ES2244617T3 - Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados. - Google Patents

Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados.

Info

Publication number
ES2244617T3
ES2244617T3 ES01930419T ES01930419T ES2244617T3 ES 2244617 T3 ES2244617 T3 ES 2244617T3 ES 01930419 T ES01930419 T ES 01930419T ES 01930419 T ES01930419 T ES 01930419T ES 2244617 T3 ES2244617 T3 ES 2244617T3
Authority
ES
Spain
Prior art keywords
inactivated
ssa
genes
salmonele
based vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01930419T
Other languages
English (en)
Inventor
David E Lowery
Michael J Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of ES2244617T3 publication Critical patent/ES2244617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composición de vacuna que incluye una cantidad inmunológicamente protectora de una primera bacteria de Salmonella mutante no reversivo, en el que han sido inactivados dos o más genes del aparato del sistema de secreción (ssa), caracterizado porque los genes ssa son seleccionados a partir del grupo constituido por ssaT, ssaJ, ssaC y ssaM.
ES01930419T 2000-03-17 2001-03-13 Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados. Expired - Lifetime ES2244617T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19017800P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
ES2244617T3 true ES2244617T3 (es) 2005-12-16

Family

ID=22700305

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01930419T Expired - Lifetime ES2244617T3 (es) 2000-03-17 2001-03-13 Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados.

Country Status (17)

Country Link
US (2) US6923957B2 (es)
EP (1) EP1267899B1 (es)
JP (1) JP2003527433A (es)
AR (1) AR027680A1 (es)
AT (1) ATE300949T1 (es)
AU (2) AU5695701A (es)
BR (1) BR0109322A (es)
CA (1) CA2402252A1 (es)
DE (1) DE60112413T2 (es)
DK (1) DK1267899T3 (es)
ES (1) ES2244617T3 (es)
MX (1) MXPA02008748A (es)
NZ (1) NZ521425A (es)
PE (1) PE20011180A1 (es)
PT (1) PT1267899E (es)
WO (1) WO2001070247A2 (es)
ZA (1) ZA200207002B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60112413T2 (de) * 2000-03-17 2006-06-01 Pharmacia & Upjohn Co. Llc, Kalamazoo Ssa inaktivierte salmonella impfstoffe
US8337861B2 (en) * 2003-01-09 2012-12-25 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
CN1297315C (zh) * 2004-11-25 2007-01-31 上海交通大学 抗仔猪细菌性疫病复合卵黄抗体制剂的制备方法
CA2608636C (en) * 2005-05-17 2015-02-10 Frank Koentgen Sequential cloning system
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
PL2066339T3 (pl) * 2006-09-18 2015-02-27 Univ Arkansas Kompozycje i sposoby zwiększania odpowiedzi immunologicznych
UA100370C2 (uk) * 2006-12-11 2012-12-25 Мериал Лимитед Спосіб вакцинації птахів проти salmonella
US7935355B2 (en) * 2007-04-19 2011-05-03 Nutritional Health Institute Laboratories, Llc Composition and method for controlling intestinal pathogenic organisms
US20080260777A1 (en) * 2007-04-19 2008-10-23 Sotomayor Konky Composition and method for controlling intestinal pathogenic organisms
WO2009059018A1 (en) * 2007-10-30 2009-05-07 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to flagellated bacterium
PT3097926T (pt) 2007-11-01 2020-01-08 Univ Guelph Composições e métodos de potenciação das respostas imunitárias frente a eimeria
EP2219671A4 (en) 2007-11-09 2011-02-09 Salk Inst For Biological Studi USE OF TAM RECEPTOR INHIBITORS AS IMMU ENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS
ES2643646T3 (es) 2010-01-21 2017-11-23 The Board Of Trustees Of The University Of Arkansas Vectores de vacuna y métodos para potenciar las respuestas inmunitarias
MX350306B (es) 2010-06-09 2017-09-04 Univ Arkansas Vacuna y metodos para reducir una infeccion por campylobacter.
WO2012123269A1 (en) 2011-03-11 2012-09-20 Proyecto De Biomedicina Cima, S.L. Immunogenic compositions and methods for their use
US8481052B2 (en) 2011-05-17 2013-07-09 Cj Cheiljedang Corporation Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
US20150238590A1 (en) * 2012-10-22 2015-08-27 The Board Of Regents For Oklahoma State University Use of the salmonella spp type iii secretion proteins as a protective vaccination
US10548962B2 (en) 2012-10-22 2020-02-04 The Board Of Regents For Oklahoma State University Use of the salmonella SPP type III secretion proteins as a protective vaccination
US9950053B2 (en) 2012-10-22 2018-04-24 The Board Of Regents For Oklahoma State University Use of the Salmonella SPP type III secretion proteins as a protective vaccination
AR094791A1 (es) 2013-02-14 2015-08-26 Univ Arkansas Composiciones y métodos para mejorar las respuestas inmunes ante una infección por eimeria o para limitar una infección por eimeria
AU2014239557B2 (en) 2013-03-15 2019-01-03 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to enteric pathogens
WO2016077453A1 (en) * 2014-11-11 2016-05-19 Ohio State Innovation Foundation Probiotic bacteria for the prevention and treatment of salmonella
US20170072042A1 (en) * 2015-09-16 2017-03-16 Boehringer Ingelheim Vetmedica, Inc. Salmonella choleraesuis-salmonella typhimurium vaccines
KR102767638B1 (ko) 2016-05-03 2025-02-20 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4877612A (en) 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
ATE71303T1 (de) 1986-01-14 1992-01-15 Nederlanden Staat Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung.
US4806352A (en) 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
KR100551104B1 (ko) 1994-12-09 2006-02-09 임페리얼 컬리지 이노베이션스 리미티드 유전자의 동정
DE69939264D1 (de) * 1998-09-04 2008-09-18 Emergent Product Dev Uk Ltd Attenuierte salmonella spi2 mutante als antigen-träger
NZ519477A (en) * 1999-12-23 2004-04-30 Microscience Ltd Attenuated microorganisms for the treatment of infection
DE60112413T2 (de) * 2000-03-17 2006-06-01 Pharmacia & Upjohn Co. Llc, Kalamazoo Ssa inaktivierte salmonella impfstoffe

Also Published As

Publication number Publication date
CA2402252A1 (en) 2001-09-27
DE60112413T2 (de) 2006-06-01
AU5695701A (en) 2001-10-03
NZ521425A (en) 2004-05-28
EP1267899B1 (en) 2005-08-03
MXPA02008748A (es) 2003-02-24
ZA200207002B (en) 2004-03-31
AR027680A1 (es) 2003-04-09
WO2001070247A3 (en) 2002-04-18
AU2001256957B2 (en) 2005-08-25
EP1267899A2 (en) 2003-01-02
US20040009191A1 (en) 2004-01-15
DE60112413D1 (de) 2005-09-08
WO2001070247A2 (en) 2001-09-27
ATE300949T1 (de) 2005-08-15
JP2003527433A (ja) 2003-09-16
PT1267899E (pt) 2005-11-30
DK1267899T3 (da) 2005-12-12
US20050260223A1 (en) 2005-11-24
BR0109322A (pt) 2002-12-10
PE20011180A1 (es) 2001-11-15
US6923957B2 (en) 2005-08-02

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