ES2237804T3 - Cemento oseo y su procedimiento de preparacion. - Google Patents

Cemento oseo y su procedimiento de preparacion.

Info

Publication number: ES2237804T3
Authority: ES; Spain
Prior art keywords: solution; polymerization; monomer; liquid; polymer
Prior art date: 1996-12-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES97947639T

Other languages

English (en)

Spanish (es)

Inventor

Eugene P. Lautenschlager

Jeremy L. Gilbert

Peter Monaghan

Steven J. Duray

Richard L. Wixson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Northwestern University

Original Assignee

Northwestern University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-02

Filing date

1997-11-26

Publication date

2005-08-01

1997-11-26 Application filed by Northwestern University filed Critical Northwestern University

2005-08-01 Application granted granted Critical

2005-08-01 Publication of ES2237804T3 publication Critical patent/ES2237804T3/es

2017-11-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002639 bone cement Substances 0.000 title claims abstract description 27
238000000034 method Methods 0.000 title claims description 29
238000002360 preparation method Methods 0.000 title claims description 5
239000000178 monomer Substances 0.000 claims abstract description 96
239000007788 liquid Substances 0.000 claims abstract description 87
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 75
238000006116 polymerization reaction Methods 0.000 claims abstract description 62
239000012190 activator Substances 0.000 claims abstract description 35
239000004568 cement Substances 0.000 claims abstract description 30
239000000203 mixture Substances 0.000 claims abstract description 30
239000003999 initiator Substances 0.000 claims abstract description 24
238000004132 cross linking Methods 0.000 claims abstract description 22
239000003112 inhibitor Substances 0.000 claims abstract description 22
229920001577 copolymer Polymers 0.000 claims abstract description 11
239000006193 liquid solution Substances 0.000 claims abstract description 11
229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 67
239000004926 polymethyl methacrylate Substances 0.000 claims description 67
229920000642 polymer Polymers 0.000 claims description 66
QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 46
239000004342 Benzoyl peroxide Substances 0.000 claims description 46
235000019400 benzoyl peroxide Nutrition 0.000 claims description 46
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 14
239000003505 polymerization initiator Substances 0.000 claims description 14
239000004971 Cross linker Substances 0.000 claims description 12
229920005684 linear copolymer Polymers 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 7
239000002245 particle Substances 0.000 claims description 7
238000004090 dissolution Methods 0.000 claims description 6
239000003605 opacifier Substances 0.000 claims description 6
210000000988 bone and bone Anatomy 0.000 claims description 5
125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 claims description 4
239000011541 reaction mixture Substances 0.000 claims description 4
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 3
230000009969 flowable effect Effects 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
GYVGXEWAOAAJEU-UHFFFAOYSA-N n,n,4-trimethylaniline Chemical compound CN(C)C1=CC=C(C)C=C1 GYVGXEWAOAAJEU-UHFFFAOYSA-N 0.000 claims 3
238000012423 maintenance Methods 0.000 claims 2
230000002829 reductive effect Effects 0.000 abstract description 5
230000000399 orthopedic effect Effects 0.000 abstract description 4
229920006037 cross link polymer Polymers 0.000 abstract 1
239000012763 reinforcing filler Substances 0.000 abstract 1
239000000243 solution Substances 0.000 description 102
150000001412 amines Chemical class 0.000 description 41
RINWGRJHXCCLOV-UHFFFAOYSA-N BPO Chemical compound BPO RINWGRJHXCCLOV-UHFFFAOYSA-N 0.000 description 32
239000000843 powder Substances 0.000 description 20
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 15
239000000499 gel Substances 0.000 description 13
230000008602 contraction Effects 0.000 description 9
230000003068 static effect Effects 0.000 description 9
BHIWKHZACMWKOJ-UHFFFAOYSA-N methyl isobutyrate Chemical compound COC(=O)C(C)C BHIWKHZACMWKOJ-UHFFFAOYSA-N 0.000 description 8
230000000694 effects Effects 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
230000002269 spontaneous effect Effects 0.000 description 6
238000001356 surgical procedure Methods 0.000 description 6
150000003512 tertiary amines Chemical class 0.000 description 6
238000002474 experimental method Methods 0.000 description 5
239000000463 material Substances 0.000 description 5
230000036961 partial effect Effects 0.000 description 5
150000003254 radicals Chemical group 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 4
238000002513 implantation Methods 0.000 description 4
WDAXFOBOLVPGLV-UHFFFAOYSA-N isobutyric acid ethyl ester Natural products CCOC(=O)C(C)C WDAXFOBOLVPGLV-UHFFFAOYSA-N 0.000 description 4
238000007792 addition Methods 0.000 description 3
239000000853 adhesive Substances 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
239000000470 constituent Substances 0.000 description 3
239000000428 dust Substances 0.000 description 3
239000007943 implant Substances 0.000 description 3
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
239000003431 cross linking reagent Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
239000005548 dental material Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
239000011259 mixed solution Substances 0.000 description 2
235000015927 pasta Nutrition 0.000 description 2
239000011049 pearl Substances 0.000 description 2
150000002978 peroxides Chemical class 0.000 description 2
239000006187 pill Substances 0.000 description 2
230000005855 radiation Effects 0.000 description 2
230000003014 reinforcing effect Effects 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 1
DFPOZTRSOAQFIK-UHFFFAOYSA-N S,S-dimethyl-beta-propiothetin Chemical compound C[S+](C)CCC([O-])=O DFPOZTRSOAQFIK-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
238000012644 addition polymerization Methods 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
230000000712 assembly Effects 0.000 description 1
238000000429 assembly Methods 0.000 description 1
229910052788 barium Inorganic materials 0.000 description 1
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
239000011324 bead Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
238000009529 body temperature measurement Methods 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
238000012669 compression test Methods 0.000 description 1
239000002978 dental impression material Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000006073 displacement reaction Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
150000002118 epoxides Chemical class 0.000 description 1
229920006335 epoxy glue Polymers 0.000 description 1
239000006260 foam Substances 0.000 description 1
239000000446 fuel Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000011256 inorganic filler Substances 0.000 description 1
229910003475 inorganic filler Inorganic materials 0.000 description 1
238000005259 measurement Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
239000004482 other powder Substances 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
-1 polyethylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
239000012744 reinforcing agent Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000012549 training Methods 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/17—Amines; Quaternary ammonium compounds
- C08K5/18—Amines; Quaternary ammonium compounds with aromatically bound amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S522/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S522/902—Air inhibition

