ES2237425T3 - Uso de glucosaminoglicanos en el tratamiento de la demencia senil. - Google Patents

Uso de glucosaminoglicanos en el tratamiento de la demencia senil.

Info

Publication number: ES2237425T3
Authority: ES; Spain
Prior art keywords: glycosaminoglycans; molecular weight; treatment; heparin; solution
Prior art date: 1999-05-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES00925281T

Other languages

English (en)

Spanish (es)

Inventor

Umberto Cornelli

Luigi De Ambrosi

Israel Hanin

Jawed Fareed

John Lee

Stanley Lorens

Ronald F. Mervis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-14

Filing date

2000-05-12

Publication date

2005-08-01

2000-05-12 Application filed by Individual filed Critical Individual

2005-08-01 Application granted granted Critical

2005-08-01 Publication of ES2237425T3 publication Critical patent/ES2237425T3/es

2020-05-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Materials Engineering (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Polymers & Plastics (AREA)
Neurology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Separation Using Semi-Permeable Membranes (AREA)

ES00925281T 1999-05-14 2000-05-12 Uso de glucosaminoglicanos en el tratamiento de la demencia senil. Expired - Lifetime ES2237425T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI991066		1999-05-14
IT1999MI001066A IT1312107B1 (it)	1999-05-14	1999-05-14	Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile

Publications (1)

Publication Number	Publication Date
ES2237425T3 true ES2237425T3 (es)	2005-08-01

Family

ID=11382970

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES00925281T Expired - Lifetime ES2237425T3 (es)	1999-05-14	2000-05-12	Uso de glucosaminoglicanos en el tratamiento de la demencia senil.

Country Status (22)

Country	Link
US (1)	US6979680B1 (de)
EP (1)	EP1181024B1 (de)
JP (1)	JP2002544233A (de)
KR (1)	KR100711142B1 (de)
CN (1)	CN1178667C (de)
AT (1)	ATE288761T1 (de)
AU (1)	AU764743C (de)
CA (1)	CA2373975A1 (de)
CZ (1)	CZ20014092A3 (de)
DE (1)	DE60018061T2 (de)
DK (1)	DK1181024T3 (de)
ES (1)	ES2237425T3 (de)
HK (1)	HK1039903B (de)
HU (1)	HUP0201100A3 (de)
IL (1)	IL146458A0 (de)
IT (1)	IT1312107B1 (de)
NO (1)	NO328902B1 (de)
PL (1)	PL198016B1 (de)
PT (1)	PT1181024E (de)
RU (1)	RU2248800C2 (de)
WO (1)	WO2000069444A1 (de)
ZA (1)	ZA200109331B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1344781A1 (de) *	2002-03-12	2003-09-17	Laboratori Derivati Organici S.P.A.	Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte
ITMI20031023A1 (it)	2003-05-21	2004-11-22	Umberto Cornelli	Glicosaminoglicani aventi peso molecolare medio 2400 d atti al trattamento delle disfunzioni emozionali.
EP1524276A1 (de) *	2003-10-16	2005-04-20	Laboratori Derivati Organici S.P.A.	Mehrstufenverfahren für die physikalisische Depolymerisation von Heparin und die so erhaltenen Produkte
US7939512B2 (en)	2004-10-13	2011-05-10	Laboratori Derivati Organici Spa	Multistep process for the physical depolymerization of heparin and products obtained therefrom
EP1968561B8 (de)	2005-12-22	2010-10-20	Kiacta Sàrl	Behandlung von diabetischer nephropathie
WO2009007224A1 (en) *	2007-07-10	2009-01-15	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Low molecular weight heparin derivatives having neuroprotective activity
EP2283711B1 (de)	2008-05-22	2018-07-11	Vladimir Yegorovich Balakin	Beschleunigungsvorrichtung für strahlen geladener teilchen als teil eines krebstherapiesystems mit geladenen teilchen
WO2010101489A1 (en)	2009-03-04	2010-09-10	Zakrytoe Aktsionernoe Obshchestvo Protom	Multi-field charged particle cancer therapy method and apparatus
EP2283705B1 (de)	2008-05-22	2017-12-13	Vladimir Yegorovich Balakin	Vorrichtung zur extraktion eines strahls geladener teilchen zur verwendung in verbindung mit einem krebstherapiesystem mit geladenen teilchen
US8896239B2 (en)	2008-05-22	2014-11-25	Vladimir Yegorovich Balakin	Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system
WO2009142549A2 (en)	2008-05-22	2009-11-26	Vladimir Yegorovich Balakin	Multi-axis charged particle cancer therapy method and apparatus
WO2009142546A2 (en)	2008-05-22	2009-11-26	Vladimir Yegorovich Balakin	Multi-field charged particle cancer therapy method and apparatus
US8609097B2 (en) *	2009-06-10	2013-12-17	Hoffmann-La Roche Inc.	Use of an anti-Tau pS422 antibody for the treatment of brain diseases
CA2851761C (en) *	2011-10-14	2021-06-15	Centre National De La Recherche Scientifique	Method of diagnosis, prognostic or treatment of neurodegenerative diseases
CN112426434A (zh) *	2020-11-04	2021-03-02	山东大学	硫酸乙酰肝素在防治阿尔兹海默症中的应用
CN114478816A (zh) *	2022-02-11	2022-05-13	上海兴糖生物技术有限公司	一种白玉蜗牛多糖及其制备方法和用途

