ES2202490T3 - Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number: ES2202490T3
Authority: ES; Spain
Prior art keywords: carbon atoms; radical; atoms; hydrogen atom; radicals
Prior art date: 1995-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES96942433T

Other languages

English (en)

Spanish (es)

Inventor

Herve Bouchard

Alain Commercon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-22

Filing date

1996-12-19

Publication date

2004-04-01

1996-12-19 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2004-04-01 Application granted granted Critical

2004-04-01 Publication of ES2202490T3 publication Critical patent/ES2202490T3/es

2016-12-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title claims abstract description 9
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 4
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 52
150000002576 ketones Chemical group 0.000 claims abstract description 13
125000004423 acyloxy group Chemical group 0.000 claims abstract description 6
125000005333 aroyloxy group Chemical group 0.000 claims abstract description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 145
125000004429 atom Chemical group 0.000 claims description 73
150000003254 radicals Chemical class 0.000 claims description 54
125000003118 aryl group Chemical group 0.000 claims description 51
239000000203 mixture Substances 0.000 claims description 51
125000000217 alkyl group Chemical group 0.000 claims description 49
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
229910052799 carbon Inorganic materials 0.000 claims description 27
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 26
239000001257 hydrogen Substances 0.000 claims description 23
229910052739 hydrogen Inorganic materials 0.000 claims description 23
125000006239 protecting group Chemical group 0.000 claims description 20
238000000034 method Methods 0.000 claims description 19
125000005843 halogen group Chemical group 0.000 claims description 18
229910052757 nitrogen Inorganic materials 0.000 claims description 18
125000003545 alkoxy group Chemical group 0.000 claims description 17
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 14
229910052760 oxygen Inorganic materials 0.000 claims description 14
239000001301 oxygen Substances 0.000 claims description 14
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 13
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
125000002252 acyl group Chemical group 0.000 claims description 11
150000002431 hydrogen Chemical class 0.000 claims description 11
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LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 claims description 10
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239000011593 sulfur Chemical group 0.000 claims description 10
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238000006243 chemical reaction Methods 0.000 claims description 5
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
230000003647 oxidation Effects 0.000 claims description 5
238000007254 oxidation reaction Methods 0.000 claims description 5
LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical group O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 claims description 5
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125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
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239000003960 organic solvent Substances 0.000 claims description 4
CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims description 3
239000002671 adjuvant Substances 0.000 claims description 3
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239000003638 chemical reducing agent Substances 0.000 claims description 3
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BGPJLYIFDLICMR-UHFFFAOYSA-N 1,4,2,3-dioxadithiolan-5-one Chemical compound O=C1OSSO1 BGPJLYIFDLICMR-UHFFFAOYSA-N 0.000 claims description 2
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YUDRVAHLXDBKSR-UHFFFAOYSA-N [CH]1CCCCC1 Chemical compound [CH]1CCCCC1 YUDRVAHLXDBKSR-UHFFFAOYSA-N 0.000 claims description 2
150000001340 alkali metals Chemical class 0.000 claims description 2
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
150000001342 alkaline earth metals Chemical class 0.000 claims description 2
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 2
125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims description 2
150000001602 bicycloalkyls Chemical group 0.000 claims description 2
125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims description 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 2
239000003085 diluting agent Substances 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
239000011707 mineral Substances 0.000 claims description 2
230000001012 protector Effects 0.000 claims description 2
230000009466 transformation Effects 0.000 claims description 2
NTJBWZHVSJNKAD-UHFFFAOYSA-N triethylazanium;fluoride Chemical compound [F-].CC[NH+](CC)CC NTJBWZHVSJNKAD-UHFFFAOYSA-N 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
125000000468 ketone group Chemical group 0.000 claims 5
150000001408 amides Chemical class 0.000 claims 1
150000001875 compounds Chemical class 0.000 claims 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 1
OLRJXMHANKMLTD-UHFFFAOYSA-N silyl Chemical compound [SiH3] OLRJXMHANKMLTD-UHFFFAOYSA-N 0.000 claims 1
125000004434 sulfur atom Chemical group 0.000 claims 1
230000000259 anti-tumor effect Effects 0.000 abstract description 3
YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 4
230000005916 anti-leucemic effect Effects 0.000 abstract 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 75
239000000047 product Substances 0.000 description 73
ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 description 48
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 37
239000000243 solution Substances 0.000 description 33
230000002829 reductive effect Effects 0.000 description 30
WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 description 28
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125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 16
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238000010828 elution Methods 0.000 description 14
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ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
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DCFKHNIGBAHNSS-UHFFFAOYSA-N chloro(triethyl)silane Chemical compound CC[Si](Cl)(CC)CC DCFKHNIGBAHNSS-UHFFFAOYSA-N 0.000 description 4
238000010908 decantation Methods 0.000 description 4
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230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
229960001052 streptozocin Drugs 0.000 description 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229960001603 tamoxifen Drugs 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
RCINICONZNJXQF-XAZOAEDWSA-N taxol® Chemical compound O([C@@H]1[C@@]2(CC(C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3(C21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-XAZOAEDWSA-N 0.000 description 1
229960001278 teniposide Drugs 0.000 description 1
NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
125000006633 tert-butoxycarbonylamino group Chemical group 0.000 description 1
150000003510 tertiary aliphatic amines Chemical class 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
229960001712 testosterone propionate Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
229960003087 tioguanine Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
QXTIBZLKQPJVII-UHFFFAOYSA-N triethylsilicon Chemical compound CC[Si](CC)CC QXTIBZLKQPJVII-UHFFFAOYSA-N 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ES96942433T 1995-12-22 1996-12-19 Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2202490T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9515379		1995-12-22
FR9515379A FR2742751B1 (fr)	1995-12-22	1995-12-22	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ES2202490T3 true ES2202490T3 (es)	2004-04-01

