ES2244617T3 - Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados. - Google Patents

Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados.

Info

Publication number
ES2244617T3
ES2244617T3 ES01930419T ES01930419T ES2244617T3 ES 2244617 T3 ES2244617 T3 ES 2244617T3 ES 01930419 T ES01930419 T ES 01930419T ES 01930419 T ES01930419 T ES 01930419T ES 2244617 T3 ES2244617 T3 ES 2244617T3
Authority
ES
Spain
Prior art keywords
inactivated
ssa
genes
salmonele
based vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01930419T
Other languages
English (en)
Inventor
David E Lowery
Michael J Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of ES2244617T3 publication Critical patent/ES2244617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composición de vacuna que incluye una cantidad inmunológicamente protectora de una primera bacteria de Salmonella mutante no reversivo, en el que han sido inactivados dos o más genes del aparato del sistema de secreción (ssa), caracterizado porque los genes ssa son seleccionados a partir del grupo constituido por ssaT, ssaJ, ssaC y ssaM.
ES01930419T 2000-03-17 2001-03-13 Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados. Expired - Lifetime ES2244617T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19017800P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
ES2244617T3 true ES2244617T3 (es) 2005-12-16

Family

ID=22700305

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01930419T Expired - Lifetime ES2244617T3 (es) 2000-03-17 2001-03-13 Vacunas a base de salmonelas en las cuales los genes ssa han sido inactivados.

Country Status (17)

Country Link
US (2) US6923957B2 (es)
EP (1) EP1267899B1 (es)
JP (1) JP2003527433A (es)
AR (1) AR027680A1 (es)
AT (1) ATE300949T1 (es)
AU (2) AU5695701A (es)
BR (1) BR0109322A (es)
CA (1) CA2402252A1 (es)
DE (1) DE60112413T2 (es)
DK (1) DK1267899T3 (es)
ES (1) ES2244617T3 (es)
MX (1) MXPA02008748A (es)
NZ (1) NZ521425A (es)
PE (1) PE20011180A1 (es)
PT (1) PT1267899E (es)
WO (1) WO2001070247A2 (es)
ZA (1) ZA200207002B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0109322A (pt) * 2000-03-17 2002-12-10 Upjohn Co Materiais e métodos de vacina de salmonella
AU2004204751A1 (en) * 2003-01-09 2004-07-29 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
CN1297315C (zh) * 2004-11-25 2007-01-31 上海交通大学 抗仔猪细菌性疫病复合卵黄抗体制剂的制备方法
ATE545701T1 (de) * 2005-05-17 2012-03-15 Ozgene Pty Ltd Sequentielles klonierungssystem
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
EP2517723B1 (en) 2006-09-18 2019-11-06 The Board of Trustees of The University of Arkansas Compositions and methods of enhancing immune responses
UA100370C2 (uk) * 2006-12-11 2012-12-25 Мериал Лимитед Спосіб вакцинації птахів проти salmonella
US7935355B2 (en) * 2007-04-19 2011-05-03 Nutritional Health Institute Laboratories, Llc Composition and method for controlling intestinal pathogenic organisms
US20080260777A1 (en) * 2007-04-19 2008-10-23 Sotomayor Konky Composition and method for controlling intestinal pathogenic organisms
BRPI0818736A2 (pt) * 2007-10-30 2017-06-13 Univ Arkansas composições e métodos para intensificar imunorrepostas à bactéria flagelada
WO2009059298A2 (en) 2007-11-01 2009-05-07 Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancinc immune responses to eimeria
CA2703519C (en) 2007-11-09 2017-04-18 The Salk Institute For Biological Studies Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors
CN102811734B (zh) 2010-01-21 2016-02-10 阿肯色大学评议会 增强免疫应答的疫苗载体和方法
CA2800830C (en) 2010-06-09 2020-09-08 The Board Of Trustees Of The University Of Arkansas Vaccine and methods to reduce campylobacter infection
WO2012123269A1 (en) 2011-03-11 2012-09-20 Proyecto De Biomedicina Cima, S.L. Immunogenic compositions and methods for their use
US8481052B2 (en) 2011-05-17 2013-07-09 Cj Cheiljedang Corporation Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
US9950053B2 (en) 2012-10-22 2018-04-24 The Board Of Regents For Oklahoma State University Use of the Salmonella SPP type III secretion proteins as a protective vaccination
US20150238590A1 (en) * 2012-10-22 2015-08-27 The Board Of Regents For Oklahoma State University Use of the salmonella spp type iii secretion proteins as a protective vaccination
US10548962B2 (en) 2012-10-22 2020-02-04 The Board Of Regents For Oklahoma State University Use of the salmonella SPP type III secretion proteins as a protective vaccination
HUE047484T2 (hu) 2013-02-14 2020-04-28 Univ Arkansas Készítmények és eljárások eimeria elleni immunválasz fokozására vagy eimeria-fertõzés korlátozására
US10376571B2 (en) 2013-03-15 2019-08-13 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to enteric pathogens
US20170333493A1 (en) * 2014-11-11 2017-11-23 Ohio State Innovation Foundation Probiotic bacteria for the prevention and treatment of salmonella
US20170072042A1 (en) * 2015-09-16 2017-03-16 Boehringer Ingelheim Vetmedica, Inc. Salmonella choleraesuis-salmonella typhimurium vaccines
KR20190015712A (ko) 2016-05-03 2019-02-14 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4877612A (en) 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
ES2039229T3 (es) 1986-01-14 1993-09-16 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.
US4806352A (en) 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
SG119177A1 (en) 1994-12-09 2006-02-28 Imp College Innovations Ltd Identification of genes
ATE403728T1 (de) * 1998-09-04 2008-08-15 Emergent Product Dev Uk Ltd Attenuierte salmonella spi2 mutante als antigen- träger
NZ519477A (en) 1999-12-23 2004-04-30 Microscience Ltd Attenuated microorganisms for the treatment of infection
BR0109322A (pt) * 2000-03-17 2002-12-10 Upjohn Co Materiais e métodos de vacina de salmonella

Also Published As

Publication number Publication date
US6923957B2 (en) 2005-08-02
CA2402252A1 (en) 2001-09-27
ZA200207002B (en) 2004-03-31
NZ521425A (en) 2004-05-28
WO2001070247A3 (en) 2002-04-18
AU5695701A (en) 2001-10-03
EP1267899B1 (en) 2005-08-03
DE60112413T2 (de) 2006-06-01
ATE300949T1 (de) 2005-08-15
US20040009191A1 (en) 2004-01-15
DK1267899T3 (da) 2005-12-12
WO2001070247A2 (en) 2001-09-27
BR0109322A (pt) 2002-12-10
JP2003527433A (ja) 2003-09-16
US20050260223A1 (en) 2005-11-24
PT1267899E (pt) 2005-11-30
PE20011180A1 (es) 2001-11-15
DE60112413D1 (de) 2005-09-08
EP1267899A2 (en) 2003-01-02
AU2001256957B2 (en) 2005-08-25
AR027680A1 (es) 2003-04-09
MXPA02008748A (es) 2003-02-24

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