ES2211073T3 - Procedimiento de molienda utilizando la energia de un fluido y aparato asociado. - Google Patents
Procedimiento de molienda utilizando la energia de un fluido y aparato asociado.Info
- Publication number
- ES2211073T3 ES2211073T3 ES99918105T ES99918105T ES2211073T3 ES 2211073 T3 ES2211073 T3 ES 2211073T3 ES 99918105 T ES99918105 T ES 99918105T ES 99918105 T ES99918105 T ES 99918105T ES 2211073 T3 ES2211073 T3 ES 2211073T3
- Authority
- ES
- Spain
- Prior art keywords
- compressed air
- procedure
- air
- humidity
- grinding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 33
- 238000000227 grinding Methods 0.000 title claims description 27
- 239000012530 fluid Substances 0.000 title claims description 15
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 3
- 239000011236 particulate material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- 238000009795 derivation Methods 0.000 claims 1
- 239000003897 fog Substances 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 8
- 150000004683 dihydrates Chemical class 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000002674 ointment Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940088679 drug related substance Drugs 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 238000003109 Karl Fischer titration Methods 0.000 description 1
- ARLZGEXVMUDUQZ-UHFFFAOYSA-N O.O.[Ca] Chemical compound O.O.[Ca] ARLZGEXVMUDUQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229940028420 bactroban Drugs 0.000 description 1
- 229940055248 bactroban nasal product Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004807 desolvation Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- -1 glycerin ester Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229960003128 mupirocin Drugs 0.000 description 1
- 229930187697 mupirocin Natural products 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C25/00—Control arrangements specially adapted for crushing or disintegrating
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Disintegrating Or Milling (AREA)
- Crushing And Grinding (AREA)
- Medicines Containing Plant Substances (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9808470 | 1998-04-22 | ||
| GBGB9808470.0A GB9808470D0 (en) | 1998-04-22 | 1998-04-22 | Novel process and apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2211073T3 true ES2211073T3 (es) | 2004-07-01 |
Family
ID=10830710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99918105T Expired - Lifetime ES2211073T3 (es) | 1998-04-22 | 1999-04-19 | Procedimiento de molienda utilizando la energia de un fluido y aparato asociado. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1073524B1 (de) |
| JP (1) | JP2002512117A (de) |
| KR (1) | KR20010042863A (de) |
| CN (1) | CN1108151C (de) |
| AR (3) | AR015000A1 (de) |
| AT (1) | ATE255466T1 (de) |
| AU (1) | AU748262B2 (de) |
| BR (1) | BR9909806A (de) |
| CA (1) | CA2329732A1 (de) |
| CO (1) | CO4820444A1 (de) |
| CZ (1) | CZ292385B6 (de) |
| DE (1) | DE69913331T2 (de) |
| ES (1) | ES2211073T3 (de) |
| GB (1) | GB9808470D0 (de) |
| HU (1) | HUP0102244A3 (de) |
| IL (1) | IL138874A0 (de) |
| NO (1) | NO20005235L (de) |
| NZ (1) | NZ507489A (de) |
| PL (1) | PL343563A1 (de) |
| TR (1) | TR200003035T2 (de) |
| TW (1) | TW558453B (de) |
| WO (1) | WO1999054048A1 (de) |
| ZA (1) | ZA200005739B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9826284D0 (en) * | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
| AR022695A1 (es) * | 1999-01-28 | 2002-09-04 | Schering Corp | PORTADOR SoLIDO PARTICULADO Y MÉTODO PARA PROVEER CONTROL DE LA PARTICULADA PARA LA DISTRIBUCIoN DE TAMANO DE PARTíCULAS Y DE CONTENIDO AMORFO CONVERTIBLE DURANTE SU PREPARACION |
| US6623760B1 (en) | 1999-01-28 | 2003-09-23 | Schering Corporation | Method of preparing particles for agglomeration |
| GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| WO2007144901A1 (en) * | 2006-06-12 | 2007-12-21 | Jubilant Organosys Limited | Process for stabilization of olanzapine polymorphic form i |
| US8235314B2 (en) * | 2009-02-12 | 2012-08-07 | Linde Aktiengesellschaft | Nonequilibrium humidity control for jet milling |
| JO3510B1 (ar) | 2011-03-04 | 2020-07-05 | Heptares Therapeutics Ltd | استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب |
| DE102012215511A1 (de) | 2012-08-31 | 2014-06-12 | Schülke & Mayr GmbH | Verfahren zur Herstellung einer Bispyridiniumalkan enthaltenden halbfesten Zubereitung |