Family

ID=9485871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES96942433T Expired - Lifetime ES2202490T3 (es)	1995-12-22	1996-12-19	Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen.

Country Status (40)

Country	Link
US (1)	US5728849A (fr)
EP (1)	EP0876362B1 (fr)
JP (1)	JP3953106B2 (fr)
KR (1)	KR100500351B1 (fr)
CN (1)	CN1103766C (fr)
AR (1)	AR005197A1 (fr)
AT (1)	ATE250593T1 (fr)
AU (1)	AU712597B2 (fr)
BG (1)	BG63204B1 (fr)
BR (1)	BR9612135A (fr)
CA (1)	CA2238884C (fr)
CO (1)	CO4520184A1 (fr)
CZ (1)	CZ294972B6 (fr)
DE (1)	DE69630145T2 (fr)
DK (1)	DK0876362T3 (fr)
DZ (1)	DZ2149A1 (fr)
EA (1)	EA001533B1 (fr)
ES (1)	ES2202490T3 (fr)
FR (1)	FR2742751B1 (fr)
HU (1)	HU225032B1 (fr)
IL (1)	IL124994A (fr)
IN (4)	IN186768B (fr)
MA (1)	MA26412A1 (fr)
MX (1)	MX9804688A (fr)
MY (1)	MY113934A (fr)
NO (1)	NO317358B1 (fr)
NZ (1)	NZ324337A (fr)
OA (1)	OA10700A (fr)
PE (1)	PE25198A1 (fr)
PL (1)	PL189311B1 (fr)
PT (1)	PT876362E (fr)
RO (1)	RO116194B1 (fr)
SK (1)	SK282835B6 (fr)
TN (1)	TNSN96169A1 (fr)
TR (1)	TR199801179T2 (fr)
TW (1)	TW371659B (fr)
UA (1)	UA48205C2 (fr)
UY (1)	UY24386A1 (fr)
WO (1)	WO1997023473A1 (fr)
ZA (1)	ZA9610737B (fr)