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
US4351938A (en) *	1980-05-19	1982-09-28	Riker Laboratories, Inc.	Anticoagulant substance
US4847338A (en) *	1985-03-28	1989-07-11	University Of Iowa Research Foundation	Low molecular weight heparin fragments as inhibitors of complement activation
EP0243974B1 (de) *	1986-05-01	1994-03-02	Toppan Printing Co., Ltd.	Vorrichtung zur Simulation der Einstellung eines Abtasters
IT1213384B (it) *	1986-11-24	1989-12-20	Lab Derivati Organici Mediolan	Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
IT1205042B (it) *	1987-05-28	1989-03-10	Crinos Industria Farmaco	Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer
EP0337327A1 (de) *	1988-04-09	1989-10-18	Bioiberica, S.A.	Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
IT1240615B (it)	1990-04-03	1993-12-17	Mediolanum Farmaceutici Spa	Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
IL100555A (en) *	1991-02-07	2000-08-31	Hoechst Marion Roussel Inc	N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
CA2067614C (en) *	1991-05-02	2002-07-30	Eiichi Otomo	Agent for improving dementia
RU2106864C1 (ru) *	1995-10-23	1998-03-20	Николай Серафимович Зефиров	Средство для лечения болезни альцгеймера

1999
- 1999-05-14 IT IT1999MI001066A patent/IT1312107B1/it active
2000
- 2000-05-12 DE DE60018061T patent/DE60018061T2/de not_active Expired - Fee Related
- 2000-05-12 RU RU2001130882/14A patent/RU2248800C2/ru not_active IP Right Cessation
- 2000-05-12 CA CA002373975A patent/CA2373975A1/en not_active Abandoned
- 2000-05-12 PL PL352070A patent/PL198016B1/pl not_active IP Right Cessation
- 2000-05-12 AT AT00925281T patent/ATE288761T1/de not_active IP Right Cessation
- 2000-05-12 AU AU44052/00A patent/AU764743C/en not_active Ceased
- 2000-05-12 HK HK02101550.8A patent/HK1039903B/en not_active IP Right Cessation
- 2000-05-12 US US10/048,542 patent/US6979680B1/en not_active Expired - Fee Related
- 2000-05-12 KR KR1020017014505A patent/KR100711142B1/ko not_active Expired - Fee Related
- 2000-05-12 IL IL14645800A patent/IL146458A0/xx not_active IP Right Cessation
- 2000-05-12 JP JP2000617903A patent/JP2002544233A/ja active Pending
- 2000-05-12 CZ CZ20014092A patent/CZ20014092A3/cs unknown
- 2000-05-12 ES ES00925281T patent/ES2237425T3/es not_active Expired - Lifetime
- 2000-05-12 WO PCT/EP2000/004311 patent/WO2000069444A1/en not_active Ceased
- 2000-05-12 PT PT00925281T patent/PT1181024E/pt unknown
- 2000-05-12 DK DK00925281T patent/DK1181024T3/da active
- 2000-05-12 CN CNB00807562XA patent/CN1178667C/zh not_active Expired - Fee Related
- 2000-05-12 EP EP00925281A patent/EP1181024B1/de not_active Expired - Lifetime
- 2000-05-12 HU HU0201100A patent/HUP0201100A3/hu unknown
2001
- 2001-11-13 ZA ZA200109331A patent/ZA200109331B/xx unknown