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Surgery (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Materials For Medical Uses (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)

ES97947639T 1996-12-02 1997-11-26 Cemento oseo y su procedimiento de preparacion. Expired - Lifetime ES2237804T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/758,680 US5902839A (en)	1996-12-02	1996-12-02	Bone cement and method of preparation
US758680		1996-12-02

Publications (1)

Publication Number	Publication Date
ES2237804T3 true ES2237804T3 (es)	2005-08-01

Family

ID=25052683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES97947639T Expired - Lifetime ES2237804T3 (es)	1996-12-02	1997-11-26	Cemento oseo y su procedimiento de preparacion.

Country Status (8)

Country	Link
US (1)	US5902839A (fr)
EP (1)	EP0971677B1 (fr)
AT (1)	ATE288286T1 (fr)
CA (1)	CA2284925A1 (fr)
DE (1)	DE69732431T2 (fr)
ES (1)	ES2237804T3 (fr)
PT (1)	PT971677E (fr)
WO (1)	WO1998024398A1 (fr)

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1996
- 1996-12-02 US US08/758,680 patent/US5902839A/en not_active Expired - Lifetime
1997
- 1997-11-26 ES ES97947639T patent/ES2237804T3/es not_active Expired - Lifetime
- 1997-11-26 EP EP97947639A patent/EP0971677B1/fr not_active Expired - Lifetime
- 1997-11-26 PT PT97947639T patent/PT971677E/pt unknown
- 1997-11-26 CA CA002284925A patent/CA2284925A1/fr not_active Abandoned
- 1997-11-26 AT AT97947639T patent/ATE288286T1/de not_active IP Right Cessation
- 1997-11-26 WO PCT/US1997/021866 patent/WO1998024398A1/fr not_active Ceased
- 1997-11-26 DE DE69732431T patent/DE69732431T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT971677E (pt)	2005-04-29
DE69732431D1 (de)	2005-03-10
EP0971677A4 (fr)	2002-05-08
EP0971677A1 (fr)	2000-01-19
ATE288286T1 (de)	2005-02-15
EP0971677B1 (fr)	2005-02-02
US5902839A (en)	1999-05-11
WO1998024398A1 (fr)	1998-06-11
DE69732431T2 (de)	2006-01-12
CA2284925A1 (fr)	1998-06-11

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