ES2244048T3 - Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis. - Google Patents

Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis.

Info

Publication number: ES2244048T3
Authority: ES; Spain
Prior art keywords: imino; glucitol; dideoxy; hepatitis; compounds
Prior art date: 1997-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES98906475T

Other languages

English (en)

Spanish (es)

Inventor

Gary S. Jacob

Timothy M. Block

Raymond A. Dwek

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-14

Filing date

1998-02-12

Publication date

2005-12-01

1998-02-12 Application filed by GD Searle LLC filed Critical GD Searle LLC

2005-12-01 Application granted granted Critical

2005-12-01 Publication of ES2244048T3 publication Critical patent/ES2244048T3/es

2018-02-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES98906475T 1997-02-14 1998-02-12 Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis. Expired - Lifetime ES2244048T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4122197P	1997-02-14	1997-02-14
US41221P		1997-02-14

Publications (1)

Publication Number	Publication Date
ES2244048T3 true ES2244048T3 (es)	2005-12-01

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ID=21915395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES98906475T Expired - Lifetime ES2244048T3 (es)	1997-02-14	1998-02-12	Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis.

Country Status (8)

Country	Link
EP (1)	EP1007058B1 (de)
JP (1)	JP2001512462A (de)
CN (1)	CN100382804C (de)
AT (1)	ATE295732T1 (de)
AU (1)	AU6169298A (de)
DE (1)	DE69830241T2 (de)
ES (1)	ES2244048T3 (de)
WO (1)	WO1998035685A1 (de)

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* Cited by examiner, † Cited by third party
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US20030100532A1 (en)	1997-02-14	2003-05-29	Gary S. Jacob	Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
PT1030839E (pt)	1997-11-10	2004-05-31	Searle & Co	Utilizacao de iminoacucares para tratar a resistencia a multifarmacos
US6465488B1 (en)	1997-12-11	2002-10-15	Chancellor, Masters & Scholars Of The University Of Oxford	Inhibition of glycolipid biosynthesis
KR20010033028A (ko)	1997-12-11	2001-04-25	더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드	막-관련 바이러스 복제의 억제
EP1714676A3 (de) *	1998-02-12	2006-11-15	G.D. Searle LLC.	N-substituierte 1,5-dideoxy-1,5-imino-D-glucitol Verbindungen für die Therapie von Hepatitis Virus Infektionen
DE69932154T2 (de) *	1998-02-12	2007-05-31	G.D. Searle Llc, Chicago	Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen
US6689759B1 (en)	1998-02-12	2004-02-10	G. D. Searle & Co.	Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1658846B1 (de) *	1999-02-12	2008-07-30	United Therapeutics Corporation	N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen
JP2003505501A (ja)	1999-02-12	2003-02-12	ジー・ディー・サール・アンド・カンパニー	肝炎ウィルス感染の処置のためのグルカミン化合物
ATE402701T1 (de) *	1999-02-12	2008-08-15	United Therapeutics Corp	N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen
ES2302697T3 (es)	1999-08-10	2008-08-01	The Chancellor, Masters And Scholars Of The University Of Oxford	Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
US7256005B2 (en)	1999-08-10	2007-08-14	The Chancellor, Masters And Scholars Of The University Of Oxford	Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
JP2003522791A (ja) *	2000-02-14	2003-07-29	ファルマシアコーポレイション	肝炎ウイルス感染症治療用ｎ‐置換‐１，５‐ジデオキシ‐１，５‐イミノ‐ｄ‐グルシトール化合物の使用
CN1694696A (zh) *	2002-09-23	2005-11-09	牛津大学校委会	亚氨基糖衍生物在抑制离子通道活性中的应用
CA3112326A1 (en)	2018-09-12	2020-03-19	Novartis Ag	Antiviral pyridopyrazinedione compounds
KR20250127350A (ko)	2019-09-26	2025-08-26	노파르티스 아게	항바이러스성 피라졸로피리디논 화합물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995006061A1 (en) *	1993-08-20	1995-03-02	G.D. Searle & Co.	Retroviral protease inhibitors and combinations thereof

1998
- 1998-02-12 EP EP98906475A patent/EP1007058B1/de not_active Expired - Lifetime
- 1998-02-12 AT AT98906475T patent/ATE295732T1/de not_active IP Right Cessation
- 1998-02-12 AU AU61692/98A patent/AU6169298A/en not_active Abandoned
- 1998-02-12 JP JP53598798A patent/JP2001512462A/ja active Pending
- 1998-02-12 DE DE69830241T patent/DE69830241T2/de not_active Expired - Lifetime
- 1998-02-12 ES ES98906475T patent/ES2244048T3/es not_active Expired - Lifetime
- 1998-02-12 CN CNB988039427A patent/CN100382804C/zh not_active Expired - Fee Related
- 1998-02-12 WO PCT/US1998/003004 patent/WO1998035685A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69830241D1 (de)	2005-06-23
EP1007058A1 (de)	2000-06-14
DE69830241T2 (de)	2006-01-26
ATE295732T1 (de)	2005-06-15
WO1998035685A1 (en)	1998-08-20
HK1027509A1 (en)	2001-01-19
JP2001512462A (ja)	2001-08-21
EP1007058B1 (de)	2005-05-18
AU6169298A (en)	1998-09-08
CN1251993A (zh)	2000-05-03
CN100382804C (zh)	2008-04-23

Publication	Publication Date	Title
ES2272054T3 (es)	2007-04-16	Uso de compuestos de n-sustituido-1,5-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
ES2244048T3 (es)	2005-12-01	Uso de compuestos (n)-sustituidos-1,5-didesoxi-1,5-imino-d-glucitol en terapia de combinacion para el tratamiento de infecciones con virus de hepatitis.
ES2649410T3 (es)	2018-01-11	Agentes antivirales para la hepatitis B
US7816560B1 (en)	2010-10-19	Long chain n-alkyl compounds and oxa-derivatives thereof
US6689759B1 (en)	2004-02-10	Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ES2311921T3 (es)	2009-02-16	N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
US20110171174A1 (en)	2011-07-14	Synergistic Combinations of a Macrocyclic Inhibitor of HCV and a Nucleoside
BR112021000938A2 (pt)	2021-04-27	composto sal farmaceuticamente aceitável, tautômero, isômero ou estereoisômero do mesmo, composição farmacêutica e processo para a síntese do dito composto
ES2325088T3 (es)	2009-08-25	Compuestos utiles en el tratamiento de hiv.
US20050119310A1 (en)	2005-06-02	Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US7612093B2 (en)	2009-11-03	Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy
PT1382343E (pt)	2010-03-10	Terapia de combinação para tratamento do vírus da hepatite b
JP2008526713A (ja)	2008-07-24	Ｈｉｖの治療に有用な化合物
JP2008526713A5 (de)	2009-04-09
EP1714676A2 (de)	2006-10-25	N-substituierte 1,5-dideoxy-1,5-imino-D-glucitol Verbindungen für die Therapie von Hepatitis Virus Infektionen
HK1027509B (en)	2008-10-31	Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in manueacturing a medicament for treating hepatitis virus infections
WO2010151672A2 (en)	2010-12-29	Amino acid derived ureas