- 2001-11-13 NO NO20015544A patent/NO328902B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT1312107B1 (it)	2002-04-04
DK1181024T3 (da)	2005-06-13
DE60018061D1 (de)	2005-03-17
HUP0201100A2 (hu)	2002-07-29
JP2002544233A (ja)	2002-12-24
HK1039903A1 (en)	2002-05-17
NO20015544L (no)	2002-01-14
EP1181024A1 (de)	2002-02-27
AU764743C (en)	2004-03-18
KR20020005033A (ko)	2002-01-16
DE60018061T2 (de)	2006-04-13
CZ20014092A3 (cs)	2002-04-17
PL352070A1 (en)	2003-07-28
US6979680B1 (en)	2005-12-27
ZA200109331B (en)	2002-08-28
IL146458A0 (en)	2002-07-25
NO20015544D0 (no)	2001-11-13
WO2000069444A1 (en)	2000-11-23
KR100711142B1 (ko)	2007-04-24
HK1039903B (en)	2005-08-26
CN1350459A (zh)	2002-05-22
ATE288761T1 (de)	2005-02-15
EP1181024B1 (de)	2005-02-09
HUP0201100A3 (en)	2003-03-28
AU4405200A (en)	2000-12-05
PL198016B1 (pl)	2008-05-30
CN1178667C (zh)	2004-12-08
AU764743B2 (en)	2003-08-28
PT1181024E (pt)	2005-06-30
ITMI991066A1 (it)	2000-11-14
NO328902B1 (no)	2010-06-14
RU2248800C2 (ru)	2005-03-27
CA2373975A1 (en)	2000-11-23

Publication	Publication Date	Title
ES2237425T3 (es)	2005-08-01	Uso de glucosaminoglicanos en el tratamiento de la demencia senil.
Plant et al.	2001	Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interface
US5605891A (en)	1997-02-25	Use of polysaccharides in acute peripheral neuropathies
JPS6214271B2 (de)	1987-04-01
JPS63213502A (ja)	1988-09-06	低分子量グルコサミノグルカンの制御製造方法
ES2205114T3 (es)	2004-05-01	Fucanos con bajo peso molecular que tienen actividad anticoagulante, antitrombinica y antitrombotica.
CN1794999B (zh)	2010-05-26	神经损伤治疗剂
JPS62174027A (ja)	1987-07-30	改良されたキモパパイン及び製薬学的組成物
AP619A (en)	1997-10-10	Use of hyaluronic acid or salt for the treatment of a human having a stroke or myocardial infarction.
CZ284739B6 (cs)	1999-02-17	Diagnostický prostředek pro vyšetření ledvin
ES2734182T3 (es)	2019-12-04	Acido polisiálico y su uso para el tratamiento de enfermedades neurodegenerativas y neuroinflamatorias
US20220380331A1 (en)	2022-12-01	Treatment of conditions of the nervous system
KR100531721B1 (ko)	2005-11-28	중추 신경계 외상 예방과 치료를 위한 저분자량 헤파린의사용
JP2002502387A (ja)	2002-01-22	脳水腫の予防及び処置のための低−分子量ヘパリンの使用
EP0065395A2 (de)	1982-11-24	Chymopapain und Verfahren zu seiner Herstellung und Verwendung
CN108601800B (zh)	2022-04-12	肌肉损伤的预防或治疗剂
EA046226B1 (ru)	2024-02-19	Применение фармацевтической композиции в качестве лекарственного средства для защиты и/или репарации/восстановления гематоэнцефалического барьера
Krzywkowski	2007	Céline Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, and Barry D. Greenberg
CA2219683A1 (en)	1999-04-28	Immunological composition and its method of use to transiently disrupt mammalian central nervous system myelin to promote neuronal regeneration