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EA007485B1 (ru) *	2001-02-24	2006-10-27	Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг	Производные ксантина, способ их получения, фармацевтическая композиция на их основе и способ ее получения
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
WO2004103344A1 (fr) *	2003-05-20	2004-12-02	Aronex Pharmaceuticals, Inc.	Chimiotherapie combinee comprenant un complexe de platine liposomal
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (fr) *	2004-12-07	2006-06-14	Aventis Pharma S.A.	Agents cytotoxiques comprenant des nouveau taxanes
DE102005035891A1 (de)	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (fr)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	Compositions d'inhibiteurs de la DPP IV
MX2008014024A (es)	2006-05-04	2008-11-14	Boehringer Ingelheim Int	Formas poliformas.
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
US20080207743A1 (en) *	2007-02-28	2008-08-28	Rodger Lamb	Biologically Active Taxane Analogs and Methods of Treatment
EP3542801A1 (fr) *	2007-08-17	2019-09-25	Boehringer Ingelheim International GmbH	Dérivés de la purine destinés à être utilisés dans le traitement de maladies associées à fab
PE20140960A1 (es)	2008-04-03	2014-08-15	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) *	2008-06-03	2010-02-23	Boehringer Ingelheim Int	Tratamiento de nafld
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
CN103816158A (zh) *	2008-08-15	2014-05-28	勃林格殷格翰国际有限公司	用于治疗fab-相关疾病的嘌呤衍生物
CN102149407A (zh)	2008-09-10	2011-08-10	贝林格尔.英格海姆国际有限公司	治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN107011345A (zh)	2008-12-23	2017-08-04	勃林格殷格翰国际有限公司	有机化合物的盐形式
TW201036975A (en)	2009-01-07	2010-10-16	Boehringer Ingelheim Int	Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
EP2504002B1 (fr)	2009-11-27	2019-10-09	Boehringer Ingelheim International GmbH	Traitement de patients diabétiques génotypés par des inhibiteurs de dpp-iv tels que la linagliptine
KR101927068B1 (ko)	2010-05-05	2018-12-10	베링거 인겔하임 인터내셔날 게엠베하	체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR20200028498A (ko)	2010-06-24	2020-03-16	베링거 인겔하임 인터내셔날 게엠베하	당뇨병 요법
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
HUE061596T2 (hu)	2011-07-15	2023-07-28	Boehringer Ingelheim Int	Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US20130303462A1 (en)	2012-05-14	2013-11-14	Boehringer Ingelheim International Gmbh	Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es)	2012-05-14	2022-11-24	Boehringer Ingelheim Int	Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
WO2013174767A1 (fr)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
CA2891280C (fr)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Lieurs hydrophiles et leurs utilisations pour la conjugaison de medicaments a des molecules se liant aux cellules
FR3010839B1 (fr) *	2013-09-17	2017-04-21	Schneider Electric Ind Sas	Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
EP3110449B1 (fr)	2014-02-28	2023-06-28	Boehringer Ingelheim International GmbH	Utilisation médicale d'un inhibiteur de dpp-4
CN106414465B (zh)	2014-02-28	2021-11-16	杭州多禧生物科技有限公司	带电荷链接体及其在共轭反应上的应用
NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
BR112018072401A2 (pt)	2016-06-10	2019-02-19	Boehringer Ingelheim International Gmbh	combinações de linagliptina e metformina
CN116143678A (zh)	2016-11-14	2023-05-23	杭州多禧生物科技有限公司	偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
WO2022078524A2 (fr)	2021-11-03	2022-04-21	Hangzhou Dac Biotech Co., Ltd.	Conjugaison spécifique d'un anticorps