| JP6454323B2 (ja) | 2013-03-15 | 2019-01-16 | パール セラピューティクス，インコーポレイテッド | 粒子状結晶性材料のコンディショニングのための方法及びシステム |
| HRP20260435T1 (hr) | 2014-09-09 | 2026-05-08 | Vectura Limited | Formulacija koja sadrži glikopirolat, postupak i uređaj |
| EP3346990B1 (de) | 2015-09-09 | 2020-03-18 | Vectura Limited | Verfahren zur strahlmahlung |
| US10967345B2 (en) | 2016-04-18 | 2021-04-06 | Premex S.A.S. | Multiple modular system for the formation of particles in powder and microcapsule form for different processes |
| CN115737610B (zh) * | 2021-12-13 | 2024-02-27 | 苏州欧米尼医药有限公司 | 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2704635A (en) * | 1951-06-02 | 1955-03-22 | Conrad M Trost | Pulverizing mill having opposed jets and circulatory classification |
| GB8415579D0 (en) * | 1984-06-19 | 1984-07-25 | Beecham Group Plc | Compounds |
| GB8530796D0 (en) | 1985-12-13 | 1986-01-22 | Beecham Group Plc | Pharmaceutical composition |
| IE59628B1 (en) | 1986-06-26 | 1994-03-09 | Beecham Group Plc | Treatment of fungal infections |
| JPH02251535A (ja) * | 1989-03-27 | 1990-10-09 | Asahi Chem Ind Co Ltd | ポリ―β―アラニン共重合体の微粉化法 |
| KR100374462B1 (ko) | 1993-10-22 | 2003-06-09 | 스미스클라인 비참 코포레이션 | 신규조성물 |
| US5711489A (en) * | 1994-08-18 | 1998-01-27 | Nihon Parkerizing Co., Ltd. | Electrostatic powder coating method and apparatus |
| JP2001504091A (ja) | 1996-10-01 | 2001-03-27 | スミスクライン・ビーチャム・コーポレイション | 病原性生物による鼻咽腔のコロニー形成に関連する細菌感染の治療のための薬剤の製造のためのミュピロシンの使用 |
-
1998
- 1998-04-22 GB GBGB9808470.0A patent/GB9808470D0/en not_active Ceased
-
1999
- 1999-04-19 EP EP99918105A patent/EP1073524B1/de not_active Expired - Lifetime
- 1999-04-19 NZ NZ507489A patent/NZ507489A/xx unknown
- 1999-04-19 ES ES99918105T patent/ES2211073T3/es not_active Expired - Lifetime
- 1999-04-19 IL IL13887499A patent/IL138874A0/xx unknown
- 1999-04-19 CA CA002329732A patent/CA2329732A1/en not_active Abandoned
- 1999-04-19 CZ CZ20003895A patent/CZ292385B6/cs not_active IP Right Cessation
- 1999-04-19 AT AT99918105T patent/ATE255466T1/de not_active IP Right Cessation
- 1999-04-19 JP JP2000544437A patent/JP2002512117A/ja active Pending
- 1999-04-19 WO PCT/GB1999/001189 patent/WO1999054048A1/en not_active Ceased
- 1999-04-19 PL PL99343563A patent/PL343563A1/xx unknown
- 1999-04-19 KR KR1020007011637A patent/KR20010042863A/ko not_active Withdrawn
- 1999-04-19 CN CN99805243A patent/CN1108151C/zh not_active Expired - Fee Related
- 1999-04-19 AR ARP990101808A patent/AR015000A1/es not_active Application Discontinuation
- 1999-04-19 HU HU0102244A patent/HUP0102244A3/hu unknown
- 1999-04-19 BR BR9909806-7A patent/BR9909806A/pt not_active IP Right Cessation
- 1999-04-19 AU AU36149/99A patent/AU748262B2/en not_active Ceased
- 1999-04-19 DE DE1999613331 patent/DE69913331T2/de not_active Expired - Fee Related
- 1999-04-19 TR TR2000/03035T patent/TR200003035T2/xx unknown
- 1999-04-20 CO CO99023658A patent/CO4820444A1/es unknown
- 1999-04-23 TW TW088106573A patent/TW558453B/zh active
-
2000
- 2000-03-08 AR ARP000101027A patent/AR022869A2/es unknown
- 2000-03-08 AR ARP000101026A patent/AR022868A2/es not_active Application Discontinuation
- 2000-10-17 ZA ZA200005739A patent/ZA200005739B/xx unknown
- 2000-10-18 NO NO20005235A patent/NO20005235L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073524B1 (de) | 2003-12-03 |
| AU3614999A (en) | 1999-11-08 |
| CZ292385B6 (cs) | 2003-09-17 |
| HK1034216A1 (en) | 2001-10-19 |
| HUP0102244A2 (hu) | 2001-10-28 |
| GB9808470D0 (en) | 1998-06-17 |
| AU748262B2 (en) | 2002-05-30 |
| WO1999054048A1 (en) | 1999-10-28 |
| CA2329732A1 (en) | 1999-10-28 |
| CN1297378A (zh) | 2001-05-30 |
| KR20010042863A (ko) | 2001-05-25 |
| NO20005235D0 (no) | 2000-10-18 |
| BR9909806A (pt) | 2000-12-26 |
| CO4820444A1 (es) | 1999-07-28 |
| AR015000A1 (es) | 2001-04-11 |
| PL343563A1 (en) | 2001-08-27 |
| JP2002512117A (ja) | 2002-04-23 |
| DE69913331T2 (de) | 2004-11-18 |
| NZ507489A (en) | 2003-06-30 |
| AR022868A2 (es) | 2002-09-04 |
| CN1108151C (zh) | 2003-05-14 |
| AR022869A2 (es) | 2002-09-04 |
| TR200003035T2 (tr) | 2001-02-21 |
| HUP0102244A3 (en) | 2002-08-28 |
| CZ20003895A3 (cs) | 2001-08-15 |
| IL138874A0 (en) | 2001-11-25 |
| ATE255466T1 (de) | 2003-12-15 |
| NO20005235L (no) | 2000-10-18 |
| DE69913331D1 (de) | 2004-01-15 |
| TW558453B (en) | 2003-10-21 |
| EP1073524A1 (de) | 2001-02-07 |
| ZA200005739B (en) | 2002-03-25 |
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