods for use |
| CN113811305A (zh) | 2019-03-11 | 2021-12-17 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
| CA3155568A1 (en) | 2019-11-06 | 2021-05-14 | Bridget Mccarthy Cole | Charged ion channel blockers and methods for use |
| AU2020380118B2 (en) | 2019-11-06 | 2026-06-11 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US12162851B2 (en) | 2020-03-11 | 2024-12-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| JP7273257B1 (ja) * | 2021-11-30 | 2023-05-12 | マルホ株式会社 | 医薬組成物 |
-
1998
- 1998-08-31 TW TW087114395A patent/TW536401B/zh active
- 1998-09-03 BR BR9812182-0A patent/BR9812182A/pt not_active IP Right Cessation
- 1998-09-03 AT AT98941201T patent/ATE238047T1/de not_active IP Right Cessation
- 1998-09-03 JP JP2000508355A patent/JP2001514216A/ja active Pending
- 1998-09-03 CN CN98810388A patent/CN1276722A/zh active Pending
- 1998-09-03 DE DE69813839T patent/DE69813839T2/de not_active Expired - Fee Related
- 1998-09-03 ES ES98941201T patent/ES2197500T3/es not_active Expired - Lifetime
- 1998-09-03 AU AU89701/98A patent/AU8970198A/en not_active Abandoned
- 1998-09-03 CA CA002303815A patent/CA2303815A1/en not_active Abandoned
- 1998-09-03 EP EP98941201A patent/EP1009397B1/en not_active Expired - Lifetime
- 1998-09-03 WO PCT/CA1998/000842 patent/WO1999011252A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999011252A3 (en) | 1999-05-06 |
| WO1999011252A2 (en) | 1999-03-11 |
| EP1009397B1 (en) | 2003-04-23 |
| BR9812182A (pt) | 2002-01-15 |
| TW536401B (en) | 2003-06-11 |
| DE69813839T2 (de) | 2004-03-04 |
| CN1276722A (zh) | 2000-12-13 |
| DE69813839D1 (de) | 2003-05-28 |
| JP2001514216A (ja) | 2001-09-11 |
| HK1028957A1 (en) | 2001-03-16 |
| ATE238047T1 (de) | 2003-05-15 |
| AU8970198A (en) | 1999-03-22 |
| CA2303815A1 (en) | 1999-03-11 |
| EP1009397A2 (en) | 2000-06-21 |
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