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1995
- 1995-12-22 FR FR9515379A patent/FR2742751B1/fr not_active Expired - Fee Related
1996
- 1996-12-04 PE PE1996000871A patent/PE25198A1/es not_active Application Discontinuation
- 1996-12-18 MA MA24431A patent/MA26412A1/fr unknown
- 1996-12-19 BR BR9612135A patent/BR9612135A/pt not_active IP Right Cessation
- 1996-12-19 ZA ZA9610737A patent/ZA9610737B/xx unknown
- 1996-12-19 EA EA199800588A patent/EA001533B1/ru not_active IP Right Cessation
- 1996-12-19 JP JP52336197A patent/JP3953106B2/ja not_active Expired - Fee Related
- 1996-12-19 CZ CZ19981961A patent/CZ294972B6/cs not_active IP Right Cessation
- 1996-12-19 UA UA98063216A patent/UA48205C2/uk unknown
- 1996-12-19 AT AT96942433T patent/ATE250593T1/de active
- 1996-12-19 RO RO98-01093A patent/RO116194B1/ro unknown
- 1996-12-19 SK SK853-98A patent/SK282835B6/sk not_active IP Right Cessation
- 1996-12-19 NZ NZ324337A patent/NZ324337A/xx not_active IP Right Cessation
- 1996-12-19 IL IL12499496A patent/IL124994A/xx not_active IP Right Cessation
- 1996-12-19 DK DK96942433T patent/DK0876362T3/da active
- 1996-12-19 ES ES96942433T patent/ES2202490T3/es not_active Expired - Lifetime
- 1996-12-19 DE DE69630145T patent/DE69630145T2/de not_active Expired - Lifetime
- 1996-12-19 KR KR10-1998-0704792A patent/KR100500351B1/ko not_active Expired - Fee Related
- 1996-12-19 EP EP96942433A patent/EP0876362B1/fr not_active Expired - Lifetime
- 1996-12-19 WO PCT/FR1996/002031 patent/WO1997023473A1/fr not_active Ceased
- 1996-12-19 CA CA002238884A patent/CA2238884C/fr not_active Expired - Fee Related
- 1996-12-19 AU AU11809/97A patent/AU712597B2/en not_active Ceased
- 1996-12-19 TR TR1998/01179T patent/TR199801179T2/xx unknown
- 1996-12-19 TW TW085115683A patent/TW371659B/zh not_active IP Right Cessation
- 1996-12-19 CN CN96199168A patent/CN1103766C/zh not_active Expired - Fee Related
- 1996-12-19 PL PL96327405A patent/PL189311B1/pl not_active IP Right Cessation
- 1996-12-19 PT PT96942433T patent/PT876362E/pt unknown
- 1996-12-19 HU HU9904046A patent/HU225032B1/hu not_active IP Right Cessation
- 1996-12-20 US US08/771,751 patent/US5728849A/en not_active Expired - Lifetime
- 1996-12-20 AR ARP960105851A patent/AR005197A1/es active IP Right Grant
- 1996-12-20 IN IN2893DE1996 patent/IN186768B/en unknown
- 1996-12-20 TN TNTNSN96169A patent/TNSN96169A1/fr unknown
- 1996-12-20 MY MYPI96005421A patent/MY113934A/en unknown
- 1996-12-20 CO CO96067023A patent/CO4520184A1/es unknown
- 1996-12-21 DZ DZ960194A patent/DZ2149A1/fr active
1998
- 1998-06-05 NO NO19982580A patent/NO317358B1/no not_active IP Right Cessation
- 1998-06-11 MX MX9804688A patent/MX9804688A/es not_active IP Right Cessation
- 1998-06-19 OA OA9800087A patent/OA10700A/fr unknown
- 1998-06-22 BG BG102569A patent/BG63204B1/bg unknown
2000
- 2000-04-10 IN IN420DE2000 patent/IN188469B/en unknown
- 2000-04-10 IN IN421DE2000 patent/IN188470B/en unknown
- 2000-04-10 IN IN419DE2000 patent/IN188680B/en unknown
- 2000-12-02 UY UY24386A patent/UY24386A1/es unknown

Also Published As

Publication number	Publication date
CN1205697A (zh)	1999-01-20
UA48205C2 (uk)	2002-08-15
FR2742751A1 (fr)	1997-06-27
IN188469B (fr)	2002-09-28
OA10700A (fr)	2002-11-27
HK1017895A1 (en)	1999-12-03
CZ196198A3 (cs)	1998-09-16
ATE250593T1 (de)	2003-10-15
PL189311B1 (pl)	2005-07-29
CZ294972B6 (cs)	2005-04-13
IN188680B (fr)	2002-10-26
EP0876362B1 (fr)	2003-09-24
SK85398A3 (en)	1998-11-04
DE69630145T2 (de)	2004-07-15
DE69630145D1 (de)	2003-10-30
DZ2149A1 (fr)	2002-10-23
NO982580L (no)	1998-06-05
SK282835B6 (sk)	2002-12-03
IL124994A (en)	2000-12-06
US5728849A (en)	1998-03-17
MA26412A1 (fr)	2004-12-20
NZ324337A (en)	2000-03-27
RO116194B1 (ro)	2000-11-30
BG102569A (en)	1999-04-30
NO317358B1 (no)	2004-10-18
EA001533B1 (ru)	2001-04-23
PE25198A1 (es)	1998-05-10
PL327405A1 (en)	1998-12-07
MX9804688A (es)	1998-10-31
TR199801179T2 (xx)	1998-10-21
CN1103766C (zh)	2003-03-26
FR2742751B1 (fr)	1998-01-30
PT876362E (pt)	2004-02-27
IN186768B (fr)	2001-11-03
NO982580D0 (no)	1998-06-05
ZA9610737B (en)	1997-06-27
IN188470B (fr)	2002-09-28
JP2000502671A (ja)	2000-03-07
EA199800588A1 (ru)	1998-12-24
BR9612135A (pt)	1999-07-13
AR005197A1 (es)	1999-04-14
UY24386A1 (es)	2001-08-27
BG63204B1 (bg)	2001-06-29
TW371659B (en)	1999-10-11
KR100500351B1 (ko)	2005-12-21
HUP9904046A1 (hu)	2001-04-28
AU1180997A (en)	1997-07-17
EP0876362A1 (fr)	1998-11-11
CO4520184A1 (es)	1997-10-15
JP3953106B2 (ja)	2007-08-08
IL124994A0 (en)	1999-01-26
DK0876362T3 (da)	2004-02-02
CA2238884C (fr)	2007-02-06
TNSN96169A1 (fr)	2005-03-15
WO1997023473A1 (fr)	1997-07-03
AU712597B2 (en)	1999-11-11
HUP9904046A3 (en)	2001-08-28
HU225032B1 (en)	2006-05-29
CA2238884A1 (fr)	1997-07-03
KR19990076680A (ko)	1999-10-15
MY113934A (en)	2002-06-29

Publication	Publication Date	Title
ES2202490T3 (es)	2004-04-01	Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen.
JP3790826B2 (ja)	2006-06-28	新規なタキソイド、その製造及びそれを含有する製薬学的組成物
US5906990A (en)	1999-05-25	Taxoids, preparation thereof, and pharmaceutical compositions containing same
AU715228B2 (en)	2000-01-20	Taxoids, preparation thereof and pharmaceutical compositions containing same
US6372780B2 (en)	2002-04-16	Methods of treating cell lines expressing multidrug resistance P-glycoprotein
AU704719B2 (en)	1999-04-29	Novel taxoids,their preparation and pharmaceutical compositions containing them
AU692269B2 (en)	1998-06-04	Taxoids, preparation thereof and pharmaceutical compositions containing them
MXPA97007427A (en)	1998-02-01	New taxoids, its preparation and the pharmaceutical compositions that contain them
KR19980703520A (ko)	1998-11-05	신규 탁소이드, 이의 제조방법 및 이를 함유하는 약학조성물
RU2144920C1 (ru)	2000-01-27	Таксоиды, способ их получения и фармацевтическая композиция на их основе
US5968931A (en)	1999-10-19	Taxoids, preparation thereof and pharmaceutical compositions containing same
JPH10500981A (ja)	1998-01-27	新規のタキソイド類、それらの製造、およびそれらを含む製薬学的組成物
HK1017895B (en)	2003-08-29	Novel taxoids, preparation thereof and pharmaceutical compositions containing same